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Journal Articles

Tandem Substitutions in Somatic Hypermutation

Marvyn T. Koning, Julieta Haydee Sepulveda Yanez, Diego Alvarez-Saravia, Bas Pilzecker, Pauline Van Schouwenburg, Mirjam van den Burg, Marcelo A. Navarrete, Heinz Jacobs, Hendrik Veelken

Blood (2021) 138 (Supplement 1): 996.

https://doi.org/10.1182/blood-2021-153604

Published: 2021

Journal Articles

AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

Blood (2021) 138 (3): 246–258.

https://doi.org/10.1182/blood.2020008654

Published: 2021

Includes: Supplemental data

Journal Articles

High-Throughput BCR Sequencing and Single-Cell Transcriptomics Reveal Distinct Transcriptional Profiles Associated with Subclonal Evolution of Follicular Lymphoma

Cornelis A.M. van Bergen, Marvyn T. Koning, BSc, Edwin Quinten, Agnieszka Mykowiecka, MSc, Julieta Sepulveda, MSc, Ramin Monajemi, PhD, Ruben A.L. De Groen, Joost Vermaat, MD PhD, Susan L. Kloet, PhD, Szymon M. Kielbasa, PhD, Marcelo A. Navarrete, PhD, Pawel Górecki, PhD, Hendrik Veelken, MD PhD

Blood (2019) 134 (Supplement_1): 298.

https://doi.org/10.1182/blood-2019-130508

Published: 2019

Journal Articles

Differential Genome-Wide Mutational Patterns in Indolent B-Cell Lymphomas

Julieta Haydee Sepulveda Yanez, MSc, Diego Alvarez, MSc, Jose Fernandez-Goycoolea, Cornelis A.M. van Bergen, PhD, Hendrik Veelken, MD PhD, Marcelo A. Navarrete, PhD

Blood (2018) 132 (Supplement 1): 4102.

https://doi.org/10.1182/blood-2018-99-116174

Published: 2018

Journal Articles

Primary Mediastinal Large B-Cell Lymphoma Exhibits Autonomous BCR Signaling and Responds to the Second Generation BTK Inhibitor Acalabrutinib

Marvyn T. Koning, BSc, Rudolf Übelhart, PhD, Sander A.J. van der Zeeuw, BSc, Philip Kluin, MD PhD, Marieke Griffioen, PhD, Hans G. Drexler, MD PhD, Szymon M. Kielbasa, PhD, Marcelo A. Navarrete, MD PhD, Hassan Jumaa, PhD, Hendrik Veelken, MD PhD

Blood (2016) 128 (22): 4171.

https://doi.org/10.1182/blood.V128.22.4171.4171

Published: 2016

Journal Articles

Endogenous Immunoglobulin-Derived Neoepitopes Are Processed and Form a Sizeable Fraction of the HLA Class I Ligandome of Human Lymphoma Cells

Cornelis A.M. van Bergen, PhD, Dirk M. van der Steen, Michel G.D. Kester, Marvyn T. Koning, BSc, Peter A. van Veelen, PhD, Marieke Griffioen, PhD, J.H. Frederik Falkenburg, MD PhD, Mirjam H.M. Heemskerk, PhD, Hendrik Veelken, MD PhD, Marcelo A Navarrete, MD PhD

Blood (2016) 128 (22): 914.

https://doi.org/10.1182/blood.V128.22.914.914

Published: 2016

Journal Articles

Antigen-Independent, Autonomous B-Cell Receptor Signaling As a Dominant Candidate Oncogenic Mechanism in ABC DLBCL

Marvyn T. Koning, BSc, Rudolf Übelhart, PhD, Arjen H.G. Cleven, PhD, Willem H. Zoutman, BSc, Sander A.J. van der Zeeuw, BSc, Philip Kluin, MD PhD, Marieke Griffioen, PhD, Cornelis P. Tensen, PhD, Maarten H. Vermeer, MD PhD, Rein Willemze, MD PhD, Szymon M. Kielbasa, PhD, Marcelo A. Navarrete, MD PhD, Hassan Jumaa, PhD, Hendrik Veelken, MD PhD

Blood (2016) 128 (22): 778.

https://doi.org/10.1182/blood.V128.22.778.778

Published: 2016

Journal Articles

Aid-Mediated Hypermutation of B-Cell Receptors with Subsequent Subclone Selection Define Biological Differences Between IgM-Expressing and Isotype-Switched Follicular Lymphoma

Florian Scherer, MD, Marlon van der Burgt, Cristina Bertinetti-Lapatki, PhD, Szymon Kielbasa, PhD, Hendrik Veelken, MD PhD, Marcelo A Navarrete, MD

