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Pau Montesinos
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A CD38/CD28xCD3 Trispecific T-Cell Engager (TCE) As a Potentially Active Agent for the Treatment of Older Patients with Acute Myeloid Leukemia (AML)

Aintzane Zabaleta, Esperanza Martín-Sánchez, Laura Blanco, Peter Kim, Kamlesh Bisht, Hongfang Wang, Helgi J. Van de Velde, Tomas Jelinek, Catia Simoes, Felipe Prosper, Jesus San-Miguel, David Martinez-Cuadron, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4178.
https://doi.org/10.1182/blood-2023-184797
Published: 2023
Journal Articles

Impact-AML: A European Master Framework for Cohort Studies and Pragmatic Clinical Trials in Relapse or Refractory Acute Myeloid Leukemia

Giovanni Marconi, Petros Kountouris, Jiri Mayer, Lars Bullinger, Dirk Reinhardt, Pau Montesinos, Pietro Merli, Marco Vignetti, Jos Dumortier, Jesús María Hernández-Rivas, Michael Heuser, Rolandas Gerbutavicius, Antonio Francesco Maturo, Gianni D'Errico, Samantha Nier, Chiara Zingaretti, Irene Azzali, Federica Campacci, Maria Del Mar Mañú-Pereira, Franco Locatelli, Rüdiger Hehlmann, Dietger W. Niederwieser, Giovanni Martinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1533.
https://doi.org/10.1182/blood-2023-184745
Published: 2023
Journal Articles

Data-Driven Multiparameter Flow Cytometry (MFC) Classification of Blast Differentiation in Elderly Patients with Acute Myeloid Leukemia (AML)

Carmen Gonzalez, Catia Simoes, Beñat Ariceta, David Martinez-Cuadron, Juan Miguel Bergua Burgues, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, Maria Vidriales Vicente, Carmen Chillon, Jorge Labrador, Jose Francisco Falantes, Maria Jose Sayas Lloris, Rosa Ayala, Joaquin Martinez-Lopez, Sara Villar, Maria Jose Calasanz, Felipe Prosper, Jesus San Miguel, Miguel A. Sanz, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 1571.
https://doi.org/10.1182/blood-2023-180646
Published: 2023
Journal Articles

Real-World Outcomes Using Front-Line Midostaurine in Combination with Intensive Chemotherapy for Patients Aged ≥ 60 Years Old with FLT3 Mutated Acute Myeloid Leukemia

Gaspar Aspas Requena, Pierre Yves Dumas, Rebeca Rodriguez Veiga, Sarah Bertoli, Cristina Gil, Celestine Simand, Fernando Jesús Ramos-Ortega, Pierre Peterlin, Josefina Serrano, Rudy Birsen, Teresa Bernal Del Castillo, Emmanuelle Tavernier, Mar Tormo, Martin Carre, Maria Jose Garcia, Adrien Contejean, Rosalia Riaza Grau, Corentin Orvain, Jose Antonio Pérez-Simón, Esther Perez Santaolla, Lauren Veronese, Beatriz De Rueda Ciller, Eric Delabesse, Antonio Gutiérrez, Ariane Mineur, Adolfo De La Fuente Burguera, Romain Guieze, Arnaud Pigneux, Pau Montesinos, Christian Recher, David Matínez-Cuadrón
Journal: Blood
Blood (2023) 142 (Supplement 1): 2864.
https://doi.org/10.1182/blood-2023-190128
Published: 2023
Journal Articles

Multiomics Characterization of Normal CD34+ Hematopoietic Progenitor Cells (HPC) and Blasts in the Bone Marrow (BM) and Peripheral Blood (PB) of Patients with Acute Myeloid Leukemia (AML)

Catia Simoes, Carmen Gonzalez, Leire Burgos, Sarai Sarvide, Diego Alignani, Aitziber Lopez, Ivan Quispe, Jose A. Pérez-Simón, María García-Fortes, Teresa Bernal Del Castillo, Mercedes Colorado, Teresa Olave, Ana Alfonso Pierola, Felipe Prosper, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2951.
https://doi.org/10.1182/blood-2023-185760
Published: 2023
Journal Articles

Cis-Acting Splicing-Associated Variants Can Redefine the Molecular Signature of Genes Commonly Mutated in Acute Myeloid Leukemia

Mireya Morote-Faubel, Maria Guaita-Céspedes, Beatriz Fernández-Blanco, Cristina Martínez-Valiente, Cristian García-Ruiz, Marta Santiago, Alvaro Diaz-Gonzalez, Alejandra Sanjuan-Pla, Mariam Ibáñez, Eva Barragan, Esperanza Such, Mireya Morote Faubel, Pau Montesinos, Javier De La Rubia, Alessandro Liquori, Jose Cervera
Journal: Blood
Blood (2023) 142 (Supplement 1): 2936.
https://doi.org/10.1182/blood-2023-177571
Published: 2023
Journal Articles

