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Lorenzo Falchi
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Journal Articles

Fixed-duration epcoritamab plus R 2 drives favorable outcomes in relapsed or refractory follicular lymphoma

Open Access
Clinical Trials & Observations
Lorenzo Falchi, Anna Sureda, Sirpa Leppä, Joost S. P. Vermaat, Marcel Nijland, Jacob Haaber Christensen, Sven de Vos, Harald Holte, Reid W. Merryman, Pieternella J. Lugtenburg, Pau Abrisqueta, Kim M. Linton, Gauri Sunkersett, Daniela Hoehn, Ali Rana, Aqeel Abbas, Jennifer Marek, Yi Hao, Andrew J. Steele, Christopher Morehouse, Martin Hutchings, David Belada
Journal: Blood
Blood (2025) 146 (22): 2629–2640.
https://doi.org/10.1182/blood.2025029909
Published: 2025
Includes: Supplemental data
Journal Articles

The simple c-reactive protein (CRP) to albumin ratio (CAR) stratifies treatment response and survival following chimeric antigen receptor T-cell therapy for non-Hodgkin's lymphoma

Free
Richard Lin, Maria Bromberg, Amethyst Saldia, Allison Parascondola, Molly Hogan, Emma Pavkovic, Roni Shouval, Mika Geva, Marina Gomez-Llobell, Silvia Escribano-Serrat, Sigrun Einarsdottir, Sandeep Raj, Lia Palomba, Parastoo Dahi, Michael Scordo, Gunjan Shah, Alexander Boardman, Lorenzo Falchi, Jennifer Lue, Gilles Salles, Craig Sauter, Jae Park, Miguel-Angel Perales, Paul Hamlin, Mithat Gonen, Sergio Giralt
Journal: Blood
Blood (2025) 146 (Supplement 1): 7090.
https://doi.org/10.1182/blood-2025-7090
Published: 2025
Journal Articles

CXCL9 is a predictive biomarker of survival with IFNγ-targeted therapy in adult HLH patients

Free
William Johnson, Joseph Rocco, Rikita Patel, Adrianna Herskovits, Elena Mead, Jae Park, Alison Moskowitz, Zachary Epstein-Peterson, Robert Stuver, Neil Bapodra, Rabeya Molla, Andrew Intlekofer, Jennifer Lue, Lia Palomba, Ariela Noy, Jasmine Zain, Colette Owens, Lynnette Henshaw, Paola Ghione, Efrat Luttwak, Pallawi Torka, Andrew Zelenetz, Philip Caron, Anita Kumar, Lorenzo Falchi, Natasha Galasso, Paul Hamlin, Alexander Boardman, Kevin David, Raphael Steiner, Nivetha Ganesan, Tiffany Chang, Zainab Shahid, Wenbin Xiao, Annamaria Ballweg, Alina Markova, Mark Geyer, Lauren Banaszak, Roni Shouval, Sergio Giralt, Gregory Goldgof, Jodi Mones, Jeffrey Zwicker, Rekha Parameswaran, Avi Leader, Cy R. Wilkins, Simon Mantha, Jeffrey Cohen, Jessica Durkee-Shock, Matthew Sedlock, Bita Shakoory, Irini Sereti, Miguel-Angel Perales, Gilles Salles, Santosha Vardhana, Joseph Oved, Steven Horwitz
Journal: Blood
Blood (2025) 146 (Supplement 1): 2996.
https://doi.org/10.1182/blood-2025-2996
Published: 2025
Journal Articles

Pembrolizumab plus gemcitabine, vinorelbine, and liposomal doxorubicin as second-line therapy in relapsed or refractory Hodgkin lymphoma: 5-year update of a multicenter, Phase 2 trial

Free
Kishan Patel, Gunjan Shah, Heiko Schoder, Nivetha Ganesan, Esther Drill, Helen Hancock, Theresa Davey, Alayna Santarosa, Natasha Galasso, Anita Kumar, Oscar Lahoud, Paul Hamlin, Colette Owens, Philip Caron, Andrew Intlekofer, Steven Horwitz, Lorenzo Falchi, William Johnson, Lia Palomba, Ariela Noy, Matthew Matasar, Gilles Salles, Santosha Vardhana, Gottfried von Keudell, Joachim Yahalom, Ahmet Dogan, Andrew Zelenetz, Craig Moskowitz, Alison Moskowitz
Journal: Blood
Blood (2025) 146 (Supplement 1): 1850.
https://doi.org/10.1182/blood-2025-1850
Published: 2025
Journal Articles

Integrated dissociated and spatial single-cell profiling reveals that HDAC inhibition restores anti-PD-1 sensitivity in Hodgkin lymphoma by disrupting monocyte-Hodgkin-reed-sternberg cell-driven immunosuppressive niches.

