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Journal Articles

Preliminary Safety and Efficacy of Emavusertib (CA-4948) in Combination with Ibrutinib in Relapsed/Refractory Primary Central Nervous System Lymphoma Patients with Prior Exposure to BTK Inhibitor

Grzegorz S. Nowakowski, Anna Paulina Dabrowska-Iwanicka, Christian Grommes, Han W. Tun, Christopher D' Angelo, Adolfo De la Fuente Burguera, Etai Levi, Radhakrishnan Ramchandren, Andrés José María Ferreri, Gaurav S Choudhary, Wanying Zhao, Dora Ferrari, Meaghan Fowle, Maureen Lane, Catherine Wang, Michal Taszner
Journal: Blood
Blood (2024) 144 (Supplement 1): 6020.
https://doi.org/10.1182/blood-2024-208359
Published: 2024
Journal Articles

CAR T-Cell Therapy for DLBCL with CNS Involvement: Overall Safe and Effective with Limited Efficacy in Patients with Leptomeningeal Disease

Efrat Luttwak, Giulio Cassanello, Samantha Brown, Sean M. Devlin, Brandon S. Imber, Andrew Ip, Lori A. Leslie, Noa Golan Accav, Ofrat Beyar-Katz, Magdalena Corona, Alejandro Luna De Abia, Alfredo Rivas-Delgado, Jennifer Kimberly Lue, Christian Grommes, Gunjan L. Shah, Jae H. Park, Miguel Angel Perales, Gilles Salles, Roni Shouval, Maria Lia Palomba, Michael Scordo
Journal: Blood
Blood (2024) 144 (Supplement 1): 4509.
https://doi.org/10.1182/blood-2024-212274
Published: 2024
Journal Articles

CNS Radiotherapy As Bridging Prior to CAR T-Cell Therapy for Non-Hodgkin B-Cell Lymphoma

Gustav Cederquist, Javin Schefflein, Sean M. Devlin, Harper Hubbeling, Kathryn Tringale, Gunjan L. Shah, Ana Alarcon Tomas, Roni Shouval, Carla Hajj, Beatrice Fregonese, Parastoo B. Dahi, Richard J. Lin, Maria Lia Palomba, Miguel-Angel Perales, Gilles Salles, Lorenzo Falchi, Christian Grommes, Michael Scordo, Joachim Yahalom, Brandon S. Imber
Journal: Blood
Blood (2023) 142 (Supplement 1): 4491.
https://doi.org/10.1182/blood-2023-190326
Published: 2023
Journal Articles

Trial in Progress: An Open-Label Expansion Trial Evaluating the Safety, PK/PD, and Clinical Activity of Emavusertib (CA-4948) + Ibrutinib in R/R Primary CNS Lymphoma

Christian Grommes, Grzegorz S. Nowakowski, Allison C. Rosenthal, Matthew A Lunning, Radhakrishnan Ramchandren, Lucia Regales, Meaghan Fowle, Maureen Lane, Catherine Wang, Antonio Omuro, Lori A. Leslie, Carole Soussain, Anna Paulina Dabrowska-Iwanicka, Andrés José María Ferreri, Han Tun
Journal: Blood
Blood (2023) 142 (Supplement 1): 3143.
https://doi.org/10.1182/blood-2023-190391
Published: 2023
Journal Articles

Radiotherapy As an Effective Bridge for Relapsed/Refractory Secondary CNS Lymphoma

Gustav Cederquist, Kathryn Tringale, Carla Hajj, Harper Hubbeling, Jennifer Ma, Alexandra Dreyfuss, Beatrice Fregonese, Gilles Salles, Christian Grommes, Michael Scordo, Lorenzo Falchi, Joachim Yahalom, Brandon S. Imber
Journal: Blood
Blood (2023) 142 (Supplement 1): 1759.
https://doi.org/10.1182/blood-2023-190236
Published: 2023
Journal Articles

Takeaim Lymphoma: An Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Combination with Ibrutinib in Patients with Relapsed or Refractory Hematologic Malignancies

Christian Grommes, Han Tun, Allison C. Rosenthal, Matthew A Lunning, Radhakrishnan Ramchandren, Lucia Regales, Wanying Zhao, Maureen Lane, Catherine Wang, Reinhard von Roemeling, Iris Isufi, Lori A. Leslie, Grzegorz S. Nowakowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 4497.
https://doi.org/10.1182/blood-2023-189746
Published: 2023
Journal Articles