Outcomes in Chemotherapy-Ineligible Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia Treated with Venetoclax Plus Azacitidine: A Pooled Analysis

Adriano Venditti, Jing-Zhou Hou, Pierre Fenaux, Brian A. Jonas, Radovan Vrhovac, Pau Montesinos, Jacqueline S. Garcia, David Rizzieri, Michael J Thirman, Stanley Kotey, Jalaja Potluri, Mazaher Dhalla, Vinod Pullarkat
Journal: Blood
Blood (2023) 142 (Supplement 1): 2886.
https://doi.org/10.1182/blood-2023-182045
Published: 2023
Journal Articles

Quantum-First Trial: FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD)-Specific Measurable Residual Disease (MRD) Clearance Assessed through Induction (IND) and Consolidation (CONS) Is Associated with Improved Overall Survival (OS) in Newly Diagnosed (nd) FLT3 -ITD+ AML Patients (pts)

Alexander Perl, Harry P. Erba, Pau Montesinos, Radovan Vrhovac, Elzbieta Patkowska, Heeje Kim, Pavel Zak, Po-Nan Wang, Jaime E Rohrbach, Ken C N Chang, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F Schlenk, Mark J. Levis
Journal: Blood
Blood (2023) 142 (Supplement 1): 832.
https://doi.org/10.1182/blood-2023-186785
Published: 2023
Journal Articles

The FLT3-like Gene Expression Signature Predicts Response to Quizartinib in Wild-Type FLT3 Acute Myeloid Leukemia: An Analysis of the Pethema Quiwi Trial

Adrian Mosquera Orgueira, Manuel Perez Encinas, Jose Angel Diaz Arias, Rebeca Rodriguez Veiga, Juan Miguel Bergua Burgues, Jesús Lorenzo Algarra, Carmen Botella, Jose Antonio Perez Simon, Teresa Bernal, Mar Tormo, Maria Calbacho, Olga Salamero, Josefina Serrano, Victor Noriega, Juan Antonio Lopez Lopez, Susana Vives, Mercedes Colorado, Jose Luis Lopez Lorenzo, Maria Vidriales Vicente, Raimundo Garcia Boyero, Maria Teresa Olave Rubio, Pilar Herrera Puente, Olga Arce, Manuel Barrios Garcia, Maria Jose Sayas Lloris, Marta Polo, Maria Isabel Gomez Roncero, Eva Barragan, Rosa Ayala, Carmen Chillon, Maria Jose Calasanz, Blanca Boluda, Andres Peleteiro Raindo, Raquel Amigo, David Martinez Cuadron, Jorge Labrador, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 974.
https://doi.org/10.1182/blood-2023-180482
Published: 2023
Journal Articles

Clinical Features and Treatment in Patients Diagnosed with Blastic Plasmacytoid Dendritic Cell Neoplasm: Interim Analysis from the Pethema Epidemiologic Registry (EPI-BLAS study)

Irene Navarro Vicente, Pilar Lloret Madrid, Antonio Solana-Altabella, Pilar Martinez Sanchez, Maria Angeles Foncillas, Carlos Cervero, Victor Noriega, Maria Paz Garrastazul Sánchez, Jose Maria Alonso Alonso, Beatriz De Rueda Ciller, Pilar Herrera Puente, Susana Vives, Josefina Serrano, Lourdes Hermosín, Fernando Jesús Ramos-Ortega, Teresa Bernal, Jesús Lorenzo Algarra, Mercedes Colorado, Raimundo García-Boyero, Juan Miguel Bergua Burgues, Lisette Costilla-Barriga, Tamara Castaño, Jorge Labrador, Armando Mena Duran, Maria Dolores Madrigal Toscano, Maria Del Mar Hermosilla-Fernandez, Carmen Couto, Esther Perez Santaolla, Jose Mario Mariz, Sandra Casal Marini, Cristina Gil, David Martinez-Cuadron, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 4234.
https://doi.org/10.1182/blood-2023-190296
Published: 2023
Journal Articles

Pivekimab Sunirine (PVEK, IMGN632), a CD123-Targeting Antibody-Drug Conjugate, in Combination with Azacitidine and Venetoclax in Patients with Newly Diagnosed Acute Myeloid Leukemia