Free
Amira Marouf, Sneha Mitra, Robert Stuver, Nivetha Ganesan, Jahan Rahman, Alexander Boardman, Philip Caron, Tiffany Chang, Kevin David, Zachary Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Paul Hamlin, Francisco Hernandez-Ilizaliturri, Steven Horwitz, Andrew Intlekofer, William Johnson, Reem Karmali, Jennifer Lue, Anita Kumar, Efrat Luttwak, Neena Mahajan, Ariela Noy, Colette Owens, Lia Palomba, Heiko Schoder, David Sermer, Venkatraman Seshan, Raphael Steiner, Pallawi Torka, Andrew Zelenetz, Gottfried von Keudell, Gilles Salles, Christina Leslie, Alison Moskowitz, Santosha Vardhana
Journal: Blood
Blood (2025) 146 (Supplement 1): 150.
https://doi.org/10.1182/blood-2025-150
Published: 2025
Journal Articles

Tumor mutational burden as a novel biomarker of resistance to CD19 CAR-T cell therapy in large B-cell lymphoma

Free
Sandeep Raj, Aaron Gillmor, Teng Fei, Allison Richards, Magdalena Corona, John Orgera, Anne Marie Noronha, Eugene Brailovski, Gunjan Shah, Zachary Epstein-Peterson, Anthony Daniyan, Alexander Boardman, Jennifer Lue, Lorenzo Falchi, Michael Scordo, Parastoo Dahi, Richard Lin, Yannis Valtis, Efrat Luttwak, Alfredo Rivas-Delgado, Kai Rejeski, Marina Gomez-Llobell, Mohammad Alhomoud, Sigrun Einarsdottir, Silvia Escribano Serrat, Craig Sauter, Lia Palomba, Omar Abdel-Wahab, Marcel van den Brink, Sergio Giralt, Gilles Salles, Jae Park, Mark Donoghue, Benjamin Greenbaum, Miguel-Angel Perales, Roni Shouval
Journal: Blood
Blood (2025) 146 (Supplement 1): 565.
https://doi.org/10.1182/blood-2025-565
Published: 2025
Journal Articles

Cytotoxic CD8⁺ T cells are required for CD20xCD3 bispecific antibody-mediated tumor control in B-cell non-Hodgkin lymphomas

Free
Philipp Berning, Kazuya Fukasawa, Jahan Rahman, Ya-Hui Lin, Gilles Salles, Hans-Guido Wendel, Lorenzo Falchi, Santosha Vardhana
Journal: Blood
Blood (2025) 146 (Supplement 1): 556.
https://doi.org/10.1182/blood-2025-556
Published: 2025
Journal Articles

Fixed-duration epcoritamab in combination with bendamustine + Rituximab (BR) for first-line (1L) treatment of follicular lymphoma (FL): 3-year results from EPCORE NHL-2 arm 3 demonstrate deep and durable responses with manageable safety

Free
Umberto Vitolo, Lorenzo Falchi, Sylvia Snauwaert, Fritz Offner, Marcel Nijland, Per-Ola Andersson, Poliana Patah, Isil Altintas, Jennifer Marek, Malene Risum, Yi Hao, Joshua Brody
Journal: Blood
Blood (2025) 146 (Supplement 1): 5357.
https://doi.org/10.1182/blood-2025-5357
Published: 2025
Journal Articles

Detection of intratumoral microorganisms in DLBCL impacts on CART-cell outcomes

Free
Paola Ghione, Roni Shouval, Rita Tavarozzi, Teng Fei, Magdalena Corona De Lapuerta, Sigrun Einarsdottir, Silvia Escribano Serrat, Gunjan Shah, Craig Sauter, Michael Scordo, Michelle Okwali, Annie Qiu, Marina Gomez-Llobell, Alexander Boardman, Philip Caron, Kevin David, Zachary Epstein-Peterson, Lorenzo Falchi, Paul Hamlin, Steven Horwitz, Andrew Intlekofer, William Johnson, Anita Kumar, Jennifer Lue, Efrat Luttwak, Alison Moskowitz, Ariela Noy, Colette Owens, Raphael Steiner, Robert Stuver, Pallawi Torka, Santosha Vardhana, Jasmine Zain, Andrew Zelenetz, Lia Palomba, Gilles Salles, Miguel-Angel Perales, Jonathan Peled, Megan Lim, Chad Vanderbilt
Journal: Blood
Blood (2025) 146 (Supplement 1): 5341.
https://doi.org/10.1182/blood-2025-5341
Published: 2025
Journal Articles

primary Phase 3 results from the epcore FL-1 trial of epcoritamab with rituximab and lenalidomide (R2) versus R2 for relapsed or refractory follicular lymphoma

