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Journal Articles

Rebalancing Iron Homeostasis and Erythropoiesis through Tfr2 Inhibition for Correction of Anemia in CKD

Violante Olivari, Maria Rosa Lidonnici, Mariam Aghajan, Mariateresa Pettinato, Simona Maria Di Modica, Alessia Pagani, Francesca Tiboni, Shuling Guo, Laura Silvestri, Giuliana Ferrari, Antonella Nai
Journal: Blood
Blood (2021) 138 (Supplement 1): 940.
https://doi.org/10.1182/blood-2021-148384
Published: 2021
Journal Articles

Tfr2 Genetic Deletion Makes Transfusion-Independent a Murine Model of Transfusion-Dependent β-Thalassemia

Simona Maria Di Modica, Violante Olivari, Emanuele Tanzi, Mariateresa Pettinato, Maria Rosa Lidonnici, Alessia Pagani, Francesca Tiboni, Giuliana Ferrari, Laura Silvestri, Stefano Rivella, Antonella Nai
Journal: Blood
Blood (2021) 138 (Supplement 1): 575.
https://doi.org/10.1182/blood-2021-148419
Published: 2021
Journal Articles

Dissecting the Mechanisms of Hepcidin and BMP-SMAD Pathway Regulation By FKBP12

Alessia Pagani, Mariateresa Pettinato, Alessandro Dulja, Silvia Colucci, Mariam Aghajan, Valeria Furiosi, Martina U. Muckenthaler, Shuling Guo, Antonella Nai, Laura Silvestri
Journal: Blood
Blood (2021) 138 (Supplement 1): 2008.
https://doi.org/10.1182/blood-2021-152172
Published: 2021
Journal Articles

Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity

Carla Casu, Mariateresa Pettinato, Alison Liu, Mariam Aghajan, Vania Lo Presti, Maria Rosa Lidonnici, Kevin A. Munoz, Emir O’Hara, Violante Olivari, Simona Maria Di Modica, Sheri Booten, Shuling Guo, Garry Neil, Reem Miari, Nir Shapir, Inbal Zafir-Lavie, Hagit Domev, Giuliana Ferrari, Despina Sitara, Antonella Nai, Stefano Rivella
Journal: Blood
Blood (2020) 136 (17): 1968–1979.
https://doi.org/10.1182/blood.2019004719
Published: 2020
Includes: Supplemental data
Journal Articles

The Immunophilin FKBP12 Inhibits Hepcidin By Modulating BMP Type I-Type II Receptors Interaction and Ligand Responsiveness

Alessandro Dulja, MSc, Alessia Pagani, PhD, Mariateresa Pettinato, Antonella Nai, PhD, Clara Camaschella, MD, Laura Silvestri, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 430.
https://doi.org/10.1182/blood-2019-130058
Published: 2019
Journal Articles

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Mariateresa Pettinato, Mariam Aghajan, PhD, Violante Olivari, MSc, Alessandro Dulja, MSc, Antonella Nai, PhD, Jessica Bordini, PhD, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, PhD, Clara Camaschella, MD, Laura Silvestri, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 955.
https://doi.org/10.1182/blood-2019-126496
Published: 2019
Journal Articles

Targeting Transferrin Receptor 2: A Novel "Erythropoiesis-Stimulating Approach" in a Model of Anemia of Chronic Kidney Disease

Violante Olivari, MSc, Maria Rosa Lidonnici, PhD, Mariateresa Pettinato, Laura Silvestri, PhD, Giuliana Ferrari, PhD, Clara Camaschella, MD, Antonella Nai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 956.
https://doi.org/10.1182/blood-2019-125783
Published: 2019
Journal Articles

Exploring the Mechanisms of Thalassemic Erythropoiesis Improvement Caused By Bone Marrow Tfr2 Deletion

Antonella Nai, PhD, Irene Artuso, MSc, Maria Rosa Lidonnici, PhD, Sandro Altamura, PhD, Giacomo Mandelli, PhD, Mariateresa Pettinato, MSc, Martina U. Muckenthaler, PhD, Laura Silvestri, PhD, Giuliana Ferrari, PhD, Clara Camaschella, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3624.
https://doi.org/10.1182/blood-2018-99-115835
Published: 2018
Journal Articles

Inhibiting the Immunophilin FKBP12: A Potential Therapeutic Approach to Iron Overload/Low Hepcidin Disorders

Mariateresa Pettinato, MSc, Mariam Aghajan, Alessandro Dulja, Antonella Nai, PhD, Violante Olivari, Jessica Bordini, MSc, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, Clara Camaschella, MD, Laura Silvestri, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2333.
https://doi.org/10.1182/blood-2018-99-118112
Published: 2018
Journal Articles

Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model

Irene Artuso, Maria Rosa Lidonnici, Sandro Altamura, Giacomo Mandelli, Mariateresa Pettinato, Martina U. Muckenthaler, Laura Silvestri, Giuliana Ferrari, Clara Camaschella, Antonella Nai
Journal: Blood
Blood (2018) 132 (21): 2286–2297.
https://doi.org/10.1182/blood-2018-05-852277
Published: 2018
Includes: Supplemental data
Journal Articles

Transient Reduction of Transferrin Saturation Contributes to Hepcidin Inhibition Independently of Erfe in Mice Treated with Erythropoietin

Irene Artuso, MSc, Antonella Nai, PhD, Mariateresa Pettinato, MSc, Alessia Pagani, PhD, Chloe Latour, Benjamin Billore, Maria Rosa Lidonnici, Giacomo Mandelli, Giuliana Ferrari, Clara Camaschella, MD, Leon C. Kautz, PhD, Laura Silvestri, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 174.
https://doi.org/10.1182/blood.V130.Suppl_1.174.174
Published: 2017
Journal Articles

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

Silvia Colucci, Alessia Pagani, Mariateresa Pettinato, Irene Artuso, Antonella Nai, Clara Camaschella, Laura Silvestri
Journal: Blood
Blood (2017) 130 (19): 2111–2120.
https://doi.org/10.1182/blood-2017-04-780692
Published: 2017
Includes: Supplemental data
Journal Articles

Unraveling the Erythroid Function of Tfr2 in Beta-Thalassemia

Antonella Nai, PhD, Maria Rosa Lidonnici, PhD, Irene Artuso, BSc, Giacomo Mandelli, PhD, Mariateresa Pettinato, BSc, Laura Silvestri, PhD, Giuliana Ferrari, PhD, Clara Camaschella, MD
Journal: Blood
Blood (2016) 128 (22): 73.
https://doi.org/10.1182/blood.V128.22.73.73
Published: 2016