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Ross L. Levine
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Journal Articles

Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations

Hartmut Döhner, Courtney D. DiNardo, Frederick R. Appelbaum, Charles Craddock, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Andrew H. Wei, Bob Löwenberg
Journal: Blood
Blood (2024) 144 (21): 2169–2173.
https://doi.org/10.1182/blood.2024025409
Published: 2024
Journal Articles

A Phase 1, Open-Label, Dose Escalation and Dose Expansion, Multicenter Clinical Trial to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of Lomonitinib (ZE46-0134) in Adults with FLT3 -Mutated Relapsed or Refractory Acute Myeloid Leukemia

Tara L. Lin, Kristin L Koenig, Ronan T. Swords, Eytan M. Stein, Maria R. Baer, Wendy Stock, Yazan F Madanat, Rebecca Olin, William Blum, Gary J. Schiller, Joshua F Zeidner, Emily K Curran, Molly Martycz, Leonard Rosenberg, Sonja Gullen Marcus, Timothy Chen, Mona Stefanos, Amy Burd, Ashley Owen Yocum, Ross L Levine, Brian J. Druker, Uma Borate, John C. Byrd, Alice Mims
Journal: Blood
Blood (2024) 144 (Supplement 1): 2883.4.
https://doi.org/10.1182/blood-2024-208822
Published: 2024
Journal Articles

A Multi-Site Break through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib (Trial In Progress)

Ghayas C. Issa, Alexander J. Ambinder, Wenbin Xiao, Scott Manalis, Alex K Shalek, Lukasz P. Gondek, Alex Kentsis, Nicholas J. Short, Naval Daver, Jing Ning, Lianchun Xiao, Michael Hemann, Ken Chen, Keyur P. Patel, Pavan Bachireddy, Andrew A. Lane, Marina Konopleva, Omar Abdel-Wahab, Jeffrey J. Molldrem, Ross L Levine, Mark J. Levis, Richard M Stone, Michael Andreeff, Farhad Ravandi, Aaron D. Goldberg, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.2.
https://doi.org/10.1182/blood-2024-201582
Published: 2024
Journal Articles

Crebbp Inhibition Potentiates JAK2 Inhibition in Post-MPN Acute Myeloid Leukemia

Kalay Bertulfo, Hannah Miller, Ryan Najac, Juan Carlos Castelan, Cindy Ma, Koen Debackere, Wenbin Xiao, Raajit Rampal, Ross L Levine, Chao Lu, Adolfo A. Ferrando, Teresa Palomero
Journal: Blood
Blood (2024) 144 (Supplement 1): 823.
https://doi.org/10.1182/blood-2024-201988
Published: 2024
Journal Articles

TMPRSS6 Antisense Oligonucleotide Therapy Reverses Inflammation in Jak2 V617F Mutant Mice

Maayan Levy, Huihui Li, Andrew Dunbar, Zixing Huang, Young Park, Min Lu, Pinanong Na Phattalung, Marina Planoutene, Carla Casu, Stefano Rivella, Shuling Guo, Ross L Levine, Ronald Hoffman, Yelena Ginzburg
Journal: Blood
Blood (2024) 144 (Supplement 1): 8.
https://doi.org/10.1182/blood-2024-203806
Published: 2024
Journal Articles

Combined Human and In Vivo Analyses Implicate the Critical Importance of Acute Myeloid Leukemia Associated CD8 T Cells and Identifies Their Molecular Dysfunction

Y. Emily Chu, Matthew A Cottam, Chad R Potts, Kirsten M Dickerson, Matthew T Jenkins, Justin A Cartailler, Rui Lu, Stanley C. Lee, Ross L Levine, Robert L. Bowman, Robert Welner, P. Brent Ferrell, Jr.
Journal: Blood
Blood (2024) 144 (Supplement 1): 2939.
https://doi.org/10.1182/blood-2024-205733
Published: 2024
Journal Articles

TET2 and TP53 Mutations Cooperate in Leukemia Development and Modulate the Response to Inflammation

Pablo Sanchez Vela, Brianna Kelly, Claudia Brady, Jonathan Foox, Jacob Glass, Ross L Levine, Alan Shih
Journal: Blood
Blood (2024) 144 (Supplement 1): 2712.
https://doi.org/10.1182/blood-2024-202521
Published: 2024
Journal Articles

