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Richard B Lock
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Journal Articles

The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia

Richard B. Lock, Cara E Toscan, Hannah McCalmont, Kathryn Evans, Louise Doculara, Hansen J Kosasih, Andrew J Gifford, Amir Ashoorzadeh, Xiaojing Lin, Toby N Trahair, Charles E De Bock, Adam V Patterson, Jeff B Smaill
Journal: Blood
Blood (2023) 142 (Supplement 1): 4251.
https://doi.org/10.1182/blood-2023-181298
Published: 2023
Journal Articles

Targeting Bone Marrow Microenvironment for Treatment of High-Risk B-Cell Acute Lymphoblastic Leukemia

Laurence C Cheung, Sarah Trinder, Anastasia Hughes, Benjamin Mullin, Sarah Rashid, Jinbo Yuan, Jiake Xu, Owen Duncan, Richard B. Lock, Sebastien Malinge, Vincent Kuek, Rishi Sury Kotecha
Journal: Blood
Blood (2023) 142 (Supplement 1): 2709.
https://doi.org/10.1182/blood-2023-173503
Published: 2023
Journal Articles

STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia

Cedric S. Tremblay, Jesslyn Saw, Jacqueline A. Boyle, Katharina Haigh, Veronique Litalien, Hannah McCalmont, Kathryn Evans, Richard B. Lock, Stephen M. Jane, Jody J. Haigh, David J. Curtis
Journal: Blood
Blood (2023) 142 (3): 274–289.
https://doi.org/10.1182/blood.2022016322
Published: 2023
Includes: Supplemental data
Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Anti-CD123 Antibody-Drug Conjugate, IMGN632, Against Patient-Derived Xenograft Models of Pediatric Acute Lymphoblastic Leukemia

Richard B Lock, Kathryn Evans, Joanna Randall, Stephen W Erickson, Eric J Earley, Steven Neuhauser, Tim Stearns, Vivek Philip, Beverly A Teicher, Krystal Watkins, Callum M Sloss, Patrick A Zweidler-McKay, Malcolm A Smith
Journal: Blood
Blood (2022) 140 (Supplement 1): 8983–8984.
https://doi.org/10.1182/blood-2022-159867
Published: 2022
Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the MCL1 Inhibitor, AMG 176, Against Xenograft Models of Acute Lymphoblastic Leukemia

Richard B Lock, Kathryn Evans, Ben Watts, Joanna Randall, Cara E Toscan, Eric J Earley, Stephen W Erickson, Brian Belmontes, Philip Wong, Beverly A Teicher, Paul E Hughes, Malcolm A Smith
Journal: Blood
Blood (2022) 140 (Supplement 1): 11690–11691.
https://doi.org/10.1182/blood-2022-159885
Published: 2022
Journal Articles

Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Peter Truong, Sylvie Shen, Swapna Joshi, Ali Afrasiabi, Ling Zhong, Mark J. Raftery, Jonas Larsson, Richard B. Lock, Carl R. Walkley, Hamid Alinejad Rokny, Julie A.I. Thoms, Christopher J. Jolly, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 220–221.
https://doi.org/10.1182/blood-2022-165713
Published: 2022
Journal Articles

A Novel Engineered Single-Chain Antibody Fragment for Targeting Pediatric Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Sara M.A. Mohamed, Keith Sia, PhD, Karl-Heinz Friedrich, PhD, Andreas Wohlmann, Dr, Savvas Savvides, PhD, Peter Schofield, PhD, Daniel Christ, PhD, Maria Kavallaris, PhD, Richard B. Lock, PhD, Narges Bayat, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36.
https://doi.org/10.1182/blood-2020-138421
Published: 2020
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

Richard B. Lock, PhD, Kathryn Evans, Connor D Jones, Narimanne El-Zein, Katerina Bendak, PhD, Cara E Toscan, PhD, Chelsea Mayoh, Stephen W Erickson, PhD, Beverly A Teicher, PhD, Malcolm A Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3875.
https://doi.org/10.1182/blood-2019-123867
Published: 2019
Journal Articles

A Single Mouse Trial Platform for Evaluation of Novel Agents in Acute Lymphoblastic Leukemia By the Pediatric Preclinical Testing Consortium

Richard B. Lock, PhD, Kathryn Evans, Tara Pritchard, Cara Toscan, Chelsea Mayoh, Beverly Teicher, Raushan T Kurmasheva, Peter J Houghton, Malcolm Smith, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4010.
https://doi.org/10.1182/blood-2018-99-113207
Published: 2018
Journal Articles

Comparison of MRD Levels and Gene Expression Patterns in MLL-R Versus Non-MLL Infant ALL

Rosemary Sutton, PhD, Tamara Law, BSc (Hons), Nicola C Venn, BSc (Hons), Carol Wadham, PhD, Emily VA Mould, PhD, Murray D Norris, PhD, Rishi S Kotecha, MB ChB FRACP PhD, Rolf Marschalek, PhD, Claus Meyer, PhD, Luciano Dalla-Pozza, MB BS FRACP, Glenn M Marshall, MBBS, MD FRACP, Richard B Lock, PhD, Toby N. Trahair, MBBS FRACP PhD
Journal: Blood
Blood (2016) 128 (22): 1740.
https://doi.org/10.1182/blood.V128.22.1740.1740
Published: 2016
Journal Articles

