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Journal Articles

Enhancing CAR-T Therapy in CLL By Modulating the Immunosuppressive Tumor Microenvironment: A Novel Approach with Significant Therapeutic Potential

Angimar Uriepero Palma, Melanie Mediavilla Varela, Maria Elena Marquez, Wael Gamal, Mohammad Ammad-ud-din, Pablo Oppezzo, Eva Sahakian, Javier Pinilla-Ibarz

Blood (2024) 144 (Supplement 1): 4607.

https://doi.org/10.1182/blood-2024-204892

Published: 2024

Journal Articles

Targeting Inflammatory Pathways to Reverse Immunosuppressive Tumor Microenvironment in Chronic Lymphocytic Leukemia

Angimar Uriepero, Melanie Mediavilla-Varela, Kamira Maharaj, Wael Gamal, Maria Elena Marquez, John J. Powers, Vishaal Kunta, Eva Sahakian, Pablo Oppezzo, Javier Pinilla Ibarz

Blood (2022) 140 (Supplement 1): 6988–6989.

https://doi.org/10.1182/blood-2022-167331

Published: 2022

Journal Articles

Unbiased NGS Approach for IGHV Mutational Status, Clonal Space and Immune Repertoire Assessment in Chronic Lymphocytic Leukemia

Jorge Gonzalez-Puelma, Julieta Sepulveda-Yanez, Jorge Torres-Almonacid, Diego Alvarez-Saravia, Maria Elena Marquez, Hermy Alvarez-Ojeda, Daniela Cardemil, Roberto Uribe-Paredes, Pablo Oppezzo, Marcelo Navarrete

Blood (2022) 140 (Supplement 1): 6979–6980.

https://doi.org/10.1182/blood-2022-168211

Published: 2022

Journal Articles

AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

Blood (2021) 138 (3): 246–258.

https://doi.org/10.1182/blood.2020008654

Published: 2021

Includes: Supplemental data

Journal Articles

Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia

Pablo Elías Morande, Mariela Sivina, Angimar Uriepero, Noé Seija, Catalina Berca, Pablo Fresia, Ana Inés Landoni, Javier M. Di Noia, Jan A. Burger, Pablo Oppezzo

Blood (2019) 133 (19): 2056–2068.

https://doi.org/10.1182/blood-2018-09-876292

Published: 2019

Includes: Supplemental data

Journal Articles

Over-Expression of Activation-Induced Cytidine Deaminase in TCL1 Mice Leads to the Development of IGHV-Mutated CLL Clones That Associate with More Aggressive Disease

Xiao J. Yan, MDPhD, Pablo Morande, PhD, Mei Qi, Ezra B Kolitz, Crystal D Grant, Gautam Nayyar, Pablo Oppezzo, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4293.

https://doi.org/10.1182/blood.V130.Suppl_1.4293.4293

Published: 2017

Journal Articles

S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression

Daniel Prieto, Natalia Sotelo, Noé Seija, Sandra Sernbo, Cecilia Abreu, Rosario Durán, Magdalena Gil, Estefanía Sicco, Victoria Irigoin, Carolina Oliver, Ana Inés Landoni, Raúl Gabus, Guillermo Dighiero, Pablo Oppezzo

Blood (2017) 130 (6): 777–788.

https://doi.org/10.1182/blood-2017-02-769851

Published: 2017

Includes: Supplemental data

Journal Articles

Overexpression of Activation-Induced Deaminase in TCL1 Mice Leads to the Development of IGHV -Mutated and -Unmutated CLL Clones That Resemble Unique Subsets of Human CLL

Xiao-Jie Yan, MD PhD, Pablo Morande, PhD, Ezra B Kolitz, BS, Crystal D Grant, BS, Gautam Nayyar, Pablo Oppezzo, PhD, Nicholas Chiorazzi, MD

Blood (2015) 126 (23): 1710.

https://doi.org/10.1182/blood.V126.23.1710.1710

Published: 2015

Journal Articles

Sphingosine Kinases (SK): Key Molecules Associated with the Activation, Proliferation and Ibrutinib-Induced Cell Death of Chronic Lympocytic Leukemia Cells

Maria Belen Almejun, PhD, Mercedes Borge, PhD, Ana Colado, Enrique Podaza, Denise Risnik, Carlos Daniel De Brasi, Pablo Oppezzo, PhD, Maria Cabrejo, MD, Horacio Fernandez Grecco, MD, Raimundo F. Bezares, MD, Santiago C Cranco, MD, Ruben A. Burgos, MD, Julio Cesar Sanchez Avalos, MD, Mirta N. Giordano, PhD, Romina Gamberale, PhD

