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Charles E. de Bock
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Journal Articles

The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia

Richard B. Lock, Cara E Toscan, Hannah McCalmont, Kathryn Evans, Louise Doculara, Hansen J Kosasih, Andrew J Gifford, Amir Ashoorzadeh, Xiaojing Lin, Toby N Trahair, Charles E De Bock, Adam V Patterson, Jeff B Smaill
Journal: Blood
Blood (2023) 142 (Supplement 1): 4251.
https://doi.org/10.1182/blood-2023-181298
Published: 2023
Journal Articles

BETter insight into PRC2-mutated T-ALL

Charles E. de Bock, Jan Cools
Journal: Blood
Blood (2021) 138 (19): 1787–1788.
https://doi.org/10.1182/blood.2021012677
Published: 2021
Journal Articles

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Michael Broux, Cristina Prieto, Sofie Demeyer, Marlies Vanden Bempt, Llucia Alberti-Servera, Inge Lodewijckx, Roel Vandepoel, Nicole Mentens, Olga Gielen, Kris Jacobs, Ellen Geerdens, Carmen Vicente, Charles E. de Bock, Jan Cools
Journal: Blood
Blood (2019) 134 (16): 1323–1336.
https://doi.org/10.1182/blood.2019000015
Published: 2019
Includes: Supplemental data
Journal Articles

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Brief Report
Sandrine Degryse, Simon Bornschein, Charles E. de Bock, Emilie Leroy, Marlies Vanden Bempt, Sofie Demeyer, Kris Jacobs, Ellen Geerdens, Olga Gielen, Jean Soulier, Christine J. Harrison, Stefan N. Constantinescu, Jan Cools
Journal: Blood
Blood (2018) 131 (4): 421–425.
https://doi.org/10.1182/blood-2017-07-797597
Published: 2018
Includes: Supplemental data
Journal Articles

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Antonis Dagklis, Sofie Demeyer, Jolien De Bie, Enrico Radaelli, Daphnie Pauwels, Sandrine Degryse, Olga Gielen, Carmen Vicente, Roel Vandepoel, Ellen Geerdens, Anne Uyttebroeck, Nancy Boeckx, Charles E. de Bock, Jan Cools
Journal: Blood
Blood (2016) 128 (23): 2642–2654.
https://doi.org/10.1182/blood-2016-03-703454
Published: 2016
Includes: Supplemental data
Journal Articles

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie Peirs, Filip Matthijssens, Steven Goossens, Inge Van de Walle, Katia Ruggero, Charles E. de Bock, Sandrine Degryse, Kirsten Canté-Barrett, Delphine Briot, Emmanuelle Clappier, Tim Lammens, Barbara De Moerloose, Yves Benoit, Bruce Poppe, Jules P. Meijerink, Jan Cools, Jean Soulier, Terence H. Rabbitts, Tom Taghon, Frank Speleman, Pieter Van Vlierberghe
Journal: Blood
Blood (2014) 124 (25): 3738–3747.
https://doi.org/10.1182/blood-2014-05-574566
Published: 2014
Includes: Supplemental data
Journal Articles

JAK3 Mutants Transform Hematopoietic Cells through JAK1 Activation Causing T-Cell Acute Lymphoblastic Leukemia in a Bone Marrow Transplant Mouse Model

Degryse Sandrine, Charles E de Bock, PhD, Carmen Vicente, PhD, Luk Cox, PhD, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Thomas Tousseyn, PhD, Jan Cools, PhD
Journal: Blood
Blood (2014) 124 (21): 361.
https://doi.org/10.1182/blood.V124.21.361.361
Published: 2014
Journal Articles

Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes

Marlies Vanden Bempt, Msc, Charles E de Bock, PhD, Nicole Mentens, Olga Gielen, Ellen Geerdens, Sofie Demeyer, PhD, Jan Cools, PhD
Journal: Blood
Blood (2014) 124 (21): 3575.
https://doi.org/10.1182/blood.V124.21.3575.3575
Published: 2014
Journal Articles

Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model

Charles E de Bock, PhD, Sandrine Degryse, Sofie Demeyer, PhD, Bram Sweron, Olga Gielen, Nicole Mentens, Ellen Geerdens, Jan Cools, PhD
Journal: Blood
Blood (2014) 124 (21): 1078.
https://doi.org/10.1182/blood.V124.21.1078.1078
Published: 2014
Journal Articles

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Sandrine Degryse, Charles E. de Bock, Luk Cox, Sofie Demeyer, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Valentina Gianfelici, Gert Hulselmans, Mark Fiers, Stein Aerts, Jules P. Meijerink, Thomas Tousseyn, Jan Cools
Journal: Blood
Blood (2014) 124 (20): 3092–3100.
https://doi.org/10.1182/blood-2014-04-566687
Published: 2014
Includes: Supplemental data