Phase Ib/II Trial of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab and Lenalidomide in Refractory/Recurrent Primary (PCNSL) and Secondary Central Nervous System Lymphoma (SCNSL)

Christian Grommes, Anna Piotrowski, Elena Pentsova, Igor Gavrilovic, Jacqueline B Stone, Andrew Lin, Venissala Wongchai, Juli T Madzsar, Rachna Malani, Craig Nolan, Jasmine Francis, Lisa DeAngelis, Lauren Schaff, Ingo K Mellinghoff
Journal: Blood
Blood (2022) 140 (Supplement 1): 3807–3808.
https://doi.org/10.1182/blood-2022-157001
Published: 2022
Journal Articles

Impact on Tumour Treatment and Outcome of Sars-Cov-2 Infection in 91 Patients with Primary CNS Lymphoma: A Real-Life Study of the International PCNSL Collaborative Group

Teresa Calimeri, Sara Steffanoni, Alice Laurenge, Christopher P. Fox, Carole Soussain, Christian Grommes, Maria Chiara Tisi, Jesca Boot, Nicola Crosbie, Carlo Visco, Luca Arcaini, Sridhar Chaganti, Alvaro J. Alencar, Daniele Armiento, Ilaria Romano, Marianna C. Sassone, Jorg Dietrich, Gilad Itchaki, Riccardo Bruna, Nicola S Fracchiolla, Laura Arletti, Adriano Venditti, Stephen Booth, Pellegrino Musto, Khe Hoang-Xuan, Tracy Batchelor, Kate Cwynarski, Andrés J.M. Ferreri
Journal: Blood
Blood (2022) 140 (Supplement 1): 3785–3787.
https://doi.org/10.1182/blood-2022-167915
Published: 2022
Journal Articles

Initial Treatment Response Is Prognostic and Predictive of Relapse Patterns: Outcomes of >500 Patients Treated for Primary CNS Lymphoma

Kathryn R. Tringale, Joachim Yahalom, Michael Scordo, Gustav Y Cederquist, Behroze Vachha, Lauren Schaff, Carla Hajj, Harper Hubbeling, Zhigang Zhang, Charlie White, Christian Grommes, Brandon S. Imber
Journal: Blood
Blood (2022) 140 (Supplement 1): 1336–1337.
https://doi.org/10.1182/blood-2022-164663
Published: 2022
Journal Articles

Radiotherapy for Secondary CNS Lymphoma: Patterns of Utilization and Clinical Outcomes

Gustav Y Cederquist, Kathryn R. Tringale, Carla Hajj, Harper Hubbeling, Beatrice Fregonese, Jisun Lee, Michael Scordo, Christian Grommes, Joachim Yahalom, Brandon S. Imber
Journal: Blood
Blood (2022) 140 (Supplement 1): 6683–6684.
https://doi.org/10.1182/blood-2022-170191
Published: 2022
Journal Articles

Trial in Progress: A Phase 1b/2 Study of GB5121, a Brain-Penetrant, Potent, Highly Selective, and Irreversible BTK Inhibitor for Relapsed/Refractory Primary/Secondary CNS Lymphoma and Primary Vitreoretinal Lymphoma

Carole Soussain, Samar Issa, Katharine L Lewis, Christian Grommes, Judith Fox, Renee Ward, Caryn Peterson, Matt Cravets, Anita Mathias, Judith Sosa, Brian J Kirby, Zhaoqing Ding, Isharat Yusuf, Mark J Rose, Marcos W Steinberg, Han W. Tun
Journal: Blood
Blood (2022) 140 (Supplement 1): 12068–12069.
https://doi.org/10.1182/blood-2022-158599
Published: 2022
Journal Articles

Primary central nervous system lymphoma

Lauren R. Schaff, Christian Grommes
Journal: Blood
Blood (2022) 140 (9): 971–979.
https://doi.org/10.1182/blood.2020008377
Published: 2022
Journal Articles

Impact of Choice of Platinum-Based Salvage Therapy on CNS Relapse in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Michael J Buege, Phuong Dao, Raymond G Dematteo, Andréa LeVoir, Terry Pak, Connie Lee Batlevi, Audrey Hamilton, Paul A. Hamlin, Steven M. Horwitz, Erel Joffe, William T Johnson, Niloufer Khan, Anita Kumar, Christina Y. Lee, Matthew J. Matasar, Alison J. Moskowitz, Ariela Noy, Colette Owens, M. Lia Palomba, David J. Straus, Gottfried von Keudell, Andrew D. Zelenetz, Christian Grommes, Craig S. Sauter, Gilles Salles, Lorenzo Falchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2529.
https://doi.org/10.1182/blood-2021-147527
Published: 2021
Journal Articles