Blood (2015) 126 (23): 1714.

https://doi.org/10.1182/blood.V126.23.1714.1714

Published: 2015

Journal Articles

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease

Florencia Palacios, Pilar Moreno, Pablo Morande, Cecilia Abreu, Agustín Correa, Valentina Porro, Ana Ines Landoni, Raul Gabus, Mirta Giordano, Guillermo Dighiero, Otto Pritsch, Pablo Oppezzo

Blood (2010) 115 (22): 4488–4496.

https://doi.org/10.1182/blood-2009-12-257758

Published: 2010

Journal Articles

The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia

Pablo Oppezzo, Yuri Vasconcelos, Catherine Settegrana, Dominique Jeannel, Françoise Vuillier, Magali Legarff-Tavernier, Eliza Yuriko Kimura, Stéphane Bechet, Gérard Dumas, Martine Brissard, Hélène Merle-Béral, Mihoko Yamamoto, Guillaume Dighiero, Frédéric Davi, for the French Cooperative Group on CLL

Blood (2005) 106 (2): 650–657.

https://doi.org/10.1182/blood-2004-08-3344

Published: 2005

Journal Articles

Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the μ and CD79a chains

Françoise Vuillier, Gérard Dumas, Christian Magnac, Marie-Christine Prevost, Ana Inés Lalanne, Pablo Oppezzo, Evie Melanitou, Guillaume Dighiero, Béatrice Payelle-Brogard

Blood (2005) 105 (7): 2933–2940.

https://doi.org/10.1182/blood-2004-09-3643

Published: 2005

Journal Articles

Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells

Pablo Oppezzo, Gérard Dumas, Ana Inés Lalanne, Béatrice Payelle-Brogard, Christian Magnac, Otto Pritsch, Guillaume Dighiero, Françoise Vuillier

Blood (2005) 105 (6): 2495–2503.

https://doi.org/10.1182/blood-2004-09-3644

Published: 2005

Journal Articles

Combination of LPL/ADAM29 Ratio and ZAP Expression Can Replace IGVH Sequencing in the Majority of CLL.

Pablo Oppezzo, Yuri Vasconcelos, Catherine Settegrana, Dominique Jeannel, Francoise Vuiller, Martine Brissard, Eliza Yuriko, Sugano Kimura, Stephane Bechet, Gerard Dumas, Magali Legarff, Helene Merle-Beral, Mihoko Yamamoto, Guillaume Dighiero, Frederic Davi

Blood (2004) 104 (11): 1097.

https://doi.org/10.1182/blood.V104.11.1097.1097

Published: 2004

Journal Articles

Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation

Pablo Oppezzo, Françoise Vuillier, Yuri Vasconcelos, Gérard Dumas, Christian Magnac, Béatrice Payelle-Brogard, Otto Pritsch, Guillaume Dighiero

Blood (2003) 101 (10): 4029–4032.

https://doi.org/10.1182/blood-2002-10-3175

Published: 2003

NARROW

Enhancing CAR-T Therapy in CLL By Modulating the Immunosuppressive Tumor Microenvironment: A Novel Approach with Significant Therapeutic Potential

Targeting Inflammatory Pathways to Reverse Immunosuppressive Tumor Microenvironment in Chronic Lymphocytic Leukemia

Unbiased NGS Approach for IGHV Mutational Status, Clonal Space and Immune Repertoire Assessment in Chronic Lymphocytic Leukemia

AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia

Over-Expression of Activation-Induced Cytidine Deaminase in TCL1 Mice Leads to the Development of IGHV-Mutated CLL Clones That Associate with More Aggressive Disease

S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression

Overexpression of Activation-Induced Deaminase in TCL1 Mice Leads to the Development of IGHV -Mutated and -Unmutated CLL Clones That Resemble Unique Subsets of Human CLL

Sphingosine Kinases (SK): Key Molecules Associated with the Activation, Proliferation and Ibrutinib-Induced Cell Death of Chronic Lympocytic Leukemia Cells

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease

The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia

Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the μ and CD79a chains

Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells

Combination of LPL/ADAM29 Ratio and ZAP Expression Can Replace IGVH Sequencing in the Majority of CLL.

Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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