The LMO2-LDB1-TAL1 Complex Regulates Transcription Networks in AML Relapse

Nicholas Dunham, Zhenjia Wang, Yaseswini Neelamraju, Yan Guo, Joyce Hardwick, Bernhard Maier, Cem Meydan, Jorge A Gandara, Tak Lee, Subhash Prajapati, Franck Rapaport, Caroline Sheridan, Paul Zumbo, Michael W. Becker, Lars Bullinger, Martin P Carroll, Richard J D'Andrea, Richard Dillon, Ross L Levine, Christopher Mason, Ari M Melnick, Donna S. Neuberg, Stefan Bekiranov, Chongzhi Zang, Utpal P. Dave, Francine E. Garrett-Bakelman
Journal: Blood
Blood (2024) 144 (Supplement 1): 2711.
https://doi.org/10.1182/blood-2024-200289
Published: 2024
Journal Articles

Demographics, Characteristics, Survival and Outcomes in Older, Untreated, Acute Myeloid Leukemia Patients with NPM1 Mutations or KMT2A rearrangements from the Beat AML Master Clinical Trial

Uma Borate, Rina Li Welkie, Ying Huang, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Yazan F Madanat, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Alice Mims, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 1564.
https://doi.org/10.1182/blood-2024-211261
Published: 2024
Journal Articles

A Randomized Phase 2 Trial of 28-Day (Arm A) Versus 14-Day (Arm B) Schedule of Venetoclax + Azacitidine in Newly Diagnosed Acute Myeloid Leukemia Patients ≥ 60 Years

Uma Borate, Ying Huang, Joshua F Zeidner, Ronan T. Swords, Kristin L Koenig, Eytan M. Stein, Maria R. Baer, Wendy Stock, Yazan F Madanat, Rebecca Olin, William Blum, Gary J. Schiller, Tara L. Lin, Emily K Curran, Molly Martycz, Leonard Rosenberg, Sonja Gullen Marcus, Timothy Chen, Mona Stefanos, Ross L Levine, Brian J. Druker, Ashley Owen Yocum, Amy Burd, Alice Mims, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 2907.2.
https://doi.org/10.1182/blood-2024-210967
Published: 2024
Journal Articles

IDH2 Mutation Is Associated with Favorable Outcome Among Older Adults with Newly Diagnosed Acute Myeloid Leukemia Treated with Lower-Intensity Therapy

Fieke W Hoff, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Uma Borate, Alice Mims, John C. Byrd, Yazan F. Madanat
Journal: Blood
Blood (2024) 144 (Supplement 1): 4325.
https://doi.org/10.1182/blood-2024-202596
Published: 2024
Journal Articles

Outcomes and Survival in Newly Diagnosed, Older, Acute Myeloid Leukemia Patients from the Beat AML Master Trial in the Venetoclax/Azacitidine Age

Uma Borate, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Yazan F Madanat, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Alice Mims, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 4324.
https://doi.org/10.1182/blood-2024-211178
Published: 2024
Journal Articles

Impact of PARP Inhibitor and Platinum Therapy on Clonal Hematopoiesis

Jeremy T. Baeten, Irenaeus C.C. Chan, Lea Moukarzel, Amber C. Carter, Minal Patel, Konrad H. Stopsack, Paul Pharoah, James Brenton, Bob T Li, Wassim Abida, Alison M. Schram, Karen Cadoo, Britta Weigelt, Carlos Cruchaga, Howard Scher, Ross L Levine, Elli Papaemmanuil, Daniel C. Link, Kelly L. Bolton
Journal: Blood
Blood (2023) 142 (Supplement 1): 1315.
https://doi.org/10.1182/blood-2023-190457
Published: 2023
Journal Articles

Dnmt3a -Mutant Haematopoietic Stem and Progenitor Cells Induce Mesenchymal Stromal Cell Senescence through the Production of Alarmins S100A8/A9

Jayna J. Mistry, Kira A. Young, Patricia Colom Diaz, Ines Fernandez Maestre, Ross L Levine, Jennifer J. Trowbridge
Journal: Blood
Blood (2023) 142 (Supplement 1): 1331.
https://doi.org/10.1182/blood-2023-181888
Published: 2023
Journal Articles

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Hiroyoshi Kunimoto, Ayaka Miura, Maiko Sagisaka, Mieko Ito, Daisuke Honma, Shinji Tsutsumi, Takayuki Sakuma, Takuma Ohashi, Hiroshi Teranaka, Junji Ikeda, Takashi Toya, Yuka Harada, Noriko Doki, Sheng F. Cai, Akihide Yoshimi, Hiroaki Goto, Ross L Levine, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2803.
https://doi.org/10.1182/blood-2023-178436
Published: 2023
Journal Articles