Free
Lorenzo Falchi, Marcel Nijland, Huiqiang Huang, Kim Linton, John Seymour, Rong Tao, Michal Kwiatek, Abel Costa, Theodoros Vassilakopoulos, Richard Greil, Ana Jiménez Ubieto, Shane Gangatharan, Ohad Benjamini, Catherine Thieblemont, Alessandra Tucci, Anna Elinder-Camburn, Arpad Illes, Jan Novak, Miguel Pavlovsky, Andrew McDonald, Dok Hyun Yoon, Yuko Mishima, Gauri Sunkersett, Jian Mei, Nabanita Mukherjee, Feng Zhu, Elena Favaro, Franck Morschhauser
Journal: Blood
Blood (2025) 146 (Supplement 1): 466.
https://doi.org/10.1182/blood-2025-466
Published: 2025
Journal Articles

Epcoritamab with rituximab + lenalidomide (R2) and epcoritamab maintenance deliver deep and durable remissions in previously untreated (1L) follicular lymphoma (FL): 3-year outcomes from epcore NHL-2 arms 6 and 7

Free
Lori Leslie, Gerardo Musuraca, Pau Abrisqueta, Joshua Brody, Jacob Christensen, Alexander Fosså, Marjolein Van Der Poel, Joost Vermaat, Fritz Offner, David Belada, Jian Mei, Isil Altintas, Malene Risum, Aidan Reilly, Liwei Wang, Lorenzo Falchi
Journal: Blood
Blood (2025) 146 (Supplement 1): 465.
https://doi.org/10.1182/blood-2025-465
Published: 2025
Journal Articles

Sequencing CD20-directed bispecific antibody and CD19-directed CAR T cell therapy in large B cell lymphoma: A multicenter real-world study

Free
David Qualls, Andrew Jallouk, Geoffrey Shouse, Swetha Thiruvengadam, Omnia Farahat, Amy Ayers, Ayushi Chauhan, Reid Merryman, Ajay Major, Yazeed Sawalha, Narendranath Epperla, Matthew Lunning, Shakthi Bhaskar, Allison Bock, Steven Bair, Gilles Salles, Christopher Flowers, Alex Herrera, Lorenzo Falchi, Jennifer Crombie, Lei Feng, Sairah Ahmed
Journal: Blood
Blood (2025) 146 (Supplement 1): 3663.
https://doi.org/10.1182/blood-2025-3663
Published: 2025
Journal Articles

Are all GELF criteria created equal? utility of individual GELF criteria as guidance for treatment initiation in patients with advanced stage FL

Free
Clare Grieve, Esther Drill, Michelle Okwali, Ahmet Dogan, Jasmine Zain, Andrew Zelenetz, Pallawi Torka, Robert Stuver, Raphael Steiner, Lia Palomba, Ariela Noy, Colette Owens, Alison Moskowitz, Efrat Luttwak, Jennifer Lue, Anita Kumar, William Johnson, Steven Horwitz, Paul Hamlin, Paola Ghione, Zachary Epstein-Peterson, Kevin David, Philip Caron, Alexander Boardman, Pallavi Kanwar Galera, Katherine Lopez, Gilles Salles, Lorenzo Falchi
Journal: Blood
Blood (2025) 146 (Supplement 1): 1008.
https://doi.org/10.1182/blood-2025-1008
Published: 2025
Journal Articles

Safety of abbreviated dose-escalation in patients (pts) receiving glofitamab (glofit) or epcoritamab (epcor)

Free
Amanda Chron, Kelsey Baron, Ashlee Joseph, Ayushi Chauhan, Sonia Godbole, Andrew Jallouk, Amy Ayers, Ajay Major, Swetha Thiruvengadam, Narendranath Epperla, Shakthi Bhaskar, Alex Herrera, Yazeed Sawalha, Sairah Ahmed, Gilles Salles, Lorenzo Falchi, Allison Bock
Journal: Blood
Blood (2025) 146 (Supplement 1): 958.
https://doi.org/10.1182/blood-2025-958
Published: 2025
Journal Articles

Respiratory viral infections are a significant cause of morbidity during long-term follow-up after CAR T cell therapy: Analysis of 445 episodes