Blood (2012) 120 (21): 680.

https://doi.org/10.1182/blood.V120.21.680.680

Published: 2012

Journal Articles

Superior Immunogenicity of Idiotype Fab Fragments As Compared to Entire Immunoglobulin for Active Lymphoma Immunotherapy

Marcelo A. Navarrete, M.D., Benjamin Kisser, Hendrik J. Veelken, MD, PhD

Blood (2011) 118 (21): 1633.

https://doi.org/10.1182/blood.V118.21.1633.1633

Published: 2011

Journal Articles

Upfront immunization with autologous recombinant idiotype Fab fragment without prior cytoreduction in indolent B-cell lymphoma

Marcelo A. Navarrete, Kristina Heining-Mikesch, Frank Schüler, Cristina Bertinetti-Lapatki, Gabriele Ihorst, Andrea Keppler-Hafkemeyer, Gottfried Dölken, Hendrik Veelken

Blood (2011) 117 (5): 1483–1491.

https://doi.org/10.1182/blood-2010-06-292342

Published: 2011

Includes: Supplemental data

Journal Articles

HLA-Dependent Immune Selection Pressure on the Idiotype Is Predominantly Driven by Somatic Hypermutation In Malignant Lymphoma but Also Modulates Vh Usage In Normal B Cells

Dimitrios Papaioannou, M.D., Anna-Maria Strothmeyer, M.D., Marcus Dühren-von Minden, M.Sc., Marcelo A. Navarrete, M.D., Katja Zirlik, MD, Kristina Heining-Mikesch, M.D., Hendrik Veelken, M.D., Ph.D.

Blood (2010) 116 (21): 3132.

https://doi.org/10.1182/blood.V116.21.3132.3132

Published: 2010

Journal Articles

Prediction of MHC Class I-Restricted Immunogenic Epitopes of B-Cell Receptors Indicates T Cell-Mediated Immunosurveillance of Malignant B Cell Clones.

Anna-Maria Strothmeyer, Marcus Duehren-von Minden, MSc, Marcelo A Navarrete, MD, Kristina Heining-Mikesch, MD, Hendrik Veelken, MD

Blood (2009) 114 (22): 1949.

https://doi.org/10.1182/blood.V114.22.1949.1949

Published: 2009

Journal Articles

Idiotype Vaccination of Untreated Indolent B-Cell Lymphoma: Durable Objective Remissions and Association of Superior Outcome with Cellular Immune Responses

Marcelo A. Navarrete, MD, Kristina Heining-Mikesch, MD, Cristina Bertinetti-Lapatki, PhD, Marcus Duehren-von Minden, Andrea Hafkemeyer, MD, Hendrik Veelken, MD

Blood (2008) 112 (11): 235.

https://doi.org/10.1182/blood.V112.11.235.235

Published: 2008

NARROW

Tandem Substitutions in Somatic Hypermutation

AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

High-Throughput BCR Sequencing and Single-Cell Transcriptomics Reveal Distinct Transcriptional Profiles Associated with Subclonal Evolution of Follicular Lymphoma

Differential Genome-Wide Mutational Patterns in Indolent B-Cell Lymphomas

Primary Mediastinal Large B-Cell Lymphoma Exhibits Autonomous BCR Signaling and Responds to the Second Generation BTK Inhibitor Acalabrutinib

Endogenous Immunoglobulin-Derived Neoepitopes Are Processed and Form a Sizeable Fraction of the HLA Class I Ligandome of Human Lymphoma Cells

Antigen-Independent, Autonomous B-Cell Receptor Signaling As a Dominant Candidate Oncogenic Mechanism in ABC DLBCL

Aid-Mediated Hypermutation of B-Cell Receptors with Subsequent Subclone Selection Define Biological Differences Between IgM-Expressing and Isotype-Switched Follicular Lymphoma

Superior Immunogenicity of Idiotype Fab Fragments As Compared to Entire Immunoglobulin for Active Lymphoma Immunotherapy

Upfront immunization with autologous recombinant idiotype Fab fragment without prior cytoreduction in indolent B-cell lymphoma

HLA-Dependent Immune Selection Pressure on the Idiotype Is Predominantly Driven by Somatic Hypermutation In Malignant Lymphoma but Also Modulates Vh Usage In Normal B Cells

Prediction of MHC Class I-Restricted Immunogenic Epitopes of B-Cell Receptors Indicates T Cell-Mediated Immunosurveillance of Malignant B Cell Clones.

Idiotype Vaccination of Untreated Indolent B-Cell Lymphoma: Durable Objective Remissions and Association of Superior Outcome with Cellular Immune Responses

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American Society of Hematology

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ASH Publications

American Society of Hematology

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