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Journal Articles

Inflammation-driven NFκB signaling represses Ferroportin transcription in macrophages via HDAC 1 and 3

Oriana Marques, Natalie K. Horvat, Laura Zechner, Silvia Colucci, Richard Sparla, Stefan Zimmermann, Christopher J. Neufeldt, Sandro Altamura, Ruiyue Qiu, Katja Müdder, Günter Weiss, Matthias W Hentze, Martina U. Muckenthaler

Blood blood.2023023417.

https://doi.org/10.1182/blood.2023023417

Published: 2024

Includes: Supplemental data

Journal Articles

Inflammation-Driven NFκB Signaling Represses Ferroportin Transcription in Macrophages Via HDAC 1 and 3

Oriana Marques, Natalie Horvat, Laura Zechner, Silvia Colucci, Richard Sparla, Stefan Zimmermann, Christopher Neufeldt, Sandro Altamura, Qiu Ruiyue, Katja Müdder, Guenter Weiss, Matthias Hentze, Martina U. Muckenthaler

Blood (2024) 144 (Supplement 1): 9.

https://doi.org/10.1182/blood-2024-210131

Published: 2024

Journal Articles

The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation

Oriana Marques, Günter Weiss, Martina U. Muckenthaler

Blood (2022) 140 (19): 2011–2023.

https://doi.org/10.1182/blood.2021013472

Published: 2022

Journal Articles

Hemochromatosis classification: update and recommendations by the BIOIRON Society

Domenico Girelli, Fabiana Busti, Pierre Brissot, Ioav Cabantchik, Martina U. Muckenthaler, Graça Porto

Blood (2022) 139 (20): 3018–3029.

https://doi.org/10.1182/blood.2021011338

Published: 2022

Includes: Supplemental data

Journal Articles

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction

Lena Muckenthaler, Oriana Marques, Silvia Colucci, Joachim Kunz, Piotr Fabrowski, Thomas Bast, Sandro Altamura, Britta Höchsmann, Hubert Schrezenmeier, Monika Langlotz, Paulina Richter-Pechanska, Tobias Rausch, Nicole Hofmeister-Mielke, Nikolas Gunkel, Matthias W. Hentze, Andreas E. Kulozik, Martina U. Muckenthaler

Blood (2022) 139 (9): 1418–1422.

https://doi.org/10.1182/blood.2021013519

Published: 2022

Includes: Supplemental data

Journal Articles

Dissecting the Mechanisms of Hepcidin and BMP-SMAD Pathway Regulation By FKBP12

Alessia Pagani, Mariateresa Pettinato, Alessandro Dulja, Silvia Colucci, Mariam Aghajan, Valeria Furiosi, Martina U. Muckenthaler, Shuling Guo, Antonella Nai, Laura Silvestri

Blood (2021) 138 (Supplement 1): 2008.

https://doi.org/10.1182/blood-2021-152172

Published: 2021

Journal Articles

SLN124, a GalNAc Conjugated 19-Mer Double-Stranded SiRNA Reduces Iron and Increases Hepcidin Levels of Healthy Volunteers in a Phase 1 Clinical Study

John B. Porter, Alison Scrimgeour, Alberto Martinez, Leo James, Manuela Aleku, Rosamund Wilson, Martina U. Muckenthaler, Ute Schaeper, Giles V Campion

Blood (2021) 138 (Supplement 1): 2009.

https://doi.org/10.1182/blood-2021-147852

Published: 2021

Journal Articles

TP53 and KRAS Variants at Initial Diagnosis Identify an Ultra-High Risk Group of Pediatric T-Lymphoblastic Leukemia (T-ALL)

Tamara Kempter, Joachim B. Kunz, Paulina Richter-Pechanska, Katarzyna Tomska, Tobias Rausch, Busra Erarslan-Uysal, Cornelia Eckert, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Renate Kirschner-Schwabe, Martina U. Muckenthaler, Jan O. Korbel, Andreas E. Kulozik