Free
Sigrun Einarsdottir, Maria Isabel Sotelo, Teng Fei, Dedipya Bhamidipati, Magdalena Corona, Silvia Escribano-Serrat, Lorenzo Falchi, Mika Geva, Marina Gomez-Llobell, Jabour Halloun, Malin Hultcrantz, Sapir Israeli, Hazim Khatib, Mini Kamboj, Sham Mailankody, Genovefa Papanicolaou, Lia Palomba, Jae Park, Sandeep Raj, Kai Rejeski, Jaime Sanz, Michael Scordo, Gilles Salles, Susan Seo, Gunjan Shah, Niveen Shibli, Swarn Arya, Yannis Valtis, Saad Usmani, Miguel-Angel Perales, Roni Shouval, Zainab Shahid
Journal: Blood
Blood (2025) 146 (Supplement 1): 4498.
https://doi.org/10.1182/blood-2025-4498
Published: 2025
Journal Articles

MSK-impact heme accurately reproduces diffuse large B-cell (DLBCL) dlbclass cluster classification across clinical scenarios, including diagnosis, relapse, and histological transformation

Free
Aaron Gillmor, Alfredo Rivas-Delgado, Manik Uppal, Michelle Okwali, Menglei Zhu, Alexander Boardman, Kevin David, Zachary Epstein-Peterson, Mark Ewalt, Lorenzo Falchi, Pallavi Kanwar Galera, Paola Ghione, Paul Hamlin, Steven Horwitz, William Johnson, Anita Kumar, Jennifer Lue, Efrat Luttwak, Lia Palomba, Raphael Steiner, Robert Stuver, Pallawi Torka, Andrew Zelenetz, Allison Richards, Roni Shouval, Ahmet Dogan, Maria Arcila, Gilles Salles
Journal: Blood
Blood (2025) 146 (Supplement 1): 1766.
https://doi.org/10.1182/blood-2025-1766
Published: 2025
Journal Articles

Real world outcomes of sequencing bispecific antibodies (BsAb) in patients with relapsed / refractory follicular lymphoma (R/R FL): A multi-center cohort study from cubic consortium

Free
Chijioke Nze, Allison Bock, Yizhe Xu, Yuxin Zhao, Amy Ayers, Lorenzo Falchi, Reid Merryman, Steven Bair, Ajay Major, Andrew Jallouk, Swetha Thiruvengadam, Christopher D'Angelo, Matthew Lunning, Shakthi Bhaskar, Yazeed Sawalha, Omnia Farahat, Ayushi Chauhan, Geoffrey Shouse, Jennifer Crombie, Alex Herrera, Gilles Salles, Christopher Flowers, Sairah Ahmed, Narendranath Epperla
Journal: Blood
Blood (2025) 146 (Supplement 1): 1837.
https://doi.org/10.1182/blood-2025-1837
Published: 2025
Journal Articles

Outcomes of CD20xCD3 bispecific antibody therapy in adult patients with Relapsed/Refractory transformed indolent lymphoma

Free
Pierre Stephan, Karan Chohan, Robert Redd, Sairah Ahmed, Christopher Flowers, Ayushi Chauhan, Amy Ayers, Geoffrey Shouse, Swetha Thiruvengadam, Alex Herrera, Allison Bock, Narendranath Epperla, Shannon Buckley, Boyu Hu, Matthew Lunning, Gilles Salles, Lorenzo Falchi, Yazeed Sawalha, Sonia Godbole, Andrew Jallouk, Shakthi Bhaskar, Ajay Major, Steven Bair, Philippe Armand, Reid Merryman, Alexey Danilov, Jennifer Crombie
Journal: Blood
Blood (2025) 146 (Supplement 1): 5521.
https://doi.org/10.1182/blood-2025-5521
Published: 2025
Journal Articles

Real-world multicenter outcomes of CD3xCD20 bispecific antibody therapies in patients with central nervous system (CNS) lymphoma

Free
Karan Chohan, James Godfrey, Steven Bair, Lorenzo Falchi, Manali Kamdar, Ajay Major, Sonia Godbole, Gilles Salles, Omnia Farahat, Amy Ayers, Ayushi Chauhan, Alex Herrera, Geoffrey Shouse, Sairah Ahmed, Yazeed Sawalha
Journal: Blood
Blood (2025) 146 (Supplement 1): 5520.
https://doi.org/10.1182/blood-2025-5520
Published: 2025
Journal Articles

Real-world outcomes of mosunetuzumab use in indolent and aggressive lymphomas

Free
Andrew Jallouk, Lorenzo Falchi, Ayushi Chauhan, Geoffrey Shouse, Swetha Thiruvengadam, Yazeed Sawalha, Sonia Godbole, Ajay Major, Reid Merryman, Shakthi Bhaskar, Allison Bock, Amy Ayers, Omnia Farahat, Narendranath Epperla, Jennifer Crombie, Steven Bair, Alex Herrera, Christopher Flowers, Gilles Salles, Sairah Ahmed
Journal: Blood
Blood (2025) 146 (Supplement 1): 4515.
https://doi.org/10.1182/blood-2025-4515
Published: 2025