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Michel Zwaan
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Journal Articles

Daratumumab in pediatric relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma: the DELPHINUS study

Clinical Trials & Observations
Teena Bhatla, Laura E. Hogan, David T. Teachey, Francisco Bautista, John Moppett, Pablo Velasco Puyó, Concetta Micalizzi, Claudia Rossig, Neerav Shukla, Gil Gilad, Franco Locatelli, André Baruchel, C. Michel Zwaan, Natalie S. Bezler, Alba Rubio-San-Simón, David C. Taussig, Elizabeth A. Raetz, Zhengwei J. Mao, Brent L. Wood, Diana Alvarez Arias, Maria Krevvata, Ivo Nnane, Nibedita Bandyopadhyay, Lorena Lopez Solano, Robyn M. Dennis, Robin Carson, Ajay Vora
Journal: Blood
Blood (2024) 144 (21): 2237–2247.
https://doi.org/10.1182/blood.2024024493
Published: 2024
Includes: Supplemental data
Journal Articles

Brigatinib Monotherapy in Children with R/R ALK+ ALCL, IMT, or Other Solid Tumors: Updated Results from the Brigaped (ITCC-098) Phase 1 Dose-Escalation Study

Charlotte Rigaud, Kim P.J. Schellekens, Christine Damm-Welk, Veronique Minard-Colin, Samuel D. Abbou, Gertruud Bakker, Auke Beishuizen, Maaike Boonstra-Schelfhorst, Laurence Brugières, Michela Casanova, Pascal Chastagner, Rana Dandis, Stéphane Ducassou, Natasha K.A. van Eijkelenburg, Nathalie Garnier, Michael J. Hanley, Alwin D.R. Huitema, Samantha Lampron, Yousif H. Matloub, Nicole Scobie, Florin Vranceanu, Jen-Hao Wu, Wilhelm Woessmann, C. Michel Zwaan, Reineke A. Schoot
Journal: Blood
Blood (2024) 144 (Supplement 1): 3108.
https://doi.org/10.1182/blood-2024-200077
Published: 2024
Journal Articles

Characterizing the Bone Marrow Stromal Niche in Pediatric Acute Myeloid Leukemia

Elizabeth K Schweighart, Cristoforo Grasso, Brigit M. te Pas, Mirjam E. Belderbos, Christian Michel Zwaan, Hendrik G. Stunnenberg, Olaf Heidenreich, Bianca F. Goemans
Journal: Blood
Blood (2024) 144 (Supplement 1): 4062.
https://doi.org/10.1182/blood-2024-204988
Published: 2024
Journal Articles

WU-CART-007 (WT-7), an Allogeneic CAR T-Cell Targeting CD7 in Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL/LBL): Phase 2 Results

Armin Ghobadi, Ibrahim Aldoss, Shannon L. Maude, Deepa Bhojwani, Rawan Faramand, Ashish Bajel, Friso G. J. Calkoen, Alan S. Wayne, Bhagirathbhai Dholaria, Ryan J Mattison, Anita W. Rijneveld, Christian Michel Zwaan, André Baruchel, Nicolas Boissel, Michael P. Rettig, Maria del Rosario, Stephen Moran, Alexander Hamil, Ouiam Bakkacha, Deborah Masters, Justo L. Gonzalez, Michael Munroe, Laura Simpson, Preeta Dasgupta, Tony Wu, John Muth, Haley Irons, Brett Ramsey, Eileen McNulty, Matthew L. Cooper, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 3450.
https://doi.org/10.1182/blood-2024-202005
Published: 2024
Journal Articles

WUC007-03: A Phase 2 Study of Anti-CD7 Allogenic CAR-T Cells (WT-7) in Patients with Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphoblastic Lymphoma (LBL)

Armin Ghobadi, Shannon L. Maude, Ibrahim Aldoss, Ashish Bajel, Ryan J Mattison, Deepa Bhojwani, Alan S. Wayne, Rawan Faramand, Bhagirathbhai Dholaria, Seong Lin Khaw, Anita W. Rijneveld, Friso G. J. Calkoen, Christian Michel Zwaan, André Baruchel, Nicolas Boissel, Andrej Lissat, Stefan Schwartz, Peter Bader, Fabian Lang, Michael P. Rettig, Haley Irons, Brett Ramsey, John Muth, Laura Simpson, Preeta Dasgupta, Stephen Moran, Michael Munroe, Maria del Rosario, Tony Wu, Ouiam Bakkacha, Justo L. Gonzalez, Deborah Masters, Alexander Hamil, Eileen McNulty, Matthew L. Cooper, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 7225.
https://doi.org/10.1182/blood-2024-201825
Published: 2024
Journal Articles

