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Journal Articles

Overcoming Ven/Aza Resistance through Imetelstat-Mediated Lipophagy in Acute Myeloid Leukemia

Claudia Bruedigam, Eunice Anne Dulatre, Carol Lee, Amy H Porter, Elisa LSP Lim, Alexander Z Shi, Mark P Hodson, Florian H. Heidel, Steven W Lane

Blood (2024) 144 (Supplement 1): 52.

https://doi.org/10.1182/blood-2024-206473

Published: 2024

Journal Articles

Dnmt3a Mutation Promotes Expansion of a Quiescent Myeloid Progenitor Population in Npm1 c -Flt3 ITD Acute Myeloid Leukemia

Paniz Tavakoli, Megan Bywater, Jasmin Straube, Victoria Ling, Emily Cooper, Rohit Haldar, Yashaswini Janardhanan, Leanne Cooper, Claudia Bruedigam, Carolyn S. Grove, Steven W Lane

Blood (2024) 144 (Supplement 1): 1347.

https://doi.org/10.1182/blood-2024-201250

Published: 2024

Journal Articles

Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging

Claudia Bruedigam, Amy H Porter, Jasmin Straube, Guidan Cheng, Florian H Heidel, Steven W Lane

Blood (2023) 142 (Supplement 1): 5598.

https://doi.org/10.1182/blood-2023-191246

Published: 2023

Journal Articles

Imetelstat-Mediated Alterations in Lipid Metabolism to Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

Blood (2022) 140 (Supplement 1): 487–488.

https://doi.org/10.1182/blood-2022-168166

Published: 2022

Journal Articles

Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia

Victoria Y Ling, Sebastien Jacquelin, Jasmin Straube, Rohit Haldar, Yashaswini Janardhanan, Leanne T Cooper, Claudia Bruedigam, Emily Cooper, William Godfrey, Siok-Keen Tey, Lars Bullinger, Marco J Herold, Jonathan Baell, Megan Bywater, Steven W Lane

Blood (2021) 138 (Supplement 1): 2241.

https://doi.org/10.1182/blood-2021-148379

Published: 2021

Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Blood (2021) 137 (20): 2721–2735.

https://doi.org/10.1182/blood.2020010167

Published: 2021

Includes: Supplemental data

Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Blood (2019) 134 (Supplement_1): 531.

https://doi.org/10.1182/blood-2019-121996

Published: 2019

Journal Articles

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Victoria Y Ling, MBBS, William Godfrey, Sebastien Jacquelin, PhD, Jasmin Straube, PhD, Leanne T Cooper, Claudia Bruedigam, PhD, Siok-Keen Tey, MBBS PhDFRACP FRCPA, Lars Bullinger, MD, Marco J Herold, Megan Bywater, PhD, Steven W. Lane, MD PhD

Blood (2018) 132 (Supplement 1): 2771.

https://doi.org/10.1182/blood-2018-99-115729

Published: 2018

Journal Articles

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

Claudia Bruedigam, Amy H Porter, Brad Wackrow, Jasmin Straube, PhD, Leanne T Cooper, Axia Song, Stanley Chun-Wei Lee, PhD, Omar Abdel-Wahab, MD, Geoffrey R Hill, MD, Steven W. Lane, MD PhD

Blood (2017) 130 (Supplement 1): 798.

https://doi.org/10.1182/blood.V130.Suppl_1.798.798

Published: 2017

Journal Articles

The Preclinical Efficacy of a Novel Telomerase Inhibitor, Imetelstat, in AML - a Randomized Trial in Patient-Derived Xenografts

Claudia Bruedigam, PhD, Brad Wackrow, Axia Song, Amy H Porter, Stanley Chun-Wei Lee, PhD, Andrew S. Moore, MBBS FRACP PhD, Omar Abdel-Wahab, MD, Steven W Lane, PhD

Blood (2016) 128 (22): 578.

https://doi.org/10.1182/blood.V128.22.578.578

Published: 2016

Journal Articles

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

Sebastien Jacquelin, PhD, Emma Dishington, Therese Vu, Axia Song, Matthew Heidecker, Solene Guignes, Claudia Bruedigam, PhD, Joanne Sutton, Geoffrey R Hill, MD PhD, Nicole Cloonan, PhD, Dirk Heckl, PhD, Steven W Lane, PhD

Blood (2016) 128 (22): 794.

https://doi.org/10.1182/blood.V128.22.794.794

Published: 2016

Journal Articles

Cdx2 Cooperates with Flt3-ITD to Induce Acute Myeloid Leukaemia in Mice

Therese Vu, BSc, Claudia Bruedigam, Axia Song, Solene Guignes, Rebecca Austin, Sebastien Jacquelin, Alistair Chalk, Carl Walkley, PhD BPharm, Claudia Scholl, Stefan Fröhling, MD, Steven W. Lane, MD

Blood (2015) 126 (23): 557.

https://doi.org/10.1182/blood.V126.23.557.557

Published: 2015

Journal Articles

Autophagy is required for stem cell mobilization by G-CSF

Lucie Leveque-El Mouttie, Therese Vu, Katie E. Lineburg, Rachel D. Kuns, Frederik O. Bagger, Bianca E. Teal, Mary Lor, Glen M. Boyle, Claudia Bruedigam, Justine D. Mintern, Geoffrey R. Hill, Kelli P. A. MacDonald, Steven W. Lane