Blood (2021) 138 (Supplement 1): 1315.

https://doi.org/10.1182/blood-2021-148420

Published: 2021

Journal Articles

Hemoglobin concentration of young men at residential altitudes between 200 and 2000 m mirrors Switzerland's topography

Kaspar Staub, Martin Haeusler, Nicole Bender, Irina Morozova, Patrick Eppenberger, Radoslaw Panczak, Marcel Zwahlen, Dominik J. Schaer, Marco Maggiorini, Silvia Ulrich, Norina N. Gassmann, Martina U. Muckenthaler, Frank Rühli, Max Gassmann

Blood (2020) 135 (13): 1066–1069.

https://doi.org/10.1182/blood.2019004135

Published: 2020

Includes: Supplemental data

Journal Articles

Sensing of Liver Iron Content Requires Cell-Cell Communication between Hepatocytes and Liver Sinusoidal Endothelial Cells

Silvia Colucci, Sandro Altamura, PhD, Matthias Hentze, Prof., Martina U. Muckenthaler, PhD

Blood (2019) 134 (Supplement_1): 432.

https://doi.org/10.1182/blood-2019-125586

Published: 2019

Journal Articles

Hepcidin-Mediated Ferroportin Control in the Bone Marrow Is Dispensable

Katja Muedder, Bonadonna Michael, Bruno Galy, PhD, Martina U. Muckenthaler, PhD, Sandro Altamura, PhD

Blood (2019) 134 (Supplement_1): 3531.

https://doi.org/10.1182/blood-2019-126655

Published: 2019

Journal Articles

Intravenous Iron Promotes Low-Grade Inflammation in Anemic Patients By Triggering Macrophage Activation

Francesca Vinchi, PhD, Annalisa Castagna, B.S., PhD, Milene Costa da Silva, Fabiana Busti, MD PhD, Giacomo Marchi, MD, Richard Sparla, Martina U. Muckenthaler, PhD, Domenico Girelli, MD, PhD

Blood (2019) 134 (Supplement_1): 957.

https://doi.org/10.1182/blood-2019-132235

Published: 2019

Journal Articles

Pediatric T-ALLs Developing into a Type 2 Relapse Originate from Cells That Carry the Potential of Variable Maturation into Subclones with Distinct Chromatin Landscapes

Blood (2018) 132 (Supplement 1): 1545.

https://doi.org/10.1182/blood-2018-99-118255

Published: 2018

Journal Articles

Exploring the Mechanisms of Thalassemic Erythropoiesis Improvement Caused By Bone Marrow Tfr2 Deletion

Antonella Nai, PhD, Irene Artuso, MSc, Maria Rosa Lidonnici, PhD, Sandro Altamura, PhD, Giacomo Mandelli, PhD, Mariateresa Pettinato, MSc, Martina U. Muckenthaler, PhD, Laura Silvestri, PhD, Giuliana Ferrari, PhD, Clara Camaschella, MD

Blood (2018) 132 (Supplement 1): 3624.

https://doi.org/10.1182/blood-2018-99-115835

Published: 2018

Journal Articles

Transfusion-Induced Impairment of Macrophage Responses Is Partially Restored By the Iron Chelator Deferasirox

Francesca Vinchi, PhD, Richard Sparla, Sara Passos, PhD, Heike Weidner, Martina Rauner, PhD, Uwe Platzbecker, Martina U. Muckenthaler, PhD

Blood (2018) 132 (Supplement 1): 3625.

https://doi.org/10.1182/blood-2018-99-113016

Published: 2018

Journal Articles

Hepatocyte Iron Content Controls BMP6-Dependent Hepcidin Regulation

Sandro Altamura, PhD, Silvia Colucci, MSc, Julia Schmidt, Katja Muedder, Joana Neves, Matthias Hentze, Prof., Martina U. Muckenthaler, PhD

Blood (2018) 132 (Supplement 1): 3626.

