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Brigitte Senechal
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Journal Articles

Optimizing Therapeutic Outcome of CD19(T2)28z1XX Chimeric Antigen Receptor (CAR) T in Adult Patients with Large B-Cell Lymphoma through a Quantitative Medicine Approach

Agnish Dey, Jia Li, Jae H. Park, Leopold Sellner, Varsha Sundaresan, Maria Lia Palomba, Jorge Mansilla-Soto, Brigitte Senechal, Xiuyan Wang, Devanjan S Sikder, Ajeeta Dash, Isabelle Riviere, Michel Sadelain, Ganesh Mugundu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7138.
https://doi.org/10.1182/blood-2024-203375
Published: 2024
Journal Articles

Role of Cell Therapy Product Characteristics in Patient Response to TAK-940 (CD19(T2)28z1xx Chimeric Antigen Receptor (CAR) T): Biomarker Analyses from a Phase I Study in Adult Patients with Relapsed or Refractory B-Cell Malignancies

Varsha Sundaresan, Brigitte Senechal, Xiuyan Wang, Shubhra Kashyap, Erica Tong, Adarsh Joshi, Ajeeta Dash, Leopold Sellner, Sharon Chen, Devin McAvoy, Kinga K Hosszu, Devanjan S Sikder, Isabelle Riviere, Michel Sadelain, Jae H. Park, Reshma Singh
Journal: Blood
Blood (2023) 142 (Supplement 1): 349.
https://doi.org/10.1182/blood-2023-177712
Published: 2023
Journal Articles

A Phase I Study of CD19-Targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Jae H. Park, Maria Lia Palomba, Sean M. Devlin, Yannis K. Valtis, Devanjan S Sikder, Brigitte Senechal, Xiuyan Wang, Elizabeth Cathcart, Kelly Liotta, Alina Yu, Kelsey Stocker, Honglei Zhang, Heiko Schoder, Doris Leithner, Jia Li, Leopold Sellner, Jorge Mansilla-Soto, Isabelle Riviere, Michel Sadelain
Journal: Blood
Blood (2023) 142 (Supplement 1): 892.
https://doi.org/10.1182/blood-2023-187623
Published: 2023
Journal Articles

A Phase I Study of CD19-Targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Jae H Park, M. Lia Palomba, Isabelle Rivière, Devanjan S. Sikder, Brigitte Senechal, Xiuyan Wang, Vladimir P. Bermudez, Elizabeth R. Cathcart, Kelly Liotta, Jannakie Joseph, Jia Li, Yunqi Zhao, Rachael Liu, Sharon Chen, Leopold Sellner, Michel Sadelain
Journal: Blood
Blood (2022) 140 (Supplement 1): 403–404.
https://doi.org/10.1182/blood-2022-168206
Published: 2022
Journal Articles

An Ongoing Pilot Study of Targeted Radioimmunotherapy (131-I Apamistamab) Conditioning Prior to CD19-Targeted CAR T-Cell Therapy for Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

Mark B. Geyer, Briana Cadzin, Kinga Hosszu, Brigitte Senechal, Jennifer A. Spross, Alexis Mark, Avinash Desai, Elizabeth R. Cathcart, M. Lia Palomba, Neeta Pandit-Taskar
Journal: Blood
Blood (2022) 140 (Supplement 1): 10341–10342.
https://doi.org/10.1182/blood-2022-167962
Published: 2022
Journal Articles

Iomab with Adoptive Cellular Therapy (Iomab-ACT): A Pilot Study of 131-I Apamistamab Followed By CD19-Targeted CAR T-Cell Therapy for Patients with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

Mark B. Geyer, Briana Cadzin, Elizabeth Halton, Peter Kane, Brigitte Senechal, Eileen M. Geoghegan, Vijay Reddy, Mark S. Berger, Dale Ludwig, Neeta Pandit-Taskar, Craig S. Sauter
Journal: Blood
Blood (2021) 138 (Supplement 1): 4810.
https://doi.org/10.1182/blood-2021-144994
Published: 2021
Journal Articles

Clinical Manufacture of FT819: Use of a Clonal Multiplexed-Engineered Master Induced Pluripotent Stem Cell Line to Mass Produce Off-the-Shelf CAR T-Cell Therapy

Xu Yuan, Raedun Clarke, Yi-Shin Lai, Chia-Wei Chang, Bi-Huei Yang, Gloria Hsia, Ramzey Abujarour, Tom Lee, Sjoukje van der Stegen, Helena Shaked, Abubakar Jalloh, Stephanie Moreno, Jason ORourke, Eric Sung, Alma Gutierrez, Betsy Rezner, Meghan Eberhart, Rebecca Magdaleno, Xiuyan Wang, Brigitte Senechal, Devanjan S. Sikder, Dell Farnan, Mark Plavsic, Jerome Bressi, Isabelle Rivière, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 1766.
https://doi.org/10.1182/blood-2021-152985
Published: 2021
Journal Articles

Phase I First-in-Class Trial of MCARH109, a G Protein Coupled Receptor Class C Group 5 Member D (GPRC5D) Targeted CAR T Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma

Sham Mailankody, Claudia Diamonte, Lisa Fitzgerald, Peter Kane, Xiuyan Wang, Devanjan S. Sikder, Brigitte Senechal, Vladimir P. Bermudez, Diana Frias, Justina Morgan, Patrick Grant, Terence J Purdon, Kinga Hosszu, Sean M Devlin, Urvi A Shah, Jonathan Landa, Alexander Lesokhin, Neha Korde, Hani Hassoun, Carlyn Tan, Malin Hultcrantz, Gunjan L. Shah, Heather J Landau, David J. Chung, Michael Scordo, Mikhail Roshal, Ola Landgren, Ahmet Dogan, Sergio A Giralt, Jae H Park, Isabelle Rivière, Renier J Brentjens, Eric L Smith
Journal: Blood
Blood (2021) 138 (Supplement 1): 827.
https://doi.org/10.1182/blood-2021-153204
Published: 2021
Journal Articles

