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Journal Articles

High Leukemic Stem Cell Frequency in FLT3-Mutated Acute Myeloid Leukemia Patients with Normal Karyotype: Implications for Prognosis

Camila Araújo Bernardino Garcia, Leticia Olops Marini, Mariana Medeiros, Amanda Fernandes Oliveira Costa, Maria Isabel Ayrosa, Katia B Pagnano, Elenaide Nunes, Ana Beatriz F Gloria, Priscila Santos Scheucher, Josiane Lillian Schiavinato, Eduardo M. Rego, Fabiola Traina, Lorena Lobo Figueiredo-Pontes

Blood (2024) 144 (Supplement 1): 6147.

https://doi.org/10.1182/blood-2024-209775

Published: 2024

Journal Articles

MLL5-Driven Leukemic Transformation Is Linked to Chromatin Remodeling and Can be Targeted with ATRA in Combination with PARP1 Inhibition

Luise Araujo De Albuquerque Simoes, Isabel Weinhäuser, Diego A Pereira-Martins, Luciana Yamamoto Almeida, Vincent Van Den Boom, Fatemeh Mojallali, Dominique Sternadt, Prodromos Chatzikyriakou, Xuesen Zheng, César Alexander Ortiz Rojas, Ghulam Jeelani Mufti, Lucio Henrique Pinheiro, Lynn Quek, Gerwin A. Huls, Eduardo M. Rego, Jan Jacob Schuringa

Blood (2024) 144 (Supplement 1): 1539.

https://doi.org/10.1182/blood-2024-209817

Published: 2024

Journal Articles

Challenges in Predicting Thromboembolic Risk in Acute Leukemia: Clinical Profiling and Limitations of Current Scoring Systems

Luisa V. Carvalho, José Vanildo R. de Oliveira, Raphael B. Melo, Fernanda R. Mendes, Cynthia Rothschild, Elvira D. R. P. Velloso, Vanderson Rocha, Eduardo M. Rego, Fernanda A. Orsi, Wellington F. Silva

Blood (2024) 144 (Supplement 1): 2639.

https://doi.org/10.1182/blood-2024-209072

Published: 2024

Journal Articles

Disparities in Clinical Outcomes in Patients with Newly Diagnosed Acute Myeloid Leukemia Treated in Public Versus Private Services in Brazil: Analysis of the Brazilian Acute Myeloid Leukemia Registry

Luiza Perruso, Abel Costa Neto, Wellington F. Silva, Marina Nascimento, Yana S Rabelo, Ederson Roberto Mattos, Fernanda R. Mendes, Juliana Martins, Verena Pfister, Maria Daniela Holthausen Perico, Carlos Chiattone, Eduardo M. Rego

Blood (2024) 144 (Supplement 1): 5181.

https://doi.org/10.1182/blood-2024-212321

Published: 2024

Journal Articles

Plinabulin and Selumetinib Enhance M1 Macrophage Traits and Trigger Cell Death in AML

Lucio Henrique Pinheiro, Isabel Weinhäuser, Diego A. Pereira-Martins, Luise Araujo De Albuquerque Simoes, Matthew Markham, Lynn Quek, Gerwin Huls, Jan Jacob Schuringa, Stuart A Rushworth, Eduardo M. Rego

Blood (2024) 144 (Supplement 1): 2775.

https://doi.org/10.1182/blood-2024-208800

Published: 2024

Journal Articles

The Oncogenic ΔNp73α Isoform Contributes to Aggressiveness in APL By Leading to ATRA Resistance through NANOG/BMP4 Axis Upregulation

César Alexander Ortiz Rojas, Diego A. Pereira-Martins, Carol Thomé, Germano Ferreira, Thiago Mantello Bianco, Isabel Weinhäuser, Cleide Lúcia Araújo Silva, Lorena Pontes, Vitor Faça, Emanuele Ammatuna, Gerwin Huls, Jan Jacob Schuringa, Eduardo M. Rego

Blood (2024) 144 (Supplement 1): 1350.

https://doi.org/10.1182/blood-2024-205613

Published: 2024

Journal Articles

The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

Diego A. Pereira-Martins, Vincent Van Den Boom, Isabel Weinhaeuser, Nisha van der Meer, Prodromos Chatzikyriakou, Noortje van Dijk, Xuesen Zheng, Lucio H Pinheiro, Douglas RA Silveira, Thiago Mantello Bianco, César Alexander Ortiz Rojas, Eduardo M. Rego, Stuart A Rushworth, Antonio R. Lucena-Araujo, Lynn Quek, Gerwin Huls, Jan Jacob Schuringa

