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Journal Articles

Hyperactive Erythropoiesis Induced By Hematopoietic Tfr2 Deletion Corrects Glucose Abnormalities in β-Thalassemic Mice

Simona Maria Di Modica, Emanuele Tanzi, Alessia Pagani, Laura Silvestri, Antonella Nai

Blood (2024) 144 (Supplement 1): 3852.

https://doi.org/10.1182/blood-2024-207290

Published: 2024

Journal Articles

Bone Marrow Tfr2 Deletion Modulates Systemic Metabolism in β-Thalassemic Mice to Sustain Augmented Erythropoiesis

Simona Maria Di Modica, Claudia Benelli, Alessia Pagani, Emanuele Tanzi, Violante Olivari, Laura Silvestri, Antonella Nai

Blood (2022) 140 (Supplement 1): 2197–2198.

https://doi.org/10.1182/blood-2022-163145

Published: 2022

Journal Articles

Rebalancing Iron Homeostasis and Erythropoiesis through Tfr2 Inhibition for Correction of Anemia in CKD

Violante Olivari, Maria Rosa Lidonnici, Mariam Aghajan, Mariateresa Pettinato, Simona Maria Di Modica, Alessia Pagani, Francesca Tiboni, Shuling Guo, Laura Silvestri, Giuliana Ferrari, Antonella Nai

Blood (2021) 138 (Supplement 1): 940.

https://doi.org/10.1182/blood-2021-148384

Published: 2021

Journal Articles

Tfr2 Genetic Deletion Makes Transfusion-Independent a Murine Model of Transfusion-Dependent β-Thalassemia

Simona Maria Di Modica, Violante Olivari, Emanuele Tanzi, Mariateresa Pettinato, Maria Rosa Lidonnici, Alessia Pagani, Francesca Tiboni, Giuliana Ferrari, Laura Silvestri, Stefano Rivella, Antonella Nai

Blood (2021) 138 (Supplement 1): 575.

https://doi.org/10.1182/blood-2021-148419

Published: 2021

Journal Articles

Dissecting the Mechanisms of Hepcidin and BMP-SMAD Pathway Regulation By FKBP12

Alessia Pagani, Mariateresa Pettinato, Alessandro Dulja, Silvia Colucci, Mariam Aghajan, Valeria Furiosi, Martina U. Muckenthaler, Shuling Guo, Antonella Nai, Laura Silvestri

Blood (2021) 138 (Supplement 1): 2008.

https://doi.org/10.1182/blood-2021-152172

Published: 2021

Journal Articles

The Immunophilin FKBP12 Inhibits Hepcidin By Modulating BMP Type I-Type II Receptors Interaction and Ligand Responsiveness

Alessandro Dulja, MSc, Alessia Pagani, PhD, Mariateresa Pettinato, Antonella Nai, PhD, Clara Camaschella, MD, Laura Silvestri, PhD

Blood (2019) 134 (Supplement_1): 430.

https://doi.org/10.1182/blood-2019-130058

Published: 2019

Journal Articles

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Mariateresa Pettinato, Mariam Aghajan, PhD, Violante Olivari, MSc, Alessandro Dulja, MSc, Antonella Nai, PhD, Jessica Bordini, PhD, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, PhD, Clara Camaschella, MD, Laura Silvestri, PhD

Blood (2019) 134 (Supplement_1): 955.

https://doi.org/10.1182/blood-2019-126496

Published: 2019

Journal Articles

Novel Insights Into Systemic Iron Regulation

Laura Silvestri, PhD, Alessia Pagani, PhD, Antonella Nai, PhD, Clara Camaschella, MD

Blood (2018) 132 (Supplement 1): SCI-1.

https://doi.org/10.1182/blood-2018-99-109518

Published: 2018

Journal Articles

Inhibiting the Immunophilin FKBP12: A Potential Therapeutic Approach to Iron Overload/Low Hepcidin Disorders

Mariateresa Pettinato, MSc, Mariam Aghajan, Alessandro Dulja, Antonella Nai, PhD, Violante Olivari, Jessica Bordini, MSc, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, Clara Camaschella, MD, Laura Silvestri, PhD

Blood (2018) 132 (Supplement 1): 2333.

https://doi.org/10.1182/blood-2018-99-118112

Published: 2018

Journal Articles

Transient Reduction of Transferrin Saturation Contributes to Hepcidin Inhibition Independently of Erfe in Mice Treated with Erythropoietin

Irene Artuso, MSc, Antonella Nai, PhD, Mariateresa Pettinato, MSc, Alessia Pagani, PhD, Chloe Latour, Benjamin Billore, Maria Rosa Lidonnici, Giacomo Mandelli, Giuliana Ferrari, Clara Camaschella, MD, Leon C. Kautz, PhD, Laura Silvestri, PhD

Blood (2017) 130 (Supplement 1): 174.

https://doi.org/10.1182/blood.V130.Suppl_1.174.174

Published: 2017

Journal Articles

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

Silvia Colucci, Alessia Pagani, Mariateresa Pettinato, Irene Artuso, Antonella Nai, Clara Camaschella, Laura Silvestri

Blood (2017) 130 (19): 2111–2120.

https://doi.org/10.1182/blood-2017-04-780692

Published: 2017

Includes: Supplemental data

Journal Articles

A new form of IRIDA due to combined heterozygous mutations of TMPRSS6 and ACVR1A encoding the BMP receptor ALK2

