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Journal Articles

Crebbp Inhibition Potentiates JAK2 Inhibition in Post-MPN Acute Myeloid Leukemia

Kalay Bertulfo, Hannah Miller, Ryan Najac, Juan Carlos Castelan, Cindy Ma, Koen Debackere, Wenbin Xiao, Raajit Rampal, Ross L Levine, Chao Lu, Adolfo A. Ferrando, Teresa Palomero

Blood (2024) 144 (Supplement 1): 823.

https://doi.org/10.1182/blood-2024-201988

Published: 2024

Journal Articles

Therapeutic Targeting of JAK/STAT Signaling and Histone Acetyltransferase Activity in Post-Myeloproliferative Neoplasm Secondary AML

Kalay Bertulfo, Koen Debackere, Hannah Miller, Ryan Najac, Cindy Ma, Adolfo A. Ferrando, Teresa Palomero

Blood (2023) 142 (Supplement 1): 2792.

https://doi.org/10.1182/blood-2023-181099

Published: 2023

Journal Articles

Role of the S1P Signaling Pathway in the Pathogenesis of Angioimmunoblastic T-Cell Lymphoma

Wen-Hsuan Wendy Lin, Jose Rodriguez Cortes, Mick Aitken, Clara Reglero, Anouchka Laurent, Anisha Cooke, Laura Belver, Govind Bhagat, Raul Rabadan, Adolfo A. Ferrando, Teresa Palomero

Blood (2023) 142 (Supplement 1): 526.

https://doi.org/10.1182/blood-2023-174090

Published: 2023

Journal Articles

Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair

Silvia Alvarez, Ana C. da Silva Almeida, Robert Albero, Mayukh Biswas, Angelica Barreto-Galvez, Thomas S. Gunning, Anam Shaikh, Tomas Aparicio, Agnieszka Wendorff, Erich Piovan, Pieter Van Vlierberghe, Steven Gygi, Jean Gautier, Advaitha Madireddy, Adolfo A. Ferrando

Blood (2022) 139 (23): 3418–3429.

https://doi.org/10.1182/blood.2021014103

Published: 2022

Includes: Supplemental data

Journal Articles

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Mateusz Antoszewski, Nadine Fournier, Gustavo A. Ruiz Buendía, Joao Lourenco, Yuanlong Liu, Tara Sugrue, Christelle Dubey, Marianne Nkosi, Colin E.J. Pritchard, Ivo J. Huijbers, Gabriela C. Segat, Sandra Alonso-Moreno, Elisabeth Serracanta, Laura Belver, Adolfo A. Ferrando, Giovanni Ciriello, Andrew P. Weng, Ute Koch, Freddy Radtke

Blood (2022) 139 (16): 2483–2498.

https://doi.org/10.1182/blood.2021012077

Published: 2022

Includes: Supplemental data

Journal Articles

Expression of Vav1-Myo1F Fusion Affects T-Cell Differentiation and Induces T-Cell Lymphoma

Jose Rodriguez Cortes, PhD, Robert Albero Gallego, PhD, Ioan Filip, PhD, Juan Angel Patino, PhD, Anisha Cooke, Wen-Hsuan Lin, Anouchka P Laurent, Bobby B Shih, Aidan Quinn, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD, Teresa Palomero, PhD

Blood (2020) 136 (Supplement 1): 4.

https://doi.org/10.1182/blood-2020-136081

Published: 2020

Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 20.

https://doi.org/10.1182/blood-2020-139305

Published: 2020

Journal Articles

Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia

Malwine J. Barz, Jana Hof, Stefanie Groeneveld-Krentz, Jui Wan Loh, Annabell Szymansky, Kathy Astrahantseff, Arend von Stackelberg, Hossein Khiabanian, Adolfo A. Ferrando, Cornelia Eckert, Renate Kirschner-Schwabe

Blood (2020) 135 (12): 921–933.

https://doi.org/10.1182/blood.2019002499

Published: 2020

Includes: Supplemental data

Journal Articles

Role of Vav1 Genomic Alterations in T-Cell Differentiation and Transformation in Peripheral T-Cell Lymphoma

Jose Rodriguez Cortes, PhD, Anisha R. Cooke, Aidan Quinn, Ioan Filip, PhD, Juan Angel Patino, PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD, Teresa Palomero, PhD

Blood (2019) 134 (Supplement_1): 1482.

https://doi.org/10.1182/blood-2019-129438

Published: 2019

Journal Articles

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Blood (2019) 134 (Supplement_1): 806.

https://doi.org/10.1182/blood-2019-128930

Published: 2019

Journal Articles

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Blood (2018) 132 (Supplement 1): 4020.

