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Journal Articles

Development of Induced Pluripotent Stem Cell-Derived T Cells Exhibiting Phenotypic and Functional Attributes of Primary CAR T Cells

Bryan Hancock, Jonatan Tuncel, Kyla Omilusik, Alison O'Connor, Bi-Huei Yang, Matthew Haynes, Amanda Yzaguirre, Karina Palomares, Sandeep Kothapally Hanok, Matthew Denholtz, Martin Hosking, Eigen Peralta, Tom Lee, Raedun Clarke, Sjoukje Van Der Stegen, John Goulding, Jode Goodridge, Michel Sadelain, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 3474.
https://doi.org/10.1182/blood-2024-210786
Published: 2024
Journal Articles

Next-Generation Off-the-Shelf CAR T-Cell Therapy Developed to Eliminate a Broad Spectrum of Pathogenic Cells in Hematological Diseases in the Absence of Conditioning Chemotherapy

John Goulding, Mark Jelcic, Daniel Morales-Mantilla, John Reiser, Alison O'Connor, Rina Mbofung, Alan Williams, Dan Lu, Bi-Huei Yang, Alma Gutierrez, Miguel Meza, Yijia Pan, Jonatan Tuncel, Bryan Hancock, Sean Sherman, Alec Witty, Eigen Peralta, Martin Hosking, Lilly Wong, Tom Lee, Jode Goodridge, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 4801.
https://doi.org/10.1182/blood-2024-209465
Published: 2024
Journal Articles

A CD3 Fusion Receptor (CD3-FR) Uniquely Enables Compatibility of Allogeneic CAR-T and -NK Cells with T Cell Engagers to Enhance Antitumor Function and Limit Antigen Escape

Eigen Peralta, Dan Lu, Mark Landon, Hui-yi Chu, Soo Park, Masanao Tsuda, Trevor Zarecki, Elena Demeester, Matthew Denholtz, Amit Mehta, Earl Avramis, Philip Chu, Jeffrey Chen, Eric Sung, Alec Witty, Tom Lee, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 7429–7430.
https://doi.org/10.1182/blood-2022-169887
Published: 2022
Journal Articles

Combination of Three Unique Anti-Tumor Modalities Engineered into iPSC-Derived T Cells Demonstrate a Synergistic Effect in Overcoming Tumor Heterogeneity and Cancer Escape

Bi-Huei Yang, Yu-Sheng Eason Lin, Soheila Shirinbak, Wen-I Yeh, Mochtar Pribadi, Hui-Yi Chu, Alma Gutierrez, Amit Mehta, Earl Avramis, Roseanna Petrovic, Benjamin Whitlock, Jason ORourke, Sjoukje van der Stegen, Tom Lee, Alec Witty, Eigen Peralta, Martin Hosking, Chia-Wei Chang, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 2793.
https://doi.org/10.1182/blood-2021-153268
Published: 2021
Journal Articles

Generation of Multiplexed Engineered, Off-the-Shelf CAR T Cells Uniformly Carrying Multiple Anti-Tumor Modalities to Prevent Tumor Relapse

Chiawei Chang, Eigen Peralta, PhD, Gloria Hsia, PhD, Bi-Huei Yang, PhD, Wen-I Yeh, PhD, Raedun Clarke, PhD, Mandal Mili, PhD, Tom Lee, PhD, Mochtar Pribadi, PhD, Ramzey Abujarour, PhD, Yi-Shin Lai, PhD, David Robbins, BS, Matthew Denholtz, PhD, Sandeep Kothapally Hanok, Emily Driver, BS, Emily Carron, PhD, Natalie Navarrete, BS, May Sumi, Amit Mehta, Philip Chu, Jason ORourke, PhD, Alma Gutierrez, Eric Sung, Suzanna Gasparian, Angela Gentile, Alec Witty, PhD, Amanda Yzaguirre, Samuel LaBarge, Cokey Nguyen, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
https://doi.org/10.1182/blood-2020-138930
Published: 2020
Journal Articles

Novel Method for Clonal Selection of Multiplexed Engineered CAR-T Cells Which Uniquely Demonstrate Anti-Tumor Functionality in the Tumor Microenvironment

Eigen Peralta, PhD, David Robbins, BS, Emily Carron, PhD, Matthew Denholtz, PhD, Natalie Navarrete, BS, Dan Lu, PhD, Joyee Yao, Sandeep Kothapally Hanok, Yinghui Sui, PhD, Angela Gentile, Eric Sung, Jason ORourke, PhD, Tom Lee, PhD, Daniel Shoemaker, PhD, Cokey Nguyen, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12.
https://doi.org/10.1182/blood-2020-141506
Published: 2020
Journal Articles

Multiplexed Engineered, Off-the-Shelf T Cells Carrying Three Tumor-Associated Antigen-Targeting Modalities: CAR + Pan-Tumor Targeting TCR + CD16 Fc Receptor

Cokey Nguyen, PhD, Eigen Peralta, PhD, Chia-Wei Chang, Wen-I Yeh, PhD, Yijia Pan, PhD, Dan Lu, PhD, May Sumi, Mochtar Pribadi, PhD, Bi-Huei Yang, PhD, Eric Sung, Alec Witty, PhD, Tom Lee, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-141507
Published: 2020
Journal Articles

Pluripotent Cell-Derived Off-the-Shelf TCR-Less CAR-Targeted Cytotoxic T Cell Therapeutic for the Allogeneic Treatment of B Cell Malignancies

Raedun Clarke, PhD, Sjoukje Van Der Stegen, PhD, Chia-Wei Chang, PhD, Mushtaq Husain, PhD, Yi-Shin Lai, PhD, Eigen Peralta, PhD, Laurel Stokely, Ramzey Abujarour, PhD, Jason Dinella, PhD, Tom Lee, PhD, Mochtar Pribadi, PhD, Helen Chu, PhD, Chris Truong, Mohsen Sabouri-Ghomi, PhD, Miguel Meza, BS, Judith Feucht, MD, Justin Eyquem, PhD, Jorge Mansilla-Soto, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4546.
https://doi.org/10.1182/blood-2018-99-116843
Published: 2018
Journal Articles

Identification of Small Molecule Modulators to Enhance the Therapeutic Properties of Chimeric Antigen Receptor T Cells

Jonathan Rosen, PhD, Betsy Rezner, BS, David Robbins, BS, Ian Hardy, PhD, Eigen Peralta, PhD, Christian Maine, PhD, Mohsen Sabouri, Sarah Reynal, Christopher Truong, Stacey Moreno, Heather Foster, Sarah Borchelt, Miguel Meza, MS, Lucas Thompson, Jason Fontenot, PhD, Ryan P Larson, PhD, Mirna Mujacic, PhD, Daniel Shoemaker, PhD
Journal: Blood
Blood (2016) 128 (22): 4712.
https://doi.org/10.1182/blood.V128.22.4712.4712
Published: 2016