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Gaurav S Choudhary
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Journal Articles

TGF-β1-SMAD2 Axis Regulates Hematopoiesis and β-Globin Gene Expression Via Super-Enhancer Associated Chromatin Reorganization

Srinivas Aluri, Kimo Bachiashvili, Anjali Budhathoki, Jong J Jeong, Shanisha Gordon Mitchell, Milagros Carbajal, Samarpana Chakraborty, Sanjay Pandey, Mahinder Paul Wadhwa, Srabani Sahu, Jung-In Yang, Gaurav S Choudhary, Tushar Damodar Bhagat, Nandini Ramachandra, Rongbao Zhao, Bianca Rivera, Ritesh Aggarwal, Kith Pradhan, Shahina Maqbool, Seong jin Kim, Sunjin Hwang, Ulrich Steidl, Aditi Shastri, Marc Raaijmakers, Andrea Pellagatti, Jacqueline Boultwood, Amittha Wickrema, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 878.
https://doi.org/10.1182/blood-2024-201101
Published: 2024
Journal Articles

Preliminary Safety and Efficacy of Emavusertib (CA-4948) in Combination with Ibrutinib in Relapsed/Refractory Primary Central Nervous System Lymphoma Patients with Prior Exposure to BTK Inhibitor

Grzegorz S. Nowakowski, Anna Paulina Dabrowska-Iwanicka, Christian Grommes, Han W. Tun, Christopher D' Angelo, Adolfo De la Fuente Burguera, Etai Levi, Radhakrishnan Ramchandren, Andrés José María Ferreri, Gaurav S Choudhary, Wanying Zhao, Dora Ferrari, Meaghan Fowle, Maureen Lane, Catherine Wang, Michal Taszner
Journal: Blood
Blood (2024) 144 (Supplement 1): 6020.
https://doi.org/10.1182/blood-2024-208359
Published: 2024
Journal Articles

Preliminary Safety, Efficacy and Molecular Characterization in Patients with Higher-Risk Myelodysplastic Syndrome Treated with Single Agent Emavusertib (CA-4948)

Guillermo Garcia-Manero, David Sallman, Stefano R Tarantolo, Amit Verma, Stefanie Groepper, Alice Mims, Yasmin Abaza, James P. Dugan, Valle Gomez G De Soria, Gaurav S Choudhary, Maureen Lane, Wanying Zhao, Ashish Jain, Cole Gallagher, Uwe Platzbecker
Journal: Blood
Blood (2024) 144 (Supplement 1): 3225.
https://doi.org/10.1182/blood-2024-208292
Published: 2024
Journal Articles

Preliminary Safety, Efficacy, and Molecular Characterization of Emavusertib (CA-4948) in Relapsed/Refractory Acute Myeloid Leukemia Patients

Eric S. Winer, David Sallman, Adolfo De la Fuente Burguera, Amit Verma, Katharina Goetze, Yasmin Abaza, James P. Dugan, Thomas Cluzeau, Eduardo Rodriguez Arboli, Alice Mims, Stefanie Groepper, Itay Zilbershatz, Jane L. Liesveld, Walter Fiedler, Stefano R Tarantolo, Lionel Ades, Nikolaos Papadantonakis, Christoph Schliemann, Gaurav S Choudhary, Maureen Lane, Wanying Zhao, Ashish Jain, Cole Gallagher, Guillermo Garcia-Manero
Journal: Blood
Blood (2024) 144 (Supplement 1): 737.
https://doi.org/10.1182/blood-2024-207953
Published: 2024
Journal Articles

A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia

Samarpana Chakraborty, Claudia Morganti, Joyoti Dey, Hui Zhang, Srinivas Aluri, Nadege Gitego, Kith Pradhan, Bianca Rivera, Yogesh Chutake, Anna Skwarska, Ioannis Mantzaris, Mendel Goldfinger, Eric J Feldman, Gaurav S Choudhary, Stefan Hubner, Yihua Qiu, Brandon D. Brown, Amit Verma, Evripidis Gavathiotis, Marina Y. Konopleva, Steven M. Kornblau, Jared Gollob, Keisuke Ito, Aditi Shastri
Journal: Blood
Blood (2023) 142 (Supplement 1): 2787.
https://doi.org/10.1182/blood-2023-186947
Published: 2023
Journal Articles

Preliminary Safety and Efficacy of Emavusertib (CA-4948) in Acute Myeloid Leukemia Patients with FLT3 Mutation

Eric S. Winer, Amit Verma, Stefanie Groepper, Katharina S. S. Götze, Yasmin Abaza, Christoph Schliemann, Gaurav S Choudhary, Wanying Zhao, Cole Gallagher, Reinhard von Roemeling, Daniel J. DeAngelo
Journal: Blood
Blood (2023) 142 (Supplement 1): 2924.
https://doi.org/10.1182/blood-2023-190007
Published: 2023
Journal Articles

Trial in Progress: A Phase 1b Single-Arm, Open-Label Study of Emavusertib (CA-4948) in Combination with Azacitidine and Venetoclax in Acute Myeloid Leukemia Patients in Complete Response with Measurable Residual Disease

Adolfo De La Fuente Burguera, Claudio Cerchione, Sebastian Scholl, Jan Moritz Middeke, Gaurav S Choudhary, Reinhard von Roemeling, Uwe Platzbecker
Journal: Blood
Blood (2023) 142 (Supplement 1): 5975.
https://doi.org/10.1182/blood-2023-190125
Published: 2023
Journal Articles

Pyrimethamine, a STAT3 Inhibitor, Synergizes with Venetoclax and Shows Efficacy in Hypomethylating Agent Resistant MDS and AML

