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Journal Articles

Decitabine Activity Against TP53 -Mutated Myeloid Neoplasms Is Enhanced By Combination with a Non-Cytotoxic p53/BAX-Independent Inhibitor of Pyrimidine Synthesis

Sudipta Biswas, Zeinab Albadry M. Zahran, Xiaorong Gu, Lisa Cardone, Akriti G. Jain, Kateryna Fedorov, Ben K. Tomlinson, Mendel Goldfinger, Amit Verma, Yogenthiran Saunthararajah

Blood (2024) 144 (Supplement 1): 1382.

https://doi.org/10.1182/blood-2024-210609

Published: 2024

Journal Articles

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

Xiaorong Gu, Zeinab Albadry M. Zahran, Ramesh Balusu, Jaroslaw Maciejewski, Babal K. Jha, Yogenthiran Saunthararajah

Blood (2024) 144 (Supplement 1): 2714.

https://doi.org/10.1182/blood-2024-205887

Published: 2024

Journal Articles

Fatty Acid Binding Protein FABP5 Inhibition Activates Retinoic Acid Signaling and Induces Differentiation in Acute Myeloid Leukemia

Divya Jyoti Singh, Metis Hasipek, Dongxu Jiang, Daniel Vail, Yahan Zhang, Jill Durkin, Naomi Kawashima, Simon Schlanger, Xiaorong Gu, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah, Hetty E. Carraway, Babal Kant Jha

Blood (2023) 142 (Supplement 1): 1422.

https://doi.org/10.1182/blood-2023-189274

Published: 2023

Journal Articles

Translating an HPFH-Mechanism into Oral Small Molecule Therapy for Beta-Hemoglobinopathies: Clinical Proof-of-Principle

Robert Molokie, Santosh L. Saraf, Lani Krauz, Michael Pacini, David Chan, Alana Aziz-Bradley, Rebeca Gansari, Taif Hassan, Philip Woost, James Jacobberger, Victor R. Gordeuk, Donald E. Lavelle, Joseph DeSimone, Yogenthiran Saunthararajah

Blood (2023) 142 (Supplement 1): 2524.

https://doi.org/10.1182/blood-2023-186228

Published: 2023

Journal Articles

BCR-ABL1 Dislocates NPM1, PU.1 and KLF1 into Cytoplasm to Thereby Skew Granulo-Monocytic and Impede Erythroid Differentiation

Zeinab Albadry M. Zahran, Xiaorong Gu, Babal K. Jha, Yogenthiran Saunthararajah

Blood (2023) 142 (Supplement 1): 1375.

https://doi.org/10.1182/blood-2023-187016

Published: 2023

Journal Articles

Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis )

Vinzon Ibanez, Kestis Vaitkus, Robert Molokie, Yogenthiran Saunthararajah, Donald Lavelle

Blood (2023) 142 (Supplement 1): 1109.

https://doi.org/10.1182/blood-2023-189523

Published: 2023

Journal Articles

Pyrimethamine, a STAT3 Inhibitor, Synergizes with Venetoclax and Shows Efficacy in Hypomethylating Agent Resistant MDS and AML

Bianca L Rivera, Samarpana Chakraborty, Yang Shi, Hui Zhang, Gaurav S Choudhary, Shanisha Gordon, Kith Pradhan, Bowen Fu, Isidora Tosic, Rongbao Zhao, Mendel Goldfinger, Ioannis Mantzaris, Milagros Carbajal, Nandini Ramachandra, Marina Konopleva, David Frank, Yogenthiran Saunthararajah, Amit Verma, Aditi Shastri

Blood (2022) 140 (Supplement 1): 6892–6893.

https://doi.org/10.1182/blood-2022-163255

Published: 2022

Journal Articles

FLT3-ITD Degrades CEBPA Via the Ubiquitin-Proteosome Pathway

Xiaorong Gu, Zeinab Albadry M. Zahran, Nneha Sakre, Caroline Schuerger, Yogenthiran Saunthararajah

Blood (2022) 140 (Supplement 1): 2993–2994.

https://doi.org/10.1182/blood-2022-166612

Published: 2022

Journal Articles

ANKRD26 Coding Variants in Myeloid Neoplasia

Teodora Kuzmanovic, Metis Hasipek, Samuel Li, Thomas Laframboise, Valeria Visconte, Sunisa Kongkiatkamon, Seth J. Corey, Sudipto Mukherjee, Anjali Advani, Aaron T. Gerds, Yogenthiran Saunthararajah, Sophia R. Balderman, Abhay Singh Singh, Hetty E. Carraway, Niroshan Nadarajah, Manja Meggendorfer, Jaroslaw P. Maciejewski, Bhumika J. Patel