Blood (2015) 125 (19): 2933–2936.

https://doi.org/10.1182/blood-2014-03-562660

Published: 2015

Includes: Supplemental data

Journal Articles

Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)

Claudia Bruedigam, Frederik Otzen Bagger, Florian H Heidel, MD, Catherine Kuhn, Solene Guignes, Axia Song, Rebecca Austin, Therese Vu, Erwin M Lee, PhD, Andrew S. Moore, MBBS, FRACP, PhD, Richard B. Lock, PhD, Lars Bullinger, MD PhD, Geoff R Hill, MD, Steven W Lane, MD PhD

Blood (2014) 124 (21): 2322.

https://doi.org/10.1182/blood.V124.21.2322.2322

Published: 2014

Journal Articles

Inhibition Of Telomerase Is a Novel and Effective Therapy In MLL-Rearranged Acute Myeloid Leukemia (AML)

Claudia Bruedigam, Frederik Otzen Bagger, MSc, Catherine Paine Kuhn, Therese Vu, Rebecca Austin, Florian H Heidel, MD, Lars Bullinger, MD, PhD, Geoff R Hill, Scott A. Armstrong, MD, PhD, David A. Williams, MD, Steven W Lane, MD, PhD

Blood (2013) 122 (21): 2887.

https://doi.org/10.1182/blood.V122.21.2887.2887

Published: 2013

Journal Articles

IL3-Receptor Signaling Is Dispensable For The Generation and Maintenance Of Jak2V617F-Induced Myeloproliferative Neoplasm (MPN

Therese Vu, Claudia Bruedigam, Rebecca Austin, Catherine Paine-Kuhn, Hayley S. Ramshaw, PhD, Angel F. Lopez, MBBS, PhD, Geoff Hill, MD, Ann Mullally, MD, Steven W Lane, MD, PhD

Blood (2013) 122 (21): 2841.

https://doi.org/10.1182/blood.V122.21.2841.2841

Published: 2013

Journal Articles

Autophagy Is Required For Long-Term Hematopoietic Stem Cell (HSC) Function and G-CSF-Induced HSC Mobilization

Lucie Leveque, Therese Vu, Rachel D Kuns, Bianca E Teal, Mary Lor, Katie E Lineburg, Claudia Bruedigam, Frederik Otzen Bagger, Glen Boyle, PhD, Geoffrey R Hill, Kelli P A MacDonald, PhD, Steven W Lane, MD, PhD

Blood (2013) 122 (21): 892.

https://doi.org/10.1182/blood.V122.21.892.892

Published: 2013

Journal Articles

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera

Ann Mullally, Claudia Bruedigam, Luke Poveromo, Florian H. Heidel, Amy Purdon, Therese Vu, Rebecca Austin, Dirk Heckl, Lawrence J. Breyfogle, Catherine Paine Kuhn, Demetrios Kalaitzidis, Scott A. Armstrong, David A. Williams, Geoff R. Hill, Benjamin L. Ebert, Steven W. Lane

Blood (2013) 121 (18): 3692–3702.

https://doi.org/10.1182/blood-2012-05-432989

Published: 2013

Includes: Supplemental data

Journal Articles

Depletion of Jak2V617F MPN Stem Cells by IFNα in a Murine Model of Polycythemia Vera

Ann Mullally, MD, Claudia Bruedigam, Dirk Heckl, Luke Poveromo, Florian H. Heidel, MD, Geoff Hill, MD, Benjamin L. Ebert, MD, PhD, Steven W. Lane, MD PhD

Blood (2012) 120 (21): 806.

https://doi.org/10.1182/blood.V120.21.806.806

Published: 2012

NARROW

Overcoming Ven/Aza Resistance through Imetelstat-Mediated Lipophagy in Acute Myeloid Leukemia

Dnmt3a Mutation Promotes Expansion of a Quiescent Myeloid Progenitor Population in Npm1 c -Flt3 ITD Acute Myeloid Leukemia

Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging

Imetelstat-Mediated Alterations in Lipid Metabolism to Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

The Preclinical Efficacy of a Novel Telomerase Inhibitor, Imetelstat, in AML - a Randomized Trial in Patient-Derived Xenografts

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

Cdx2 Cooperates with Flt3-ITD to Induce Acute Myeloid Leukaemia in Mice

Autophagy is required for stem cell mobilization by G-CSF

Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)

Inhibition Of Telomerase Is a Novel and Effective Therapy In MLL-Rearranged Acute Myeloid Leukemia (AML)

IL3-Receptor Signaling Is Dispensable For The Generation and Maintenance Of Jak2V617F-Induced Myeloproliferative Neoplasm (MPN

Autophagy Is Required For Long-Term Hematopoietic Stem Cell (HSC) Function and G-CSF-Induced HSC Mobilization

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera

Depletion of Jak2V617F MPN Stem Cells by IFNα in a Murine Model of Polycythemia Vera

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American Society of Hematology

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