Interventions and outcomes of adult patients with B-ALL progressing after CD19 chimeric antigen receptor T-cell therapy

Clinical Trials & Observations
Kitsada Wudhikarn, Jessica R. Flynn, Isabelle Rivière, Mithat Gönen, Xiuyan Wang, Brigitte Senechal, Kevin J. Curran, Mikhail Roshal, Peter G. Maslak, Mark B. Geyer, Elizabeth F. Halton, Claudia Diamonte, Marco L. Davila, Michel Sadelain, Renier J. Brentjens, Jae H. Park
Journal: Blood
Blood (2021) 138 (7): 531–543.
https://doi.org/10.1182/blood.2020009515
Published: 2021
Includes: Supplemental data
Journal Articles

A Phase I Study of CD19-Targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory B-Cell Malignancies

Jae H. Park, MD, Isabelle Riviere, PhD, Devanjan S. Sikder, Vladimir P. Bermudez, Brigitte Senechal, Xiuyan Wang, PhD, Thomas H. Auchincloss, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, M. Lia Palomba, MD, Renier J. Brentjens, MD PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–44.
https://doi.org/10.1182/blood-2020-143088
Published: 2020
Journal Articles

Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL

Clinical Trials & Observations
Kevin J. Curran, Steven P. Margossian, Nancy A. Kernan, Lewis B. Silverman, David A. Williams, Neerav Shukla, Rachel Kobos, Christopher J. Forlenza, Peter Steinherz, Susan Prockop, Farid Boulad, Barbara Spitzer, Maria I. Cancio, Jaap Jan Boelens, Andrew L. Kung, Yasmin Khakoo, Victoria Szenes, Jae H. Park, Craig S. Sauter, Glenn Heller, Xiuyan Wang, Brigitte Senechal, Richard J. O’Reilly, Isabelle Riviere, Michel Sadelain, Renier J. Brentjens
Journal: Blood
Blood (2019) 134 (26): 2361–2368.
https://doi.org/10.1182/blood.2019001641
Published: 2019
Includes: Supplemental data
Journal Articles

CD19 CAR T cells following autologous transplantation in poor-risk relapsed and refractory B-cell non-Hodgkin lymphoma

Clinical Trials & Observations
Craig S. Sauter, Brigitte Senechal, Isabelle Rivière, Ai Ni, Yvette Bernal, Xiuyan Wang, Terence Purdon, Malloury Hall, Ashvin N. Singh, Victoria Z. Szenes, Sarah Yoo, Ahmet Dogan, Yongzeng Wang, Craig H. Moskowitz, Sergio Giralt, Matthew J. Matasar, Miguel-Angel Perales, Kevin J. Curran, Jae Park, Michel Sadelain, Renier J. Brentjens
Journal: Blood
Blood (2019) 134 (7): 626–635.
https://doi.org/10.1182/blood.2018883421
Published: 2019
Includes: Supplemental data
Journal Articles

Clinical Responses and Pharmacokinetics of MCARH171, a Human-Derived Bcma Targeted CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma: Final Results of a Phase I Clinical Trial

Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Mikhail Roshal, MD PhD, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, John Pineda, RN, Pavan Anant, BS, Yvette Bernal, MS, Analisa Wills, Neha Korde, MD, Nikoletta Lendvai, MDPhD, Alexander M. Lesokhin, MD, Hani Hassoun, MD, Malin Hultcrantz, MD PhD, Heather J. Landau, MD, Gunjan L. Shah, MD, Michael Scordo, MD, David J. Chung, MDPhD, Oscar B Lahoud, MD, Pallavi Khattar, MD, Carlos Fernandez de Larrea, MD PhD, Qi Gao, Achim Jungbluth, MDPhD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Maria Lia Palomba, MD, Brigitte Senechal, PhD, Xiuyan Wang, PhD, Ahmet Dogan, MD PhD, Sergio Giralt, MD, Isabelle Riviere, PhD, Ola Landgren, MD PhD, Renier J. Brentjens, MD PhD, Eric L. Smith, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 959.
https://doi.org/10.1182/blood-2018-99-119717
Published: 2018
Journal Articles

A Phase I First-in-Human Clinical Trial of CD19-Targeted 19-28z/4-1BBL "Armored" CAR T Cells in Patients with Relapsed or Refractory NHL and CLL Including Richter's Transformation

Jae H. Park, MD, Maria Lia Palomba, MD, Connie Lee Batlevi, MD, Isabelle Riviere, PhD, Xiuyan Wang, PhD, Brigitte Senechal, PhD, Richard R. Furman, MD, Yvette Bernal, MS, Malloury Hall, BA, John Pineda, RN, Claudia Diamonte, RN, Elizabeth Halton, NP-BC AOCNP, Renier J. Brentjens, MD PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 224.
https://doi.org/10.1182/blood-2018-99-117737
Published: 2018
Journal Articles

Implications of Concurrent Ibrutinib Therapy on CAR T-Cell Manufacturing and Phenotype and on Clinical Outcomes Following CD19-Targeted CAR T-Cell Administration in Adults with Relapsed/Refractory CLL

Mark Blaine Geyer, MD, Jae H. Park, MD, Isabelle Riviere, PhD, Brigitte Senechal, PharmD, PhD, Xiuyan Wang, PhD, Terence J. Purdon, Michel W. Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2016) 128 (22): 58.
https://doi.org/10.1182/blood.V128.22.58.58
Published: 2016