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Eva Sahakian
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Journal Articles

Enhancing CAR-T Therapy in CLL By Modulating the Immunosuppressive Tumor Microenvironment: A Novel Approach with Significant Therapeutic Potential

Angimar Uriepero Palma, Melanie Mediavilla Varela, Maria Elena Marquez, Wael Gamal, Mohammad Ammad-ud-din, Pablo Oppezzo, Eva Sahakian, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4607.
https://doi.org/10.1182/blood-2024-204892
Published: 2024
Journal Articles

Identifying the Role of Endoplasmic Reticulum Stress in CLL T-Cell Dysfunction

Wael Gamal, Melanie Mediavilla Varela, Angimar Uriepero Palma, Mohammad Ammad Ud Din, Julio C. Chavez, Eva Sahakian, Paulo C. Rodriguez, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1848.
https://doi.org/10.1182/blood-2024-210608
Published: 2024
Journal Articles

Reprogramming CLL T-Cell Mitochondrial Fitness Using PI3K Inhibition for Enhancing CAR T-Cell Therapy

Wael Gamal, Nienke B. Goedhart, Helga Simon-Molas, Melanie Mediavilla Varela, Angimar Uriepero Palma, Fleur S. Peters, Eva Sahakian, Arnon P. Kater, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4803.
https://doi.org/10.1182/blood-2024-210992
Published: 2024
Journal Articles

A Phase I Study of Duvelisib in Combination with Oral Azacitidine (BMS-986345) in Mature T Cell Lymphoma

Hayder Saeed, Melanie Mediavilla Varela, Eva Sahakian, Mahrukh Naqvi, Qiangxing Mo, Ling Zhang, Rikesh Makanji, Yumeng Zhang, Ning Dong, Leidy Lismeris Isenalumhe, Sameh Gaballa, Julio C. Chavez, Bijal D Shah, Celeste M. Bello, Lubomir Sokol, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 3065.
https://doi.org/10.1182/blood-2024-205173
Published: 2024
Journal Articles

Efficacy of Combinatorial Treatment Approaches in CTCL

Melanie Mediavilla-Varela, Eva Sahakian, Carly Harro, John J. Powers, Jose Conejo-Garcia, Lubomir Sokol, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 11880–11881.
https://doi.org/10.1182/blood-2022-169915
Published: 2022
Journal Articles

Targeting Inflammatory Pathways to Reverse Immunosuppressive Tumor Microenvironment in Chronic Lymphocytic Leukemia

Angimar Uriepero, Melanie Mediavilla-Varela, Kamira Maharaj, Wael Gamal, Maria Elena Marquez, John J. Powers, Vishaal Kunta, Eva Sahakian, Pablo Oppezzo, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 6988–6989.
https://doi.org/10.1182/blood-2022-167331
Published: 2022
Journal Articles

Metabolic Abnormalities Associated with T-Cell Exhaustion in CLL Eµ-TCL1 Murine Model

Wael Gamal, Melanie Mediavilla-Varela, Kamira Maharaj, Angimar Uriepero, Vishaal Kunta, Eva Sahakian, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 6994–6995.
https://doi.org/10.1182/blood-2022-166704
Published: 2022
Journal Articles

Second Treatment Free Remission after Combination Therapy with Ruxolitinib Plus Tyrosine Kinase Inhibitors in Chronic Phase Chronic Myeloid Leukemia (CML)

Kendra Sweet, Ehab L. Atallah, Jerry P. Radich, Mei-Jie Zhang, Eva Sahakian, Melanie Mediavilla-Varela, Alexis Vistocky, Michael C. Heinrich, James E. Thompson, Michael J. Mauro, Kathryn E Flynn, Arielle Baim, Javier Pinilla Ibarz
Journal: Blood
Blood (2021) 138 (Supplement 1): 2555.
https://doi.org/10.1182/blood-2021-147954
Published: 2021
Journal Articles

Efficacy of Vecabrutinib Treatment in a Murine Model of Sclerodermatous Graft-Versus-Host-Disease

Kamira Maharaj, Melanie Mediavilla-Varela, Angimar Uriepero, Judith A. Fox, Pietro Taverna, Wael Gamal, Eva Sahakian, Javier Pinilla Ibarz
Journal: Blood
Blood (2021) 138 (Supplement 1): 1685.
https://doi.org/10.1182/blood-2021-150598
Published: 2021
Journal Articles

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Lanzhu Yue, Vasundhara Sharma, Nathan P. Horvat, Afua A. Akuffo, Matthew S. Beatty, Cem Murdun, Christelle Colin, Julia M. R. Billington, William E. Goodheart, Eva Sahakian, Ling Zhang, John J. Powers, Narmin E. Amin, Que T. Lambert-Showers, Lancia N. Darville, Javier Pinilla-Ibarz, Gary W. Reuther, Kenneth L. Wright, Chiara Conti, Jennifer Y. Lee, Xiaozhang Zheng, Pui Yee Ng, Matthew W. Martin, C. Gary Marshall, John M. Koomen, Ross L. Levine, Amit Verma, H. Leighton Grimes, Eduardo M. Sotomayor, Zonghong Shao, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2020) 135 (3): 191–207.
https://doi.org/10.1182/blood.2019895326
Published: 2020
Includes: Supplemental data
Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

