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Kristian M Bowles
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Journal Articles

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Aisha Jibril, Charlotte Hellmich, Edyta E. Wojtowicz, Katherine Hampton, Rebecca Maynard, Ravindu De Silva, Dominic J. Fowler-Shorten, Jayna J. Mistry, Jamie A. Moore, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2023) 141 (25): 3065–3077.
https://doi.org/10.1182/blood.2022018711
Published: 2023
Includes: Supplemental data
Journal Articles

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Rebecca S Maynard, Katherine Hampton, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 856.
https://doi.org/10.1182/blood-2022-158523
Published: 2022
Journal Articles

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

Katherine Hampton, Charlotte Hellmich, Rebecca S Maynard, Jamie A Moore, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 5759.
https://doi.org/10.1182/blood-2022-169240
Published: 2022
Journal Articles

Sting Agonists Activate Bone Marrow Macrophages and Synergise with Anti-CD47 Blockade Improving Survival in Animal Models of Acute Myeloid Leukemia

Rebecca S Maynard, Charlotte Hellmich, Katherine Hampton, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 9096.
https://doi.org/10.1182/blood-2022-157935
Published: 2022
Journal Articles

Extended Intensified Post-ASCT Consolidation with Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (Dara-VRd) for Ultra-High Risk (UHiR) Newly Diagnosed Myeloma (NDMM) and Primary Plasma Cell Leukemia (pPCL): The UK Optimum/Muknine Trial

Martin F. Kaiser, Andrew Hall, Isabelle Smith, Ruth M. de Tute, Sadie Roberts, Emma Ingleson, Kristian M Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Richard S. Houlston, Graham Jackson, Gordon Cook, Guy Pratt, Mark T Drayson, Roger G Owen, Sarah R Brown, Matthew W Jenner
Journal: Blood
Blood (2022) 140 (Supplement 1): 1833–1835.
https://doi.org/10.1182/blood-2022-159540
Published: 2022
Journal Articles

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Charlotte Hellmich, Edyta Wojtowicz, Rebecca S Maynard, Katherine Hampton, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Charlotte L Utting, Iain Macauley, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 8580–8581.
https://doi.org/10.1182/blood-2022-158264
Published: 2022
Journal Articles

Daratumumab, Cyclophosphamide, Bortezomib, Lenalidomide, Dexamethasone (Dara-CVRd), V-Augmented Autologous Stem Cell Transplant (V-ASCT) and Dara-Vrd Consolidation in Ultra-High Risk (UHiR) Newly Diagnosed Myeloma (NDMM) and Primary Plasma Cell Leukemia (pPCL) Compared with Myeloma XI/XI+ Trial Treatment for Uhir MM: The UK Optimum/Muknine Trial

Martin F. Kaiser, Andrew Hall, Katrina Walker, Nicola Newnham, Ruth M. de Tute, Sadie Roberts, Emma Ingleson, Kristian M Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Graham Jackson, Gordon Cook, Guy Pratt, Roger G Owen, Mark T Drayson, Sarah R Brown, Matthew W Jenner
Journal: Blood
Blood (2021) 138 (Supplement 1): 465.
https://doi.org/10.1182/blood-2021-144990
Published: 2021
Journal Articles

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Jamie A Moore, Jayna J Mistry, Charlotte Hellmich, Rebecca H Horton, Edyta Wojtowicz, Aisha Jibril, Tom Wileman, Matthew Jefferson, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2021) 138 (Supplement 1): 3441.
https://doi.org/10.1182/blood-2021-152778
Published: 2021
Journal Articles

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Stuart A Rushworth, Kristian M Bowles, Victoria Willimott
Journal: Blood
Blood (2021) 138 (Supplement 1): 2654.
https://doi.org/10.1182/blood-2021-149191
Published: 2021
Journal Articles