Bianca L Rivera, Samarpana Chakraborty, Yang Shi, Hui Zhang, Gaurav S Choudhary, Shanisha Gordon, Kith Pradhan, Bowen Fu, Isidora Tosic, Rongbao Zhao, Mendel Goldfinger, Ioannis Mantzaris, Milagros Carbajal, Nandini Ramachandra, Marina Konopleva, David Frank, Yogenthiran Saunthararajah, Amit Verma, Aditi Shastri
Journal: Blood
Blood (2022) 140 (Supplement 1): 6892–6893.
https://doi.org/10.1182/blood-2022-163255
Published: 2022
Journal Articles

Preclinical Activity of the Clinical Stage Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Splicing Mutant Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Leya Y Schwartz, Gaurav S Choudhary, Nandini Ramachandra, Srabani Sahu, Shanisha Gordon, Bruce Ruggeri, Diane Heiser, Peggy Scherle, Daniel Starczynowski, Amit Verma
Journal: Blood
Blood (2021) 138 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2021-148494
Published: 2021
Journal Articles

A Transgenic Murine Model Expressing Hyperactive STAT3 Recapitulates the Features of MDS/AML

Bianca L Rivera, Shanisha Gordon, Srinivas Aluri, Yang Shi, Samarpana Chakraborty, Gaurav S Choudhary, Lauren C Shapiro, Kith Pradhan, David A. Frank, Sergei B. Koralov, Amit Verma, Aditi Shastri
Journal: Blood
Blood (2021) 138 (Supplement 1): 3308.
https://doi.org/10.1182/blood-2021-151691
Published: 2021
Journal Articles

Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition

Kathryn S Potts, Rosannah C. Cameron, Noura Ghazale, Varun Gupta, Juan Martin Barajas, LaShanale Wallace, Ana Leal-Cervantes, Srinivas Aluri, Kith Pradhan, Mia McKinstry, Xiaoying Bai, Gaurav S Choudhary, Aditi Shastri, Amit Verma, Esther A. Obeng, Teresa V. Bowman
Journal: Blood
Blood (2021) 138 (Supplement 1): 1509.
https://doi.org/10.1182/blood-2021-151338
Published: 2021
Journal Articles

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Gaurav S Choudhary, PhD, Molly A Smith, PhD, Andrea Pellagatti, Tushar D Bhagat, PhD, Shanisha Gordon, Sanjay Pandey, PhD, Nishi Shah, MBBS, MPH, Srinivas Aluri, Robert N Booher, PhD, Murali Ramachandra, PhD, Maria Elena Samson, Kith Pradhan, PhD, Teresa V. Bowman, PhD, Manoj M Pillai, MD, Chandan Guha, MBBS, Amittha Wickrema, PhD, Britta Will, PhD, Aditi Shastri, MD, Ulrich G. Steidl, MD PhD, Jacqueline Boultwood, Daniel T. Starczynowski, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4224.
https://doi.org/10.1182/blood-2019-124458
Published: 2019
Journal Articles

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

Srinivas Aluri, Kimo Bachiashvili, MD, Anjali Budhathoki, MD, Tushar D Bhagat, PhD, Gaurav S Choudhary, PhD, Shanisha Gordon, Nandini Ramachandra, Kith Pradhan, PhD, Shahina Maqbool, Aditi Shastri, MD, Jung Im Huh, Sunjin Hwang, Kim Seong-Jin, PhD, Hui Zhang, Britta Will, PhD, Amittha Wickrema, PhD, Ulrich G. Steidl, MD PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2990.
https://doi.org/10.1182/blood-2019-127561
Published: 2019
Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Sakshi Jasra, MD, Orsi Giricz, PhD, Rachel Zeig-Owens, M.P.H, David Goldfarb, M.P.H, Angelica Barreto-Galvez, Kith Pradhan, PhD, Jiahao Chen, PhD, Gaurav S Choudhary, PhD, Srinivas Aluri, Tushar D Bhagat, PhD, Aditi Shastri, MD, Victor Thiruthuvanathan, M.S, Hiroki Goto, MD PhD, Jeannine Gerhardt, PhD, Shanisha Gordon, Arul Veerappan, PhD, Syed Hissam Haider, MD, Matthias Bartenstein, MD, George Nwankwo, Ola Landgren, MD PhD, Michael Weiden, MD, Frederick Fletcher, Lee Greenberger, PhD, Benjamin L. Ebert, MD PhD, Ulrich G. Steidl, MD PhD, Britta Will, PhD, Anna Nolan, MD MS, David Prezant, MD, Advaitha Madireddy, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3720.
https://doi.org/10.1182/blood-2019-129276
Published: 2019
Journal Articles

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Urvi A. Shah, Elaine Y. Chung, Orsi Giricz, Kith Pradhan, Keisuke Kataoka, Shanisha Gordon-Mitchell, Tushar D. Bhagat, Yun Mai, Yongqiang Wei, Elise Ishida, Gaurav S. Choudhary, Ancy Joseph, Ronald Rice, Nadege Gitego, Crystall Parrish, Matthias Bartenstein, Swati Goel, Ioannis Mantzaris, Aditi Shastri, Olga Derman, Adam Binder, Kira Gritsman, Noah Kornblum, Ira Braunschweig, Chirag Bhagat, Jeff Hall, Armin Graber, Lee Ratner, Yanhua Wang, Seishi Ogawa, Amit Verma, B. Hilda Ye, Murali Janakiram
Journal: Blood
Blood (2018) 132 (14): 1507–1518.
https://doi.org/10.1182/blood-2018-01-824607
Published: 2018
Includes: Supplemental data