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Journal Articles

Snake Venom Botrocetin Induces GPIb-Independent Platelet Aggregation

Chuanbin Shen, Daniel Mackeigan, Guangheng Zhu, Miguel A. D. Neves, Wenjing Ma, Eric Cerenzia, Heyu Ni

Blood (2021) 138 (Supplement 1): 4203.

https://doi.org/10.1182/blood-2021-152314

Published: 2021

Journal Articles

Thiol Isomerase Activity of β 3 Integrin Psi Domain and L33P Polymorphism: Implications in Blood Coagulation and Anti-Thrombotic Therapy

Eric Gaetano Cerenzia, Tyler W. Stratton, Daniel Mackeigan, Zhenze Liu, Guangheng Zhu, Xi Lei, Preeti Bhoria, Heyu Ni

Blood (2021) 138 (Supplement 1): 1052.

https://doi.org/10.1182/blood-2021-151294

Published: 2021

Journal Articles

Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fcγ receptor inhibition

Peter A. A. Norris, Gurleen Kaur, Ramsha Khan, Guangheng Zhu, Heyu Ni, Alan H. Lazarus

Blood (2021) 137 (15): 2114–2124.

https://doi.org/10.1182/blood.2020009497

Published: 2021

Includes: Supplemental data

Journal Articles

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Tyler W. Stratton, MSc, Guangheng Zhu, MD, Yiming Wang, MD PhD, Pingguo Chen, PhD, Miguel A. D. Neves, PhD MSc, Reid C. Gallant, MSc, Peter A. A. Norris, BSc, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2018) 132 (Supplement 1): 1246.

https://doi.org/10.1182/blood-2018-99-119964

Published: 2018

Journal Articles

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

Miao Xu, June Li, Miguel Antonio Dias Neves, Guangheng Zhu, Naadiya Carrim, Ruoying Yu, Sahil Gupta, John Marshall, Ori Rotstein, Jun Peng, Ming Hou, Shinji Kunishima, Jerry Ware, Donald R. Branch, Alan H. Lazarus, Zaverio M. Ruggeri, John Freedman, Heyu Ni

Blood (2018) 132 (6): 622–634.

https://doi.org/10.1182/blood-2017-12-820779

Published: 2018

Includes: Supplemental data

Journal Articles

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets

M. Edward Quach, Matthew A. Dragovich, Wenchun Chen, Anum K. Syed, Wenpeng Cao, Xin Liang, Wei Deng, Simon F. De Meyer, Guangheng Zhu, Jun Peng, Heyu Ni, Carolyn M. Bennett, Ming Hou, Jerry Ware, Hans Deckmyn, X. Frank Zhang, Renhao Li

Blood (2018) 131 (7): 787–796.

https://doi.org/10.1182/blood-2017-05-784975

Published: 2018

Includes: Supplemental data

Journal Articles

Antibodies Against Macrophage CD44 Protect Platelets from FcγR-Mediated Phagocytosis: A Potential Mechanism for CD44 Antibody Amelioration of Murine Immune Thrombocytopenia

Peter A A Norris, BSc, Yawen Wang, MD, Guangheng Zhu, MD, Lin Wang, MD, Ming Huo, MD, Gregory D Fairn, PhD, Heyu Ni, MD MSc, PhD, Alan H Lazarus, PhD

Blood (2017) 130 (Supplement 1): 3639.

https://doi.org/10.1182/blood.V130.Suppl_1.3639.3639

Published: 2017

Journal Articles

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

Blood (2017) 129 (13): 1840–1854.

https://doi.org/10.1182/blood-2016-07-729400

Published: 2017

Includes: Supplemental data

Journal Articles

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Miao Xu, MSc, MD, Li Ma, PhD, Naadiya Carrim, PhD, Issaka Yougbare, PhD, June Li, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 12.

https://doi.org/10.1182/blood.V126.23.12.12

Published: 2015

Journal Articles

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

Issaka Yougbare, PhD, Tai Wei-she, Bsc, Darko Zdravic, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Howard Leong-Poi, MD, Qu Dawei, PhD, X. Lisa Yu, MD, S. Adamson Lee, PhD, John Sled, PhD, Freedman John, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 2254.

