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Journal Articles

Let’s YAP about ITP

Rick Kapur, John W. Semple
Journal: Blood
Blood (2024) 144 (20): 2072–2073.
https://doi.org/10.1182/blood.2024026571
Published: 2024
Journal Articles

T-Cell Transcriptomic Signatures in Adults with Primary Untreated Immune Thrombocytopenia Segregate By Age, Revealing Distinct Druggable Pathways

Lipei Shao, Aaron Boothby, S. Lawrence Bailey, Aastha Chauhan, Martin Boechenek, Terry B. Gernsheimer, John W. Semple, James L. Zehnder, V. Koneti Rao, Jin Ping, David F. Stroncek, Moritz Stolla, Sandya R. Panch
Journal: Blood
Blood (2024) 144 (Supplement 1): 124.
https://doi.org/10.1182/blood-2024-203670
Published: 2024
Journal Articles

Ianalumab, an ADCC-Enhanced Anti-BAFF-Receptor Antibody, Has Beneficial Effects in an Active Mouse Model of Immune Thrombocytopenia (ITP)

Johan Rebetz, Genevieve Marcoux, Marc Bigaud, Elissa Furutani, Tatjana Uffelmann, Sabina Pfister, Barbara Nüsslein-Hildesheim, Pascal Edrich, Isabelle Isnardi, Christoph Burkhart, John W Semple
Journal: Blood
Blood (2024) 144 (Supplement 1): 552.
https://doi.org/10.1182/blood-2024-194446
Published: 2024
Journal Articles

Platelet TGF-β triggers immunosuppression in ITP

Rick Kapur, John W. Semple
Journal: Blood
Blood (2024) 144 (1): 7–8.
https://doi.org/10.1182/blood.2024024825
Published: 2024
Journal Articles

Mitochondrial Damage-Associated Molecular Patterns (DAMPs) Contribute to the Development of Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Genevieve Marcoux, Johan Rebetz, Ellen Moore, Hilma Cederholm, David McGauran, Karl Johansson, John W Semple
Journal: Blood
Blood (2023) 142 (Supplement 1): 2660.
https://doi.org/10.1182/blood-2023-174197
Published: 2023
Journal Articles

Recipient Platelet-Derived Extracellular Vesicles (PEV) Suppress Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Genevieve Marcoux, Johan Rebetz, Hilma Cederholm, Ellen Moore, David McGauran, Karl Johansson, John W Semple
Journal: Blood
Blood (2023) 142 (Supplement 1): 4033.
https://doi.org/10.1182/blood-2023-173797
Published: 2023
Journal Articles

TEMRA: the CD8 subset in chronic ITP?

Alan H. Lazarus, John W. Semple
Journal: Blood
Blood (2023) 141 (20): 2409–2410.
https://doi.org/10.1182/blood.2023019859
Published: 2023
Journal Articles

Protecting the fetus from FNAIT

John W. Semple, Rick Kapur
Journal: Blood
Blood (2022) 140 (20): 2097–2099.
https://doi.org/10.1182/blood.2022017937
Published: 2022
Journal Articles

Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules

Genevieve Marcoux, Audrée Laroche, Stephan Hasse, Marie Bellio, Maroua Mbarik, Marie Tamagne, Isabelle Allaeys, Anne Zufferey, Tania Lévesque, Johan Rebetz, Annie Karakeussian-Rimbaud, Julie Turgeon, Sylvain G. Bourgoin, Hind Hamzeh-Cognasse, Fabrice Cognasse, Rick Kapur, John W. Semple, Marie-Josée Hébert, France Pirenne, Herman S. Overkleeft, Bogdan I. Florea, Mélanie Dieude, Benoît Vingert, Eric Boilard
Journal: Blood
Blood (2021) 138 (25): 2607–2620.
https://doi.org/10.1182/blood.2020009957
Published: 2021
Includes: Supplemental data
Journal Articles

Decitabine revives Treg function in ITP

Rick Kapur, John W. Semple
Journal: Blood
Blood (2021) 138 (8): 591–592.
https://doi.org/10.1182/blood.2021012108
Published: 2021
Journal Articles

Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat

Mark J. McVey, Sarah Weidenfeld, Mazharul Maishan, Chris Spring, Michael Kim, Arata Tabuchi, Victoria Srbely, Alisa Takabe-French, Szandor Simmons, Christoph Arenz, John W. Semple, Wolfgang M. Kuebler
Journal: Blood
Blood (2021) 137 (5): 690–701.
https://doi.org/10.1182/blood.2020005985
Published: 2021
Includes: Supplemental data
Journal Articles

Osteopontin mediates murine transfusion-related acute lung injury via stimulation of pulmonary neutrophil accumulation

Rick Kapur, Gopinath Kasetty, Johan Rebetz, Arne Egesten, John W. Semple
Journal: Blood
Blood (2019) 134 (1): 74–84.
https://doi.org/10.1182/blood.2019000972
Published: 2019
Includes: Supplemental data
Journal Articles

Transfusion-associated circulatory overload and transfusion-related acute lung injury

John W. Semple, Johan Rebetz, Rick Kapur
Journal: Blood
Blood (2019) 133 (17): 1840–1853.
https://doi.org/10.1182/blood-2018-10-860809
Published: 2019
Journal Articles

Osteopontin Mediates Murine Transfusion-Related Acute Lung Injury through Stimulation of Pulmonary Neutrophil Accumulation

Rick Kapur, MDPhDMSc, Gopinath Kasetty, PhD, Johan Rebetz, PhD, Arne Egesten, MD PhD, John W Semple, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 739.
https://doi.org/10.1182/blood-2018-99-115770
Published: 2018
Journal Articles

Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia

Peter A. A. Norris, BSc, George B. Segel, MD, Ulrich J Sachs, MD PhD, Behnaz Bayat, PhD, Gestur Vidarsson, PhD, Rick Kapur, MDPhDMSc, Christine M. Cserti-Gazdewich, BSc, MD FRCPC, Jeannie Callum, MD, Yulia Lin, MD FRCPC, Richard Burack, MD PhD, John W Semple, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 129.
https://doi.org/10.1182/blood-2018-99-117650
Published: 2018
Journal Articles

Moving target PF4 directs HIT responses

John W. Semple, Rick Kapur
Journal: Blood
Blood (2018) 132 (7): 678–679.
https://doi.org/10.1182/blood-2018-07-859975
Published: 2018
Journal Articles

Gastrointestinal Flora Dictates the Biological Response in Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MDPhDMSc, Michael Kim, BSc, Johan Rebetz, PhD, Alisa Takabe-French, Noel Kim, Shanjeevan Shanmugabhavananthan, BSc, Edwin R. Speck, BRT, John W Semple, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 766.
https://doi.org/10.1182/blood.V130.Suppl_1.766.766
Published: 2017
Journal Articles

Splenic Mechanisms of Thrombocytopenia

John W. Semple, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): SCI-33.
https://doi.org/10.1182/blood.V130.Suppl_1.SCI-33.SCI-33
Published: 2017
Journal Articles

Erythrocyte-Specific Antibodies As a Potential New Therapeutic Modality in Autoimmune and Inflammatory Disorders Beyond Immune Thrombocytopenia (ITP)

Andrew R Crow, BRT, Rick Kapur, MDPhDMSc, Mark Jen, MSc, Patrick J Mott, MSc, Danielle Marjoram, MSc, Alaa Amash, PhD, Simrat S Kahlon, BSc, Issaka Yougbare, PhD, Heyu Ni, MD MSc, PhD, Michael Kim, BSc, John W Semple, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 231.
https://doi.org/10.1182/blood.V130.Suppl_1.231.231
Published: 2017
Journal Articles

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

Rick Kapur, Michael Kim, Rukhsana Aslam, Mark J. McVey, Arata Tabuchi, Alice Luo, Jonathan Liu, Yuan Li, Shanjeevan Shanmugabhavananthan, Edwin R. Speck, Anne Zufferey, George Yousef, Haibo Zhang, Matthew T. Rondina, Andrew S. Weyrich, Leendert Porcelijn, Wolfgang M. Kuebler, Arthur S. Slutsky, John W. Semple
Journal: Blood
Blood (2017) 129 (18): 2557–2569.
https://doi.org/10.1182/blood-2016-12-758185
Published: 2017
Includes: Supplemental data