Sinusoidal Obstruction Syndrome in Children with CD22+ B-Cell Precursors Acute Lymphoblastic Leukemia (BCP-ALL) Treated with Inotuzumab Ozogamicin in Trial ITCC-059: Risk Factors and Outcomes

Erica Brivio, Edoardo Pennesi, Yilin Jang, Anneke Ammerlaan, Susana Rives, Inge M. van der Sluis, Caroline Lindemans, Bella Bielorai, Cristina Díaz De Heredia, Andrej Lissat, Claudia Rossig, Arnaud Petit, Fanny Rialland Battisti, Carmelo Rizzari, Anna B Nilsson, Benedicte Bruno, Alba Rubio-san-Simón, Lucie Sramkova, Gernot Engstler, Uta Dirksen, Benoit Brethon, Barbara De Moerloose, Marlène Pasquet, Peter McCarthy, Karsten Nysom, Carine Halfon-Domenech, Nicoletta Bertorello, Jochen Büchner, Franco Locatelli, C. Michel Zwaan
Journal: Blood
Blood (2024) 144 (Supplement 1): 310.
https://doi.org/10.1182/blood-2024-193946
Published: 2024
Journal Articles

The Interplay between Macrophages and Pediatric AML Blasts

Alicia Perzolli, Joost B. Koedijk, Elizabeth K Schweighart, Bianca F. Goemans, Christian Michel Zwaan, Olaf Heidenreich
Journal: Blood
Blood (2024) 144 (Supplement 1): 5653.
https://doi.org/10.1182/blood-2024-204948
Published: 2024
Journal Articles

WU-CART-007 (WT-7) Is an Effective Treatment for Adolescent Patients with Relapsed or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma (T-ALL/LBL) - Subgroup Analysis of WU-CART-007 1001

Shannon L. Maude, Deepa Bhojwani, Alan S. Wayne, Friso G. J. Calkoen, André Baruchel, Christian Michel Zwaan, Michael P. Rettig, Ouiam Bakkacha, Justo L. Gonzalez, Deborah Masters, Maria del Rosario, Laura Simpson, Preeta Dasgupta, Tony Wu, Stephen Moran, Michael Munroe, Haley Irons, Eileen McNulty, Matthew L. Cooper, Alexander Hamil, John Muth, Brett Ramsey, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 3461.
https://doi.org/10.1182/blood-2024-201998
Published: 2024
Journal Articles

Updated Results and Longer Follow-up from the AUGMENT-101 Phase 2 Study of Revumenib in All Patients with Relapsed or Refractory (R/R) KMT2Ar Acute Leukemia

Ibrahim Aldoss, Ghayas C. Issa, James S. Blachly, Michael J. Thirman, Gabriel N Mannis, Martha L. Arellano, John F. DiPersio, Elie Traer, C. Michel Zwaan, Neerav Shukla, Branko Cuglievan, Carolyn S. Grove, Matthew Greenwood, Christine M. McMahon, Alexander E. Perl, Richard M. Stone, Cristina Papayannidis, David S. Dickens, Maël Heiblig, Andrius Žučenka, Pau Montesinos, Ioannis Mantzaris, Tibor Kovacsovics, Paul J. Shami, Li Yu, Rebecca G. Bagley, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 211.
https://doi.org/10.1182/blood-2024-194384
Published: 2024
Journal Articles

When InO says no: understanding escape

Judith M. Boer, C. Michel Zwaan
Journal: Blood
Blood (2024) 144 (1): 2–4.
https://doi.org/10.1182/blood.2024024713
Published: 2024
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

First-in-Human Study of the CD123 NK Cell Engager SAR443579 in Relapsed or Refractory Acute Myeloid Leukemia, B-Cell Acute Lymphoblastic Leukemia or High Risk-Myelodysplasia: Updated Safety, Efficacy, Pharmacokinetics and Pharmacodynamics

Ashish Bajel, Sylvain Garciaz, Pinkal Desai, Gerwin A Huls, Abhishek Maiti, Mojca Jongen-Lavrencic, Nicolas Boissel, Stephane De Botton, David C. de Leeuw, Shaun Fleming, C. Michel Zwaan, Martha Arellano, David Avigan, Jennifer N. Saultz, Ioannis Mantzaris, Kyle Jensen, Timothy Wagenaar, Gu Mi, Samira Ziti-Ljajic, Dobrin Draganov, Giovanni Abbadessa, Anthony Selwyn Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 3474.
https://doi.org/10.1182/blood-2023-173162
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023
Journal Articles

Europeanpediatric Acute Leukemia (EuPAL) Registry

Katarzyna Majstrowicz, Katharina Waack, Evangelia Antoniou, Naghmeh Niktoreh, Gwen Nichols, Laura Di Laurenzio, Michele S. Redell, Todd Cooper, E. Anders Kolb, Sarah K. Tasian, Franco Locatelli, C. Michel Zwaan, Dirk Reinhardt
Journal: Blood
Blood (2023) 142 (Supplement 1): 1496.
https://doi.org/10.1182/blood-2023-189684
Published: 2023
Journal Articles