https://doi.org/10.1182/blood.V126.23.2254.2254

Published: 2015

Journal Articles

CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Li Ma, Elisa Simpson, June Li, Min Xuan, Miao Xu, Laura Baker, Yan Shi, Issaka Yougbaré, Xiaozhong Wang, Guangheng Zhu, Pingguo Chen, Gerald J. Prud’homme, Alan H. Lazarus, John Freedman, Heyu Ni

Blood (2015) 126 (2): 247–256.

https://doi.org/10.1182/blood-2015-03-635417

Published: 2015

Includes: Supplemental data

Journal Articles

Response to TPO-Receptor Agonists: Role of Immature Platelet Fraction and Anti-GP1b

Alexandra Kruse, Alexa M. Sughroue, Patrick Morrissey, Claudia Tchatchouang, M.A., Guangheng Zhu, MD, Marina Izak, MD, Heyu Ni, MD PhD, James B. Bussel, MD

Blood (2014) 124 (21): 4190.

https://doi.org/10.1182/blood.V124.21.4190.4190

Published: 2014

Journal Articles

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Blood (2014) 124 (21): 2772.

https://doi.org/10.1182/blood.V124.21.2772.2772

Published: 2014

Journal Articles

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Li Ma, PhD, Elisa K. Simpson, MSc., June Li, MSc, Min Xuan, PhD, Miao Xu, MSc, MD, Laura Baker, BSc., Yan Shi, MD, Guangheng Zhu, MD, Pingguo Chen, MD PhD, Alan H Lazarus, PhD, John J. Freedman, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 576.

https://doi.org/10.1182/blood.V124.21.576.576

Published: 2014

Journal Articles

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Blood (2014) 124 (21): 92.

https://doi.org/10.1182/blood.V124.21.92.92

Published: 2014

Journal Articles

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

June Li, MSc, Dianne Evertdina van der Wal, PhD, Guangheng Zhu, MD, Miao Xu, MSc, MD, Issaka Yougbare, PhD, Li Ma, PhD, Brian Vadasz, BSc, Renata Grozovsky, PhD, Min Ruan, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, Lili Tao, MD, Zhi-min Zhai, MD, Jun Peng, MD, Ming Hou, MD, Valery Leytin, PhD, John J. Freedman, MD, Karin M Hoffmeister, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 467.

https://doi.org/10.1182/blood.V124.21.467.467

Published: 2014

Journal Articles

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Li Ma, Elisa K. Simpson, H.B.Sc., June Li, BSc, Guangheng Zhu, MD, Pingguo Chen, PhD, John W. Semple, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 1076.

https://doi.org/10.1182/blood.V122.21.1076.1076

Published: 2013

Journal Articles

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Brian Vadasz, BSc, Pingguo Chen, PhD, Yougbare Issaka, PhD, Guangheng Zhu, MD, Frampton Jonathan, Ph.D, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 2314.

https://doi.org/10.1182/blood.V122.21.2314.2314

Published: 2013

Journal Articles

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Guangheng Zhu, MD, Pingguo Chen, PhD, Adili Reheman, MD, June Li, BSc, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 382.

https://doi.org/10.1182/blood.V120.21.382.382

Published: 2012

Journal Articles

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Dianne E. van Der Wal, PhD, Guangheng Zhu, MD, June Li, BSc, Brian Vadasz, BSc, Yougbare Issaka, PhD, Sean Lang, MSc, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 265.

https://doi.org/10.1182/blood.V120.21.265.265

Published: 2012

NARROW

Snake Venom Botrocetin Induces GPIb-Independent Platelet Aggregation

Thiol Isomerase Activity of β 3 Integrin Psi Domain and L33P Polymorphism: Implications in Blood Coagulation and Anti-Thrombotic Therapy

Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fcγ receptor inhibition

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets

Antibodies Against Macrophage CD44 Protect Platelets from FcγR-Mediated Phagocytosis: A Potential Mechanism for CD44 Antibody Amelioration of Murine Immune Thrombocytopenia

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Response to TPO-Receptor Agonists: Role of Immature Platelet Fraction and Anti-GP1b

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

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American Society of Hematology

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American Society of Hematology

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