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Journal Articles

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

Miao Xu, June Li, Miguel Antonio Dias Neves, Guangheng Zhu, Naadiya Carrim, Ruoying Yu, Sahil Gupta, John Marshall, Ori Rotstein, Jun Peng, Ming Hou, Shinji Kunishima, Jerry Ware, Donald R. Branch, Alan H. Lazarus, Zaverio M. Ruggeri, John Freedman, Heyu Ni

Blood (2018) 132 (6): 622–634.

https://doi.org/10.1182/blood-2017-12-820779

Published: 2018

Includes: Supplemental data

Journal Articles

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

Blood (2017) 129 (13): 1840–1854.

https://doi.org/10.1182/blood-2016-07-729400

Published: 2017

Includes: Supplemental data

Journal Articles

CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Li Ma, Elisa Simpson, June Li, Min Xuan, Miao Xu, Laura Baker, Yan Shi, Issaka Yougbaré, Xiaozhong Wang, Guangheng Zhu, Pingguo Chen, Gerald J. Prud’homme, Alan H. Lazarus, John Freedman, Heyu Ni

Blood (2015) 126 (2): 247–256.

https://doi.org/10.1182/blood-2015-03-635417

Published: 2015

Includes: Supplemental data

Journal Articles

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Blood (2014) 124 (21): 2772.

https://doi.org/10.1182/blood.V124.21.2772.2772

Published: 2014

Journal Articles

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Blood (2014) 124 (21): 92.

https://doi.org/10.1182/blood.V124.21.92.92

Published: 2014

Journal Articles

Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI)

Christopher G. J. McKenzie, Michael Kim, Tarandeep K. Singh, Youli Milev, John Freedman, John W. Semple

Blood (2014) 123 (22): 3496–3503.

https://doi.org/10.1182/blood-2013-11-536755

Published: 2014

Includes: Supplemental data

Journal Articles

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

Li Guo, Lei Yang, Edwin R. Speck, Rukhsana Aslam, Michael Kim, Christopher G. J. McKenzie, Alan H. Lazarus, Heyu Ni, Ming Hou, John Freedman, John W. Semple

Blood (2014) 123 (3): 422–427.

https://doi.org/10.1182/blood-2013-08-523308

Published: 2014

Includes: Supplemental data

Journal Articles

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Li Ma, Elisa K. Simpson, H.B.Sc., June Li, BSc, Guangheng Zhu, MD, Pingguo Chen, PhD, John W. Semple, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 1076.

https://doi.org/10.1182/blood.V122.21.1076.1076

Published: 2013

Journal Articles

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Dianne E. van Der Wal, PhD, Guangheng Zhu, MD, June Li, BSc, Brian Vadasz, BSc, Yougbare Issaka, PhD, Sean Lang, MSc, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 265.

https://doi.org/10.1182/blood.V120.21.265.265

Published: 2012

Journal Articles

Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Rukhsana Aslam, Yu Hu, Simon Gebremeskel, George B. Segel, Edwin R. Speck, Li Guo, Michael Kim, Heyu Ni, John Freedman, John W. Semple

Blood (2012) 120 (10): 2127–2132.

https://doi.org/10.1182/blood-2012-02-413526

Published: 2012

Includes: Supplemental data

Journal Articles

Thymic Retention of CD4+CD25 hi +FoxP3+ T Regulatory (Treg) Cells Is Responsible for Peripheral Treg Deficiency and Platelet and Megakaryocyte Destruction in Active Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Simon Gebremeskel, BSc, Rukhsana Aslam, Ph.D., Heyu Ni, John Freedman, MD

Blood (2011) 118 (21): 523.

https://doi.org/10.1182/blood.V118.21.523.523

Published: 2011

Journal Articles

Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy

Pingguo Chen, Conglei Li, Sean Lang, Guangheng Zhu, Adili Reheman, Christopher M. Spring, John Freedman, Heyu Ni

Blood (2010) 116 (18): 3660–3668.

https://doi.org/10.1182/blood-2010-05-284919

Published: 2010

Journal Articles

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

Yoke Lin Fung, Michael Kim, Arata Tabuchi, Rukhsana Aslam, Edwin R. Speck, Leola Chow, Wolfgang M. Kuebler, John Freedman, John W. Semple

