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Carlo Castruccio Castracani
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Journal Articles

Real-world comparative effects of curative and disease-modifying therapies on ineffective erythropoiesis in beta-thalassemia

Free
Carlo Castruccio Castracani, Madison Bright, Jaladhikumar Patel, Scott Peslak, Aaron Cheng, Laura Breda, Stefano Rivella, Janet Kwiatkowski
Journal: Blood
Blood (2025) 146 (Supplement 1): 176.
https://doi.org/10.1182/blood-2025-176
Published: 2025
Journal Articles

Norad long noncoding RNA, a decoy for pumilio RNA-binding proteins, elevates fetal hemoglobin levels

Free
Anita Dhara, Parina Patel, Rachael White, Sarah Adams, Raja Sundari Sundaram, Chiara Federici, Sumayea Mahmood Meem, Ada Chang, Carlo Castruccio Castracani, Stefano Rivella, Jane Little, Umut Gurkan, Mahesh Ramamoorthy, Merlin Nithya Gnanapragasam
Journal: Blood
Blood (2025) 146 (Supplement 1): 610.
https://doi.org/10.1182/blood-2025-610
Published: 2025
Journal Articles

TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation

Available to Purchase
Amaliris Guerra, Vania Lo Presti, Ding-Wen Chen, Ana Catarina Martins, Ariel Rivera, Nolan Hamilton, Pankja Sharma, Yelena Z. Ginzburg, Carlo Castruccio Castracani, Carla Casu, Ritama Gupta, Raffaella Gozzelino, Edward M. Behrens, Laura F. Bennett, Robert F. Paulson, Peter Kurre, Stefano Rivella
Journal: Blood
Blood (2025) 146 (8): 984–997.
https://doi.org/10.1182/blood.2025029352
Published: 2025
Includes: Supplemental data
Journal Articles

An erythroid-specific lentiviral vector improves anemia and iron metabolism in a new model of XLSA

Available to Purchase
Carlo Castruccio Castracani, Laura Breda, Tyler E. Papp, Amaliris Guerra, Enrico Radaelli, Charles-Antoine Assenmacher, Giovanni Finesso, Barbara L. Mui, Ying K. Tam, Simona Fontana, Chiara Riganti, Veronica Fiorito, Sara Petrillo, Emanuela Tolosano, Hamideh Parhiz, Stefano Rivella
Journal: Blood
Blood (2025) 145 (1): 98–113.
https://doi.org/10.1182/blood.2024025846
Published: 2025
Includes: Supplemental data
Journal Articles

An Erythroid-Specific Lentiviral Vector Improves Anemia and Iron Metabolism in a New Model of Xlsa

Free
Carlo Castruccio Castracani, Laura Breda, Tyler E. Papp, Amaliris Guerra, Enrico Radaelli, Charles-Antoine Assenmacher, Giovanni Finesso, Barbara Mui, Ying K. Tam, Simona Fontana, Chiara Riganti, Veronica Fiorito, Sara Petrillo, Emanuela Tolosano, Hamideh Parhiz, Stefano Rivella
Journal: Blood
Blood (2024) 144 (Supplement 1): 2195.
https://doi.org/10.1182/blood-2024-200747
Published: 2024
Journal Articles

TNFα Plays Essential Role in Resolution of Anemia of Inflammation in Tnfαko Mice Treated with Heat-Killed Brucella Abortus

Free
Vania Lo Presti, Ding-wen Chen, Ana Martins, Pankaj Sharma, Yelena Ginzburg, Carlo Castruccio Castracani, Carla Casu, Ritama Gupta, Raffaella Gozzelino, Edward Behrens, Laura F Bennett, Robert Paulson, Peter Kurre, Stefano Rivella, Amaliris Guerra
Journal: Blood
Blood (2024) 144 (Supplement 1): 168.
https://doi.org/10.1182/blood-2024-212272
Published: 2024
Journal Articles

Use of HSC-targeted LNP to generate a mouse model of lethal α-thalassemia and treatment via lentiviral gene therapy

Free
Maxwell E. Chappell, Laura Breda, Lucas Tricoli, Amaliris Guerra, Danuta Jarocha, Carlo Castruccio Castracani, Tyler E. Papp, Naoto Tanaka, Nolan Hamilton, Michael P. Triebwasser, Valentina Ghiaccio, Megan T. Fedorky, Kandace L. Gollomp, Veronica Bochenek, Aoife M. Roche, John K. Everett, Emma J. Cook, Frederic D. Bushman, Nattiya Teawtrakul, Stavros Glentis, Antonis Kattamis, Barbara L. Mui, Ying K. Tam, Drew Weissman, Osheiza Abdulmalik, Hamideh Parhiz, Stefano Rivella
Journal: Blood
Blood (2024) 144 (15): 1633–1645.
https://doi.org/10.1182/blood.2023023349
Published: 2024
Includes: Supplemental data
Journal Articles

TNFα and Anti-IFNγ Rescues Chronic Anemia of Inflammation Phenotype in Tnfαko Mice Treated with Heat-Killed Brucella Abortus

Free
Amaliris Guerra, Vania Lo Presti, Ding-Wen Chen, Ana Catarina Martins, Carlo Castruccio Castracani, Ritama Gupta, Laura Bennett, Raffaella Gozzelino, Robert Paulson, Peter Kurre, Stefano Rivella, Carla Casu
Journal: Blood
Blood (2022) 140 (Supplement 1): 5302–5303.
https://doi.org/10.1182/blood-2022-166643
Published: 2022
Journal Articles

Combination of a TGF-β Ligand Trap (RAP-GRL) and TMPRSS6 -ASO Is Superior for Correcting β-Thalassemia

Free
Amaliris Guerra, Perry Demsko, Ariel Rivera, Carlo Castruccio Castracani, Laura Breda, Naoto Tanaka, Shuling Guo, Stefano Rivella
Journal: Blood
Blood (2022) 140 (Supplement 1): 1944–1945.
https://doi.org/10.1182/blood-2022-166801
Published: 2022
Journal Articles

Combination of a Luspatercept-like Drug (RAP-GRL) and Tmprss6 -ASO Is Superior to Either Drug Alone for Correcting β-Thalassemia

Free
Amaliris Guerra, Perry Demsko, Paige McVeigh, Sayantani Sinha, Carlo Castruccio Castracani, Laura Breda, Carla Casu, Shuling Guo, Stefano Rivella
Journal: Blood
Blood (2021) 138 (Supplement 1): 2013.
https://doi.org/10.1182/blood-2021-151181
Published: 2021
Journal Articles

TNFα Controls the Delicate Balance between Erythropoiesis and Stem Cell Exhaustion during Inflammatory Stress

Free
Amaliris Guerra, Vania Lo Presti, Ana Catarina Martins, Carlo Castruccio Castracani, Ritama Gupta, Rea Oikonomidou, Emir O'Hara, Carla Casu, Laura Bennett, Robert Paulson, Peter Kurre, Stefano Rivella, Raffaella Gozzelino
Journal: Blood
Blood (2021) 138 (Supplement 1): 2184.
https://doi.org/10.1182/blood-2021-152473
Published: 2021