Alessia Pagani, Silvia Colucci, Renata Bocciardi, Marta Bertamino, Carlo Dufour, Roberto Ravazzolo, Laura Silvestri, Clara Camaschella

Blood (2017) 129 (25): 3392–3395.

https://doi.org/10.1182/blood-2017-03-773481

Published: 2017

Includes: Supplemental data

Journal Articles

A Novel Crosstalk Between Iron Homeostasis and mTOR Mediated By the Immunophilin FKBP12

Laura Silvestri, PhD, Silvia Colucci, Alessia Pagani, PhD, Irene Artuso, BSc, Mariatesera Pettinato, BSc, Antonella Nai, PhD, Clara Camaschella, MD

Blood (2016) 128 (22): 261.

https://doi.org/10.1182/blood.V128.22.261.261

Published: 2016

Journal Articles

The second transferrin receptor regulates red blood cell production in mice

Antonella Nai, Maria Rosa Lidonnici, Marco Rausa, Giacomo Mandelli, Alessia Pagani, Laura Silvestri, Giuliana Ferrari, Clara Camaschella

Blood (2015) 125 (7): 1170–1179.

https://doi.org/10.1182/blood-2014-08-596254

Published: 2015

Includes: Supplemental data

Journal Articles

Is Tmprss6 Required for Hepcidin Inhibition By Erythroferrone?

Laura Silvestri, PhD, Grazia Rita Gelsomino, Antonella Nai, PhD, Marco Rausa, Alessia Pagani, PhD, Clara Camaschella, MD

Blood (2014) 124 (21): 1347.

https://doi.org/10.1182/blood.V124.21.1347.1347

Published: 2014

Journal Articles

The Role Of Liver Endothelial Sinusoidal Cells In Iron-Mediated Bmp6 Regulation

Laura Silvestri, PhD, Marco Rausa, Antonella Nai, PhD, Alessia Pagani, PhD, Clara Camaschella, MD

Blood (2013) 122 (21): 177.

https://doi.org/10.1182/blood.V122.21.177.177

Published: 2013

Journal Articles

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia

Antonella Nai, Alessia Pagani, Giacomo Mandelli, Maria Rosa Lidonnici, Laura Silvestri, Giuliana Ferrari, Clara Camaschella

Blood (2012) 119 (21): 5021–5029.

https://doi.org/10.1182/blood-2012-01-401885

Published: 2012

Includes: Supplemental data

Journal Articles

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals

Antonella Nai, Alessia Pagani, Laura Silvestri, Natascia Campostrini, Michela Corbella, Domenico Girelli, Michela Traglia, Daniela Toniolo, Clara Camaschella

Blood (2011) 118 (16): 4459–4462.

https://doi.org/10.1182/blood-2011-06-364034

Published: 2011

Includes: Supplemental data

Journal Articles

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

Alessia Pagani, Antonella Nai, Gianfranca Corna, Lidia Bosurgi, Patrizia Rovere-Querini, Clara Camaschella, Laura Silvestri

Blood (2011) 118 (3): 736–746.

https://doi.org/10.1182/blood-2011-02-337212

Published: 2011

Includes: Supplemental data

Journal Articles

Increased susceptibility to iron deficiency of Tmprss 6-haploinsufficient mice

Antonella Nai, Alessia Pagani, Laura Silvestri, Clara Camaschella

Blood (2010) 116 (5): 851–852.

https://doi.org/10.1182/blood-2010-04-278655

Published: 2010

NARROW

Hyperactive Erythropoiesis Induced By Hematopoietic Tfr2 Deletion Corrects Glucose Abnormalities in β-Thalassemic Mice

Bone Marrow Tfr2 Deletion Modulates Systemic Metabolism in β-Thalassemic Mice to Sustain Augmented Erythropoiesis

Rebalancing Iron Homeostasis and Erythropoiesis through Tfr2 Inhibition for Correction of Anemia in CKD

Tfr2 Genetic Deletion Makes Transfusion-Independent a Murine Model of Transfusion-Dependent β-Thalassemia

Dissecting the Mechanisms of Hepcidin and BMP-SMAD Pathway Regulation By FKBP12

The Immunophilin FKBP12 Inhibits Hepcidin By Modulating BMP Type I-Type II Receptors Interaction and Ligand Responsiveness

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Novel Insights Into Systemic Iron Regulation

Inhibiting the Immunophilin FKBP12: A Potential Therapeutic Approach to Iron Overload/Low Hepcidin Disorders

Transient Reduction of Transferrin Saturation Contributes to Hepcidin Inhibition Independently of Erfe in Mice Treated with Erythropoietin

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

A new form of IRIDA due to combined heterozygous mutations of TMPRSS6 and ACVR1A encoding the BMP receptor ALK2

A Novel Crosstalk Between Iron Homeostasis and mTOR Mediated By the Immunophilin FKBP12

The second transferrin receptor regulates red blood cell production in mice

Is Tmprss6 Required for Hepcidin Inhibition By Erythroferrone?

The Role Of Liver Endothelial Sinusoidal Cells In Iron-Mediated Bmp6 Regulation

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

Increased susceptibility to iron deficiency of Tmprss 6-haploinsufficient mice

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American Society of Hematology

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American Society of Hematology

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