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Journal Articles

Gastrointestinal Flora Dictates the Biological Response in Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MDPhDMSc, Michael Kim, BSc, Johan Rebetz, PhD, Alisa Takabe-French, Noel Kim, Shanjeevan Shanmugabhavananthan, BSc, Edwin R. Speck, BRT, John W Semple, PhD

Blood (2017) 130 (Supplement 1): 766.

https://doi.org/10.1182/blood.V130.Suppl_1.766.766

Published: 2017

Journal Articles

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

Rick Kapur, Michael Kim, Rukhsana Aslam, Mark J. McVey, Arata Tabuchi, Alice Luo, Jonathan Liu, Yuan Li, Shanjeevan Shanmugabhavananthan, Edwin R. Speck, Anne Zufferey, George Yousef, Haibo Zhang, Matthew T. Rondina, Andrew S. Weyrich, Leendert Porcelijn, Wolfgang M. Kuebler, Arthur S. Slutsky, John W. Semple

Blood (2017) 129 (18): 2557–2569.

https://doi.org/10.1182/blood-2016-12-758185

Published: 2017

Includes: Supplemental data

Journal Articles

Interleukin (IL)-10 Is an Effective Therapeutic for Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD M.Sc., Michael Kim, BSc, Shanjee Shanmugabhavananthan, Jonathan Liu, Noel Kim, Stefan Milosevic, Edwin R. Speck, BRT, John W. Semple, PhD

Blood (2016) 128 (22): 92.

https://doi.org/10.1182/blood.V128.22.92.92

Published: 2016

Journal Articles

CD20 + B-cell depletion therapy suppresses murine CD8 + T-cell–mediated immune thrombocytopenia

Li Guo, Rick Kapur, Rukshana Aslam, Edwin R. Speck, Anne Zufferey, Yajing Zhao, Michael Kim, Alan H. Lazarus, Heyu Ni, John W. Semple

Blood (2016) 127 (6): 735–738.

https://doi.org/10.1182/blood-2015-06-655126

Published: 2016

Includes: Supplemental data

Journal Articles

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michael Kim, BSc, Anne Zufferey, PhD, Heyu Ni, MD PhD, Michelle Catalina, PhD, Richard Francovitch, PhD

Blood (2015) 126 (23): 1045.

https://doi.org/10.1182/blood.V126.23.1045.1045

Published: 2015

Journal Articles

CD4+CD25+Foxp3+ T Regulatory Cells Protect Against Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD

Blood (2015) 126 (23): 2342.

https://doi.org/10.1182/blood.V126.23.2342.2342

Published: 2015

Journal Articles

Murine Bone Marrow-Derived Megakaryocytes Are Capable of Antigen Cross-Presentation on Major Histocompatibility Class (MHC) I Molecules

Anne Zufferey, PhD, Edwin R. Speck, BRT, Li Guo, MD, Rukhsana Aslam, PhD, Rick Kapur, MD PhD, John W. Semple, PhD

Blood (2015) 126 (23): 3465.

https://doi.org/10.1182/blood.V126.23.3465.3465

Published: 2015

Journal Articles

C-Reactive Protein (CRP) Enhances Murine Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD

Blood (2015) 126 (23): 3561.

https://doi.org/10.1182/blood.V126.23.3561.3561

Published: 2015

Journal Articles

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

Rick Kapur, MD PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, Michael Kim, BSc, Anne Zufferey, PhD, Li Guo, MD, George B. Segel, MD, Heyu Ni, MD PhD, John W. Semple, PhD

Blood (2015) 126 (23): 2251.

https://doi.org/10.1182/blood.V126.23.2251.2251

Published: 2015

Journal Articles

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Li Guo, MD, Rukhsana Aslam, PhD, Yajing Zhao, Edwin R. Speck, BRT, Heyu Ni, MD PhD, John W. Semple, PhD

Blood (2014) 124 (21): 2785.

https://doi.org/10.1182/blood.V124.21.2785.2785

Published: 2014

Journal Articles

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

Li Guo, Lei Yang, Edwin R. Speck, Rukhsana Aslam, Michael Kim, Christopher G. J. McKenzie, Alan H. Lazarus, Heyu Ni, Ming Hou, John Freedman, John W. Semple