https://doi.org/10.1182/blood-2018-99-116109

Published: 2018

Journal Articles

Longitudinal Multilevel Omic Analysis of Pediatric T-ALL Reveals Distinct Mechanisms for Disease Progression in Type 1 and in Type 2 Relapses

Blood (2018) 132 (Supplement 1): 2826.

https://doi.org/10.1182/blood-2018-99-117978

Published: 2018

Journal Articles

SLN124, a Galnac-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such As in Beta-Thalassemia

Sandro Altamura, PhD, Sandro Altamura, PhD, Martina U. Muckenthaler, PhD, Sibylle Dames, MSc, Christian Frauendorf, PhD, Steffen Schubert, PhD, Manuela Aleku, MSc, Jim Vadolas, PhD, George Grigoriadis, MBBS PhD FRACP FRCPA, Ulrich Zügel, PhD

Blood (2018) 132 (Supplement 1): 2340.

https://doi.org/10.1182/blood-2018-99-110163

Published: 2018

Journal Articles

Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model

Irene Artuso, Maria Rosa Lidonnici, Sandro Altamura, Giacomo Mandelli, Mariateresa Pettinato, Martina U. Muckenthaler, Laura Silvestri, Giuliana Ferrari, Clara Camaschella, Antonella Nai

Blood (2018) 132 (21): 2286–2297.

https://doi.org/10.1182/blood-2018-05-852277

Published: 2018

Includes: Supplemental data

Journal Articles

Hepatic Smad7 overexpression causes severe iron overload in mice

Dilay Lai, Feng Teng, Seddik Hammad, Julia Werle, Thorsten Maas, Andreas Teufel, Martina U. Muckenthaler, Steven Dooley, Maja Vujić Spasić

Blood (2018) 131 (5): 581–585.

https://doi.org/10.1182/blood-2017-07-796797

Published: 2018

Includes: Supplemental data

NARROW

Inflammation-driven NFκB signaling represses Ferroportin transcription in macrophages via HDAC 1 and 3

Inflammation-Driven NFκB Signaling Represses Ferroportin Transcription in Macrophages Via HDAC 1 and 3

The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation

Hemochromatosis classification: update and recommendations by the BIOIRON Society

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction

Dissecting the Mechanisms of Hepcidin and BMP-SMAD Pathway Regulation By FKBP12

SLN124, a GalNAc Conjugated 19-Mer Double-Stranded SiRNA Reduces Iron and Increases Hepcidin Levels of Healthy Volunteers in a Phase 1 Clinical Study

TP53 and KRAS Variants at Initial Diagnosis Identify an Ultra-High Risk Group of Pediatric T-Lymphoblastic Leukemia (T-ALL)

Hemoglobin concentration of young men at residential altitudes between 200 and 2000 m mirrors Switzerland's topography

Sensing of Liver Iron Content Requires Cell-Cell Communication between Hepatocytes and Liver Sinusoidal Endothelial Cells

Hepcidin-Mediated Ferroportin Control in the Bone Marrow Is Dispensable

Intravenous Iron Promotes Low-Grade Inflammation in Anemic Patients By Triggering Macrophage Activation

Pediatric T-ALLs Developing into a Type 2 Relapse Originate from Cells That Carry the Potential of Variable Maturation into Subclones with Distinct Chromatin Landscapes

Exploring the Mechanisms of Thalassemic Erythropoiesis Improvement Caused By Bone Marrow Tfr2 Deletion

Transfusion-Induced Impairment of Macrophage Responses Is Partially Restored By the Iron Chelator Deferasirox

Hepatocyte Iron Content Controls BMP6-Dependent Hepcidin Regulation

Longitudinal Multilevel Omic Analysis of Pediatric T-ALL Reveals Distinct Mechanisms for Disease Progression in Type 1 and in Type 2 Relapses

SLN124, a Galnac-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such As in Beta-Thalassemia

Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model

Hepatic Smad7 overexpression causes severe iron overload in mice

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American Society of Hematology

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American Society of Hematology

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