Genomic Characterization of Newly Diagnosed Acute Myeloid Leukemia in Patients Age 60 Years and Older; A Report from the Beat AML Master Trial

Fieke W Hoff, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L Lin, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F. Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Uma M. Borate, Alice Mims, John C. Byrd, Yazan F. Madanat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4296.
https://doi.org/10.1182/blood-2023-187044
Published: 2023
Journal Articles

Genomic Profiles and Associated Survival Prognosticators in Black Patients with Acute Myeloid Leukemia

Andrew Stiff, Deedra Nicolet, Maarten Fornerod, Ben Kelly, Katherine Miller, Krzysztof Mrózek, Isaiah Boateng, Bailee Nicole Kain, Elizabeth Garfinkle, Eileen Y Hu, Saranga Wijeratne, Gregory Wheeler, Christopher J. Walker, Jill Buss, Adrienne Heyrosa, Helee Desai, Andrea Laganson, Yazan Abu-Shihab, Hasan Abaza, Alice Mims, Christopher C. Oakes, Bethany L Mundy-Bosse, Andrew J Carroll, Bayard L Powell, Jonathan E Kolitz, Richard Stone, Electra D Paskett, Ross L Levine, Kamal Menghrajani, Debyani Chakravarty, Michael F. Berger, Nathan Salomonis, Daniel Bottomly, Shannon K McWeeney, Jeffrey W Tyner, John C. Byrd, H. Leighton Grimes, Elaine R Mardis, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2023) 142 (Supplement 1): 837.
https://doi.org/10.1182/blood-2023-181876
Published: 2023
Journal Articles

Deconvoluting Clonal and Cellular Architecture in IDH -Mutant Acute Myeloid Leukemia

Maria Sirenko, Soobeom Lee, Zhengxi Sun, Ronan Chaligne, Georgios Asimomitis, Charlotte K Brierley, Elsa Bernard, Sheng F. Cai, Robert M Myers, Bettina Nadorp, Max F Levine, Dylan Domenico, Juan E Arango Ossa, Juan Santiago Medina Martinez, Kamal Menghrajani, Audrey Lasry, Alice Mims, Helee Desai, Andrea Laganson, Christopher Famulare, Minal Patel, Gerard Lozanski, Sanam Loghavi, Kelly L. Bolton, Aaron D. Viny, Mikhail Roshal, Ross L Levine, Eytan M. Stein, Dan A. Landau, Ann-Kathrin Eisfeld, Iannis Aifantis, Elli Papaemmanuil
Journal: Blood
Blood (2023) 142 (Supplement 1): 1591.
https://doi.org/10.1182/blood-2023-186322
Published: 2023
Journal Articles

A Randomized Phase 2 Trial of 28-Day (Arm A) Versus 14-Day (Arm B) Schedule of Venetoclax + Azacitidine in Newly Diagnosed Acute Myeloid Leukemia Patients ≥ 60 Years

Uma M. Borate, Ying Huang, Mary F. Johnson, Joshua F. Zeidner, Ronan T. Swords, Kristin L Koenig, Eytan M. Stein, Maria R. Baer, Wendy Stock, Yazan F. Madanat, Rebecca Olin, William Blum, Gary J. Schiller, Tara L Lin, Robert L. Redner, Emily K Curran, Nyla A. Heerema, Molly Martycz, Leonard Rosenberg, Sonja Gullen Marcus, Timothy Chen, Mona Stefanos, Ross L Levine, Brian J. Druker, Ashley Owen Yocum, Amy Burd, Alice Mims, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1535.
https://doi.org/10.1182/blood-2023-187383
Published: 2023
Journal Articles

A Phase 1b Multi-Center Study of the FLT3 Inhibitor Gilteritinib in Combination with the IDH1 Inhibitor Ivosidenib or the IDH2 Inhibitor Enasidenib for Patients with Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-Occurring FLT3/IDH1 or FLT3/IDH2 Mutations

Eytan M. Stein, Andriy Derkach, Gabrielle Melamed, Alana Block, Janet Kim, Gergana Georgieva, Vanessa Thompson, Ross L Levine, Andrew M. Intlekofer, Omar Abdel-Wahab, Martin S. Tallman
Journal: Blood
Blood (2023) 142 (Supplement 1): 5945.
https://doi.org/10.1182/blood-2023-190801
Published: 2023