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Journal Articles

The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia

Richard B. Lock, Cara E Toscan, Hannah McCalmont, Kathryn Evans, Louise Doculara, Hansen J Kosasih, Andrew J Gifford, Amir Ashoorzadeh, Xiaojing Lin, Toby N Trahair, Charles E De Bock, Adam V Patterson, Jeff B Smaill

Blood (2023) 142 (Supplement 1): 4251.

https://doi.org/10.1182/blood-2023-181298

Published: 2023

Journal Articles

STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia

Cedric S. Tremblay, Jesslyn Saw, Jacqueline A. Boyle, Katharina Haigh, Veronique Litalien, Hannah McCalmont, Kathryn Evans, Richard B. Lock, Stephen M. Jane, Jody J. Haigh, David J. Curtis

Blood (2023) 142 (3): 274–289.

https://doi.org/10.1182/blood.2022016322

Published: 2023

Includes: Supplemental data

Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia

Richard B Lock, Kathryn Evans, Joanna Randall, Stephen W Erickson, Eric J Earley, Steven Neuhauser, Tim Stearns, Vivek Philip, Beverly A Teicher, Krystal Watkins, Callum M Sloss, Patrick A Zweidler-McKay, Malcolm A Smith

Blood (2022) 140 (Supplement 1): 8983–8984.

https://doi.org/10.1182/blood-2022-159867

Published: 2022

Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the MCL1 Inhibitor, AMG 176, Against Xenograft Models of Acute Lymphoblastic Leukemia

Richard B Lock, Kathryn Evans, Ben Watts, Joanna Randall, Cara E Toscan, Eric J Earley, Stephen W Erickson, Brian Belmontes, Philip Wong, Beverly A Teicher, Paul E Hughes, Malcolm A Smith

Blood (2022) 140 (Supplement 1): 11690–11691.

https://doi.org/10.1182/blood-2022-159885

Published: 2022

Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

Richard B. Lock, PhD, Kathryn Evans, Connor D Jones, Narimanne El-Zein, Katerina Bendak, PhD, Cara E Toscan, PhD, Chelsea Mayoh, Stephen W Erickson, PhD, Beverly A Teicher, PhD, Malcolm A Smith, MD PhD

Blood (2019) 134 (Supplement_1): 3875.

https://doi.org/10.1182/blood-2019-123867

Published: 2019

Journal Articles

A Single Mouse Trial Platform for Evaluation of Novel Agents in Acute Lymphoblastic Leukemia By the Pediatric Preclinical Testing Consortium

Richard B. Lock, PhD, Kathryn Evans, Tara Pritchard, Cara Toscan, Chelsea Mayoh, Beverly Teicher, Raushan T Kurmasheva, Peter J Houghton, Malcolm Smith, MD PhD

Blood (2018) 132 (Supplement 1): 4010.

https://doi.org/10.1182/blood-2018-99-113207

Published: 2018

Journal Articles

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

Seong Lin Khaw, Santi Suryani, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Raushan T. Kurmasheva, Catherine A. Billups, Stephen W. Erickson, Yuelong Guo, Peter J. Houghton, Malcolm A. Smith, Hernan Carol, Andrew W. Roberts, David C. S. Huang, Richard B. Lock

Blood (2016) 128 (10): 1382–1395.

https://doi.org/10.1182/blood-2016-03-707414

Published: 2016

Includes: Supplemental data

Journal Articles

Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia

Michelle L. Churchman, PhD, Luke Jones, BSc(Hons), Kathryn Evans, BSc(Hons), Jennifer Richmond, BSc(Hons), Irina M Shapiro, PhD, Jonathan A. Pachter, PhD, David T. Weaver, PhD, Peter J Houghton, PhD, Malcolm A. Smith, MD PhD, Richard B Lock, PhD, Charles G. Mullighan, MBBS, MSc, MD

Blood (2015) 126 (23): 3766.

https://doi.org/10.1182/blood.V126.23.3766.3766

Published: 2015

Journal Articles

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

Donya Moradi Manesh, Jad El-Hoss, Kathryn Evans, Jennifer Richmond, Cara E. Toscan, Lauryn S. Bracken, Ashlee Hedrick, Rosemary Sutton, Glenn M. Marshall, William R. Wilson, Raushan T. Kurmasheva, Catherine Billups, Peter J. Houghton, Malcolm A. Smith, Hernan Carol, Richard B. Lock

Blood (2015) 126 (10): 1193–1202.

https://doi.org/10.1182/blood-2014-12-618900

Published: 2015

Includes: Supplemental data

Journal Articles

Effective Targeting Of The P53/MDM2 Axis In Preclinical Models Of Infant MLL-Rearranged Acute Lymphoblastic Leukemia

Richard B Lock, PhD, Jennifer Richmond, BSc (Hons), Laura High, PhD, Hernan Carol, PhD, Kathryn Evans, BSc (Hons), Agnes M. Mendomo, MSc, Raushan T. Kurmasheva, PhD, Peter J. Houghton, PhD, Malcolm A. Smith, MD, PhD

Blood (2013) 122 (21): 71.

https://doi.org/10.1182/blood.V122.21.71.71

Published: 2013

Journal Articles

Dual Inhibition of JAK/STAT and MAPK Pathways Results in Synergistic Cell Killing of JAK-Mutated Pediatric Acute Lymphoblastic Leukemia

Santi Suryani, PhD, Keith CS Sia, Lauryn Bracken, Hernan Carol, PhD, Kathryn Evans, Raushan Kurmasheva, PhD, Peter J. Houghton, PhD, Malcolm A. Smith, MD, PhD, Richard B. Lock, PhD

Blood (2012) 120 (21): 3562.

https://doi.org/10.1182/blood.V120.21.3562.3562

Published: 2012

Journal Articles

Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNFα and Synergizes with TNFα in Vitro – A Report From the Pediatric Preclinical Testing Program (PPTP)

Malcolm A. Smith, MD, PhD, Hernan Carol, PhD, Kathryn Evans, Jennifer Richmond, Min Kang, PhD, C. Patrick Reynolds, MD, PhD, Srinivas Chunduru, PhD, Martin A. Graham, PhD, Brian Geier, M.Sc., Raushan Kurmasheva, PhD, Peter J. Houghton, PhD, Richard B. Lock, PhD

Blood (2012) 120 (21): 3565.

https://doi.org/10.1182/blood.V120.21.3565.3565

Published: 2012

NARROW

The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia

STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia

Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia

Pediatric Preclinical Testing Consortium Evaluation of the MCL1 Inhibitor, AMG 176, Against Xenograft Models of Acute Lymphoblastic Leukemia

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

A Single Mouse Trial Platform for Evaluation of Novel Agents in Acute Lymphoblastic Leukemia By the Pediatric Preclinical Testing Consortium

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

Effective Targeting Of The P53/MDM2 Axis In Preclinical Models Of Infant MLL-Rearranged Acute Lymphoblastic Leukemia

Dual Inhibition of JAK/STAT and MAPK Pathways Results in Synergistic Cell Killing of JAK-Mutated Pediatric Acute Lymphoblastic Leukemia

Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNFα and Synergizes with TNFα in Vitro – A Report From the Pediatric Preclinical Testing Program (PPTP)

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American Society of Hematology

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ASH Publications

American Society of Hematology

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