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

Seong Lin Khaw, Santi Suryani, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Raushan T. Kurmasheva, Catherine A. Billups, Stephen W. Erickson, Yuelong Guo, Peter J. Houghton, Malcolm A. Smith, Hernan Carol, Andrew W. Roberts, David C. S. Huang, Richard B. Lock
Journal: Blood
Blood (2016) 128 (10): 1382–1395.
https://doi.org/10.1182/blood-2016-03-707414
Published: 2016
Includes: Supplemental data
Journal Articles

Investigation of a Novel Cyclin-Dependent-Kinase (CDK) Inhibitor Cdki-73 As an Effective Treatment Option for MLL-AML

Ka Leung Li, BSc (Hons), Sarah C Bray, PhD, Diana Iarossi, BSc (Hons), Julian Adams, PhD, Longjin Zhong, Ben Noll, BSc (Hons), Muhammed H Rahaman, BSc (Hons), Jennifer Richmond, BSc(Hons), Luen Bik To, MBBS, PhD, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Richard B Lock, PhD, Shudong Wang, PhD, Richard J D'Andrea, PhD
Journal: Blood
Blood (2015) 126 (23): 1365.
https://doi.org/10.1182/blood.V126.23.1365.1365
Published: 2015
Journal Articles

Evaluation of Patient-Derived Xenografts for Modeling Outcome of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Abdulmohsen M Alruwetei, Msc, Hernan Carol, PhD, Rosemary Sutton, PhD, Glenn M Marshall, MBBS, MD FRACP, Richard B Lock, PhD
Journal: Blood
Blood (2015) 126 (23): 3759.
https://doi.org/10.1182/blood.V126.23.3759.3759
Published: 2015
Journal Articles

Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia

Michelle L. Churchman, PhD, Luke Jones, BSc(Hons), Kathryn Evans, BSc(Hons), Jennifer Richmond, BSc(Hons), Irina M Shapiro, PhD, Jonathan A. Pachter, PhD, David T. Weaver, PhD, Peter J Houghton, PhD, Malcolm A. Smith, MD PhD, Richard B Lock, PhD, Charles G. Mullighan, MBBS, MSc, MD
Journal: Blood
Blood (2015) 126 (23): 3766.
https://doi.org/10.1182/blood.V126.23.3766.3766
Published: 2015
Journal Articles

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

Donya Moradi Manesh, Jad El-Hoss, Kathryn Evans, Jennifer Richmond, Cara E. Toscan, Lauryn S. Bracken, Ashlee Hedrick, Rosemary Sutton, Glenn M. Marshall, William R. Wilson, Raushan T. Kurmasheva, Catherine Billups, Peter J. Houghton, Malcolm A. Smith, Hernan Carol, Richard B. Lock
Journal: Blood
Blood (2015) 126 (10): 1193–1202.
https://doi.org/10.1182/blood-2014-12-618900
Published: 2015
Includes: Supplemental data
Journal Articles

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

Shannon L. Maude, Sibasish Dolai, Cristina Delgado-Martin, Tiffaney Vincent, Alissa Robbins, Arthavan Selvanathan, Theresa Ryan, Junior Hall, Andrew C. Wood, Sarah K. Tasian, Stephen P. Hunger, Mignon L. Loh, Charles G. Mullighan, Brent L. Wood, Michelle L. Hermiston, Stephan A. Grupp, Richard B. Lock, David T. Teachey
Journal: Blood
Blood (2015) 125 (11): 1759–1767.
https://doi.org/10.1182/blood-2014-06-580480
Published: 2015
Includes: Supplemental data
Journal Articles

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Duohui Jing, Vivek A. Bhadri, Dominik Beck, Julie A. I. Thoms, Nurul A. Yakob, Jason W. H. Wong, Kathy Knezevic, John E. Pimanda, Richard B. Lock
Journal: Blood
Blood (2015) 125 (2): 273–283.
https://doi.org/10.1182/blood-2014-05-576470
Published: 2015
Includes: Supplemental data
Journal Articles

5-Aza-2'-Deoxycytidine Promotes Cytotoxic Effect of CART-Cells on Leukaemia Cells

Alla Dolnikov, PhD, Swapna Rossi, Ning Xu, PhD, Guy Klamer, PhD, Sylvie Shen, PhD, Kenneth P. Micklethwaite, MD PhD, Richard B Lock, PhD, Tracey O'Brien, MD
Journal: Blood
Blood (2014) 124 (21): 5812.
https://doi.org/10.1182/blood.V124.21.5812.5812
Published: 2014
Journal Articles

Identifying the Factors Modulating the Efficacy of CAR-T Cell Therapy

Alla Dolnikov, PhD, Guy Klamer, PhD, Arjanna Chitranjan, Ning Xu, PhD, Sylvie Shen, PhD, Kenneth P. Micklethwaite, MD PhD, Richard B. Lock, PhD, Tracey O'Brien, MD
Journal: Blood
Blood (2014) 124 (21): 5813.
https://doi.org/10.1182/blood.V124.21.5813.5813
Published: 2014