Naval Daver, Pau Montesinos, Jessica K. Altman, Eunice S. Wang, Giovanni Martinelli, Gail J. Roboz, Kebede Begna, Paresh Vyas, Monia Lunghi, Uwe Platzbecker, Patrick W. Burke, Roland B. Walter, Anjali S. Advani, Sylvain Garciaz, Lauris Gastaud, David A Sallman, Naveen Pemmaraju, Laura Torres, Yasmin Abaza, Onyee Chan, Hagop M. Kantarjian, Benjamin Oshrine, Yining Du, Kara Malcolm, Kendra Sweet
Journal: Blood
Blood (2023) 142 (Supplement 1): 2906.
https://doi.org/10.1182/blood-2023-173413
Published: 2023
Journal Articles

Kinetics of Complete Remission (CR) and CR Duration and Its Impact on Overall Survival (OS) and Event-Free Survival (EFS) in Quantum-First

Pau Montesinos, Alexander Perl, Mikkael A. Sekeres, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Richard F Schlenk, Harry P. Erba, Hervé Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 4254.
https://doi.org/10.1182/blood-2023-187286
Published: 2023
Journal Articles

Role of Allogeneic Stem Cell Transplantation in Preventing Relapse in Adult BCR::ABL1-like Acute Lymphoblastic Leukemia

Jordi Ribera, Mireia Morgades, Isabel Granada, Teresa González, Ricardo Sánchez, Rosa Ayala, Esperanza Such, Gayane Avetisyan, Susana Barrera, Beatriz Soriano, Anna Torrent, Cristina Gil, Carmen Botella, Clara Maluquer Artigal, Pere Barba, Pau Montesinos, José González-Campos, Pilar Martínez-Sánchez, Rosa Coll, Jordi Esteve, Maria Rocio Benito Sanchez, Thaysa Lopes, Celia González Gil, Eulàlia Genescà, Joaquin Martínez-López, Jesús María Hernández-Rivas, Alberto Orfao, Josep-Maria Ribera
Journal: Blood
Blood (2023) 142 (Supplement 1): 1461.
https://doi.org/10.1182/blood-2023-186265
Published: 2023
Journal Articles

A High Percentage of DNAM-1+ and Low Percentage of Tactile+ NK Cells at Diagnosis Correlate with Complete Response and Survival in AML: A Sub-Analysis of the Ven-a-Qui Pethema Trial

Juan Miguel Bergua Burgues, Raquel Tarazona, Javier Garcia Casado, Juan J Gordillo, Ignacio Casas Aviles, Rebeca Rodriguez Veiga, Isabel Cano, Ferran Vall-Llovera Calmet, Antonio Garcia, Joaquin Gomez Espuch, Mercedes Colorado, Jordi Esteve, Victoria Verdugo Cabeza De Vaca, Maria Antonia Sanpol, Fernando Ramos, Marta Valero, Evelyn Acuña-Cruz, Blanca Boluda, Joaquin Martinez-Lopez, Rosa Ayala, Eva Barragán, David Martinez-Cuadron, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 2960.
https://doi.org/10.1182/blood-2023-189676
Published: 2023
Journal Articles

Exploring Potential Molecular Mechanisms of Drug Response in FLT3-ITD Negative AML Patients Treated with Quizartinib Vs Placebo Plus Standard Chemotherapy in the Quiwi Trial

Adrian Mosquera Orgueira, Manuel Perez Encinas, Jose Angel Diaz Arias, Rebeca Rodriguez Veiga, Juan Miguel Bergua Burgues, Lorenzo Algarra, Carmen Botella, Jose Antonio Perez Simon, Teresa Bernal, Mar Tormo, Maria Calbacho, Olga Salamero, Josefina Serrano, Victor Noriega, Juan Antonio Lopez Lopez, Susana Vives, Mercedes Colorado, Jose Luis Lopez Lorenzo, Maria Vidriales Vicente, Raimundo Garcia Boyero, Maria Teresa Olave Rubio, Pilar Herrera Puente, Olga Arce, Manuel Barrios Garcia, Maria Jose Sayas Lloris, Marta Polo, Maria Isabel Gomez Roncero, Eva Barragan, Rosa Ayala, Carmen Chillon, Maria Jose Calasanz, Blanca Boluda, Andres Peleteiro Raindo, Raquel Amigo, Jorge Labrador, David Martinez Cuadron, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 6037.
https://doi.org/10.1182/blood-2023-180710
Published: 2023
Journal Articles

Secondary Acute Myeloid Leukemia from a Previous Chronic Myeloproliferative Neoplasm: A Study of Grelam-Chile Concerning Chilean Patients on Behalf of AML Pethema Registry

