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Journal Articles

Efficacy of Combinatorial Treatment Approaches in CTCL

Melanie Mediavilla-Varela, Eva Sahakian, Carly Harro, John J. Powers, Jose Conejo-Garcia, Lubomir Sokol, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 11880–11881.
https://doi.org/10.1182/blood-2022-169915
Published: 2022
Journal Articles

Targeting Inflammatory Pathways to Reverse Immunosuppressive Tumor Microenvironment in Chronic Lymphocytic Leukemia

Angimar Uriepero, Melanie Mediavilla-Varela, Kamira Maharaj, Wael Gamal, Maria Elena Marquez, John J. Powers, Vishaal Kunta, Eva Sahakian, Pablo Oppezzo, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 6988–6989.
https://doi.org/10.1182/blood-2022-167331
Published: 2022
Journal Articles

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Lanzhu Yue, Vasundhara Sharma, Nathan P. Horvat, Afua A. Akuffo, Matthew S. Beatty, Cem Murdun, Christelle Colin, Julia M. R. Billington, William E. Goodheart, Eva Sahakian, Ling Zhang, John J. Powers, Narmin E. Amin, Que T. Lambert-Showers, Lancia N. Darville, Javier Pinilla-Ibarz, Gary W. Reuther, Kenneth L. Wright, Chiara Conti, Jennifer Y. Lee, Xiaozhang Zheng, Pui Yee Ng, Matthew W. Martin, C. Gary Marshall, John M. Koomen, Ross L. Levine, Amit Verma, H. Leighton Grimes, Eduardo M. Sotomayor, Zonghong Shao, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2020) 135 (3): 191–207.
https://doi.org/10.1182/blood.2019895326
Published: 2020
Includes: Supplemental data
Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

Conventional Real Time Quantitative Polymerase Chain Reaction Method Yields Similar Level of Sensitivity to Digital Droplet Polymerase Chain Reaction for Detection of BCR-ABL p210 Transcripts in Patients with Chronic Phase Chronic Myeloid Leukemia

Hannah Asghari, MD BS, Chetasi Talati, MD, Alexandra Achille, John J. Powers, BS, Eva Sahakian, PhD, Onyee Chan, MD, Dawne N Shelton, PhD, Leidy Isenalumhe, MD, Lisa Nodzon, PhD ARNP, AOCNP, Kendra L. Sweet, MD, Javier Pinilla Ibarz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3382.
https://doi.org/10.1182/blood-2019-131207
Published: 2019
Journal Articles

Functional Analysis of HDAC11 in Plasma Cell Development and Multiple Myeloma Survival

AGM Mostofa, PhD, Allison Distler, Mark B. Meads, PhD, Eva Sahakian, PhD, John J. Powers, BS, Tuan Nguyen, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla Ibarz, MD, Eduardo Sotomayor, MD, Kenneth H. Shain, MD PhD, Jason B. Brayer, PhD MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2018-99-119119
Published: 2018
Journal Articles

Loss of HDAC11 Promotes Myeloid-Derived Suppressor Cells Inhibition of T Cell Function in a Murine Lymphoma Microenvironment

Jie Chen, PhD, Fengdong Cheng, MD, Michael Wang, Bachelor of Science, Eva Sahakian, PhD, John J. Powers, BS, Javier Pinilla Ibarz, MD, Mitchell R. Smith, MDPhD, Eduardo Sotomayor, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1105.
https://doi.org/10.1182/blood-2018-99-117007
Published: 2018
Journal Articles

Differential Regulation of T Cells By PI3K Delta Inhibitors in a CLL Murine Model

Kamira Maharaj, PhDCandidate, John J. Powers, BS, Alex Achille, BS, Mibel Pabon-Saldana, PhD, Renee Fonseca, BS, Susan Deng, BS, Hari P Miskin, MSc, Dave Maryanski, BS, Eva Sahakian, PhD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3009.
https://doi.org/10.1182/blood.V130.Suppl_1.3009.3009
Published: 2017
Journal Articles

HDAC11 Is a Candidate Therapeutic Target in Multiple Myeloma

Jason B. Brayer, PhDMD, Allison Distler, Mark B. Meads, PhD, Eva Sahakian, PhD, John J. Powers, BS, Tuan Nguyen, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla-Ibarz, MD PhD, Eduardo Martin Sotomayor, MD, Ken H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1800.
https://doi.org/10.1182/blood.V130.Suppl_1.1800.1800
Published: 2017
Journal Articles

A Phase I Study of Ruxolitinib Plus Nilotinib in Chronic Phase CML Patients with Molecular Evidence of Disease

Kendra L. Sweet, MD, Lori Hazlehurst, PhD, Eva Sahakian, PhD, John J. Powers, B.S., Lisa Nodzon, PhD ANP, Fadi Kayali, MD, Kelly Hyland, Ashley Nelson, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1892.
https://doi.org/10.1182/blood.V128.22.1892.1892
Published: 2016
Journal Articles

Combinatorial Effect of HDAC6i and Ibrutinib Therapy in CLL Murine Model

Kamira Karen Maharaj, BS, John J. Powers, B.S., Susan Deng, BS, Alex Achille, BS, Mibel Pabon-Saldana, Renee Fonseca, Steven N Quayle, Simon S Jones, PhD, Eva Sahakian, PhD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2035.
https://doi.org/10.1182/blood.V128.22.2035.2035
Published: 2016
Journal Articles

