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Journal Articles

PAI-1 Mediates the Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support Hematopoietic Stem and Progenitor Cell Expansion during the Initial Stages of Infection

Katherine Hampton, Jayna J Mistry, Rebecca S Maynard, Alyssa Nicole Polski-Delve, Dominic Fowler-Shorten, Charlotte Hellmich, Naiara Beraza, Kristian Bowles, Stuart A Rushworth

Blood (2024) 144 (Supplement 1): 5662.

https://doi.org/10.1182/blood-2024-209758

Published: 2024

Journal Articles

Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging

Kira A. Young, Maria A. Telpoukhovskaia, Johanna Hofmann, Jayna J. Mistry, Konstantinos D. Kokkaliaris, Jennifer J. Trowbridge

Blood (2024) 144 (4): 378–391.

https://doi.org/10.1182/blood.2024024275

Published: 2024

Includes: Supplemental data

Journal Articles

Bone Marrow Microenvironment and Hematopoietic Cell Types Are Differentially Affected By Transcriptomic Quality Control Filtering Metrics in Single Cell Data

Maria A. Telpoukhovskaia, Kira A. Young, Jayna J. Mistry, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 5621.

https://doi.org/10.1182/blood-2023-181867

Published: 2023

Journal Articles

Reduction in Lymphoid-Supporting Factors By Mesenchymal Stromal Cells Drives Myeloid-Biased Hematopoiesis at Middle Age

Kira A. Young, Maria A. Telpoukhovskaia, Johanna Hofmann, Konstantinos D. Kokkaliaris, Jayna J. Mistry, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 2701.

https://doi.org/10.1182/blood-2023-181924

Published: 2023

Journal Articles

Dnmt3a -Mutant Haematopoietic Stem and Progenitor Cells Induce Mesenchymal Stromal Cell Senescence through the Production of Alarmins S100A8/A9

Jayna J. Mistry, Kira A. Young, Patricia Colom Diaz, Ines Fernandez Maestre, Ross L Levine, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 1331.

https://doi.org/10.1182/blood-2023-181888

Published: 2023

Journal Articles

Hematopoietic stem cell aging and leukemia transformation

Patricia A. Colom Díaz, Jayna J. Mistry, Jennifer J. Trowbridge

Blood (2023) 142 (6): 533–542.

https://doi.org/10.1182/blood.2022017933

Published: 2023

Journal Articles

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Aisha Jibril, Charlotte Hellmich, Edyta E. Wojtowicz, Katherine Hampton, Rebecca Maynard, Ravindu De Silva, Dominic J. Fowler-Shorten, Jayna J. Mistry, Jamie A. Moore, Kristian M. Bowles, Stuart A. Rushworth

Blood (2023) 141 (25): 3065–3077.

https://doi.org/10.1182/blood.2022018711

Published: 2023

Includes: Supplemental data

Journal Articles

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Rebecca S Maynard, Katherine Hampton, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 856.

https://doi.org/10.1182/blood-2022-158523

Published: 2022

Journal Articles

Bone Marrow Stromal Cell Senescence Induced By Dnmt3a -Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia

Jayna J Mistry, Kira A Young, Jennifer J Trowbridge

Blood (2022) 140 (Supplement 1): 1265.

https://doi.org/10.1182/blood-2022-169485

Published: 2022

Journal Articles

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Charlotte Hellmich, Edyta Wojtowicz, Rebecca S Maynard, Katherine Hampton, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Charlotte L Utting, Iain Macauley, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 8580–8581.

https://doi.org/10.1182/blood-2022-158264

Published: 2022

Journal Articles

Metallothionein 1 (MT1) Is Selectively Required for DNMT3A;NPM1 -Mutant Acute Myeloid Leukemia Proliferation

Patricia A. Colom Diaz, Chih-Hsing Chou, Jayna J Mistry, Nathan Salomonis, Mohammad Daud Khan, H. Leighton Grimes, Jennifer J Trowbridge

Blood (2022) 140 (Supplement 1): 9103–9104.

https://doi.org/10.1182/blood-2022-163355

Published: 2022

Journal Articles

Robust Mitochondrial Metabolism Provides a Fitness Advantage to Dnmt3a -Mutant Hematopoietic Stem Cells in the Context of Aging

Kira A Young, Jayna J Mistry, James Chavez, Eric Pietras, Jennifer J Trowbridge

Blood (2022) 140 (Supplement 1): 2866–2867.

https://doi.org/10.1182/blood-2022-163707

Published: 2022

Journal Articles

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Jamie A Moore, Jayna J Mistry, Charlotte Hellmich, Rebecca H Horton, Edyta Wojtowicz, Aisha Jibril, Tom Wileman, Matthew Jefferson, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 3441.

https://doi.org/10.1182/blood-2021-152778

Published: 2021

Journal Articles

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Stuart A Rushworth, Kristian M Bowles, Victoria Willimott

Blood (2021) 138 (Supplement 1): 2654.

https://doi.org/10.1182/blood-2021-149191

Published: 2021

Journal Articles

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Charlotte Hellmich, Jayna J Mistry, Aisha Jibril, Jamie A Moore, Benjamin B Johnson, James G W Smith, Edyta Wojtowicz, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 1097.

https://doi.org/10.1182/blood-2021-148405

Published: 2021

Journal Articles

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Charlotte Hellmich, MBBChir, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-140311

Published: 2020

Journal Articles

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Aisha Jibril, BSc, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Victoria Willimott, MB BS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-139811

Published: 2020

Journal Articles

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Jayna J Mistry, BSc, Charlotte Hellmich, Amelia Lambert, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Angela Collins, MBBS, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 10.

https://doi.org/10.1182/blood-2020-139527

Published: 2020

Journal Articles

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, Aisha Jibril, BSc, Iain Macauley, PhD BSc, Mar Moreno-Gonzalez, Federica Di Palma, PhD, Naiara Beraza, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-139454

Published: 2020

Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 2490.

https://doi.org/10.1182/blood-2019-128241

Published: 2019

NARROW

PAI-1 Mediates the Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support Hematopoietic Stem and Progenitor Cell Expansion during the Initial Stages of Infection

Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging

Bone Marrow Microenvironment and Hematopoietic Cell Types Are Differentially Affected By Transcriptomic Quality Control Filtering Metrics in Single Cell Data

Reduction in Lymphoid-Supporting Factors By Mesenchymal Stromal Cells Drives Myeloid-Biased Hematopoiesis at Middle Age

Dnmt3a -Mutant Haematopoietic Stem and Progenitor Cells Induce Mesenchymal Stromal Cell Senescence through the Production of Alarmins S100A8/A9

Hematopoietic stem cell aging and leukemia transformation

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Bone Marrow Stromal Cell Senescence Induced By Dnmt3a -Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Metallothionein 1 (MT1) Is Selectively Required for DNMT3A;NPM1 -Mutant Acute Myeloid Leukemia Proliferation

Robust Mitochondrial Metabolism Provides a Fitness Advantage to Dnmt3a -Mutant Hematopoietic Stem Cells in the Context of Aging

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

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American Society of Hematology

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ASH Publications

American Society of Hematology

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