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Journal Articles

Human Gene Therapy Optimized for the Platelet Bleeding Disorder Glanzmann Thrombasthenia

Juan Fang, Matthew Hogenauer, Aoife M. Roche, Sevasti B. Koukouritaki, Lily M. Du, Huiqing Xu, John Everett, Frederic D. Bushman, Myriam Armant, Peiman Hematti, David A. Wilcox

Blood (2024) 144 (Supplement 1): 5409.

https://doi.org/10.1182/blood-2024-199243

Published: 2024

Journal Articles

Validation of the Impede VTE Score for Prediction of Venous Thromboembolism in Chinese Patients with Multiple Myeloma: A Retrospective Cohort Study

Li Bao, Yu-Tong Wang, Min-qiu Lu, Junling Zhuang, Bin Chu, Lei Shi, Shan Gao, Li-juan Fang, Qiu-qing Xiang, Xi Liu, Yue-hua Ding, Kai Sun

Blood (2022) 140 (Supplement 1): 5146–5147.

https://doi.org/10.1182/blood-2022-168633

Published: 2022

Journal Articles

An Unexpected Role For αIIbβ3 In Immune Complex Disorders

Huiying Zhi, MD, PhD, Nannan Wu, Jing Dai, Juan Fang, MD, Pu Liu, Junling Liu, Hu Hu, PhD, Jieqing Zhu, PhD, Debra K. Newman, PhD, Peter J. Newman, PhD, Cunji Gao, MD, PhD

Blood (2013) 122 (21): 2293.

https://doi.org/10.1182/blood.V122.21.2293.2293

Published: 2013

Journal Articles

Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT)

Spencer K. Sullivan, MD, Jason A. Mills, PhD, Li Zhai, MD, Prasuna Paluru, MS, Karen Vo, Michele Lambert, MD, Sevasti B. Koukouritaki, PhD, Juan Fang, MD, David A. Wilcox, PhD, Deborah L. French, PhD, Mortimer Poncz, MD, Paul Gadue, PhD

Blood (2012) 120 (21): 387.

https://doi.org/10.1182/blood.V120.21.387.387

Published: 2012

Journal Articles

Disaggregation Signals Initiated by Ligand Binding and Platelet Aggregation

Cunji Gao, MD, PhD, Juan Fang, MD, Huiying Zhi, PhD, David A. Wilcox, PhD, Peter J. Newman, PhD

Blood (2011) 118 (21): 2196.

https://doi.org/10.1182/blood.V118.21.2196.2196

Published: 2011

Journal Articles

Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling

Cunji Gao, Brian Boylan, Juan Fang, David A. Wilcox, Debra K. Newman, Peter J. Newman

Blood (2011) 117 (18): 4946–4952.

https://doi.org/10.1182/blood-2010-09-307751

Published: 2011

Includes: Supplemental data

Journal Articles

De Novo Synthesis & Storage of Human Factor VIII In Platelets Reduces Bleeding In Canine Hemophilia A

Lily M. Du, MD, Helen W.G. Franck, BS, Elizabeth P. Merricks, PhD, Paquita Nurden, MD, Eric S. Jensen, DVM, Sandra L. Haberichter, PhD, Troy B. Hawkins, PhD, Paula M. Jacobi, BS, Juan Fang, MD, Timothy C. Nichols, MD, Sevasti B. Koukouritaki, PhD, Qizhen Shi, MD, PhD, Robert R. Montgomery, MD, Kenneth Cornetta, MD, Alan T. Nurden, PhD, David A. Wilcox, PhD

Blood (2010) 116 (21): 2198.

https://doi.org/10.1182/blood.V116.21.2198.2198

Published: 2010

Journal Articles

Platelet-Targeted Expression of Human BDD-FVIII Reduces Bleeding in Canine Hemophilia A.

Lily M. Du, MS, MD, Timothy C. Nichols, MD, Sandra L. Haberichter, PhD, Paula M. Jacobi, Eric S. Jensen, DVM, Juan Fang, MD, Qizhen Shi, MD, PhD, Robert R. Montgomery, MD, David A. Wilcox, PhD

Blood (2009) 114 (22): 691.

https://doi.org/10.1182/blood.V114.22.691.691

Published: 2009

Journal Articles

High Mortality in Mice with Platelets Expressing Integrin αIIbβ3 Lockedin Its High Affinity State.

