Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 40

Sort by

Sort Order Select

Journal Articles

The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

Diego A. Pereira-Martins, Vincent Van Den Boom, Isabel Weinhaeuser, Nisha van der Meer, Prodromos Chatzikyriakou, Noortje van Dijk, Xuesen Zheng, Lucio H Pinheiro, Douglas RA Silveira, Thiago Mantello Bianco, César Alexander Ortiz Rojas, Eduardo M. Rego, Stuart A Rushworth, Antonio R. Lucena-Araujo, Lynn Quek, Gerwin Huls, Jan Jacob Schuringa

Blood (2024) 144 (Supplement 1): 4321.

https://doi.org/10.1182/blood-2024-207421

Published: 2024

Journal Articles

Plinabulin and Selumetinib Enhance M1 Macrophage Traits and Trigger Cell Death in AML

Lucio Henrique Pinheiro, Isabel Weinhäuser, Diego A. Pereira-Martins, Luise Araujo De Albuquerque Simoes, Matthew Markham, Lynn Quek, Gerwin Huls, Jan Jacob Schuringa, Stuart A Rushworth, Eduardo M. Rego

Blood (2024) 144 (Supplement 1): 2775.

https://doi.org/10.1182/blood-2024-208800

Published: 2024

Journal Articles

Age-Associated Macrophage Polarization to an M2 Phenotype Drives Myeloma Proliferation in the Aged Bone Marrow By Loss of Tumor-Associated Phagocytosis

Dominic James Fowler-Shorten, Charlotte Hellmich, Annalisa Altera, Rebecca S Maynard, Katherine Hampton, Matthew Markham, Alyssa Nicole Polski-Delve, Kristian Bowles, Stuart A Rushworth

Blood (2024) 144 (Supplement 1): 1893.

https://doi.org/10.1182/blood-2024-194721

Published: 2024

Journal Articles

Repolarisation of M2 Macrophages Via Cgas-Sting Activation Enhances Phagocytosis of Acute Myeloid Leukaemia

Matthew Markham, Rebecca S Maynard, George Bell, Katherine Hampton, Dominic James Fowler-Shorten, Alyssa Nicole Polski-Delve, Annalisa Altera, Rosie Taylor, Charlotte Hellmich, Kristian Bowles, Stuart A Rushworth

Blood (2024) 144 (Supplement 1): 4113.

https://doi.org/10.1182/blood-2024-205265

Published: 2024

Journal Articles

Acute Myeloid Leukemia Induces an Increased Senescent Phenotype in the Large Intestine Which Protects Barrier Function and Reduces Leakiness

Katherine Hampton, Alyssa Nicole Polski-Delve, Rebecca S Maynard, Kristian Bowles, Naiara Beraza, Stuart A Rushworth

Blood (2024) 144 (Supplement 1): 6125.

https://doi.org/10.1182/blood-2024-209897

Published: 2024

Journal Articles

PAI-1 Mediates the Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support Hematopoietic Stem and Progenitor Cell Expansion during the Initial Stages of Infection

Katherine Hampton, Jayna J Mistry, Rebecca S Maynard, Alyssa Nicole Polski-Delve, Dominic Fowler-Shorten, Charlotte Hellmich, Naiara Beraza, Kristian Bowles, Stuart A Rushworth

Blood (2024) 144 (Supplement 1): 5662.

https://doi.org/10.1182/blood-2024-209758

Published: 2024

Journal Articles

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Aisha Jibril, Charlotte Hellmich, Edyta E. Wojtowicz, Katherine Hampton, Rebecca Maynard, Ravindu De Silva, Dominic J. Fowler-Shorten, Jayna J. Mistry, Jamie A. Moore, Kristian M. Bowles, Stuart A. Rushworth

Blood (2023) 141 (25): 3065–3077.

https://doi.org/10.1182/blood.2022018711

Published: 2023

Includes: Supplemental data

Journal Articles

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Charlotte Hellmich, Edyta Wojtowicz, Rebecca S Maynard, Katherine Hampton, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Charlotte L Utting, Iain Macauley, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 8580–8581.

https://doi.org/10.1182/blood-2022-158264

Published: 2022

Journal Articles

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

Katherine Hampton, Charlotte Hellmich, Rebecca S Maynard, Jamie A Moore, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 5759.

