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Journal Articles

Multi-Antigen Targeting By Novel Combination of CAR-T Cells and hnCD16 Transgene, Yields in Complete Tumor Clearance Via Antibody Dependent Cellular Cytotoxicity

Soheila Shirinbak, Joy Grant, Wen-I Yeh, Angela Gentile, Bishwas Shrestha, Bi-Huei Yang, Mochtar Pribadi, Shohreh Sikaroodi, Amit Mehta, Amanda D Yzaguirre, Yijia Pan, Chia-Wei Chang, Tom Lee, Layton Smith, Jianming Wu, Bruce Walcheck, Martin Hosking, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 10253–10254.
https://doi.org/10.1182/blood-2022-169462
Published: 2022
Journal Articles

Clinical Manufacture of FT819: Use of a Clonal Multiplexed-Engineered Master Induced Pluripotent Stem Cell Line to Mass Produce Off-the-Shelf CAR T-Cell Therapy

Xu Yuan, Raedun Clarke, Yi-Shin Lai, Chia-Wei Chang, Bi-Huei Yang, Gloria Hsia, Ramzey Abujarour, Tom Lee, Sjoukje van der Stegen, Helena Shaked, Abubakar Jalloh, Stephanie Moreno, Jason ORourke, Eric Sung, Alma Gutierrez, Betsy Rezner, Meghan Eberhart, Rebecca Magdaleno, Xiuyan Wang, Brigitte Senechal, Devanjan S. Sikder, Dell Farnan, Mark Plavsic, Jerome Bressi, Isabelle Rivière, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 1766.
https://doi.org/10.1182/blood-2021-152985
Published: 2021
Journal Articles

Combination of Three Unique Anti-Tumor Modalities Engineered into iPSC-Derived T Cells Demonstrate a Synergistic Effect in Overcoming Tumor Heterogeneity and Cancer Escape

Bi-Huei Yang, Yu-Sheng Eason Lin, Soheila Shirinbak, Wen-I Yeh, Mochtar Pribadi, Hui-Yi Chu, Alma Gutierrez, Amit Mehta, Earl Avramis, Roseanna Petrovic, Benjamin Whitlock, Jason ORourke, Sjoukje van der Stegen, Tom Lee, Alec Witty, Eigen Peralta, Martin Hosking, Chia-Wei Chang, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 2793.
https://doi.org/10.1182/blood-2021-153268
Published: 2021
Journal Articles

Multiplexed Engineered, Off-the-Shelf T Cells Carrying Three Tumor-Associated Antigen-Targeting Modalities: CAR + Pan-Tumor Targeting TCR + CD16 Fc Receptor

Cokey Nguyen, PhD, Eigen Peralta, PhD, Chia-Wei Chang, Wen-I Yeh, PhD, Yijia Pan, PhD, Dan Lu, PhD, May Sumi, Mochtar Pribadi, PhD, Bi-Huei Yang, PhD, Eric Sung, Alec Witty, PhD, Tom Lee, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-141507
Published: 2020
Journal Articles

Generation of Multiplexed Engineered, Off-the-Shelf CAR T Cells Uniformly Carrying Multiple Anti-Tumor Modalities to Prevent Tumor Relapse

Chiawei Chang, Eigen Peralta, PhD, Gloria Hsia, PhD, Bi-Huei Yang, PhD, Wen-I Yeh, PhD, Raedun Clarke, PhD, Mandal Mili, PhD, Tom Lee, PhD, Mochtar Pribadi, PhD, Ramzey Abujarour, PhD, Yi-Shin Lai, PhD, David Robbins, BS, Matthew Denholtz, PhD, Sandeep Kothapally Hanok, Emily Driver, BS, Emily Carron, PhD, Natalie Navarrete, BS, May Sumi, Amit Mehta, Philip Chu, Jason ORourke, PhD, Alma Gutierrez, Eric Sung, Suzanna Gasparian, Angela Gentile, Alec Witty, PhD, Amanda Yzaguirre, Samuel LaBarge, Cokey Nguyen, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
https://doi.org/10.1182/blood-2020-138930
Published: 2020
Journal Articles

FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

Chiawei Chang, Sjoukje Van Der Stegen, PhD, Mandal Mili, PhD, Raedun Clarke, PhD, Yi-Shin Lai, PhD, Alec Witty, PhD, Pieter Lindenbergh, Bi-Huei Yang, PhD, Mushtaq Husain, PhD, Helena Shaked, PhD, Brian Groff, Laurel Stokely, Ramzey Abujarour, PhD, Tom Lee, PhD, Hui-Yi Chu, PhD, Mochtar Pribadi, PhD, Jason ORourke, PhD, Alma Gutierrez, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4434.
https://doi.org/10.1182/blood-2019-130584
Published: 2019