A Phase II Trial of Ibrutinib and PD-1 Blockade in Asymptomatic High Risk Chronic Lymphocytic Leukemia to Improve Immune Function

Julio C. Chavez, MD, Ariel F Grajales-Cruz, MD, Virginia Olivia Volpe, MD, Elyce P. Turba, MSN, RN, Lisa Nodzon, PhD ARNP, AOCNP, Eva Sahakian, PhD, Nicole Rozario, Javier Pinilla Ibarz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5483.
https://doi.org/10.1182/blood-2019-132211
Published: 2019
Journal Articles

Conventional Real Time Quantitative Polymerase Chain Reaction Method Yields Similar Level of Sensitivity to Digital Droplet Polymerase Chain Reaction for Detection of BCR-ABL p210 Transcripts in Patients with Chronic Phase Chronic Myeloid Leukemia

Hannah Asghari, MD BS, Chetasi Talati, MD, Alexandra Achille, John J. Powers, BS, Eva Sahakian, PhD, Onyee Chan, MD, Dawne N Shelton, PhD, Leidy Isenalumhe, MD, Lisa Nodzon, PhD ARNP, AOCNP, Kendra L. Sweet, MD, Javier Pinilla Ibarz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3382.
https://doi.org/10.1182/blood-2019-131207
Published: 2019
Journal Articles

Functional Analysis of HDAC11 in Plasma Cell Development and Multiple Myeloma Survival

AGM Mostofa, PhD, Allison Distler, Mark B. Meads, PhD, Eva Sahakian, PhD, John J. Powers, BS, Tuan Nguyen, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla Ibarz, MD, Eduardo Sotomayor, MD, Kenneth H. Shain, MD PhD, Jason B. Brayer, PhD MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2018-99-119119
Published: 2018
Journal Articles

Loss of HDAC11 Promotes Myeloid-Derived Suppressor Cells Inhibition of T Cell Function in a Murine Lymphoma Microenvironment

Jie Chen, PhD, Fengdong Cheng, MD, Michael Wang, Bachelor of Science, Eva Sahakian, PhD, John J. Powers, BS, Javier Pinilla Ibarz, MD, Mitchell R. Smith, MDPhD, Eduardo Sotomayor, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1105.
https://doi.org/10.1182/blood-2018-99-117007
Published: 2018
Journal Articles

Differential Regulation of T Cells By PI3K Delta Inhibitors in a CLL Murine Model

Kamira Maharaj, PhDCandidate, John J. Powers, BS, Alex Achille, BS, Mibel Pabon-Saldana, PhD, Renee Fonseca, BS, Susan Deng, BS, Hari P Miskin, MSc, Dave Maryanski, BS, Eva Sahakian, PhD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3009.
https://doi.org/10.1182/blood.V130.Suppl_1.3009.3009
Published: 2017
Journal Articles

HDAC11 Is a Candidate Therapeutic Target in Multiple Myeloma

Jason B. Brayer, PhDMD, Allison Distler, Mark B. Meads, PhD, Eva Sahakian, PhD, John J. Powers, BS, Tuan Nguyen, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla-Ibarz, MD PhD, Eduardo Martin Sotomayor, MD, Ken H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1800.
https://doi.org/10.1182/blood.V130.Suppl_1.1800.1800
Published: 2017
Journal Articles

A Phase I Study of Ruxolitinib Plus Nilotinib in Chronic Phase CML Patients with Molecular Evidence of Disease

Kendra L. Sweet, MD, Lori Hazlehurst, PhD, Eva Sahakian, PhD, John J. Powers, B.S., Lisa Nodzon, PhD ANP, Fadi Kayali, MD, Kelly Hyland, Ashley Nelson, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1892.
https://doi.org/10.1182/blood.V128.22.1892.1892
Published: 2016
Journal Articles

Combinatorial Effect of HDAC6i and Ibrutinib Therapy in CLL Murine Model

Kamira Karen Maharaj, BS, John J. Powers, B.S., Susan Deng, BS, Alex Achille, BS, Mibel Pabon-Saldana, Renee Fonseca, Steven N Quayle, Simon S Jones, PhD, Eva Sahakian, PhD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2035.
https://doi.org/10.1182/blood.V128.22.2035.2035
Published: 2016
Journal Articles

Modulation of T Cell Compartment in a Preclinical CLL Murine Model By a Selective PI3K Delta Inhibitor, TGR-1202

Kamira Karen Maharaj, BS, John J. Powers, B.S., Mibel Pabon-Saldana, Renee Fonseca, Alex Achille, BS, Susan Deng, BS, Hari P. Miskin, MS, Dave Maryanski, Eva Sahakian, PhD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3236.
https://doi.org/10.1182/blood.V128.22.3236.3236
Published: 2016