Phase Ib Trial with Dose Expansion of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab and Lenalidomide in Patients with Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL)

Christian Grommes, MD, Anna Piotrowski, MD, Elena Pentsova, MD, Craig Nolan, MD, Jasmine Francis, Lisa DeAngelis, MD, Lauren Schaff, MD, Ingo K Mellinghoff, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 48.
https://doi.org/10.1182/blood-2020-143075
Published: 2020
Journal Articles

Increased Number of High Dose Methotrexate Cycles and the Addition of Rituximab Is Associated with Better Outcomes in a Large Primary CNSL Cohort

Prakirthi Yerram, PharmD, Samantha Nicole Reiss, PharmD, Lisa Modelevsky, PharmD, Lauren Schaff, MD, Anne Reiner, MPH, Katherine Panageas, DrPH, Christian Grommes, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4125.
https://doi.org/10.1182/blood-2019-130349
Published: 2019
Journal Articles

Phase Ib of Copanlisib in Combination with Ibrutinib in Recurrent/Refractory Primary CNS Lymphoma (PCNSL)

Christian Grommes, MD, Igor Gavrilovic, MD, Alexandra M Miller, MD PhD, Jacqueline B Stone, MD, Thomas Kaley, MD, Juli T Madzsar, Alyssa Schumpp, Brittany T Butler, Lauren Schaff, MD, Ingo K Mellinghoff, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1598.
https://doi.org/10.1182/blood-2019-126214
Published: 2019
Journal Articles

Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma

Clinical Trials & Observations
Christian Grommes, Sarah S. Tang, Julia Wolfe, Thomas J. Kaley, Mariza Daras, Elena I. Pentsova, Anna F. Piotrowski, Jacqueline Stone, Andrew Lin, Craig P. Nolan, Malbora Manne, Paolo Codega, Carl Campos, Agnes Viale, Alissa A. Thomas, Michael F. Berger, Vaios Hatzoglou, Anne S. Reiner, Katherine S. Panageas, Lisa M. DeAngelis, Ingo K. Mellinghoff
Journal: Blood
Blood (2019) 133 (5): 436–445.
https://doi.org/10.1182/blood-2018-09-875732
Published: 2019
Includes: Supplemental data
Journal Articles

Phase II of Single-Agent Ibrutinib in Recurrent/Refractory Primary (PCNSL) and Secondary CNS Lymphoma (SCNSL)

Christian Grommes, MD, Julia Wolfe, Igor Gavrilovic, MD, Thomas Kaley, MD, Jacqueline Stone, MD, Mariza Daras, MD, Craig Nolan, MD, Elena Pentsova, MD, Vaios Hatzoglou, MD, Ingo Mellinghoff, MD, Lisa DeAngelis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2965.
https://doi.org/10.1182/blood-2018-99-118538
Published: 2018
Journal Articles

Phase 1 study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreoretinal lymphoma

Clinical Trials & Observations
Han W. Tun, Patrick B. Johnston, Lisa M. DeAngelis, Pamela J. Atherton, Levi D. Pederson, Patricia A. Koenig, Craig B. Reeder, Antonio M. Padula Omuro, David Schiff, Brian O’Neill, Jose Pulido, Kurt A. Jaeckle, Christian Grommes, Thomas E. Witzig
Journal: Blood
Blood (2018) 132 (21): 2240–2248.
https://doi.org/10.1182/blood-2018-02-835496
Published: 2018
Includes: Supplemental data
Journal Articles

Single-Agent Ibrutinib in Recurrent/Refractory Central Nervous System Lymphoma

Christian Grommes, MD, Alessandro Pastore, MD, Igor Gavrilovic, MD, Thomas Kaley, MD, Craig Nolan, MD, Antonio M. Omuro, MD, Julia Wolfe, Elena Pentsova, MD, Vaois Hatzoglou, MD, Ingo Mellinghoff, MD, Lisa DeAngelis, MD
Journal: Blood
Blood (2016) 128 (22): 783.
https://doi.org/10.1182/blood.V128.22.783.783
Published: 2016