Blood (2010) 116 (16): 3073–3079.

https://doi.org/10.1182/blood-2010-05-284570

Published: 2010

Includes: Supplemental data

Journal Articles

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8 + T cell–mediated responses that are differentially sensitive to therapy

Leola Chow, Rukhsana Aslam, Edwin R. Speck, Michael Kim, Norman Cridland, Michelle Lee Webster, Pingguo Chen, Kim Sahib, Heyu Ni, Alan H. Lazarus, M. Bernadette Garvey, John Freedman, John W. Semple

Blood (2010) 115 (6): 1247–1253.

https://doi.org/10.1182/blood-2009-09-244772

Published: 2010

Includes: Supplemental data

Journal Articles

Robotic High Thoroughput Multiplex PCR Single-Nucleotide Polymorphism Genotyping of Apheresis Platelet Donors.

Nadine Shehata, MD, MSC, Barbara Hannach, MD, Nancy Banning, John Freedman, MD, Greg Denomme, PhD

Blood (2009) 114 (22): 2106.

https://doi.org/10.1182/blood.V114.22.2106.2106

Published: 2009

Journal Articles

Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI).

Yoke Lin Fung, PhD, Michael Kim, Edwin R Speck, John Freedman, MD, John W. Semple, PhD

Blood (2009) 114 (22): 641.

https://doi.org/10.1182/blood.V114.22.641.641

Published: 2009

Journal Articles

Apolipoprotein AIV (ApoA-IV) Is a Novel Ligand of Platelet β3 Integrin That Negatively Regulates Platelet Adhesion, Aggregation, and Thrombosis.

Christopher M. Spring, MSc, Wuxun Jin, PhD, Hong Yang, MD, Adili Reheman, MD, Guangheng Zhu, MD, Yimin She, PhD, Terry Cyr, PhD, Patrick Tso, PhD, Sean Davidson, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2009) 114 (22): 156.

https://doi.org/10.1182/blood.V114.22.156.156

Published: 2009

Journal Articles

The GPIIbIIIa Antagonist Drugs Eptifibatide and Tirofiban Inhibit Caspase-3 Activation in Thrombin- and Calcium Ionophore-Stimulated Human Platelets.

Valery Leytin, PhD, Asuman Mutlu, PhD, Sergiy Mykhaylov, PhD, David J. Allen, BSc, Armen V. Gyulkhandanyan, PhD, Elena Lyubimov, PhD, John Freedman, MD

Blood (2009) 114 (22): 2998.

https://doi.org/10.1182/blood.V114.22.2998.2998

Published: 2009

Journal Articles

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

Hong Yang, Sean Lang, Zhimin Zhai, Ling Li, Walter H. A. Kahr, Pingguo Chen, Jelena Brkić, Christopher M. Spring, Matthew J. Flick, Jay L. Degen, John Freedman, Heyu Ni

Blood (2009) 114 (2): 425–436.

https://doi.org/10.1182/blood-2008-03-145821

Published: 2009

Journal Articles

Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor

Adili Reheman, Hong Yang, Guangheng Zhu, Wuxun Jin, Feng He, Christopher M. Spring, Xufang Bai, Peter L. Gross, John Freedman, Heyu Ni

Blood (2009) 113 (8): 1809–1817.

https://doi.org/10.1182/blood-2008-04-148361

Published: 2009

NARROW

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI)

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Thymic Retention of CD4+CD25 hi +FoxP3+ T Regulatory (Treg) Cells Is Responsible for Peripheral Treg Deficiency and Platelet and Megakaryocyte Destruction in Active Immune Thrombocytopenia (ITP)

Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8 + T cell–mediated responses that are differentially sensitive to therapy

Robotic High Thoroughput Multiplex PCR Single-Nucleotide Polymorphism Genotyping of Apheresis Platelet Donors.

Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI).

Apolipoprotein AIV (ApoA-IV) Is a Novel Ligand of Platelet β3 Integrin That Negatively Regulates Platelet Adhesion, Aggregation, and Thrombosis.

The GPIIbIIIa Antagonist Drugs Eptifibatide and Tirofiban Inhibit Caspase-3 Activation in Thrombin- and Calcium Ionophore-Stimulated Human Platelets.

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor

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American Society of Hematology

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American Society of Hematology

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