Chip-AML22 Master Protocol: An Open-Label Clinical Trial in Newly Diagnosed Pediatric De Novo Acute Myeloid Leukemia (AML) Patients Including a Linked Phase II Trial with Quizartinib in FLT3 -ITD/ NPM1 wt Patients - a Study By the NOPHO-DB-SHIP Consortium

Gertjan J.L. Kaspers, Noa E. Wijnen, Joost B. Koedijk, Sae Ishimaru, Renske Benedictus, Ellen C. Van Opstal, Harm Van Tinteren, C. Michel Zwaan, Noha Biserna, Pamela Downs, Yvonne Duong, Yasser Mostafa Kamel, Jonas Abrahamsson, Nira Arad-Cohen, Nicole Bodmer, Luis Castillo, Daniel Cheuk, Vitor Costa, Barbara De Moerloose, Jose Maria Fernandez Navarro, Linda Fogelstrand, Bianca F. Goemans, Henrik Hasle, Olafur G. Jonsson, Zhanna Kovalova, Monica C. Munthe-Kaas, Ulrika Norén-Nyström, Sauli Palmu, Ramune Pasauliene, Kadri Saks, Anne Maria Tierens, Dominik Turkiewicz, Cornelis Jan Pronk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1532.
https://doi.org/10.1182/blood-2023-181792
Published: 2023
Journal Articles

Treatment of Molecular Relapses in Pediatric AML Saves Toxicities Prior to Hematopoietic Stem Cell Transplantation (HSCT) - Results of AMoRe2017 Trial

Amelie Polutta, Dirk Reinhardt, Andre Baruchel, Henrik Hasle, Franco Locatelli, C. Michel Zwaan, Michael Frühwald, Silke Westphal, Michael Dworzak, Heidrun Boztug, Gabriele Escherich, Thomas Lehrnbecher, Bianca F. Goemans, Brigitte Strahm, Markus Schneider, Lina Hoffmeister, Katharina Waack
Journal: Blood
Blood (2023) 142 (Supplement 1): 1521.
https://doi.org/10.1182/blood-2023-180820
Published: 2023
Journal Articles

Transcriptional Heterogeneity and Clonal Evolution between Diagnosis and Relapse in Pediatric Acute Myeloid Leukemia

Cristoforo Grasso, Peter Brazda, Brigit M. te Pas, Gitanjali Dharmadhikari, Joost B. Koedijk, Bianca F. Goemans, Olaf Heidenreich, Mirjam E. Belderbos, C. Michel Zwaan, Hendrik G. Stunnenberg, Wout Megchelenbrink
Journal: Blood
Blood (2023) 142 (Supplement 1): 2746.
https://doi.org/10.1182/blood-2023-182852
Published: 2023
Journal Articles

APAL2020SC Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias

Michele S. Redell, Todd A. Alonzo, Robert Gerbing, Jim Wang, Maureen M. O'Brien, Gwen Nichols, Laura Di Laurenzio, Sarah K. Tasian, C. Michel Zwaan, Dirk Reinhardt, E. Anders Kolb, Todd Cooper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1492.
https://doi.org/10.1182/blood-2023-190947
Published: 2023
Journal Articles

Hydrocortisone or Placebo to Reduce Dexamethasone-Induced Neurobehavioral Side Effects: Results of a Phase 3 National, Double-Blind, Placebo-Controlled Randomized Trial with Crossover Design

Annelienke M. van Hulst, Erica L.T. van den Akker, Emma J. Verwaaijen, Marta Fiocco, Niki Rensen, Raphaële R.L. van Litsenburg, Saskia M.F. Pluijm, C. Michel Zwaan, Hanneke M. Van Santen, Rob Pieters, Andrea W.M. Evers, Martha A. Grootenhuis, Marry M. van den Heuvel-Eibrink
Journal: Blood
Blood (2022) 140 (Supplement 1): 3162–3163.
https://doi.org/10.1182/blood-2022-163329
Published: 2022
Journal Articles

Retrospective Lineage Tracing of Pediatric Acute Myeloid Leukemia Using Single-Cell Whole Genome Sequencing

Eline J.M. Bertrums, Sjors Middelkamp, Inge M. van der Werf, Freek Manders, Arianne M. Brandsma, Niels M. Groenen, Mark Verheul, Markus J. van Roosmalen, C. Michel Zwaan, Marry M. van den Heuvel-Eibrink, Bianca F. Goemans, Ruben Van Boxtel
Journal: Blood
Blood (2022) 140 (Supplement 1): 8725–8726.
https://doi.org/10.1182/blood-2022-166051
Published: 2022