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Journal Articles

Population Pharmacokinetic Model Identifies an Optimal Fludarabine Exposure for Improved Outcomes after CD19-Directed CAR T Cell Therapy for Aggressive B-NHL: Analysis from the Cell Therapy Consortium

Michael Scordo, Jessica R. Flynn, Sean M. Devlin, Mithat Gonen, Allison Parascondola, Ana Alarcon Tomas, Roni Shouval, Jamie Brower, David L. Porter, Stephen J. Schuster, Veronika Bachanova, Joseph E. Maakaron, Richard T. Maziarz, Loretta J. Nastoupil, Joseph P. McGuirk, Olalekan O. Oluwole, Andrew Ip, Lori A. Leslie, Michael R. Bishop, Peter A. Riedell, Miguel-Angel Perales
Journal: Blood
Blood (2022) 140 (Supplement 1): 1588–1591.
https://doi.org/10.1182/blood-2022-164674
Published: 2022
Journal Articles

Interventions and outcomes of adult patients with B-ALL progressing after CD19 chimeric antigen receptor T-cell therapy

Clinical Trials & Observations
Kitsada Wudhikarn, Jessica R. Flynn, Isabelle Rivière, Mithat Gönen, Xiuyan Wang, Brigitte Senechal, Kevin J. Curran, Mikhail Roshal, Peter G. Maslak, Mark B. Geyer, Elizabeth F. Halton, Claudia Diamonte, Marco L. Davila, Michel Sadelain, Renier J. Brentjens, Jae H. Park
Journal: Blood
Blood (2021) 138 (7): 531–543.
https://doi.org/10.1182/blood.2020009515
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Factors Associated with Improved Survival Following Allogeneic HSCT after CD19 CAR Therapy in Adult Patients with Relapsed B-ALL

Jae H. Park, MD, Jessica Flynn, BS, Mithat Gonen, Yvette Bernal, MS, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, Xiuyan Wang, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1348.
https://doi.org/10.1182/blood-2019-129343
Published: 2019
Journal Articles

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Ly P. Vu, PhD, Camila Prieto, Elianna Amin, PhD, Gerard Minuesa, PhD, Sagar Chhangawala, Maria J Vidal, PhD, Andrei V. Krivtsov, PhD, Tim Chou, Trevor Barlowe, BA, James Taggart, BS, Patrick Tivnan, BS, Raquel P. Deering, Mithat Gonen, PhD, Maria E Figueroa, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Ari Melnick, MD, Ross L. Levine, MD, Fatima Al-Shahrour, PhD, Marcus Järås, Lisa Chu, Ralph Garippa, PhD, Christopher Lengner, PhD, Scott A. Armstrong, MD PhD, Glenn Cowley, PhD, David Root, PhD, John G Doench, PhD, Leandro Cerchietti, MD, Christina Leslie, PhD, Benjamin Ebert, Michael G. Kharas, PhD
Journal: Blood
Blood (2016) 128 (22): 739.
https://doi.org/10.1182/blood.V128.22.739.739
Published: 2016
Journal Articles

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia

Fiona Brown, PhD, Eric Still, Paolo Cifani, PhD, Scott Ficarro, PhD, Gayle Pouliot, MD PhD, Esther Drill, PhD, Mithat Gonen, PhD, Jie He, PhD, Sohail Balasubramanian, M.S., Shan Zhong, PhD, Dean Pavlick, Bahar Yilmazel, Andrei V. Krivtsov, PhD, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD, Steven M. Kornblau, MD, Richard M. Stone, MD, Guido Marcucci, MD, John C. Byrd, MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2015) 126 (23): 88.
https://doi.org/10.1182/blood.V126.23.88.88
Published: 2015
Journal Articles

Integrative Analysis of the Mutational Landscape of Mouse and Human AML Identifies Functionally Relevant Leukemia Disease Alleles

Megan A. Hatlen, PhD, Kanika Arora, MS, Vladimir Vacic, PhD, Ewa A. Grabowska, BS, Willey Liao, BS, Bridget Riley-Gillis, PhD, Dayna M. Oschwald, BS, Lan Wang, PhD, Jacob E. Joergens, Alan H. Shih, MD PhD, Franck Rapaport, PhD, Shengqing Gu, PhD, Francesca Voza, BS, Takashi Asai, MD PhD, Benjamin Neel, MD PhD, Michael G. Kharas, PhD, Mithat Gonen, PhD, Ross L. Levine, MD, Stephen D. Nimer, MD
Journal: Blood
Blood (2015) 126 (23): 1247.
https://doi.org/10.1182/blood.V126.23.1247.1247
Published: 2015
Journal Articles

