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Journal Articles

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

Seong Lin Khaw, Santi Suryani, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Raushan T. Kurmasheva, Catherine A. Billups, Stephen W. Erickson, Yuelong Guo, Peter J. Houghton, Malcolm A. Smith, Hernan Carol, Andrew W. Roberts, David C. S. Huang, Richard B. Lock
Journal: Blood
Blood (2016) 128 (10): 1382–1395.
https://doi.org/10.1182/blood-2016-03-707414
Published: 2016
Includes: Supplemental data
Journal Articles

Evaluation of Patient-Derived Xenografts for Modeling Outcome of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Abdulmohsen M Alruwetei, Msc, Hernan Carol, PhD, Rosemary Sutton, PhD, Glenn M Marshall, MBBS, MD FRACP, Richard B Lock, PhD
Journal: Blood
Blood (2015) 126 (23): 3759.
https://doi.org/10.1182/blood.V126.23.3759.3759
Published: 2015
Journal Articles

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

Donya Moradi Manesh, Jad El-Hoss, Kathryn Evans, Jennifer Richmond, Cara E. Toscan, Lauryn S. Bracken, Ashlee Hedrick, Rosemary Sutton, Glenn M. Marshall, William R. Wilson, Raushan T. Kurmasheva, Catherine Billups, Peter J. Houghton, Malcolm A. Smith, Hernan Carol, Richard B. Lock
Journal: Blood
Blood (2015) 126 (10): 1193–1202.
https://doi.org/10.1182/blood-2014-12-618900
Published: 2015
Includes: Supplemental data
Journal Articles

Effective Targeting Of The P53/MDM2 Axis In Preclinical Models Of Infant MLL-Rearranged Acute Lymphoblastic Leukemia

Richard B Lock, PhD, Jennifer Richmond, BSc (Hons), Laura High, PhD, Hernan Carol, PhD, Kathryn Evans, BSc (Hons), Agnes M. Mendomo, MSc, Raushan T. Kurmasheva, PhD, Peter J. Houghton, PhD, Malcolm A. Smith, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 71.
https://doi.org/10.1182/blood.V122.21.71.71
Published: 2013
Journal Articles

Dual Inhibition of JAK/STAT and MAPK Pathways Results in Synergistic Cell Killing of JAK-Mutated Pediatric Acute Lymphoblastic Leukemia

Santi Suryani, PhD, Keith CS Sia, Lauryn Bracken, Hernan Carol, PhD, Kathryn Evans, Raushan Kurmasheva, PhD, Peter J. Houghton, PhD, Malcolm A. Smith, MD, PhD, Richard B. Lock, PhD
Journal: Blood
Blood (2012) 120 (21): 3562.
https://doi.org/10.1182/blood.V120.21.3562.3562
Published: 2012
Journal Articles

Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNFα and Synergizes with TNFα in Vitro – A Report From the Pediatric Preclinical Testing Program (PPTP)

Malcolm A. Smith, MD, PhD, Hernan Carol, PhD, Kathryn Evans, Jennifer Richmond, Min Kang, PhD, C. Patrick Reynolds, MD, PhD, Srinivas Chunduru, PhD, Martin A. Graham, PhD, Brian Geier, M.Sc., Raushan Kurmasheva, PhD, Peter J. Houghton, PhD, Richard B. Lock, PhD
Journal: Blood
Blood (2012) 120 (21): 3565.
https://doi.org/10.1182/blood.V120.21.3565.3565
Published: 2012
Journal Articles

Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104

Juliana Benito, Ph.D., Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Bohem, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy Fang, Steven M. Kornblau, MD, Patrick Zweidler-McKay, MD, PhD, William Wilson, PhD, Dario Campana, MD, PhD, Gautam Borthakur, MD, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, MD, Elizabeth J. Shpall, Deborah A Thomas, MD, Craig T. Jordan, PhD, Richard B Lock, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 868.
https://doi.org/10.1182/blood.V116.21.868.868
Published: 2010