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Journal Articles

Clonal Heterogeneity and Evolution during Treatment in High Hyperdiploid B-Cell Acute Lymphoblastic Leukemia

Margo Aertgeerts, Sofie Demeyer, Jochen Lamote, Jolien De Bie, Lucienne Michaux, Jan Cools, Heidi Segers

Blood (2023) 142 (Supplement 1): 1606.

https://doi.org/10.1182/blood-2023-180760

Published: 2023

Journal Articles

Targeting STAT5B in T-cell acute lymphoblastic leukemia

Alexandra Veloso, Jan Cools

Blood (2023) 142 (3): 215–217.

https://doi.org/10.1182/blood.2023020639

Published: 2023

Journal Articles

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

Marlies Vanden Bempt, Koen Debackere, Sofie Demeyer, Quentin Van Thillo, Nienke Meeuws, Cristina Prieto, Sarah Provost, Nicole Mentens, Kris Jacobs, Olga Gielen, David Nittner, Seishi Ogawa, Keisuke Kataoka, Carlos Graux, Thomas Tousseyn, Jan Cools, Daan Dierickx

Blood (2022) 140 (23): 2463–2476.

https://doi.org/10.1182/blood.2022016428

Published: 2022

Includes: Supplemental data

Journal Articles

A Noncoding Germline Variant Creates a Gain-of-Function De Novo Enhancer That up-Regulates IL5 Transcription to Cause Familial Hypereosinophilia, Revealing a Previously Undescribed Mechanism for Human Disease

Jung-Hyun Kim, Abbie Bowman, Senbagavalli Babu, Jan Cools, Sofie Demeyer, Majid Kazemian, Warren Leonard, Jian-Xin Lin, Michelle Makiya, Mathieu Perez, Colin L. Sweeney, Luis M Franco, Neelam Redekar, Justin Lack, Linda Resar, Amy D Klion

Blood (2022) 140 (Supplement 1): 1399–1400.

https://doi.org/10.1182/blood-2022-169953

Published: 2022

Journal Articles

BETter insight into PRC2-mutated T-ALL

Charles E. de Bock, Jan Cools

Blood (2021) 138 (19): 1787–1788.

https://doi.org/10.1182/blood.2021012677

Published: 2021

Journal Articles

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

Ana Silva, Afonso R. M. Almeida, Ana Cachucho, João L. Neto, Sofie Demeyer, Mafalda de Matos, Thea Hogan, Yunlei Li, Jules Meijerink, Jan Cools, Ana Rita Grosso, Benedict Seddon, João T. Barata

Blood (2021) 138 (12): 1040–1052.

https://doi.org/10.1182/blood.2019000553

Published: 2021

Includes: Supplemental data

Journal Articles

14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia

Blood (2021) 138 (9): 773–784.

https://doi.org/10.1182/blood.2020010510

Published: 2021

Includes: Supplemental data

Journal Articles

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia

Llucia Albertí-Servera, Sofie Demeyer, Inge Govaerts, Toon Swings, Jolien De Bie, Olga Gielen, Marco Brociner, Lucienne Michaux, Johan Maertens, Anne Uyttebroeck, Kim De Keersmaecker, Nancy Boeckx, Heidi Segers, Jan Cools

Blood (2021) 137 (6): 801–811.

https://doi.org/10.1182/blood.2020006996

Published: 2021

Includes: Supplemental data

Journal Articles

Opportunities of Genome Imaging for Genetic Diagnosis in Acute Lymphoblastic Leukemia

Jolien De Bie, MD PhD, Barbara Dewaele, Olga Gielen, Katrina Rack, PhD, Johan A. Maertens, MD PhD, Heidi Segers, MD PhD, Joris Vermeesch, PhD, Kim De Keersmaecker, PhD, Jan Cools, PhD, Lucienne Michaux, MD PhD

Blood (2020) 136 (Supplement 1): 10–11.

https://doi.org/10.1182/blood-2020-139541

Published: 2020

Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 20.

https://doi.org/10.1182/blood-2020-139305

Published: 2020

Journal Articles

FER and FES tyrosine kinase fusions in follicular T-cell lymphoma

Koen Debackere, Jo-Anne van der Krogt, Thomas Tousseyn, Julio Antonio Finalet Ferreiro, Katrien Van Roosbroeck, Lukas Marcelis, Carlos Graux, Daan Dierickx, Geneviève Ameye, Peter Vandenberghe, Lucienne Michaux, Jan Cools, Iwona Wlodarska

Blood (2020) 135 (8): 584–588.

https://doi.org/10.1182/blood.2019002401

Published: 2020

Includes: Supplemental data

Journal Articles

Evolution of Clinically Relevant Subclones during Chemotherapy Treatment of ALL As Determined By Single-Cell DNA and RNA Sequencing

Llucia Albertí Servera, PhD, Sofie Demeyer, PhD, Inge Govaerts, MD PhD, Olga Gielen, Heidi Segers, MD PhD, Anne Uyttebroeck, MD, Nancy Boeckx, Johan A. Maertens, MD PhD, Kim De Keersmaecker, PhD, Jan Cools, PhD

