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Jorge Mansilla-Soto
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Journal Articles

Optimizing Therapeutic Outcome of CD19(T2)28z1XX Chimeric Antigen Receptor (CAR) T in Adult Patients with Large B-Cell Lymphoma through a Quantitative Medicine Approach

Agnish Dey, Jia Li, Jae H. Park, Leopold Sellner, Varsha Sundaresan, Maria Lia Palomba, Jorge Mansilla-Soto, Brigitte Senechal, Xiuyan Wang, Devanjan S Sikder, Ajeeta Dash, Isabelle Riviere, Michel Sadelain, Ganesh Mugundu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7138.
https://doi.org/10.1182/blood-2024-203375
Published: 2024
Journal Articles

A Phase I Study of CD19-Targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Jae H. Park, Maria Lia Palomba, Sean M. Devlin, Yannis K. Valtis, Devanjan S Sikder, Brigitte Senechal, Xiuyan Wang, Elizabeth Cathcart, Kelly Liotta, Alina Yu, Kelsey Stocker, Honglei Zhang, Heiko Schoder, Doris Leithner, Jia Li, Leopold Sellner, Jorge Mansilla-Soto, Isabelle Riviere, Michel Sadelain
Journal: Blood
Blood (2023) 142 (Supplement 1): 892.
https://doi.org/10.1182/blood-2023-187623
Published: 2023
Journal Articles

Novel extragenic genomic safe harbors for precise therapeutic T-cell engineering

Ashlesha Odak, Han Yuan, Judith Feucht, Vito Adrian Cantu, Jorge Mansilla-Soto, Friederike Kogel, Justin Eyquem, John Everett, Frederic D. Bushman, Christina S. Leslie, Michel Sadelain
Journal: Blood
Blood (2023) 141 (22): 2698–2712.
https://doi.org/10.1182/blood.2022018924
Published: 2023
Includes: Supplemental data
Journal Articles

Target Densities in Malignant and Normal Cells Determine CAR T Cell Efficacy and Off-Target Hematotoxicity

Sascha Haubner, Jorge Mansilla-Soto, Sarah Nataraj, Friederike Kogel, Qing Chang, Elisa De Stanchina, Kathryn Fraser, Jae H Park, Xiuyan Wang, Isabelle Rivière, Michel Sadelain
Journal: Blood
Blood (2022) 140 (Supplement 1): 869–870.
https://doi.org/10.1182/blood-2022-162968
Published: 2022
Journal Articles

Overcoming Heterogeneity in AML with a Novel or-Gated Hitcar-1XX Platform

Sascha Haubner, Jorge Mansilla-Soto, Andreina Garcia Angus, Qing Chang, Elisa De Stanchina, Michel Sadelain
Journal: Blood
Blood (2022) 140 (Supplement 1): 865–866.
https://doi.org/10.1182/blood-2022-162579
Published: 2022
Journal Articles

"IF-Better" Gating: Combinatorial Targeting and Synergistic Signaling for Enhanced CAR T Cell Efficacy

Sascha Haubner, Jorge Mansilla-Soto, Sarah Nataraj, Xingyue He, Jae H Park, Xiuyan Wang, Isabelle Rivière, Michel Sadelain
Journal: Blood
Blood (2021) 138 (Supplement 1): 2774.
https://doi.org/10.1182/blood-2021-149263
Published: 2021
Journal Articles

Targeted Integration of a CAR at a Novel Genomic Safe Harbor Directs Potent Therapeutic Outcomes

Ashlesha Odak, MS, Han Yuan, PhD, Judith Feucht, MD, Jorge Mansilla - Soto, PhD, Justin Eyquem, PhD, Christina Leslie, PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28.
https://doi.org/10.1182/blood-2020-141967
Published: 2020
Journal Articles

Pluripotent Cell-Derived Off-the-Shelf TCR-Less CAR-Targeted Cytotoxic T Cell Therapeutic for the Allogeneic Treatment of B Cell Malignancies

Raedun Clarke, PhD, Sjoukje Van Der Stegen, PhD, Chia-Wei Chang, PhD, Mushtaq Husain, PhD, Yi-Shin Lai, PhD, Eigen Peralta, PhD, Laurel Stokely, Ramzey Abujarour, PhD, Jason Dinella, PhD, Tom Lee, PhD, Mochtar Pribadi, PhD, Helen Chu, PhD, Chris Truong, Mohsen Sabouri-Ghomi, PhD, Miguel Meza, BS, Judith Feucht, MD, Justin Eyquem, PhD, Jorge Mansilla-Soto, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4546.
https://doi.org/10.1182/blood-2018-99-116843
Published: 2018
Journal Articles

Systematic Combinatorial Chimeric Antigen Receptor Therapies to AML

Fabiana Perna, MD, Samuel Berman, Rajesh K Soni, PhD, Jorge Mansilla-Soto, PhD, Justin Eyquem, PhD, Mohamad Hamieh, PhD, Ronald C Hendrickson, PhD, Cameron Brennan, MD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 856.
https://doi.org/10.1182/blood.V130.Suppl_1.856.856
Published: 2017
Journal Articles

Generation of Clonal Antigen Specific CD8αβ + Cytotoxic T Lymphocytes from Renewable Pluripotent Stem Cells for Off-the-Shelf T Cell Therapeutics

Sjoukje Van Der Stegen, PhD, Raedun Clarke, PhD, Jorge Mansilla - Soto, PhD, Edwin Ortiz, Chia-Wei Chang, Jeff Sasaki, Tom Lee, PhD, Weijie Lan, PhD, Daniel Shoemaker, PhD, Isabelle Riviere, PhD, Bahram Valamehr, PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 163.
https://doi.org/10.1182/blood.V130.Suppl_1.163.163
Published: 2017
Journal Articles

Probing the AML Surfaceome for Chimeric Antigen Receptor (CAR) Targets

Fabiana Perna, MDPhD, Samuel Berman, Jorge Mansilla-Soto, PhD, Mohamad Hamieh, PhD, Rupa Juthani, MD, Rajesh Soni, PhD, Justin Eyquem, PhD, Ronald Hendrickson, PhD, Cameron Brennan, MD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2016) 128 (22): 526.
https://doi.org/10.1182/blood.V128.22.526.526
Published: 2016