Blood (2022) 140 (Supplement 1): 4013–4015.

https://doi.org/10.1182/blood-2022-170645

Published: 2022

Journal Articles

A Non-Cytotoxic Regimen Using a Weekly Low Dose Decitabine and Venetoclax for MDS and AML in a Real World Cohort

David Levitz, Kateryna Fedorov, Kith Pradhan, Lauren C Shapiro, Aditi Shastri, Kira Gritsman, Nishi Shah, Noah Kornblum, R. Alejandro Sica, Ira Braunschweig, Marina Konopleva, Eric J. Feldman, Amit Verma, Ioannis Mantzaris, Yogenthiran Saunthararajah, Mendel Goldfinger

Blood (2022) 140 (Supplement 1): 6218–6219.

https://doi.org/10.1182/blood-2022-170059

Published: 2022

Journal Articles

Prolonged Combinatorial Pharmacological Therapy Targeting the Epigenome Increases Fetal Hemoglobin to Clinically Relevant Levels in Normal, Nonanemic Baboons

Vinzon Ibanez, Kestis Vaitkus, Robert E. Molokie, Jagadeesh Ramasamy, Yogenthiran Saunthararajah, Donald Lavelle

Blood (2022) 140 (Supplement 1): 961–962.

https://doi.org/10.1182/blood-2022-155954

Published: 2022

Journal Articles

Effect of the NAMPT Activator P7C3-A20 on γ-Globin Expression in Baboon CD34+ Erythroid Cell Cultures

Vinzon Ibanez, Kestis Vaitkus, Jagadeesh Ramasamy, Yogenthiran Saunthararajah, Robert E. Molokie, Donald Lavelle

Blood (2021) 138 (Supplement 1): 961.

https://doi.org/10.1182/blood-2021-145126

Published: 2021

Journal Articles

A Novel Approach to Induce ATRA Mediated Differentiation in NPM1 Mutant Acute Myeloid Leukemia

Metis Hasipek, Yihong Guan, Dale Grabowski, Xiaorong Gu, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah, Hetty E. Carraway, Babal K. Jha

Blood (2021) 138 (Supplement 1): 786.

https://doi.org/10.1182/blood-2021-151394

Published: 2021

Journal Articles

Co-Occurrence of MDS with MGUS Represents a Unique Disease Entity with Specific Molecular Phenotype and Potential Improved Clinical Outcome

Tariq Kewan, Ramsha Ahmed, Carmelo Gurnari, Waled Bahaj, Simona Pagliuca, Yogenthiran Saunthararajah, Bhumika J. Patel, Sudipto Mukherjee, Aaron T. Gerds, Anjali Advani, Valeria Visconte, Jaroslaw P. Maciejewski, Hetty E. Carraway

Blood (2021) 138 (Supplement 1): 1529.

https://doi.org/10.1182/blood-2021-151858

Published: 2021

Journal Articles

Low-Dose Weekly Decitabine and Venetoclax in TP53-Mutated Myeloid Malignancies

Lauren C Shapiro, Ioannis Mantzaris, Aditi Shastri, R. Alejandro Sica, Lizamarie Bachier-Rodriguez, Noah Kornblum, Kira Gritsman, Eric J. Feldman, Amit Verma, Ira Braunschweig, Yogenthiran Saunthararajah, Mendel Goldfinger

Blood (2021) 138 (Supplement 1): 4428.

https://doi.org/10.1182/blood-2021-145960

Published: 2021

Journal Articles

The Drive to Acquire Biallelic Hits Inversely Correlates with the Functional Impact of the Primary TP53 Lesion: The Complexity of TP53 Role Assessment

Waled Bahaj, Carmelo Gurnari, Tariq Kewan, Suresh Kumar Balasubramanian, Simona Pagliuca, Yogenthiran Saunthararajah, Laila Terkawi, Misam Zawit, Hassan Awada, Babal K. Jha, Valeria Visconte, Betty K. Hamilton, Hetty E. Carraway, Jaroslaw P. Maciejewski

Blood (2021) 138 (Supplement 1): 3322.

