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Ellen Geerdens
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Journal Articles

Whole-Genome Sequencing Reveals Evidence of Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Myeloma Precursor Disease

Bénedith Oben, Guy Froyen, Kylee H Maclachlan, Binbin Zheng-Lin, MDMSc, Venkata Yellapantula, PhD, Federico Abascal, Daniel A. Leongamornlert, PhD, Andriy Derkach, PhD, Ellen Geerdens, Benjamin Diamond, MD, Ingrid Arijs, Brigitte Maes, Kimberly Vanhees, Malin Hultcrantz, MD PhD, Ahmet Dogan, MD PhD, Yanming Zhang, MD, Aneta Mikulasova, Brian Walker, PhD, Gareth Morgan, MDPhDFRCP, Peter J Campbell, Ola Landgren, MD PhD, Jean-Luc Rummens, Niccolo Bolli, MD PhD, Francesco Maura, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-136403
Published: 2020
Journal Articles

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Michael Broux, Cristina Prieto, Sofie Demeyer, Marlies Vanden Bempt, Llucia Alberti-Servera, Inge Lodewijckx, Roel Vandepoel, Nicole Mentens, Olga Gielen, Kris Jacobs, Ellen Geerdens, Carmen Vicente, Charles E. de Bock, Jan Cools
Journal: Blood
Blood (2019) 134 (16): 1323–1336.
https://doi.org/10.1182/blood.2019000015
Published: 2019
Includes: Supplemental data
Journal Articles

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Brief Report
Sandrine Degryse, Simon Bornschein, Charles E. de Bock, Emilie Leroy, Marlies Vanden Bempt, Sofie Demeyer, Kris Jacobs, Ellen Geerdens, Olga Gielen, Jean Soulier, Christine J. Harrison, Stefan N. Constantinescu, Jan Cools
Journal: Blood
Blood (2018) 131 (4): 421–425.
https://doi.org/10.1182/blood-2017-07-797597
Published: 2018
Includes: Supplemental data
Journal Articles

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Antonis Dagklis, Sofie Demeyer, Jolien De Bie, Enrico Radaelli, Daphnie Pauwels, Sandrine Degryse, Olga Gielen, Carmen Vicente, Roel Vandepoel, Ellen Geerdens, Anne Uyttebroeck, Nancy Boeckx, Charles E. de Bock, Jan Cools
Journal: Blood
Blood (2016) 128 (23): 2642–2654.
https://doi.org/10.1182/blood-2016-03-703454
Published: 2016
Includes: Supplemental data
Journal Articles

RPL5 Is a Candidate Tumor Suppressor on 1p22.1 in Multiple Myeloma of Which the Expression Is Linked to Bortezomib Response

Isabel JF Hofman, Mark van Duin, PhD, George Mulligan, PhD, Ellen Geerdens, Emanuela Garelli, Cecilia Mancini, Heidi Lemmens, Michel Delforge, Peter Vandenberghe, MDPhD, Iwona Wlodarska, Anna Aspesi, Lucienne Michaux, Pieter Sonneveld, MD PhD, Kim De Keersmaecker
Journal: Blood
Blood (2015) 126 (23): 2969.
https://doi.org/10.1182/blood.V126.23.2969.2969
Published: 2015
Journal Articles

JAK3 Mutants Transform Hematopoietic Cells through JAK1 Activation Causing T-Cell Acute Lymphoblastic Leukemia in a Bone Marrow Transplant Mouse Model

Degryse Sandrine, Charles E de Bock, PhD, Carmen Vicente, PhD, Luk Cox, PhD, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Thomas Tousseyn, PhD, Jan Cools, PhD
Journal: Blood
Blood (2014) 124 (21): 361.
https://doi.org/10.1182/blood.V124.21.361.361
Published: 2014
Journal Articles

Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes

Marlies Vanden Bempt, Msc, Charles E de Bock, PhD, Nicole Mentens, Olga Gielen, Ellen Geerdens, Sofie Demeyer, PhD, Jan Cools, PhD
Journal: Blood
Blood (2014) 124 (21): 3575.
https://doi.org/10.1182/blood.V124.21.3575.3575
Published: 2014
Journal Articles

The NOTCH1 Driven Long Non-Coding RNA Repertoire in T-Cell Acute Lymphoblastic Leukemia

Annelynn Wallaert, Kaat Durinck, Pieter Rondou, PhD, Inge van de Walle, Wouter Vanloocke, Pieter-Jan Volders, Suzanne Vanhauwaert, Ellen Geerdens, Maté Ongenaert, Nadine Van Roy, Bruce Graham Poppe, MD PhD, Yves Benoit, Jan Cools, PhD, Jo Vandesompele, PhD, Jean Soulier, MD PhD, Pieter Van Vlierberghe, Tom Taghon, PhD, Frank Speleman
Journal: Blood
Blood (2014) 124 (21): 900.
https://doi.org/10.1182/blood.V124.21.900.900
Published: 2014
Journal Articles

Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model

Charles E de Bock, PhD, Sandrine Degryse, Sofie Demeyer, PhD, Bram Sweron, Olga Gielen, Nicole Mentens, Ellen Geerdens, Jan Cools, PhD
Journal: Blood
Blood (2014) 124 (21): 1078.
https://doi.org/10.1182/blood.V124.21.1078.1078
Published: 2014
Journal Articles

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Sandrine Degryse, Charles E. de Bock, Luk Cox, Sofie Demeyer, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Valentina Gianfelici, Gert Hulselmans, Mark Fiers, Stein Aerts, Jules P. Meijerink, Thomas Tousseyn, Jan Cools
Journal: Blood
Blood (2014) 124 (20): 3092–3100.
https://doi.org/10.1182/blood-2014-04-566687
Published: 2014
Includes: Supplemental data
Journal Articles

Whole Transcriptome Sequencing In Refractory T-Cell Acute Lymphoblastic Leukemia

Valentina Gianfelici, Sabina Chiaretti, Zeynep Kalender Atak, Fulvia Brugnoletti, Messina Monica, Gert Hulselmans, Kim de Keersmaecker, Ellen Geerdens, Marco Mancini, Antonella Vitale, Loredana Elia, Mabel Matarazzo, Davide Rossi, Gianluca Gaidano, Anna Guarini, Stein Aerts, Jan Cools, Robin Foà
Journal: Blood
Blood (2013) 122 (21): 350.
https://doi.org/10.1182/blood.V122.21.350.350
Published: 2013
Journal Articles

Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia

Brief Report
Michaël Porcu, Maria Kleppe, Valentina Gianfelici, Ellen Geerdens, Kim De Keersmaecker, Marco Tartaglia, Robin Foà, Jean Soulier, Barbara Cauwelier, Anne Uyttebroeck, Elizabeth Macintyre, Peter Vandenberghe, Vahid Asnafi, Jan Cools
Journal: Blood
Blood (2012) 119 (19): 4476–4479.
https://doi.org/10.1182/blood-2011-09-379958
Published: 2012
Includes: Supplemental data