Integrated DNA/RNA Profiling for Somatic Alterations in Adult B-Cell ALL

Franck Rapaport, PhD, Jay Patel, Jie He, PhD, Timothy A Brennan, MS, Michelle Nahas, PhD, Sohail Balassubramanian, MS, Geoff Otto, PhD, Doron Lipson, PhD, Phil Stephens, PhD, Vincent A. Miller, MD, Janis Racevskis, MD, Mark R Litzow, MD, Peter H. Wiernik, MD, Anthony H. Goldstone, FRCP, FRCPath, Selina Luger, MD, Marcel van den Brink, MD PhD, Agnes Viale, PhD, Jacob M. Rowe, MD, Martin S. Tallman, MD, Ari Melnick, MD, Elisabeth Paietta, PhD, Mithat Gonen, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 1422.
https://doi.org/10.1182/blood.V126.23.1422.1422
Published: 2015
Journal Articles

Safety and Efficacy of Ferumoxytol for the Treatment of Iron Deficiency Anemia in a Community Based Hematology Clinic

Erin DeBolt, B.S., PharmD candidate 2016, John A Wagoner, BS candidate 2016, Mark Tharnish, PharmD, Mithat Gonen, PhD, Dron Gauchan, MD, Ryan C. Ramaekers, MD, Douglas Clark, MD, Max Norvell, PharmD, Mehmet Copur, MD
Journal: Blood
Blood (2015) 126 (23): 4553.
https://doi.org/10.1182/blood.V126.23.4553.4553
Published: 2015
Journal Articles

Genomic Analysis of Serial Samples from CLL Patients Identifies Clonal Events Associated with Disease Progression

Jeffrey R Gardner, BS, MBA, Michelle Nahas, PhD, Jie He, PhD, Shlomzion Aumann, Mithat Gonen, Minal Patel, Kristina M. Knapp, BS, Maria Lia Palomba, MD, Roman Yelensky, PhD, Amy L Donahue, MS, Geoff Otto, PhD, Maria Arcila, MD, Nicole Lamanna, Mark G. Frattini, MD PhD, Ahmet Dogan, MD PhD, Jae H Park, MD, Doron Lipson, PhD, Martin S. Tallman, MD, Ross L. Levine, MD, Philip J. Stephens, PhD, Marcel R. M. van den Brink, MD PhD, Mark L Heaney, MD PhD, Vincent A. Miller, MD, Andrew D. Zelenetz, MD PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2014) 124 (21): 1954.
https://doi.org/10.1182/blood.V124.21.1954.1954
Published: 2014
Journal Articles

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program

Sun Mi Park, PhD, Mithat Gönen, PhD, Ly P. Vu, PhD, Gerard Minuesa, PhD, Patrick Tivnan, Trevor Barlowe, James Taggart, Yuheng Lu, Raquel P Deering, PhD, Nir Hacohen, PhD, Maria Figueroa, MD, Elisabeth M. Paietta, PhD, Martin S. Tallman, MD, Ari M. Melnick, MD, Ross L. Levine, MD, Christina Leslie, PhD, Christopher J Lengner, PhD, Michael G Kharas, PhD
Journal: Blood
Blood (2014) 124 (21): 836.
https://doi.org/10.1182/blood.V124.21.836.836
Published: 2014
Journal Articles

Effect of Genetic Profiling on Prediction of Therapeutic Resistance and Survival in Adult Acute Myeloid Leukemia

Roland B. Walter, MD PhD MS, Megan Othus, PhD, Elisabeth M. Paietta, PhD, Janis Racevskis, PhD, Hugo F Fernandez, MD, Ju-Whei Lee, PhD, Zhuoxin Sun, PhD, Martin S. Tallman, MD, Jay P. Patel, Mithat Gönen, PhD, Omar Abdel-Wahab, MD, Ross L Levine, MD, Elihu H. Estey, MD
Journal: Blood
Blood (2014) 124 (21): 941.
https://doi.org/10.1182/blood.V124.21.941.941
Published: 2014
Journal Articles

Minimal Residual Disease Assessment By Flow Cytometry in AML Is an Independant Prognostic Factor Even after Adjusting for Cytogenetic/Molecular Abnormalities

Chezi Ganzel, MD, Zhuoxin Sun, PhD, Mithat Gonen, Jay P. Patel, Omar Abdel-Wahab, MD, Hugo F Fernandez, MD, Jacob M. Rowe, MD, Martin S. Tallman, MD, Ross L. Levine, MD, Elisabeth M. Paietta, PhD
Journal: Blood
Blood (2014) 124 (21): 1016.
https://doi.org/10.1182/blood.V124.21.1016.1016
Published: 2014
Journal Articles

Pilot Study To Evaluate The Prevalence Of Actionable Oncogenic Mutations In Patients With Relapsed Refractory Multiple Myeloma

