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Journal Articles

TNFα Plays Essential Role in Resolution of Anemia of Inflammation in Tnfαko Mice Treated with Heat-Killed Brucella Abortus

Vania Lo Presti, Ding-wen Chen, Ana Martins, Pankaj Sharma, Yelena Ginzburg, Carlo Castruccio Castracani, Carla Casu, Ritama Gupta, Raffaella Gozzelino, Edward Behrens, Laura F Bennett, Robert Paulson, Peter Kurre, Stefano Rivella, Amaliris Guerra

Blood (2024) 144 (Supplement 1): 168.

https://doi.org/10.1182/blood-2024-212272

Published: 2024

Journal Articles

TMPRSS6 Antisense Oligonucleotide Therapy Reverses Inflammation in Jak2 V617F Mutant Mice

Maayan Levy, Huihui Li, Andrew Dunbar, Zixing Huang, Young Park, Min Lu, Pinanong Na Phattalung, Marina Planoutene, Carla Casu, Stefano Rivella, Shuling Guo, Ross L Levine, Ronald Hoffman, Yelena Ginzburg

Blood (2024) 144 (Supplement 1): 8.

https://doi.org/10.1182/blood-2024-203806

Published: 2024

Journal Articles

TNFα and Anti-IFNγ Rescues Chronic Anemia of Inflammation Phenotype in Tnfαko Mice Treated with Heat-Killed Brucella Abortus

Amaliris Guerra, Vania Lo Presti, Ding-Wen Chen, Ana Catarina Martins, Carlo Castruccio Castracani, Ritama Gupta, Laura Bennett, Raffaella Gozzelino, Robert Paulson, Peter Kurre, Stefano Rivella, Carla Casu

Blood (2022) 140 (Supplement 1): 5302–5303.

https://doi.org/10.1182/blood-2022-166643

Published: 2022

Journal Articles

Lack of IL6 Improves Recovery from Anemia of Inflammation Which Gets Hampered in Presence of Excess Iron

Sayantani Sinha, Ritama Gupta, Amaliris Guerra, Paige Mc Veigh, Sara Gardenghi, Carla Casu, Francesca Vinchi, Stefano Rivella

Blood (2021) 138 (Supplement 1): 3072.

https://doi.org/10.1182/blood-2021-153126

Published: 2021

Journal Articles

TNFα Controls the Delicate Balance between Erythropoiesis and Stem Cell Exhaustion during Inflammatory Stress

Amaliris Guerra, Vania Lo Presti, Ana Catarina Martins, Carlo Castruccio Castracani, Ritama Gupta, Rea Oikonomidou, Emir O'Hara, Carla Casu, Laura Bennett, Robert Paulson, Peter Kurre, Stefano Rivella, Raffaella Gozzelino

Blood (2021) 138 (Supplement 1): 2184.

https://doi.org/10.1182/blood-2021-152473

Published: 2021

Journal Articles

Combination of a Luspatercept-like Drug (RAP-GRL) and Tmprss6 -ASO Is Superior to Either Drug Alone for Correcting β-Thalassemia

Amaliris Guerra, Perry Demsko, Paige McVeigh, Sayantani Sinha, Carlo Castruccio Castracani, Laura Breda, Carla Casu, Shuling Guo, Stefano Rivella

Blood (2021) 138 (Supplement 1): 2013.

https://doi.org/10.1182/blood-2021-151181

Published: 2021

Journal Articles

Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity

Blood (2020) 136 (17): 1968–1979.

https://doi.org/10.1182/blood.2019004719

Published: 2020

Includes: Supplemental data

Journal Articles

Erythroferrone Regulates Bone Remodeling in β-Thalassemia

Melanie Castro-Mollo, MD, Marc Ruiz Martinez, PhD, Maria Feola, PhD, Anisa Azatovna Gumerova, MD, Carla Casu, PhD, Robert E Fleming, MD, Stefano Rivella, PhD, Tony Yuen, PhD, Mone Zaidi, MD PhD, Yelena Ginzburg, MD

Blood (2019) 134 (Supplement_1): 2.

https://doi.org/10.1182/blood-2019-125822

Published: 2019

Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM

Blood (2019) 134 (Supplement_1): 73.

https://doi.org/10.1182/blood-2019-128646

Published: 2019

Journal Articles

Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies

Laura Breda, PhD, Valentina Ghiaccio, PhD, Silvia Pires Lourenco, MSc, Danuta Jadwiga Jarocha, PhD, Yasuhiro Ikawa, MD PhD, Naoto Tanaka, PhD, Virginia Guzikowski, Carla Casu, PhD, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD MSCE, Stefano Rivella, PhD

Blood (2019) 134 (Supplement_1): 2242.

https://doi.org/10.1182/blood-2019-124043

Published: 2019

Journal Articles

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Blood (2019) 134 (Supplement_1): 2244.

https://doi.org/10.1182/blood-2019-127017

Published: 2019

Journal Articles

Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis

Nermi L. Parrow, Yihang Li, Maria Feola, Amaliris Guerra, Carla Casu, Princy Prasad, Luke Mammen, Faris Ali, Edvinas Vaicikauskas, Stefano Rivella, Yelena Z. Ginzburg, Robert E. Fleming

Blood (2019) 134 (17): 1373–1384.