Blood (2019) 134 (Supplement_1): 2749.

https://doi.org/10.1182/blood-2019-123046

Published: 2019

Journal Articles

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Michael Broux, Cristina Prieto, Sofie Demeyer, Marlies Vanden Bempt, Llucia Alberti-Servera, Inge Lodewijckx, Roel Vandepoel, Nicole Mentens, Olga Gielen, Kris Jacobs, Ellen Geerdens, Carmen Vicente, Charles E. de Bock, Jan Cools

Blood (2019) 134 (16): 1323–1336.

https://doi.org/10.1182/blood.2019000015

Published: 2019

Includes: Supplemental data

Journal Articles

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

Blood (2019) 133 (21): 2291–2304.

https://doi.org/10.1182/blood-2018-10-882944

Published: 2019

Includes: Supplemental data

Journal Articles

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Sandrine Degryse, Simon Bornschein, Charles E. de Bock, Emilie Leroy, Marlies Vanden Bempt, Sofie Demeyer, Kris Jacobs, Ellen Geerdens, Olga Gielen, Jean Soulier, Christine J. Harrison, Stefan N. Constantinescu, Jan Cools

Blood (2018) 131 (4): 421–425.

https://doi.org/10.1182/blood-2017-07-797597

Published: 2018

Includes: Supplemental data

Journal Articles

The genetics and molecular biology of T-ALL

Tiziana Girardi, Carmen Vicente, Jan Cools, Kim De Keersmaecker

Blood (2017) 129 (9): 1113–1123.

https://doi.org/10.1182/blood-2016-10-706465

Published: 2017

Journal Articles

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Antonis Dagklis, Sofie Demeyer, Jolien De Bie, Enrico Radaelli, Daphnie Pauwels, Sandrine Degryse, Olga Gielen, Carmen Vicente, Roel Vandepoel, Ellen Geerdens, Anne Uyttebroeck, Nancy Boeckx, Charles E. de Bock, Jan Cools

Blood (2016) 128 (23): 2642–2654.

https://doi.org/10.1182/blood-2016-03-703454

Published: 2016

Includes: Supplemental data

Journal Articles

Benzene-Induced Leukemogenesis: Irreversible Inhibition of PTPN2 and Subsequent STAT1 Signaling Alteration By the Hematotoxic Metabolite Benzoquinone

Romain Duval, Linh-Chi Bui, PhD, Cécile Mathieu, Emile Petit, Jean-Marie Dupret, PhD, Jan Cools, PhD, Fabien Guidez, PhD, Christine Chomienne, MD PhD, Fernando Rodrigues-Lima, PhD

Blood (2015) 126 (23): 3671.

https://doi.org/10.1182/blood.V126.23.3671.3671

Published: 2015

Journal Articles

ALK-Positive Anaplastic Large Cell Lymphoma with the Variant EEF1G-, RNF213- and Atic-ALK Fusions Is Featured By Copy Number Gain of the Rearranged ALK Gene

Iwona Wlodarska, Jo-Anne van der Krogt, Julio Finalet Ferreiro, Jacobs Kris, Geerdens Ellen, Anne Uyttebroeck, Peter Vandenberghe, MDPhD, Thomas Tousseyn, MDPhD, Jan Cools, PhD

Blood (2015) 126 (23): 3654.

https://doi.org/10.1182/blood.V126.23.3654.3654

Published: 2015

Journal Articles

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Blood (2014) 124 (25): 3738–3747.

https://doi.org/10.1182/blood-2014-05-574566

Published: 2014

Includes: Supplemental data

NARROW

Clonal Heterogeneity and Evolution during Treatment in High Hyperdiploid B-Cell Acute Lymphoblastic Leukemia

Targeting STAT5B in T-cell acute lymphoblastic leukemia

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

A Noncoding Germline Variant Creates a Gain-of-Function De Novo Enhancer That up-Regulates IL5 Transcription to Cause Familial Hypereosinophilia, Revealing a Previously Undescribed Mechanism for Human Disease

BETter insight into PRC2-mutated T-ALL

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia

Opportunities of Genome Imaging for Genetic Diagnosis in Acute Lymphoblastic Leukemia

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

FER and FES tyrosine kinase fusions in follicular T-cell lymphoma

Evolution of Clinically Relevant Subclones during Chemotherapy Treatment of ALL As Determined By Single-Cell DNA and RNA Sequencing

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

The genetics and molecular biology of T-ALL

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Benzene-Induced Leukemogenesis: Irreversible Inhibition of PTPN2 and Subsequent STAT1 Signaling Alteration By the Hematotoxic Metabolite Benzoquinone

ALK-Positive Anaplastic Large Cell Lymphoma with the Variant EEF1G-, RNF213- and Atic-ALK Fusions Is Featured By Copy Number Gain of the Rearranged ALK Gene

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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