Alexander Lesokhin, MD, Mithat Gonen, Kaitlyn Redling, Nikoletta Lendvai, MD PhD, Hani Hassoun, MD, Heather Landau, MD, David J Chung, MD PhD, Guenther Koehne, MD, PhD, Minal Patel, Kristina W. Brennan, BS, Kai Wang, MD PhD, Eric M Sanford, BS, Tim Brennan, PhD, Geoff A. Otto, PhD, Michelle K. Nahas, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Roman Yelensky, PhD, Vincent A. Miller, MD, Marcel Van Den Brink, MD, PhD, Ross L. Levine, MD, Ahmet Dogan, MD, PhD, Sergio A Giralt, MD
Journal: Blood
Blood (2013) 122 (21): 755.
https://doi.org/10.1182/blood.V122.21.755.755
Published: 2013
Journal Articles

CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900

Clinical Trials & Observations
Mithat Gönen, Zhuoxin Sun, Maria E. Figueroa, Jay P. Patel, Omar Abdel-Wahab, Janis Racevskis, Rhett P. Ketterling, Hugo Fernandez, Jacob M. Rowe, Martin S. Tallman, Ari Melnick, Ross L. Levine, Elisabeth Paietta
Journal: Blood
Blood (2012) 120 (11): 2297–2306.
https://doi.org/10.1182/blood-2012-02-414425
Published: 2012
Includes: Supplemental data
Journal Articles

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

Su-Jiang Zhang, Raajit Rampal, Taghi Manshouri, Jay Patel, Nana Mensah, Andrew Kayserian, Todd Hricik, Adriana Heguy, Cyrus Hedvat, Mithat Gönen, Hagop Kantarjian, Ross L. Levine, Omar Abdel-Wahab, Srdan Verstovsek
Journal: Blood
Blood (2012) 119 (19): 4480–4485.
https://doi.org/10.1182/blood-2011-11-390252
Published: 2012
Includes: Supplemental data
Journal Articles

Heterodimeric JAK-STAT Activation As a Mechanism of Persistence to JAK2 Inhibitor Therapy

Neha Bhagwat, Priya Koppikar, Outi Kilpivaara, Taghi Manshouri, PhD, Mazhar Adli, Ann Mullally, MD, Omar Abdel-Wahab, MD, Laura Leung, Abby Weinstein, Sachie Marubayashi, Aviva Goel, Mithat Gonen, Zeev Estrov, Benjamin L. Ebert, MD, D.Phil, Gabriela Chiosis, PhD, Bradley Bernstein, Srdan Verstovsek, MD, PhD, Ross L Levine, MD
Journal: Blood
Blood (2011) 118 (21): 122.
https://doi.org/10.1182/blood.V118.21.122.122
Published: 2011
Journal Articles

Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells

Min Tang, Mithat Gonen, Alfonso Quintas-Cardama, Jorge Cortes, Hagop Kantarjian, Chani Field, Timothy P. Hughes, Susan Branford, Franziska Michor
Journal: Blood
Blood (2011) 118 (6): 1622–1631.
https://doi.org/10.1182/blood-2011-02-339267
Published: 2011
Includes: Supplemental data
Journal Articles

High-Throughput Mutational Profiling In AML: Mutational Analysis of the ECOG E1900 Trial

Jay P. Patel, Omar Abdel-Wahab, Mithat Gonen, Maria E. Figueroa, MD, Hugo F. Fernandez, MD, Zhuoxin Sun, PhD, Janis Racevskis, Pieter Van lierberghe, Igor Dolgalev, Janice Cheng, Agnes Viale, Nicholas Socci, Adriana Heguy, Rhett Ketterling, Robert E. Gallagher, MD, Mark R. Litzow, MD, Jacob M. Rowe, Adolfo Ferrando, MD, PhD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Ari M. Melnick, Ross Levine, MD
Journal: Blood
Blood (2010) 116 (21): 851.
https://doi.org/10.1182/blood.V116.21.851.851
Published: 2010
Journal Articles

Molecular Responses to Dasatinib and Nilotinib in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP).

Alfonso QuintαsCardama, Hagop Kantarjian, Franziska Michor, Adam Olshen, Mithat Gonen, Dan Jones, Mary Beth Rios, Susan O’Brien, Jorge Cortes, MD
Journal: Blood
Blood (2008) 112 (11): 3244.
https://doi.org/10.1182/blood.V112.11.3244.3244
Published: 2008
Journal Articles

Modelling BCR-ABL1 Dynamics in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) during Frontline Therapy with High-Dose Imatinib, Nilotinib, or Dasatinib.

Adam Olshen, Alfonso Quintαs-Cardama, Hagop M. Kantarjian, Mithat Gonen, Franziska Michor, Jorge Cortes, MD
Journal: Blood
Blood (2008) 112 (11): 3240.
https://doi.org/10.1182/blood.V112.11.3240.3240
Published: 2008