https://doi.org/10.1182/blood-2021-152848

Published: 2021

Journal Articles

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Sunisa Kongkiatkamon, Xiaorong Gu, Kwok Peng Ng, Simona Pagliuca, Vera Adema, Wencke Walter, Yasunobu Nagata, Cassandra M Kerr, Cassandra M Kerr, Manja Meggendorfer, Hassan Awada, Stephan Hutter, Carmelo Gurnari, Claudia Haferlach, Babal K. Jha, Valeria Visconte, Torsten Haferlach, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah

Blood (2021) 138 (Supplement 1): 1148.

https://doi.org/10.1182/blood-2021-153618

Published: 2021

Journal Articles

Nicotinamide Improves Anemia and Decreases Reactive Oxygen Species in Sickle Cell Disease Mice

Jagadeesh Ramasamy, Vinzon Ibanez, Vijaya Lakshmi Yalagala, Yogenthiran Saunthararajah, Robert E. Molokie, Angela Rivers, Donald Lavelle

Blood (2021) 138 (Supplement 1): 2019.

https://doi.org/10.1182/blood-2021-144956

Published: 2021

Journal Articles

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

Metis Hasipek, PhD, Yihong Guan, PhD, Dale Grabowski, BS, Xiaorong Gu, PhD, Yogenthiran Saunthararajah, MD, Robert Silverman, PhD, George R Stark, PhD, Jaroslaw Maciejewski, PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 29–30.

https://doi.org/10.1182/blood-2020-142457

Published: 2020

Journal Articles

Double Genetic Hits and Subclonal Mosaicism in the Ras Signaling Pathway in Myeloid Neoplasia

Sunisa Kongkiatkamon, MD, Yasunobu Nagata, MD PhD, Vera Adema, PhD, Hassan Awada, MD, Misam Zawit, MD, Laila Terkawi, Simona Pagliuca, MD, Carmelo Gurnari, MD, Cassandra M Kerr, MS, Mikkael A. Sekeres, MD MS, Hetty E. Carraway, MD MBA, Yogenthiran Saunthararajah, MD, Bhumika J. Patel, MD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD

Blood (2020) 136 (Supplement 1): 34–35.

https://doi.org/10.1182/blood-2020-143210

Published: 2020

NARROW

Decitabine Activity Against TP53 -Mutated Myeloid Neoplasms Is Enhanced By Combination with a Non-Cytotoxic p53/BAX-Independent Inhibitor of Pyrimidine Synthesis

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

Fatty Acid Binding Protein FABP5 Inhibition Activates Retinoic Acid Signaling and Induces Differentiation in Acute Myeloid Leukemia

Translating an HPFH-Mechanism into Oral Small Molecule Therapy for Beta-Hemoglobinopathies: Clinical Proof-of-Principle

BCR-ABL1 Dislocates NPM1, PU.1 and KLF1 into Cytoplasm to Thereby Skew Granulo-Monocytic and Impede Erythroid Differentiation

Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis )

Pyrimethamine, a STAT3 Inhibitor, Synergizes with Venetoclax and Shows Efficacy in Hypomethylating Agent Resistant MDS and AML

FLT3-ITD Degrades CEBPA Via the Ubiquitin-Proteosome Pathway

ANKRD26 Coding Variants in Myeloid Neoplasia

A Non-Cytotoxic Regimen Using a Weekly Low Dose Decitabine and Venetoclax for MDS and AML in a Real World Cohort

Prolonged Combinatorial Pharmacological Therapy Targeting the Epigenome Increases Fetal Hemoglobin to Clinically Relevant Levels in Normal, Nonanemic Baboons

Effect of the NAMPT Activator P7C3-A20 on γ-Globin Expression in Baboon CD34+ Erythroid Cell Cultures

A Novel Approach to Induce ATRA Mediated Differentiation in NPM1 Mutant Acute Myeloid Leukemia

Co-Occurrence of MDS with MGUS Represents a Unique Disease Entity with Specific Molecular Phenotype and Potential Improved Clinical Outcome

Low-Dose Weekly Decitabine and Venetoclax in TP53-Mutated Myeloid Malignancies

The Drive to Acquire Biallelic Hits Inversely Correlates with the Functional Impact of the Primary TP53 Lesion: The Complexity of TP53 Role Assessment

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Nicotinamide Improves Anemia and Decreases Reactive Oxygen Species in Sickle Cell Disease Mice

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

Double Genetic Hits and Subclonal Mosaicism in the Ras Signaling Pathway in Myeloid Neoplasia

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American Society of Hematology

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American Society of Hematology

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