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Journal Articles

TRIP13 Is a Fetal-Enriched Therapeutic Target in NUP98-JARID1A + Pediatric Non-Down Syndrome AMKL

Luca Nunzio Cifarelli, Hasan Issa, Konstantin Schuschel, Katja Menge, Lucie Gack, Christian Ihling, Andrea Sinz, Jan-Henning Klusmann, Dirk Heckl

Blood (2023) 142 (Supplement 1): 711.

https://doi.org/10.1182/blood-2023-182843

Published: 2023

Journal Articles

In Vivo Modeling of T-Cell Acute Lymphoblastic Leukemia Reveals Synergistic Oncogenic Pathways and Bcl11b Haploinsufficiency As a Potential Therapeutic Vulnerability

Maximilian Schinke, Marc-Jens Kleppa, Dirk Heckl, Michael Heuser, Axel Schambach, Adrian Schwarzer

Blood (2023) 142 (Supplement 1): 4149.

https://doi.org/10.1182/blood-2023-190515

Published: 2023

Journal Articles

RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia

Blood (2023) 141 (10): 1105–1118.

https://doi.org/10.1182/blood.2022017619

Published: 2023

Includes: Supplemental data

Journal Articles

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

Oriol Alejo-Valle, Karoline Weigert, Raj Bhayadia, Michelle Ng, Hasan Issa, Christoph Beyer, Stephan Emmrich, Konstantin Schuschel, Christian Ihling, Andrea Sinz, Martin Zimmermann, Claudia Wickenhauser, Marius Flasinski, Eniko Regenyi, Maurice Labuhn, Dirk Reinhardt, Marie-Laure Yaspo, Dirk Heckl, Jan-Henning Klusmann

Blood (2022) 139 (5): 651–665.

https://doi.org/10.1182/blood.2021012231

Published: 2022

Includes: Supplemental data

Journal Articles

Myeloid Leukemia Dependencies at CTCF-Enriched Long Noncoding RNA Loci

Michelle Ng, Lonneke Verboon, Hasan Issa, Raj Bhayadia, Oriol Alejo, Dorit Borchert, Eniko Regenyi, Dirk Reinhardt, Marie-Laure Yaspo, Dirk Heckl, Jan-Henning Klusmann

Blood (2021) 138 (Supplement 1): 500.

https://doi.org/10.1182/blood-2021-153984

Published: 2021

Journal Articles

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Ursula S.A. Stalmann, MD, Fabio Ticconi, MSc, Ronghui Li, MSc, Aaron B. Wong, PhD, Glenn Cowley, PhD, David E. Root, PhD, Dirk Heckl, PhD, Inge Snoeren, MSc, Sergio Martinez, PhDMSc, Tim H Brümmendorf, MD, Andreas Schuppert, PhD, Ivan Costa, PhD, Benjamin L. Ebert, MD PhD, Rebekka K. Schneider, MD PhD

Blood (2019) 134 (Supplement_1): 559.

https://doi.org/10.1182/blood-2019-122588

Published: 2019

Journal Articles

Exome Sequencing of Relapsed Multiple Myeloma Combined with Pooled CRISPR/Cas9 Screens Identifies Gene Mutations Associated with Drug-Specific Resistance

Stephan Bohl, Laura K. Schmalbrock, MD, Imke Bauhuf, Anna Dolnik, Tamara J. Blätte, MSc, Stefanie Lindner, Dr., Tatjana Meyer, MSc, BSc, Sarah Knödler, Denise Miller, Miriam Kull, Christian Langer, MD, Hartmut Döhner, MD, Dirk Heckl, PhD, Lars Bullinger, Jan Krönke, MD

Blood (2019) 134 (Supplement_1): 809.

https://doi.org/10.1182/blood-2019-131245

Published: 2019

Journal Articles

Characterization of a Novel JAK1 Pseudokinase Mutation in the First Case of Trisomy 21-Independent GATA1-Mutated Transient Abnormal Myelopoiesis

Julius Lukes, Jr., MD, Petr Danek, MSc, Oriol Alejo, Eliska Potuckova, Ondrej Gahura, Dirk Heckl, PhD, Julia Starkova, PhD, Jan Zuna, Jan Stary, Prof., MD PhD, Jan Trka, Prof., MD PhD, Jan-Henning Klusmann, Marketa Zaliova, MD PhD

Blood (2019) 134 (Supplement_1): 4208.

https://doi.org/10.1182/blood-2019-122168

Published: 2019

Journal Articles

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Blood (2018) 132 (26): 2707–2721.

https://doi.org/10.1182/blood-2018-04-846220

Published: 2018

Includes: Supplemental data

Journal Articles

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 2627.

https://doi.org/10.1182/blood-2018-99-116256

Published: 2018

Journal Articles

Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome

Blood (2018) 132 (Supplement 1): 543.

https://doi.org/10.1182/blood-2018-99-116661

Published: 2018

Journal Articles

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Arnold Kloos, PhD, Felicitas Thol, MD, Lina Winckler, Razif Gabdoulline, PhD, Konstantinos Mintzas, Nidhi Jyotsana, PhD, Renate Schottmann, Felix F. Adams, Adrian Schwarzer, MD PhD, Dirk Heckl, PhD, Suzan Imren, MD, R. Keith Humphries, Arnold Ganser, MD, Michael Heuser, MD