https://doi.org/10.1182/blood-2022-169240

Published: 2022

Journal Articles

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Rebecca S Maynard, Katherine Hampton, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 856.

https://doi.org/10.1182/blood-2022-158523

Published: 2022

Journal Articles

Sting Agonists Activate Bone Marrow Macrophages and Synergise with Anti-CD47 Blockade Improving Survival in Animal Models of Acute Myeloid Leukemia

Rebecca S Maynard, Charlotte Hellmich, Katherine Hampton, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 9096.

https://doi.org/10.1182/blood-2022-157935

Published: 2022

Journal Articles

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Stuart A Rushworth, Kristian M Bowles, Victoria Willimott

Blood (2021) 138 (Supplement 1): 2654.

https://doi.org/10.1182/blood-2021-149191

Published: 2021

Journal Articles

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Jamie A Moore, Jayna J Mistry, Charlotte Hellmich, Rebecca H Horton, Edyta Wojtowicz, Aisha Jibril, Tom Wileman, Matthew Jefferson, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 3441.

https://doi.org/10.1182/blood-2021-152778

Published: 2021

Journal Articles

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Charlotte Hellmich, Jayna J Mistry, Aisha Jibril, Jamie A Moore, Benjamin B Johnson, James G W Smith, Edyta Wojtowicz, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 1097.

https://doi.org/10.1182/blood-2021-148405

Published: 2021

Journal Articles

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, Aisha Jibril, BSc, Iain Macauley, PhD BSc, Mar Moreno-Gonzalez, Federica Di Palma, PhD, Naiara Beraza, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-139454

Published: 2020

Journal Articles

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Jayna J Mistry, BSc, Charlotte Hellmich, Amelia Lambert, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Angela Collins, MBBS, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 10.

https://doi.org/10.1182/blood-2020-139527

Published: 2020

Journal Articles

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Aisha Jibril, BSc, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Victoria Willimott, MB BS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-139811

Published: 2020

Journal Articles

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Charlotte Hellmich, MBBChir, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-140311

Published: 2020

Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 2490.

https://doi.org/10.1182/blood-2019-128241

Published: 2019

Journal Articles

Diffuse Large B Cell Lymphoma (DLBCL)-Released NM23-H1 Promotes Monocyte Survival and Inflammatory Cytokine Release: A Mechanistic Link between the Dual Impacts of NM23-H1 Expression and Reduced Lymphocyte:Monocyte Ratio in DLBCL Prognosis

Sandro Trova, PhD, Maiss Al-Amere, PhD, Jayna J Mistry, BSc, Zuhal Eraslan, Bader Alhazmi, Joy Harris-Folb, Alessandro Di Maio, Mark T Drayson, MB ChB, PhD FRCPath, Christopher M Bunce, BSc, Stuart A Rushworth, PhD, Farhat Latif Khanim, PhD

Blood (2019) 134 (Supplement_1): 2803.

https://doi.org/10.1182/blood-2019-130889

Published: 2019

NARROW

The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

Plinabulin and Selumetinib Enhance M1 Macrophage Traits and Trigger Cell Death in AML

Age-Associated Macrophage Polarization to an M2 Phenotype Drives Myeloma Proliferation in the Aged Bone Marrow By Loss of Tumor-Associated Phagocytosis

Repolarisation of M2 Macrophages Via Cgas-Sting Activation Enhances Phagocytosis of Acute Myeloid Leukaemia

Acute Myeloid Leukemia Induces an Increased Senescent Phenotype in the Large Intestine Which Protects Barrier Function and Reduces Leakiness

PAI-1 Mediates the Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support Hematopoietic Stem and Progenitor Cell Expansion during the Initial Stages of Infection

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Sting Agonists Activate Bone Marrow Macrophages and Synergise with Anti-CD47 Blockade Improving Survival in Animal Models of Acute Myeloid Leukemia

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Diffuse Large B Cell Lymphoma (DLBCL)-Released NM23-H1 Promotes Monocyte Survival and Inflammatory Cytokine Release: A Mechanistic Link between the Dual Impacts of NM23-H1 Expression and Reduced Lymphocyte:Monocyte Ratio in DLBCL Prognosis

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only