https://doi.org/10.1182/blood-2018-99-117310

Published: 2018

Journal Articles

Role of Rhoa G17V in Cell Migration and Transformation in Angioimmunoblastic T-Cell Lymphoma

Teresa Palomero, PhD, Jose R. Cortes, PhD, Anisha R. Cooke, Laura Belver, PhD, Govind Bhagat, Adolfo A. Ferrando, MD PhD

Blood (2018) 132 (Supplement 1): 4122.

https://doi.org/10.1182/blood-2018-99-115005

Published: 2018

Journal Articles

Suppression of GATA3 Binding Drives Selective Abrogation of NOTCH1-MYC Enhancer Activity By Nucleosome Invasion in Thymocyte Development and Leukemia

Laura Belver, PhD, Alexander Y Yang, Daniel Herranz, PharmD, Aidan Quinn, Francesco G Brundu, PhD, Pablo Perez-Duran, PhD, Silvia Alvarez, PhD, Devya Gurung, Pedro P Rocha, PhD, Ramya Raviram, PhD, Marissa Rashkovan, PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD

Blood (2018) 132 (Supplement 1): 545.

https://doi.org/10.1182/blood-2018-99-119423

Published: 2018

Journal Articles

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Blood (2017) 130 (Supplement 1): 858.

https://doi.org/10.1182/blood.V130.Suppl_1.858.858

Published: 2017

Journal Articles

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Farhad Forouhar, Zachary Carpenter, PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Liang Tong, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 715.

https://doi.org/10.1182/blood.V130.Suppl_1.715.715

Published: 2017

Journal Articles

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Koichi Oshima, MD PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Maria Luisa Sulis, MD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Maddalena Paganin, PhD, Giuseppe Basso, MD, Julie M. Gastier-Foster, PhD, Mignon L. Loh, MD, Renate Kirschner-Schwabe, PhD, Chioma Madubata, Raul Rabadan, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 2602.

https://doi.org/10.1182/blood.V130.Suppl_1.2602.2602

Published: 2017

Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD

Blood (2017) 130 (Supplement 1): 1208.

https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208

Published: 2017

Journal Articles

Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia

Blood (2016) 128 (22): 4068.

https://doi.org/10.1182/blood.V128.22.4068.4068

Published: 2016

Journal Articles

Mitochondrial Complex I Inhibition with Iacs-010759 in T-ALL Preclinical Models

Natalia Baran, PhD, Jennifer Molina, PhD, Antonio Cavazos, MS, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason Gay, MS, Sujan Piya, PhD, Sriram Shanmuga Velandy, MS, Elias J. Jabbour, MD, Michael Andreeff, MD PhD, Stefano Tiziani, PhD, Adolfo A. Ferrando, MD PhD, Patrick Zweidler-McKay, MD PhD, M. Emilia Di Francesco, PhD, Joseph R. Marszalek, PhD, Marina Konopleva, MD PhD

Blood (2016) 128 (22): 4028.

https://doi.org/10.1182/blood.V128.22.4028.4028

Published: 2016

Journal Articles

Role and Mechanisms of Rhoa G17V in the Pathogenesis of AITL

Jose R Cortes, PhD, Alberto Ambesi-Impiombato, MD PhD, Lucile Couronne, Christine S Kim, Zachary West, Laura Belver, PhD, Ana Carolina da Silva Almeida, PhD, Govind Bhagat, MD MBBS, Olivier A. Bernard, PhD, Adolfo A. Ferrando, MD PhD, Teresa Palomero, PhD

Blood (2016) 128 (22): 608.

https://doi.org/10.1182/blood.V128.22.608.608

Published: 2016

NARROW

Crebbp Inhibition Potentiates JAK2 Inhibition in Post-MPN Acute Myeloid Leukemia

Therapeutic Targeting of JAK/STAT Signaling and Histone Acetyltransferase Activity in Post-Myeloproliferative Neoplasm Secondary AML

Role of the S1P Signaling Pathway in the Pathogenesis of Angioimmunoblastic T-Cell Lymphoma

Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Expression of Vav1-Myo1F Fusion Affects T-Cell Differentiation and Induces T-Cell Lymphoma

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia

Role of Vav1 Genomic Alterations in T-Cell Differentiation and Transformation in Peripheral T-Cell Lymphoma

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Role of Rhoa G17V in Cell Migration and Transformation in Angioimmunoblastic T-Cell Lymphoma

Suppression of GATA3 Binding Drives Selective Abrogation of NOTCH1-MYC Enhancer Activity By Nucleosome Invasion in Thymocyte Development and Leukemia

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia

Mitochondrial Complex I Inhibition with Iacs-010759 in T-ALL Preclinical Models

Role and Mechanisms of Rhoa G17V in the Pathogenesis of AITL

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American Society of Hematology

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American Society of Hematology

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