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Aoife M. Roche
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Journal Articles

Use of HSC Targeted LNP to Generate a Mouse Model of Lethal α-Thalassemia and Treatment via Lentiviral Gene Therapy

Maxwell Elliott Chappell, Laura Breda, Lucas Tricoli, Amaliris Guerra, Danuta Jadwiga Jarocha, Carlo Castruccio Castracani, Tyler Ellis Papp, Naoto Tanaka, Nolan Hamilton, Michael Paul Triebwasser, Valentina Ghiaccio, Megan Fedorky, Kandace Gollomp, Veronica Bochenek, Aoife M Roche, John K Everett, Emma J Cook, Frederic D. Bushman, Nattiya Teawtrakul, Stavros Glentis, Antonis Kattamis, Prof, Barbara L Mui, Ying K. Tam, Drew Weissman, Osheiza Abdulmalik, Hamideh Parhiz, Stefano Rivella
Journal: Blood
Blood blood.2023023349.
https://doi.org/10.1182/blood.2023023349
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome

Clinical Trials & Observations
Roxane Labrosse, Julia I. Chu, Myriam A. Armant, John K. Everett, Danilo Pellin, Niharika Kareddy, Andrew L. Frelinger, Lauren A. Henderson, Amy E. O’Connell, Amlan Biswas, Jet Coenen-van der Spek, Alexandra Miggelbrink, Claudia Fiorini, Hriju Adhikari, Charles C. Berry, Vito Adrian Cantu, Johnson Fong, Jason Jaroslavsky, Derin F. Karadeniz, Quan-Zhen Li, Shantan Reddy, Aoife M. Roche, Chengsong Zhu, Jennifer S. Whangbo, Colleen Dansereau, Brenda Mackinnon, Emily Morris, Stephanie M. Koo, Wendy B. London, Safa Baris, Ahmet Ozen, Elif Karakoc-Aydiner, Jenny M. Despotovic, Lisa R. Forbes Satter, Akihiko Saitoh, Yuta Aizawa, Alejandra King, Mai Anh Thi Nguyen, Vy Do Uyen Vu, Scott B. Snapper, Anne Galy, Luigi D. Notarangelo, Frederic D. Bushman, David A. Williams, Sung-Yun Pai
Journal: Blood
Blood (2023) 142 (15): 1281–1296.
https://doi.org/10.1182/blood.2022019117
Published: 2023
Includes: Supplemental data
Journal Articles

Long-term outcomes after gene therapy for adenosine deaminase severe combined immune deficiency

Clinical Trials & Observations
Bryanna Reinhardt, Omar Habib, Kit L. Shaw, Elizabeth Garabedian, Denise A. Carbonaro-Sarracino, Dayna Terrazas, Beatriz Campo Fernandez, Satiro De Oliveira, Theodore B. Moore, Alan K. Ikeda, Barbara C. Engel, Gregory M. Podsakoff, Roger P. Hollis, Augustine Fernandes, Connie Jackson, Sally Shupien, Suparna Mishra, Alejandra Davila, Jack Mottahedeh, Andrej Vitomirov, Wenzhao Meng, Aaron M. Rosenfeld, Aoife M. Roche, Pascha Hokama, Shantan Reddy, John Everett, Xiaoyan Wang, Eline T. Luning Prak, Kenneth Cornetta, Michael S. Hershfield, Robert Sokolic, Suk See De Ravin, Harry L. Malech, Frederic D. Bushman, Fabio Candotti, Donald B. Kohn
Journal: Blood
Blood (2021) 138 (15): 1304–1316.
https://doi.org/10.1182/blood.2020010260
Published: 2021
Includes: Supplemental data
Journal Articles

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis

Christopher B. Hergott, Aoife M. Roche, Edwin Tamashiro, Thomas B. Clarke, Aubrey G. Bailey, Alice Laughlin, Frederic D. Bushman, Jeffrey N. Weiser
Journal: Blood
Blood (2016) 127 (20): 2460–2471.
https://doi.org/10.1182/blood-2015-10-675173
Published: 2016
Includes: Supplemental data