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Richard O. Hynes
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Journal Articles

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

Guangheng Zhu, Qing Zhang, Emily C. Reddy, Naadiya Carrim, Yunfeng Chen, Xiaohong Ruby Xu, Miao Xu, Yiming Wang, Yan Hou, Li Ma, Yan Li, Min Rui, Tania N. Petruzziello-Pellegrini, Christopher Lavalle, Tyler W. Stratton, Xi Lei, Reheman Adili, Pingguo Chen, Cheng Zhu, John A. Wilkins, Richard O. Hynes, John Freedman, Heyu Ni
Journal: Blood
Blood (2017) 129 (13): 1840–1854.
https://doi.org/10.1182/blood-2016-07-729400
Published: 2017
Includes: Supplemental data
Journal Articles

Proteomic Characterization of the Multiple Myeloma Bone Marrow Extracellular Matrix

Siobhan Glavey, MD, Alexandra Naba, PhD, Salomon Manier, MD, Manuela Gambella, Alberto Rocci, MD, Antonio Sacco, BS, John M. Asara, PhD, Michele Moschetta, MD, Michaela R. Reagan, PhD, Yuji Mishima, PhD, Yawara Kawano, MD PhD, Aldo M Roccaro, MD PhD, Antonio Palumbo, MD, Richard O. Hynes, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2014) 124 (21): 2051.
https://doi.org/10.1182/blood.V124.21.2051.2051
Published: 2014
Journal Articles

Platelets, Tumor Cell Invasiveness, and Metastasis

Richard O. Hynes, PhD, Shahinoor Begum, PhD, Myriam Labelle, PhD
Journal: Blood
Blood (2013) 122 (21): SCI-31.
https://doi.org/10.1182/blood.V122.21.SCI-31.SCI-31
Published: 2013
Journal Articles

Structure-function analysis reveals discrete β3 integrin inside-out and outside-in signaling pathways in platelets

Zhiying Zou, Hong Chen, Alec A. Schmaier, Richard O. Hynes, Mark L. Kahn
Journal: Blood
Blood (2006) 109 (8): 3284–3290.
https://doi.org/10.1182/blood-2006-10-051664
Published: 2006
Includes: Supplemental data
Journal Articles

A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy

Heyu Ni, Pingguo Chen, Christopher M. Spring, Ebrahim Sayeh, John W. Semple, Alan H. Lazarus, Richard O. Hynes, John Freedman
Journal: Blood
Blood (2006) 107 (7): 2976–2983.
https://doi.org/10.1182/blood-2005-06-2562
Published: 2006
Journal Articles

Fibrinogen and von Willebrand Factor-Independent Platelet Aggregation: The Essential Roles of β3 Integrin, Thrombin, and Divalent Ca 2+ Cations.

Hong Yang, MD, Adili Reheman, MD, Pingguo Chen, MD, PhD, Richard O. Hynes, PhD, John Freedman, MD, Denisa D. Wagner, PhD, Heyu Ni, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 2651.
https://doi.org/10.1182/blood.V106.11.2651.2651
Published: 2005
Journal Articles

Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia

Juan Fang, Kairbaan Hodivala-Dilke, Bryon D. Johnson, Lily M. Du, Richard O. Hynes, Gilbert C. White, II, David A. Wilcox
Journal: Blood
Blood (2005) 106 (8): 2671–2679.
https://doi.org/10.1182/blood-2004-12-4619
Published: 2005
Journal Articles

Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis

Kishore R. Alugupalli, Alan D. Michelson, Isabelle Joris, Tom G. Schwan, Kairbaan Hodivala-Dilke, Richard O. Hynes, John M. Leong
Journal: Blood
Blood (2003) 102 (8): 2843–2850.
https://doi.org/10.1182/blood-2003-02-0426
Published: 2003
Journal Articles

Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins

Patrick André, Cécile V. Denis, Jerry Ware, Simin Saffaripour, Richard O. Hynes, Zaverio M. Ruggeri, Denisa D. Wagner
Journal: Blood
Blood (2000) 96 (10): 3322–3328.
https://doi.org/10.1182/blood.V96.10.3322
Published: 2000
Journal Articles

Overlapping Functions of E- and P-Selectin in Neutrophil Recruitment During Acute Inflammation

Jonathon W. Homeister, Mengkun Zhang, Paul S. Frenette, Richard O. Hynes, Denisa D. Wagner, John B. Lowe, Rory M. Marks
Journal: Blood
Blood (1998) 92 (7): 2345–2352.
https://doi.org/10.1182/blood.V92.7.2345
Published: 1998
Journal Articles

Platelet-Endothelial Interactions in Inflamed Mesenteric Venules

Paul S. Frenette, Caitlin Moyna, Daqing W. Hartwell, John B. Lowe, Richard O. Hynes, Denisa D. Wagner
Journal: Blood
Blood (1998) 91 (4): 1318–1324.
https://doi.org/10.1182/blood.V91.4.1318
Published: 1998
Journal Articles

Fibronectins Are Essential for Heart and Blood Vessel Morphogenesis But Are Dispensable for Initial Specification of Precursor Cells

Elizabeth L. George, H. Scott Baldwin, Richard O. Hynes
Journal: Blood
Blood (1997) 90 (8): 3073–3081.
https://doi.org/10.1182/blood.V90.8.3073
Published: 1997