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Urszula Pakulska
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Journal Articles

River-81: A Multicenter, Open-Label, Dose-Finding Clinical Trial to Assess Safety, PK, PD, Clinical Efficacy of RVU120 in Combination with Venetoclax in Patients with AML Failing Prior Venetoclax Plus Hypomethylating Agent Therapy

Maria Benedetta Giannini, Adolfo De la Fuente Burguera, Adriano Venditti, Witold Prejzner, Sara García, Noemi Angelosanto, Hendrik Nogai, Renata Dudziak, Vakul Mohanty, Natalia Baran, Marta Obacz, Urszula Pakulska, Jerzy Woźnicki, Katarzyna Wiklik, Marta Micek, Tomasz Rzymski, Milena Mazan, Agnieszka Sroka-Porada, Gary Wilkinson, Aleksandra Butrym, Erika Borlenghi, Krzysztof Mądry, Jan Kulis, Diego Coelho, Daniel Grzywczak
Journal: Blood
Blood (2024) 144 (Supplement 1): 5999.
https://doi.org/10.1182/blood-2024-200055
Published: 2024
Journal Articles

Novel Clinically Useful Inhibitor of Mediator Complex, RVU120, Relives Differentiation Block in MDS/AML

Opeyemi Ajibade, Urszula Pakulska, Emma Rabinovich, Ariel Fromowitz, Srabani Sahu, Sarah Aminov, Nandini Ramachandra, Srinivas Aluri, Shanisha Gordon Mitchell, Milagros Carbajal, Kinga Keska-Izworska, Michał Combik, Marta Obacz, Elżbieta Adamczyk, Jan M. Zaucha, Ewa Zarzycka, Przemyslaw Juszczynski, Jacqueline Boultwood, Andrea Pellagatti, Kith Pradhan, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Milena Mazan, Tomasz Rzymski, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 3225.
https://doi.org/10.1182/blood-2023-186227
Published: 2023
Journal Articles

Preclinical and Clinical Evidence for Erythroid-Stimulating Activity of RVU120 CDK8/19 Inhibitor in AML and MDS

Noemi Angelosanto, Ewa Lech Marańda, Jan Maciej Zaucha, Camille N. Abboud, Agnieszka Sroka-Porada, Wiktoria Ogrodzińska, Magdalena Kozakowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Tomasz Rzymski, Milena Mazan, Urszula Pakulska, Kristina Göller, Ewa Zarzycka, Hendrik Nogai
Journal: Blood
Blood (2023) 142 (Supplement 1): 2800.
https://doi.org/10.1182/blood-2023-189064
Published: 2023
Journal Articles

Targeting CDK8/CDK19 to Disrupt Leukemic Stem Cell-like Population in Acute Myeloid Leukemia: Exploring RVU120 As a Promising Frontline Therapy

Milena Mazan, Urszula Pakulska, Adrianna Moszyńska, Agnieszka Sroka-Porada, Krzysztof Tomasz Szade, Michał Mikula, Magdalena Kozakowska, Przemysław Juszczyński, Katarzyna Wiklik, Kristina Göller, Marta Obacz, Camille N. Abboud, Jan Maciej Zaucha, Ewa Lech Marańda, Noemi Angelosanto, Hendrik Nogai, Tomasz Rzymski
Journal: Blood
Blood (2023) 142 (Supplement 1): 4175.
https://doi.org/10.1182/blood-2023-188866
Published: 2023
Journal Articles

Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action

Tomasz Rzymski, Agnieszka Sroka-Porada, Magdalena Kozakowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Marta Obacz, Peter Littlewood, Kamil Kuś, Kristina Goller, Kinga Kęska, Urszula Pakulska, Kamila Kozłowska-Tomczyk, Monika Madej, Milena Mazan, Przemyslaw Juszczynski, Jan M. Zaucha, Agnieszka Zarzycka, Noemi Angelosanto, Hendrik Nogai, Krzysztof Brzózka
Journal: Blood
Blood (2022) 140 (Supplement 1): 5939–5940.
https://doi.org/10.1182/blood-2022-168906
Published: 2022
Journal Articles

Preclinical and Clinical Signs of Efficacy of RVU120 (SEL120), a Specific CDK8/19 Inhibitor in DNMT3A-Mutated AML

Tomasz Rzymski, Urszula Pakulska, Camille Abboud, Sr., Howard A. Burris, Sr., Scott R. Solomon, Marta Obacz, Kristina Goller, Michal Combik, Jan Zaucha, Milena Mazan, Michal Mikula, Magdalena Cybulska, Anna Polak, Przemyslaw Juszczynski, Marcus Järås, Marion Chapellier, Johan Flygare, Magdalena Zawadzka, Karolina Bukowska Strakova, Krzysztof Brzozka, Setareh Shamsili, Noemi Angelosanto
Journal: Blood
Blood (2021) 138 (Supplement 1): 2371.
https://doi.org/10.1182/blood-2021-152273
Published: 2021
Journal Articles

RVU120 (SEL120) CDK8/19 Inhibitor - a Drug Candidate for the Treatment of MDS Can Induce Erythroid Differentiation

Urszula Pakulska, Marta Obacz, Kristina Goller, Michal Combik, Kinga Keska, Jan Zaucha, Ewa Zarzycka, Milena Mazan, Michal Mikula, Magdalena Cybulska, Anna Polak, Przemyslaw Juszczynski, Johan Flygare, Jun Chen, Krzysztof Brzozka, Marcus Järås, Katarzyna Dziedzic, Noemi Angelosanto, Setareh Shamsili, Tomasz Rzymski
Journal: Blood
Blood (2021) 138 (Supplement 1): 1518.
https://doi.org/10.1182/blood-2021-150662
Published: 2021