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Journal Articles

Dnmt3a Mutation Promotes Expansion of a Quiescent Myeloid Progenitor Population in Npm1 c -Flt3 ITD Acute Myeloid Leukemia

Paniz Tavakoli, Megan Bywater, Jasmin Straube, Victoria Ling, Emily Cooper, Rohit Haldar, Yashaswini Janardhanan, Leanne Cooper, Claudia Bruedigam, Carolyn S. Grove, Steven W Lane
Journal: Blood
Blood (2024) 144 (Supplement 1): 1347.
https://doi.org/10.1182/blood-2024-201250
Published: 2024
Journal Articles

Single Cell Genotype-Phenotype Analysis Demonstrates That Post-MPN AML Is Driven By Clonal Evolution and Loss of Transcriptional Heterogeneity within Stem Cell Compartments

Jasmin Straube, Julian Grabek, Leanne Cooper, Rohit Haldar, Caroline McNamara, David M Ross, Andrew Perkins, Megan Bywater, Steven W Lane
Journal: Blood
Blood (2024) 144 (Supplement 1): 1346.
https://doi.org/10.1182/blood-2024-199841
Published: 2024
Journal Articles

Trp53 -Loss in Hematopoietic Stem Cells Drives the Evolutionary Process of Leukemic Transformation in a Jak2 V617F -Driven Myeloproliferative Neoplasms Mouse Model

Ranran Zhang, Yashaswini Janardhanan, Rohit Haldar, Leanne Cooper, Sebastien Jaquelin, Jasmin Straube, Megan Bywater, Steven W Lane
Journal: Blood
Blood (2023) 142 (Supplement 1): 4522.
https://doi.org/10.1182/blood-2023-188150
Published: 2023
Journal Articles

Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging

Claudia Bruedigam, Amy H Porter, Jasmin Straube, Guidan Cheng, Florian H Heidel, Steven W Lane
Journal: Blood
Blood (2023) 142 (Supplement 1): 5598.
https://doi.org/10.1182/blood-2023-191246
Published: 2023
Journal Articles

Imetelstat-Mediated Alterations in Lipid Metabolism to Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

Claudia Bruedigam, Amy H Porter, Axia Song, Gerjanne Vroeg in de Wei, Thomas Stoll, Jasmin Straube, Leanne T Cooper, Guidan Cheng, Vivian FS Kahl, Alexander Sobinoff, Victoria Y Ling, Billy Michael Chelliah Jebaraj, Laura J Bray, Lars Bullinger, Florian H Heidel, Glen A Kennedy, Michelle M Hill, Hilda Pickett, Omar Abdel-Wahab, Gunter Hartel, Steven W Lane
Journal: Blood
Blood (2022) 140 (Supplement 1): 487–488.
https://doi.org/10.1182/blood-2022-168166
Published: 2022
Journal Articles

Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia

Victoria Y Ling, Sebastien Jacquelin, Jasmin Straube, Rohit Haldar, Yashaswini Janardhanan, Leanne T Cooper, Claudia Bruedigam, Emily Cooper, William Godfrey, Siok-Keen Tey, Lars Bullinger, Marco J Herold, Jonathan Baell, Megan Bywater, Steven W Lane
Journal: Blood
Blood (2021) 138 (Supplement 1): 2241.
https://doi.org/10.1182/blood-2021-148379
Published: 2021
Journal Articles

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Sebastien Jacquelin, Jasmin Straube, Leanne Cooper, Therese Vu, Axia Song, Megan Bywater, Eva Baxter, Matthew Heidecker, Brad Wackrow, Amy Porter, Victoria Ling, Joanne Green, Rebecca Austin, Stephen Kazakoff, Nicola Waddell, Luke B. Hesson, John E. Pimanda, Frank Stegelmann, Lars Bullinger, Konstanze Döhner, Raajit K. Rampal, Dirk Heckl, Geoffrey R. Hill, Steven W. Lane
Journal: Blood
Blood (2018) 132 (26): 2707–2721.
https://doi.org/10.1182/blood-2018-04-846220
Published: 2018
Includes: Supplemental data
Journal Articles

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Victoria Y Ling, MBBS, William Godfrey, Sebastien Jacquelin, PhD, Jasmin Straube, PhD, Leanne T Cooper, Claudia Bruedigam, PhD, Siok-Keen Tey, MBBS PhDFRACP FRCPA, Lars Bullinger, MD, Marco J Herold, Megan Bywater, PhD, Steven W. Lane, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2771.
https://doi.org/10.1182/blood-2018-99-115729
Published: 2018
Journal Articles

Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia

Rebecca Austin, BSc, Megan Bywater, PhD, Jasmin Straube, PhD, Leanne T Cooper, Madeleine Headlam, PhD, Keyur Dave, PhD, Matthias Braun, PhD, Tobias Bald, PhD, Fernando Guimaraes, PhD, Sebastien Jacquelin, PhD, Matthew Witkowski, PhD, Iannis Aifantis, PhD, Geoffrey R Hill, MD PhD, Mark J Smyth, PhD, Steven W. Lane, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 904.
https://doi.org/10.1182/blood-2018-99-112009
Published: 2018
Journal Articles

The impact of age, NPM1 mut , and FLT3 ITD allelic ratio in patients with acute myeloid leukemia

Clinical Trials & Observations
Jasmin Straube, Victoria Y. Ling, Geoffrey R. Hill, Steven W. Lane
Journal: Blood
Blood (2018) 131 (10): 1148–1153.
https://doi.org/10.1182/blood-2017-09-807438
Published: 2018
Includes: Supplemental data
Journal Articles

Integrated Molecular Analysis Identifies Replicative Stress As Sensitizer to Imetelstat Therapy in AML

Claudia Bruedigam, Amy H Porter, Brad Wackrow, Jasmin Straube, PhD, Leanne T Cooper, Axia Song, Stanley Chun-Wei Lee, PhD, Omar Abdel-Wahab, MD, Geoffrey R Hill, MD, Steven W. Lane, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 798.
https://doi.org/10.1182/blood.V130.Suppl_1.798.798
Published: 2017
Journal Articles

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

Wei Shi, Therese Vu, Didier Boucher, Anna Biernacka, Jules Nde, Raj K. Pandita, Jasmin Straube, Glen M. Boyle, Fares Al-Ejeh, Purba Nag, Jessie Jeffery, Janelle L. Harris, Amanda L. Bain, Marta Grzelak, Magdalena Skrzypczak, Abhishek Mitra, Norbert Dojer, Nicola Crosetto, Nicole Cloonan, Olivier J. Becherel, John Finnie, Jeffrey R. Skaar, Carl R. Walkley, Tej K. Pandita, Maga Rowicka, Krzysztof Ginalski, Steven W. Lane, Kum Kum Khanna
Journal: Blood
Blood (2017) 129 (18): 2479–2492.
https://doi.org/10.1182/blood-2016-06-725093
Published: 2017
Includes: Supplemental data