Marcela Espinoza, Monica Alejandra Romero, Joaquín Jerez, Francisca Bass, Veronica Lizama, Rafael Benavente, Matias Eugenio Sanchez, Natalia Aranguiz, Miguel Nicolas Lopez, Maria Carolina Guerra, Sebastián Hidalgo, Verónica Pérez, Belkys Mercedes Linares, Robert Holloway Melo, Lucas Carcamo, Christine Rojas, Hernán López-Vidal, Juan Manuel Sanchez, Francisco Samaniego, Pau Montesinos, David Martinez-Cuadron
Journal: Blood
Blood (2023) 142 (Supplement 1): 5921.
https://doi.org/10.1182/blood-2023-185288
Published: 2023
Journal Articles

Covalent Menin Inhibitor Bmf-219 in Patients with Relapsed or Refractory (R/R) Acute Leukemia (AL): Preliminary Phase 1 Data from the Covalent-101 Study

Jeffrey Lancet, Farhad Ravandi, Pau Montesinos, Jacqueline C. Barrientos, Talha Badar, Adrián Alegre, Asad Bashey, Juan Miguel Bergua Burgues, Lorenzo Brunetti, Emily K Curran, David C. Christian de Leeuw, Enrico Derenzini, Geert A. Huls, Jeroen J.W.M. Janssen, Deepa Jeyakumar, Mojca Jongen-Lavrencic, Ashwin Kishtagari, Maria-Victoria Mateos, Daniel Morillo, Alessandro Rambaldi, Aaron S. Rosenberg, Gary J. Schiller, Uzma Ahmed, Alexandru Cacovean, Stephan W. Morris, Courtney Follit, Brian Munneke, Ganesh Waghmare, Clarissa Mandap, Mona Vimal, Thomas Butler, Hetty E. Carraway
Journal: Blood
Blood (2023) 142 (Supplement 1): 2916.
https://doi.org/10.1182/blood-2023-173149
Published: 2023
Journal Articles

Ponatinib Versus Imatinib in Patients with Newly Diagnosed Ph+ ALL: Subgroup Analysis of the Phase 3 Phallcon Study

Ibrahim Aldoss, Josep-Maria Ribera, Hagop Kantarjian, Pau Montesinos, Jessica T. Leonard, David Gomez-Almaguer, Maria R. Baer, Carlo Gambacorti-Passerini, James McCloskey, Yosuke Minami, Cristina Papayannidis, Vanderson Rocha, Philippe Rousselot, Pankit Vachhani, Eunice S. Wang, Meliessa Hennessy, Niti Patel, Alexander Vorog, Bingxia Wang, Elias Jabbour
Journal: Blood
Blood (2023) 142 (Supplement 1): 2871.
https://doi.org/10.1182/blood-2023-179537
Published: 2023
Journal Articles

Treatment Outcomes in Unfit Patients with Newly Acute Myeloid Leukemia According to IDH1 Mutational Status: Real World Evidence from the Pethema Epidemiologic Registry

David Martinez-Cuadron, Blanca Boluda, Jesús Lorenzo Algarra, Juan Miguel Bergua Burgues, Rebeca Rodriguez Veiga, Pilar Martinez Sanchez, Josefina Serrano, Fernando Jesús Ramos-Ortega, Jose A. Pérez-Simón, Mar Tormo, Jose Luis Lopez Lorenzo, Esperanza Lavilla, Teresa Bernal Del Castillo, Carlos Rodríguez-Medina, Maria Carmen GARCIA Garay, Maria Jose Sayas Lloris, Cristina Gil, Maria Teresa Olave Rubio, Raimundo Garcia Boyero, Susana Vives, Maria Angeles Foncillas, Jorge Labrador, Francisco Ibañez, Ana Cabello, Pilar Herrera Puente, Bernardo Javier González González, Eva Barragán, Claudia Sargas, Rosa Ayala, Carmen Chillon, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 4223.
https://doi.org/10.1182/blood-2023-189800
Published: 2023
Journal Articles

Dose Escalation of HLA-A2-WT1 CD3 T-Cell Bispecific Antibody in a Phase I Study in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)

Martin Hutchings, Pau Montesinos, Armando Santoro, Hsin-An Hou, Maria Pilar Martinez-Sanchez, Susana Vives, Sara Galimberti, Tsai-Yun Chen, Marco Frigeni, Sylvain Garciaz, Olga Salamero, Su-Peng Yeh, Karen Yee, Gabriel Schnetzler, Teresa Barata, Silke Simon, Heather Hinton, Koorosh Korfi, Muriel Richard, Nino Keshelava, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 1537.
https://doi.org/10.1182/blood-2023-173302
Published: 2023