Response to COVID-19 Vaccines in Patients Receiving Intensified Post-ASCT Therapy with Daratumumab, Lenalidomide, Bortezomib (Dara-VR) Due to Ultra-High Risk (UHiR) Newly Diagnosed Myeloma (NDMM) or Primary Plasma Cell Leukemia (pPCL): Exploratory Analysis of the UK Optimum/Muknine Trial

Matthew W Jenner, Andrew Hall, Sian E Faustini, Alexandra Pitchford, Ruth M. de Tute, Sadie Roberts, Emma Ingleson, Kristian M Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Graham Jackson, Guy Pratt, Gordon Cook, Roger G Owen, Sarah R Brown, Mark T Drayson, Martin F. Kaiser
Journal: Blood
Blood (2021) 138 (Supplement 1): 2699.
https://doi.org/10.1182/blood-2021-149268
Published: 2021
Journal Articles

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Charlotte Hellmich, Jayna J Mistry, Aisha Jibril, Jamie A Moore, Benjamin B Johnson, James G W Smith, Edyta Wojtowicz, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2021) 138 (Supplement 1): 1097.
https://doi.org/10.1182/blood-2021-148405
Published: 2021
Journal Articles

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Charlotte Hellmich, MBBChir, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-140311
Published: 2020
Journal Articles

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Aisha Jibril, BSc, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Victoria Willimott, MB BS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-139811
Published: 2020
Journal Articles

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Jayna J Mistry, BSc, Charlotte Hellmich, Amelia Lambert, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Angela Collins, MBBS, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10.
https://doi.org/10.1182/blood-2020-139527
Published: 2020
Journal Articles

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, Aisha Jibril, BSc, Iain Macauley, PhD BSc, Mar Moreno-Gonzalez, Federica Di Palma, PhD, Naiara Beraza, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-139454
Published: 2020
Journal Articles

Real-World Data of High-Grade Lymphoma Patients Treated with CD19 CAR-T in England

Andrea Kuhnl, Claire Roddie, PhD MD, Nuria Martinez-Cibrian, Tobias F Menne, MD PhD FRCPath, Kim Linton, MBChB PhD, Sanne Lugthart, Sridhar Chaganti, MDPhDMRCP,FRCPath, Robin Sanderson, MRCP,FRCPath, Maria A V Marzolini, Jane Norman, MD, Wendy Osborne, MD, John Radford, Stephen Robinson, MBBS, PhD BSc, Ram Malladi, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Maeve A O'Reilly, MBBCHBAO, Muhammad Saif, MD, Geoff Shenton, Adrian Bloor, FRCPath, Clare J Rowntree, MBBS, PhD FRCP, FRCPath, David A. Irvine, BSc, MBBChir, MRCP, FRCPath, PhD, Orla Stewart, Arzhang Ardavan, Kate Robinson, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Kristian M Bowles, MBBS, PhD, Graham P. Collins, MA, MBBS, MRCP, FRCPath, DPhil, Rod Johnson, Andrew K McMillan, FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 767.
https://doi.org/10.1182/blood-2019-124177
Published: 2019
Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2490.
https://doi.org/10.1182/blood-2019-128241
Published: 2019
Journal Articles

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Yu Sun, BSc, MSc, PhD, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Anna Haestier, Cesar A. Gomez, MD PhD FRCPath, Christopher J Morris, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 689.
https://doi.org/10.1182/blood-2019-128268
Published: 2019
Journal Articles

Free Fatty Acid Uptake By Hematopoietic Stem and Progenitor Cells Drives Immune Cell Expansion in Response to Salmonella Typhimurium infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Naiara Beraza, PhD, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1197.
https://doi.org/10.1182/blood-2019-128237
Published: 2019
Journal Articles

Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment

Jayna J Mistry, BSc, Charlotte Hellmich, MBBChir, Jamie A Moore, BSc, MSc, Christopher R Marlein, PhD, Genevra Pillinger, MB BS, Angela Collins, MBBS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1385.
https://doi.org/10.1182/blood-2019-128592
Published: 2019