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Nandini Ramachandra
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Journal Articles

TGF-β1-SMAD2 Axis Regulates Hematopoiesis and β-Globin Gene Expression Via Super-Enhancer Associated Chromatin Reorganization

Srinivas Aluri, Kimo Bachiashvili, Anjali Budhathoki, Jong J Jeong, Shanisha Gordon Mitchell, Milagros Carbajal, Samarpana Chakraborty, Sanjay Pandey, Mahinder Paul Wadhwa, Srabani Sahu, Jung-In Yang, Gaurav S Choudhary, Tushar Damodar Bhagat, Nandini Ramachandra, Rongbao Zhao, Bianca Rivera, Ritesh Aggarwal, Kith Pradhan, Shahina Maqbool, Seong jin Kim, Sunjin Hwang, Ulrich Steidl, Aditi Shastri, Marc Raaijmakers, Andrea Pellagatti, Jacqueline Boultwood, Amittha Wickrema, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 878.
https://doi.org/10.1182/blood-2024-201101
Published: 2024
Journal Articles

Inhibition of Toll-like Receptor 4 (TLR4) Promotes Erythroid and Myeloid Differentiation in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Ariel Fromowitz, Srinivas Aluri, Jesus D Gonzalez Lugo, Emma Rabinovich, Nandini Ramachandra, Sarah Aminov, Srabani Sahu, Shanisha Gordon Mitchell, Ritesh Aggarwal, Opeyemi Ajibade, Milagros Carbajal, Kith Pradhan, Andrea Pellagatti, Jacqueline Boultwood, Aditi Shastri, Rongbao Zhao, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 5615.
https://doi.org/10.1182/blood-2023-182059
Published: 2023
Journal Articles

Preclinical Activity of Novel TGF Beta Receptor I Kinase Inhibitors IOA-359 and IOA-360 for Treatment of Anemia in MDS/AML

Nandini Ramachandra, Charan Thej Reddy Vegivinti, Srabani Sahu, Bianca Rivera, Sarah Aminov, Ariel Fromowitz, Jinghang Zhang, Fnu Aodengtuya, Kith Pradhan, Rongbao Zhao, Leya Schwartz, Victor Thiruthuvanathan, Rahul Sanawar, Emma Rabinovich, Opeyemi Ajibade, Aditi Shastri, Michael Lahn, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 4589.
https://doi.org/10.1182/blood-2023-179921
Published: 2023
Journal Articles

Novel Clinically Useful Inhibitor of Mediator Complex, RVU120, Relives Differentiation Block in MDS/AML

Opeyemi Ajibade, Urszula Pakulska, Emma Rabinovich, Ariel Fromowitz, Srabani Sahu, Sarah Aminov, Nandini Ramachandra, Srinivas Aluri, Shanisha Gordon Mitchell, Milagros Carbajal, Kinga Keska-Izworska, Michał Combik, Marta Obacz, Elżbieta Adamczyk, Jan M. Zaucha, Ewa Zarzycka, Przemyslaw Juszczynski, Jacqueline Boultwood, Andrea Pellagatti, Kith Pradhan, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Milena Mazan, Tomasz Rzymski, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 3225.
https://doi.org/10.1182/blood-2023-186227
Published: 2023
Journal Articles

The Dual Inflammasome/Myddosome Inhibitor HT-6184 Restores Erythropoiesis in MDS/AML

Emma Rabinovich, Ariel Fromowitz, Opeyemi Ajibade, Srabani Sahu, Divij Verma, Sarah Aminov, Nandini Ramachandra, Christopher Selverian, Nailya Khalizova, Srinivas Aluri, Rahul Sanawar, Shanisha Gordon Mitchell, Milagros Carbajal, Jacqueline Boultwood, Andrea Pellagatti, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Alexis Mollard, Margit Janat-Amsbury, David J. Bearss, Alan F. List, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 1417.
https://doi.org/10.1182/blood-2023-182289
Published: 2023
Journal Articles

Pyrimethamine, a STAT3 Inhibitor, Synergizes with Venetoclax and Shows Efficacy in Hypomethylating Agent Resistant MDS and AML

Bianca L Rivera, Samarpana Chakraborty, Yang Shi, Hui Zhang, Gaurav S Choudhary, Shanisha Gordon, Kith Pradhan, Bowen Fu, Isidora Tosic, Rongbao Zhao, Mendel Goldfinger, Ioannis Mantzaris, Milagros Carbajal, Nandini Ramachandra, Marina Konopleva, David Frank, Yogenthiran Saunthararajah, Amit Verma, Aditi Shastri
Journal: Blood
Blood (2022) 140 (Supplement 1): 6892–6893.
https://doi.org/10.1182/blood-2022-163255
Published: 2022
Journal Articles

Preclinical Activity of the Clinical Stage Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Splicing Mutant Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Leya Y Schwartz, Gaurav S Choudhary, Nandini Ramachandra, Srabani Sahu, Shanisha Gordon, Bruce Ruggeri, Diane Heiser, Peggy Scherle, Daniel Starczynowski, Amit Verma
Journal: Blood
Blood (2021) 138 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2021-148494
Published: 2021
Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2989.
https://doi.org/10.1182/blood-2019-126850
Published: 2019
Journal Articles

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

Srinivas Aluri, Kimo Bachiashvili, MD, Anjali Budhathoki, MD, Tushar D Bhagat, PhD, Gaurav S Choudhary, PhD, Shanisha Gordon, Nandini Ramachandra, Kith Pradhan, PhD, Shahina Maqbool, Aditi Shastri, MD, Jung Im Huh, Sunjin Hwang, Kim Seong-Jin, PhD, Hui Zhang, Britta Will, PhD, Amittha Wickrema, PhD, Ulrich G. Steidl, MD PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2990.
https://doi.org/10.1182/blood-2019-127561
Published: 2019
Journal Articles

Targeting MDS and AML Stem Cells with AZD-9150 Mediated Inhibition of STAT3

Aditi Shastri, MD, Margarida Teixeira, PhD, Sanchari Bhattacharyya, PhD, Nandini Ramachandra, Msc, Robert Lopez, MD, Goutham Ravipati, Jonathan Feld, MD, Yosman Dhar, Tushar Damodar Bhagat, PhD, Gaurav Choudhary, PhD, Orsolya Giricz, PhD, Matthias Bartenstein, Ashwin Sridharan, MD, Shanisha Gordon-Mitchell, George Nawanko, Kith Pradhan, PhD, Amal Ahmed, Keshav Raghavendran, Rubashruti Kanna, Hina Khan, MD, Ioannis Mantzaris, MD, Andrea Pellagatti, PhD, Jacqueline Boultwood, PhD, Youngsoo Kim, PhD, Robert McLeod, Richard Woessner, PhD, Ulrich Steidl, MDPhD, Britta Will, PhD, Amit Verma, MD
Journal: Blood
Blood (2016) 128 (22): 4314.
https://doi.org/10.1182/blood.V128.22.4314.4314
Published: 2016
Journal Articles

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Carolina Schinke, Orsolya Giricz, Weijuan Li, Aditi Shastri, Shanisha Gordon, Laura Barreyro, Tushar Bhagat, Sanchari Bhattacharyya, Nandini Ramachandra, Matthias Bartenstein, Andrea Pellagatti, Jacqueline Boultwood, Amittha Wickrema, Yiting Yu, Britta Will, Sheng Wei, Ulrich Steidl, Amit Verma
Journal: Blood
Blood (2015) 125 (20): 3144–3152.
https://doi.org/10.1182/blood-2015-01-621631
Published: 2015
Includes: Supplemental data