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Journal Articles

Multiple Myeloma Induced IL-6 Reprograms Lipid Metabolism through a CD36 Dependent Mechanism

Martha Ehikioya, Annalisa Altera, Katherine Hampton, Rebecca S Maynard, Dominic Fowler-Shorten, Charlotte Hellmich, Kristian Bowles, Matthew Markham, Ravindu De Silva, Stuart Rushworth
Journal: Blood
Blood (2023) 142 (Supplement 1): 6566.
https://doi.org/10.1182/blood-2023-177900
Published: 2023
Journal Articles

Sphingomyelinase Regulates the Release of Protumoral Mitochondria Containing-Vesicles from AML Cells

Matthew Markham, David Riley, Rebecca S Maynard, Katherine Hampton, Ravindu De Silva, Charlotte Hellmich, Kristian Bowles, Stuart Rushworth
Journal: Blood
Blood (2023) 142 (Supplement 1): 4337.
https://doi.org/10.1182/blood-2023-186059
Published: 2023
Journal Articles

The Aging Bone Marrow Niche Disrupts Glutamine Metabolism By Upregulating HSC Derived Glutamine Synthetase

Charlotte Hellmich, Edyta E Wojtowicz, Dominic Fowler-Shorten, Rebecca S Maynard, Katherine Hampton, Iain Macaulay, Kristian Bowles, Stuart Rushworth
Journal: Blood
Blood (2023) 142 (Supplement 1): 1304.
https://doi.org/10.1182/blood-2023-180194
Published: 2023
Journal Articles

Acute Myeloid Leukemia Driven IL-3 Dependent Upregulation of BCL-2 in Non-Malignant Hematopoietic Progenitor Cells Increases Venetoclax Induced Cytopenias

Dominic Fowler-Shorten, Rebecca S Maynard, Katherine Hampton, Martha Ehikioya, Edyta E Wojtowicz, Kristian Bowles, Stuart Rushworth, Charlotte Hellmich
Journal: Blood
Blood (2023) 142 (Supplement 1): 293.
https://doi.org/10.1182/blood-2023-173835
Published: 2023
Journal Articles

IL-6 Mediates a Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support HSC Expansion during Infection

Katherine Hampton, Jayna Mistry, Rebecca S Maynard, Dominic Fowler-Shorten, Charlotte Hellmich, Naiara Beraza, Kristian Bowles, Stuart Rushworth
Journal: Blood
Blood (2023) 142 (Supplement 1): 1332.
https://doi.org/10.1182/blood-2023-178618
Published: 2023
Journal Articles

Sting Activation in Bone Marrow Macrophages Targets AML Blasts for Phagocytosis in an ICAM-1 Dependent Mechanism

Ravindu De Silva, Matthew Markham, Rebecca S Maynard, Katherine Hampton, Charlotte Hellmich, Dominic Fowler-Shorten, Kristian Bowles, Stuart Rushworth
Journal: Blood
Blood (2023) 142 (Supplement 1): 1597.
https://doi.org/10.1182/blood-2023-185880
Published: 2023
Journal Articles

AML Inhibits Lipid Uptake By the Liver through an HGF/c-MET Dependent Mechanism Which Results in an Increased Supply of Free Fatty Acid to the Tumor

Rebecca S Maynard, Charlotte Hellmich, Katherine Hampton, Dominic Fowler-Shorten, Matthew Markham, Annalisa Altera, Thomas Flint, Ravindu De Silva, Naiara Beraza, Kristian Bowles, Stuart Rushworth
Journal: Blood
Blood (2023) 142 (Supplement 1): 6031.
https://doi.org/10.1182/blood-2023-178574
Published: 2023
Journal Articles

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Aisha Jibril, Charlotte Hellmich, Edyta E. Wojtowicz, Katherine Hampton, Rebecca Maynard, Ravindu De Silva, Dominic J. Fowler-Shorten, Jayna J. Mistry, Jamie A. Moore, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2023) 141 (25): 3065–3077.
https://doi.org/10.1182/blood.2022018711
Published: 2023
Includes: Supplemental data
Journal Articles

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

Katherine Hampton, Charlotte Hellmich, Rebecca S Maynard, Jamie A Moore, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 5759.
https://doi.org/10.1182/blood-2022-169240
Published: 2022
Journal Articles

Sting Agonists Activate Bone Marrow Macrophages and Synergise with Anti-CD47 Blockade Improving Survival in Animal Models of Acute Myeloid Leukemia

Rebecca S Maynard, Charlotte Hellmich, Katherine Hampton, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 9096.
https://doi.org/10.1182/blood-2022-157935
Published: 2022
Journal Articles

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Charlotte Hellmich, Edyta Wojtowicz, Rebecca S Maynard, Katherine Hampton, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Charlotte L Utting, Iain Macauley, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 8580–8581.
https://doi.org/10.1182/blood-2022-158264
Published: 2022
Journal Articles

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Rebecca S Maynard, Katherine Hampton, Kristian M Bowles, Stuart A Rushworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 856.
https://doi.org/10.1182/blood-2022-158523
Published: 2022