https://doi.org/10.1182/blood.2018893099

Published: 2019

Includes: Supplemental data

Journal Articles

Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia

Amaliris Guerra, Paraskevi Rea Oikonomidou, Sayantani Sinha, Jianbing Zhang, Vania Lo Presti, Callum R. Hamilton, Laura Breda, Carla Casu, Ping La, Ana C. Martins, Anoop K. Sendamarai, Mark Fleming, Stefano Rivella

Blood (2019) 134 (6): 568–572.

https://doi.org/10.1182/blood.2019001057

Published: 2019

Includes: Supplemental data

Journal Articles

Improved Lentiviral Vectors for the Cure of Hemoglobinopathies

Laura Breda, PhD, Valentina Ghiaccio, PhD, Hanyia Zaidi, Silvia Pires Lourenco, MSc, Carla Casu, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD, Vanessa Carrion, RN, CPN, Virginia Guzikowski, RN, MSN, CRNP, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stefano Rivella, PhD

Blood (2018) 132 (Supplement 1): 3477.

https://doi.org/10.1182/blood-2018-99-111319

Published: 2018

Journal Articles

Correcting Non-Transfusion Dependent β-Thalassemia by Utilizing a Combined Therapy that Modulates EPO Activity by Limiting Erythroid Cellular Iron Intake

Carla Casu, Vania Lo Presti, Mariam Aghajan, Alison Liu, Kevin A Munoz, Emir O'Hara, Garry Neil, Reem Miari, Hagit Domev, Nir Shapir, Shuling Guo, Stefano Rivella

Blood (2018) 132 (Supplement 1): 164.

https://doi.org/10.1182/blood-2018-164

Published: 2018

Journal Articles

Lack of GDF11 Does Not Ameliorate Erythropoiesis in β-Thalassemia and Does Not Prevent the Activity of the Trap-Ligand RAP-536

Amaliris Guerra, PhD, Rea Oikonomidou, MD, Sinha Gonzalez, PhD, Jianbing Zhang, PhD, Vania Lo Presti, Callum R Hamilton, Laura Breda, PhD, Carla Casu, Mark D. Fleming, MD DPhil, Pedro Martinez, PhD, Rajasekhar Suragani, PhD, Ravi Kumar, PhD, Stefano Rivella

Blood (2018) 132 (Supplement 1): 165.

https://doi.org/10.1182/blood-2018-165

Published: 2018

Journal Articles

Hepcidin agonists as therapeutic tools

Carla Casu, Elizabeta Nemeth, Stefano Rivella

Blood (2018) 131 (16): 1790–1794.

https://doi.org/10.1182/blood-2017-11-737411

Published: 2018

Journal Articles

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Sharraya Aschemeyer, Bo Qiao, Deborah Stefanova, Erika V. Valore, Albert C. Sek, T. Alex Ruwe, Kyle R. Vieth, Grace Jung, Carla Casu, Stefano Rivella, Mika Jormakka, Bryan Mackenzie, Tomas Ganz, Elizabeta Nemeth

Blood (2018) 131 (8): 899–910.

https://doi.org/10.1182/blood-2017-05-786590

Published: 2018

Includes: Supplemental data

Journal Articles

Absence of TNF-α Promotes Anemia of Inflammation and Inflammatory Bowel Disease

Ritama Gupta, PhD, Lo Presti Vania, Carla Casu, PhD, Rea Oikonomidou, MD, Emir OHara, Stefano Rivella, PhD

Blood (2017) 130 (Supplement 1): 3577.

https://doi.org/10.1182/blood.V130.Suppl_1.3577.3577

Published: 2017

Journal Articles

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome

Roberta B. Nowak, Julien Papoin, David S. Gokhin, Carla Casu, Stefano Rivella, Jeffrey M. Lipton, Lionel Blanc, Velia M. Fowler

Blood (2017) 130 (9): 1144–1155.

https://doi.org/10.1182/blood-2017-05-787051

Published: 2017

Includes: Multimedia, Supplemental data

NARROW

TNFα Plays Essential Role in Resolution of Anemia of Inflammation in Tnfαko Mice Treated with Heat-Killed Brucella Abortus

TMPRSS6 Antisense Oligonucleotide Therapy Reverses Inflammation in Jak2 V617F Mutant Mice

TNFα and Anti-IFNγ Rescues Chronic Anemia of Inflammation Phenotype in Tnfαko Mice Treated with Heat-Killed Brucella Abortus

Lack of IL6 Improves Recovery from Anemia of Inflammation Which Gets Hampered in Presence of Excess Iron

TNFα Controls the Delicate Balance between Erythropoiesis and Stem Cell Exhaustion during Inflammatory Stress

Combination of a Luspatercept-like Drug (RAP-GRL) and Tmprss6 -ASO Is Superior to Either Drug Alone for Correcting β-Thalassemia

Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity

Erythroferrone Regulates Bone Remodeling in β-Thalassemia

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis

Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia

Improved Lentiviral Vectors for the Cure of Hemoglobinopathies

Correcting Non-Transfusion Dependent β-Thalassemia by Utilizing a Combined Therapy that Modulates EPO Activity by Limiting Erythroid Cellular Iron Intake

Lack of GDF11 Does Not Ameliorate Erythropoiesis in β-Thalassemia and Does Not Prevent the Activity of the Trap-Ligand RAP-536

Hepcidin agonists as therapeutic tools

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Absence of TNF-α Promotes Anemia of Inflammation and Inflammatory Bowel Disease

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome

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American Society of Hematology

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American Society of Hematology

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