Modulation of T Cell Compartment in a Preclinical CLL Murine Model By a Selective PI3K Delta Inhibitor, TGR-1202

Kamira Karen Maharaj, BS, John J. Powers, B.S., Mibel Pabon-Saldana, Renee Fonseca, Alex Achille, BS, Susan Deng, BS, Hari P. Miskin, MS, Dave Maryanski, Eva Sahakian, PhD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3236.
https://doi.org/10.1182/blood.V128.22.3236.3236
Published: 2016
Journal Articles

Selective Inhibition of HDAC6 Decreases Viability of Cutaneous T-Cell Lymphoma and Improves Immune Recognition

Tessa Knox, MS, Maritza Lienlaf, MS, Patricio Perez-Villarroel, BS., Calvin Lee, MD, Eva Sahakian, PhD, John J. Powers, B.S., Fengdong Cheng, MD, Jorge Canales, MS, Danay Marante, MS, Ed Seto, PhD, Eduardo M. Sotomayor, MD, Alejandro Villagra, PhD, Pedro Horna, MD
Journal: Blood
Blood (2014) 124 (21): 5423.
https://doi.org/10.1182/blood.V124.21.5423.5423
Published: 2014
Journal Articles

Histone Deacetylase 6 (HDAC6) As a Regulator of Immune Check-Point Molecules in Chronic Lymphocytic Leukemia (CLL)

John J. Powers, B.S., Kamira K. Maharaj, B.S., Eva Sahakian, PhD, Limin Xing, PhD, Patricio PerezVillarroel, BS, Tessa Knox, MS, Steven Quayle, Simon S Jones, PhD, Alejandro Villagra, PhD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3311.
https://doi.org/10.1182/blood.V124.21.3311.3311
Published: 2014
Journal Articles

Histone Deacetylase 11 (HDAC11) As a Novel Transcriptional Regulator of C/EBP-β, in Immature Myeloid Cell to Myeloid Derived Suppressor Cell Transition

Jie Chen, MA, Eva Sahakian, PhD, John J. Powers, B.S., Maritza LienlafMoreno, BS, Limin Xing, PhD, Susan Deng, Allison Distler, Fengdong Cheng, MD, Alejandro Villagra, PhD, Pedro Horna, MD, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD PhD
Journal: Blood
Blood (2014) 124 (21): 225.
https://doi.org/10.1182/blood.V124.21.225.225
Published: 2014
Journal Articles

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice

Crystina L. Kriss, Javier A. Pinilla-Ibarz, Adam W. Mailloux, John J. Powers, Chih-Hang Anthony Tang, Chang Won Kang, Nicola Zanesi, Pearlie K. Epling-Burnette, Eduardo M. Sotomayor, Carlo M. Croce, Juan R. Del Valle, Chih-Chi Andrew Hu
Journal: Blood
Blood (2012) 120 (5): 1027–1038.
https://doi.org/10.1182/blood-2011-11-394346
Published: 2012
Includes: Supplemental data
Journal Articles

Hypercalcemia Following Treatment with Lenalidomide in Chronic Lymphocytic Leukemia (CLL).

Bijal D. Shah, MD, Marays Veliz, MD, Ricardo Santana, Jeffrey E Lancet, MD, John J. Powers, B.S., Jason A Dubovsky, B.S., Sara Tinsley, Darcie Deaver, ANP, MS, Eduardo M. Sotomayor, MD, Javier Pinilla, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 4413.
https://doi.org/10.1182/blood.V114.22.4413.4413
Published: 2009
Journal Articles

Molecular Profiling of Cancer Testis Antigens in Chronic Lymphocytic Leukemia.

Jason A Dubovsky, B.S., Emmanuel Berchmans, B.S., John J. Powers, B.S., Lin Hui-Yi, Yang Gao, Eduardo Sotomayor, Javier Pinilla, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 4701.
https://doi.org/10.1182/blood.V114.22.4701.4701
Published: 2009
Journal Articles

Phase II Study of Lenalidomide in Combination with Rituximab for Patients with CD5+/CD20+ Hematologic Malignancies Who Relapse or Progress After Rituximab. Interim Analysis.

Marays Veliz, MD, Ricardo Santana, Jeffrey E Lancet, MD, Rami S. Komrokji, MD, Mohamed A Kharfan-Dabaja, MD, John J. Powers, B.S., Jason A Dubovsky, B.S., Sara Tinsley, Darcie Deaver, ANP, MS, Eduardo M. Sotomayor, MD, Javier Pinilla-Ibarz, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2376.
https://doi.org/10.1182/blood.V114.22.2376.2376
Published: 2009
Journal Articles

Restoring the Functional Immunogenicity of Chronic Lymphocytic Leukemia Using Epigenetic Modifiers.

Jason A Dubovsky, B.S., John J. Powers, B.S., Daniel Wang, Eduardo M. Sotomayor, MD, Javier Pinilla, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 5116.
https://doi.org/10.1182/blood.V114.22.5116.5116
Published: 2009