Blood (2017) 130 (Supplement 1): 4236.

https://doi.org/10.1182/blood.V130.Suppl_1.4236.4236

Published: 2017

Journal Articles

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Blood (2016) 128 (22): 1534.

https://doi.org/10.1182/blood.V128.22.1534.1534

Published: 2016

Journal Articles

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

Sebastien Jacquelin, PhD, Emma Dishington, Therese Vu, Axia Song, Matthew Heidecker, Solene Guignes, Claudia Bruedigam, PhD, Joanne Sutton, Geoffrey R Hill, MD PhD, Nicole Cloonan, PhD, Dirk Heckl, PhD, Steven W Lane, PhD

Blood (2016) 128 (22): 794.

https://doi.org/10.1182/blood.V128.22.794.794

Published: 2016

Journal Articles

Crispr-Cas9 Induced MLL-Rearrangements Cause Clonal Outgrowth in CD34+ Hematopoietic Stem Cells

Jana Reimer, Sabine Knoess, Maurice Labuhn, Emmanuelle Marie Charpentier, PhD, Jan-Henning Klusmann, MD, Dirk Heckl, PhD

Blood (2015) 126 (23): 165.

https://doi.org/10.1182/blood.V126.23.165.165

Published: 2015

Journal Articles

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Blood (2015) 126 (23): 1244.

https://doi.org/10.1182/blood.V126.23.1244.1244

Published: 2015

Journal Articles

GATA1-Centered Genetic Network on Chromosome 21 Drives Down Syndrome Acute Megakaryoblastic Leukemia

Lena Stachorski, Dirk Heckl, PhD, Veera Raghavan Thangapandi, Aliaksandra Maroz, PhD, Dirk Reinhardt, MD PhD, Jan-Henning Klusmann, MD

Blood (2014) 124 (21): 4310.

https://doi.org/10.1182/blood.V124.21.4310.4310

Published: 2014

Journal Articles

Lenalidomide Promotes CRBN-Mediated Ubiquitination and Degradation of IKZF1 and IKZF3

Jan Krönke, Namrata Udeshi, Anupama Narla, Peter Grauman, Slater Hurst, Marie McConkey, Tanya Svinkina, Dirk Heckl, Eamon Comer, Xiaoyu Li, Christie Ciarlo, Emily Hartman, Monica Schenone, Stuart Schreiber, Steven A. Carr, Benjamin L. Ebert

Blood (2013) 122 (21): LBA-5.

https://doi.org/10.1182/blood.V122.21.LBA-5.LBA-5

Published: 2013

Journal Articles

Critical Role Of Casein Kinase (Ck)1α Heterozygote Gene Inactivation In The Clonal Advantage Of Hematopoietic Stem Cells In Del(5q) MDS

Rebekka K. Schneider, MD, Dirk Heckl, PhD, Marcus Järås, PhD, Lisa Chu, McConkey Marie, PhD, Ann Mullally, MD, Benjamin L Ebert, MD, PhD

Blood (2013) 122 (21): 98.

https://doi.org/10.1182/blood.V122.21.98.98

Published: 2013

Journal Articles

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera

Ann Mullally, Claudia Bruedigam, Luke Poveromo, Florian H. Heidel, Amy Purdon, Therese Vu, Rebecca Austin, Dirk Heckl, Lawrence J. Breyfogle, Catherine Paine Kuhn, Demetrios Kalaitzidis, Scott A. Armstrong, David A. Williams, Geoff R. Hill, Benjamin L. Ebert, Steven W. Lane

Blood (2013) 121 (18): 3692–3702.

https://doi.org/10.1182/blood-2012-05-432989

Published: 2013

Includes: Supplemental data

NARROW

TRIP13 Is a Fetal-Enriched Therapeutic Target in NUP98-JARID1A + Pediatric Non-Down Syndrome AMKL

In Vivo Modeling of T-Cell Acute Lymphoblastic Leukemia Reveals Synergistic Oncogenic Pathways and Bcl11b Haploinsufficiency As a Potential Therapeutic Vulnerability

RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

Myeloid Leukemia Dependencies at CTCF-Enriched Long Noncoding RNA Loci

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Exome Sequencing of Relapsed Multiple Myeloma Combined with Pooled CRISPR/Cas9 Screens Identifies Gene Mutations Associated with Drug-Specific Resistance

Characterization of a Novel JAK1 Pseudokinase Mutation in the First Case of Trisomy 21-Independent GATA1-Mutated Transient Abnormal Myelopoiesis

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

Crispr-Cas9 Induced MLL-Rearrangements Cause Clonal Outgrowth in CD34+ Hematopoietic Stem Cells

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

GATA1-Centered Genetic Network on Chromosome 21 Drives Down Syndrome Acute Megakaryoblastic Leukemia

Lenalidomide Promotes CRBN-Mediated Ubiquitination and Degradation of IKZF1 and IKZF3

Critical Role Of Casein Kinase (Ck)1α Heterozygote Gene Inactivation In The Clonal Advantage Of Hematopoietic Stem Cells In Del(5q) MDS

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera

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American Society of Hematology

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American Society of Hematology

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