David A. Wilcox, PhD, Juan Fang, MD, Paula North, MD, PhD, Paquita Nurden, MD, Alan T. Nurden, PhD, Nathalie Valentin, PhD

Blood (2008) 112 (11): 1832.

https://doi.org/10.1182/blood.V112.11.1832.1832

Published: 2008

Journal Articles

Recombinant Human HPA-1A Antibodies for Treatment of Fetomaternal Alloimmune Thrombocytopenia (FMAIT): Proof of Principle in An in Vivo Murine Model and Human Volunteer Studies

Cedric Ghevaert, David A. Wilcox, PhD, Juan Fang, Kathryn Armour, Mike R Clark, Willem H. Ouwehand, Lorna M Williamson

Blood (2008) 112 (11): 85.

https://doi.org/10.1182/blood.V112.11.85.85

Published: 2008

Journal Articles

Platelet-Targeted Expression of Coagulation Factor VIII (FVIII) Shows Efficacy for Using the Dog as a Large Animal Model for Gene Therapy of Hemophilia a

David A. Wilcox, PhD, Lily M. Du, MS, MD, Sandra L. Haberichter, PhD, Paula M. Jacobi, Juan Fang, MD, Eric S. Jensen, DVM, Qizhen Shi, MD, PhD, Robert R. Montgomery, MD

Blood (2008) 112 (11): 3525.

https://doi.org/10.1182/blood.V112.11.3525.3525

Published: 2008

Journal Articles

Intravenous Immunoglobulin (IVIG) Diminishes Immune-Mediated Clearance of Platelets Expressing an Integrin αIIbβ3 Transgene Product That Restores Hemostasis in a Canine Model for Glanzmann Thrombasthenia.

Juan Fang, MD, Eric S. Jensen, DVM, Lily M. Du, MD,Ms, Mary K. Boudreaux, DVM,PhD, David A. Wilcox, PhD

Blood (2006) 108 (11): 3263.

https://doi.org/10.1182/blood.V108.11.3263.3263

Published: 2006

Journal Articles

Phenotypic Correction of a Canine Model for Glanzmann Thrombasthenia Demonstrates Efficacy for Using Platelets To Deliver Therapeutics at the Site of Vascular Injury.

David A. Wilcox, PhD, Juan Fang, Lily M. Du, Mary K. Boudreaux, PhD, DVM

Blood (2005) 106 (11): 3045.

https://doi.org/10.1182/blood.V106.11.3045.3045

Published: 2005

Journal Articles

Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia

Juan Fang, Kairbaan Hodivala-Dilke, Bryon D. Johnson, Lily M. Du, Richard O. Hynes, Gilbert C. White, II, David A. Wilcox

Blood (2005) 106 (8): 2671–2679.

https://doi.org/10.1182/blood-2004-12-4619

Published: 2005

Journal Articles

Murine Platelets Expressing a Polymorphism of Integrin β3 Associated with Acute Coronary Thrombosis in Humans.

David A. Wilcox, PhD, Juan Fang, MD, Bryon D. Johnson, PhD

Blood (2004) 104 (11): 3896.

https://doi.org/10.1182/blood.V104.11.3896.3896

Published: 2004

NARROW

Human Gene Therapy Optimized for the Platelet Bleeding Disorder Glanzmann Thrombasthenia

Validation of the Impede VTE Score for Prediction of Venous Thromboembolism in Chinese Patients with Multiple Myeloma: A Retrospective Cohort Study

An Unexpected Role For αIIbβ3 In Immune Complex Disorders

Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT)

Disaggregation Signals Initiated by Ligand Binding and Platelet Aggregation

Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling

De Novo Synthesis & Storage of Human Factor VIII In Platelets Reduces Bleeding In Canine Hemophilia A

Platelet-Targeted Expression of Human BDD-FVIII Reduces Bleeding in Canine Hemophilia A.

High Mortality in Mice with Platelets Expressing Integrin αIIbβ3 Lockedin Its High Affinity State.

Recombinant Human HPA-1A Antibodies for Treatment of Fetomaternal Alloimmune Thrombocytopenia (FMAIT): Proof of Principle in An in Vivo Murine Model and Human Volunteer Studies

Platelet-Targeted Expression of Coagulation Factor VIII (FVIII) Shows Efficacy for Using the Dog as a Large Animal Model for Gene Therapy of Hemophilia a

Intravenous Immunoglobulin (IVIG) Diminishes Immune-Mediated Clearance of Platelets Expressing an Integrin αIIbβ3 Transgene Product That Restores Hemostasis in a Canine Model for Glanzmann Thrombasthenia.

Phenotypic Correction of a Canine Model for Glanzmann Thrombasthenia Demonstrates Efficacy for Using Platelets To Deliver Therapeutics at the Site of Vascular Injury.

Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia

Murine Platelets Expressing a Polymorphism of Integrin β3 Associated with Acute Coronary Thrombosis in Humans.

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American Society of Hematology

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American Society of Hematology

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