Blood (2014) 123 (3): 422–427.

https://doi.org/10.1182/blood-2013-08-523308

Published: 2014

Includes: Supplemental data

Journal Articles

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Kristin Hunt, Yu Hou, Rukhsana Aslam, PhD, Edwin R. Speck, Heyu Ni, MD, PhD, Alan H Lazarus, PhD

Blood (2013) 122 (21): 3537.

https://doi.org/10.1182/blood.V122.21.3537.3537

Published: 2013

Journal Articles

Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Xu Zhang, Yu Hu, Li Guo, Edwin R. Speck, Heyu Ni, MD, PhD, Rukhsana Aslam, PhD

Blood (2012) 120 (21): 1088.

https://doi.org/10.1182/blood.V120.21.1088.1088

Published: 2012

Journal Articles

Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Rukhsana Aslam, Yu Hu, Simon Gebremeskel, George B. Segel, Edwin R. Speck, Li Guo, Michael Kim, Heyu Ni, John Freedman, John W. Semple

Blood (2012) 120 (10): 2127–2132.

https://doi.org/10.1182/blood-2012-02-413526

Published: 2012

Includes: Supplemental data

Journal Articles

Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP).

Li Guo, Rukhsana Aslam, Edwin R Speck, Heyu Ni, Ming Hou, John J. Freedman, MD, FRCPC, John W. Semple, PhD

Blood (2010) 116 (21): 3686.

https://doi.org/10.1182/blood.V116.21.3686.3686

Published: 2010

Journal Articles

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

Yoke Lin Fung, Michael Kim, Arata Tabuchi, Rukhsana Aslam, Edwin R. Speck, Leola Chow, Wolfgang M. Kuebler, John Freedman, John W. Semple

Blood (2010) 116 (16): 3073–3079.

https://doi.org/10.1182/blood-2010-05-284570

Published: 2010

Includes: Supplemental data

Journal Articles

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8 + T cell–mediated responses that are differentially sensitive to therapy

Leola Chow, Rukhsana Aslam, Edwin R. Speck, Michael Kim, Norman Cridland, Michelle Lee Webster, Pingguo Chen, Kim Sahib, Heyu Ni, Alan H. Lazarus, M. Bernadette Garvey, John Freedman, John W. Semple

Blood (2010) 115 (6): 1247–1253.

https://doi.org/10.1182/blood-2009-09-244772

Published: 2010

Includes: Supplemental data

Journal Articles

Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI).

Yoke Lin Fung, PhD, Michael Kim, Edwin R Speck, John Freedman, MD, John W. Semple, PhD

Blood (2009) 114 (22): 641.

https://doi.org/10.1182/blood.V114.22.641.641

Published: 2009

Journal Articles

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

Leola Chow, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michelle Lee Webster, MSc, Pingguo Chen, PhD, Heyu Ni, MD, PhD, John Freedman, MD, John W. Semple, PhD

Blood (2008) 112 (11): 399.

https://doi.org/10.1182/blood.V112.11.399.399

Published: 2008

Journal Articles

A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction.

Leola Chow, PhD, Heyu Ni, MD, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Pingguo Chen, John Freedman, MD, John W. Semple, PhD

Blood (2007) 110 (11): 99.

https://doi.org/10.1182/blood.V110.11.99.99

Published: 2007

NARROW

Gastrointestinal Flora Dictates the Biological Response in Murine Transfusion Related Acute Lung Injury (TRALI)

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

Interleukin (IL)-10 Is an Effective Therapeutic for Murine Transfusion Related Acute Lung Injury (TRALI)

CD20 + B-cell depletion therapy suppresses murine CD8 + T-cell–mediated immune thrombocytopenia

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

CD4+CD25+Foxp3+ T Regulatory Cells Protect Against Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Murine Bone Marrow-Derived Megakaryocytes Are Capable of Antigen Cross-Presentation on Major Histocompatibility Class (MHC) I Molecules

C-Reactive Protein (CRP) Enhances Murine Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP)

Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP).

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8 + T cell–mediated responses that are differentially sensitive to therapy

Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI).

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction.

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American Society of Hematology

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American Society of Hematology

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