Blood (2024) 144 (Supplement 1): 4321.

https://doi.org/10.1182/blood-2024-207421

Published: 2024

Journal Articles

Impact of Ph-like Gene Signatures on Clinical Outcomes in Adult B-ALL Patients in Resource-Constrained Settings

Keli Lima, César Alexander Ortiz Rojas, Frederico Lisboa Nogueira, Wellington F. Silva, Rita de Cássia Cavaglieri Medeiros, Luciana Nardinelli, Aline de Medeiros Leal, Elvira D. R. P. Velloso, Israel Bendit, Alvaro J Alencar, Charles G. Mullighan, João Agostinho Machado-Neto, Eduardo M. Rego

Blood (2024) 144 (Supplement 1): 2802.

https://doi.org/10.1182/blood-2024-208763

Published: 2024

Journal Articles

Clinical networking results in continuous improvement of the outcome of patients with acute promyelocytic leukemia

Blood (2024) 144 (12): 1257–1270.

https://doi.org/10.1182/blood.2024023890

Published: 2024

Includes: Supplemental data

Journal Articles

M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment

Isabel Weinhaeuser, Diego Pereira-Martins, Luciana Yamamoto de Almeida, Jacobien R Hilberink, Douglas RA Silveira, Lynn Quek, César Alexander Ortiz, Antonio R. Lucena-Araujo, Nienke Visser, Emanuele Ammatuna, Gerwin A. Huls, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 1259–1260.

https://doi.org/10.1182/blood-2022-165130

Published: 2022

Journal Articles

Functional Drug Screen Identifies Thiostrepton, NAMPT Inhibitors and Metformin As Potential Candidates to Target the Macrophage Tumor Microenvironment in Acute Myeloid Leukemia

Isabel Weinhaeuser, Diego Pereira-Martins, Jacobien R Hilberink, Emanuele Ammatuna, Gerwin A. Huls, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 8793–8794.

https://doi.org/10.1182/blood-2022-165115

Published: 2022

Journal Articles

High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia

Diego Pereira-Martins, Noortje van Dijk, Isabel Weinhaeuser, Douglas RA Silveira, Juan Coelho Da Silva, Thiago M Bianco, César Alexander Ortiz, Fabiola Traina, Lorena L Figueiredo-Pontes, Emanuele Ammatuna, Lynn Quek, Gerwin A. Huls, Antonio R. Lucena-Araujo, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 6265–6266.

https://doi.org/10.1182/blood-2022-165151

Published: 2022

Journal Articles

Patterns and Prognostic Impact of CNS Infiltration in Adults with Newly Diagnosed Acute Lymphoblastic Leukemia

Luiza Lapolla Perruso, Elvira Velloso, Vanderson Rocha, Eduardo M Rego, Wellington F Silva

Blood (2022) 140 (Supplement 1): 11862–11863.

https://doi.org/10.1182/blood-2022-155823

Published: 2022

Journal Articles

Ezrin Is a Potential Druggable Target in Chronic Lymphocytic Leukemia

Jean Carlos Lipreri Da Silva, Felipe Saldanha-Araujo, Raphael Costa Bandeira de Melo, Hugo Passos Vicari, Amandda Évelin Silva De Carvalho, Eduardo M Rego, Valeria Buccheri, João Agostinho Machado-Neto

Blood (2022) 140 (Supplement 1): 12359–12360.

https://doi.org/10.1182/blood-2022-160267

Published: 2022

Journal Articles

Dysregulated Activating and Inhibitory Receptors on Natural Killer Cells Predicts Immune Escape and Poor Outcomes in Acute Myeloid Leukemia

Amanda F O Costa, Valeriya Kuznetsova, Leticia O Marani, Izabela A Lopes, Larissa S Binelli, Priscila S Scheucher, Josiane L Schiavinato, Joana T B Faria, Maria Isabel A Madeira, Katia B Pagnano, Bruno K Duarte, Ana Beatriz F Gloria, Eduardo M Rego, Fabiola Traina, Robert Welner, Lorena L Figueiredo-Pontes

Blood (2022) 140 (Supplement 1): 9113–9114.

https://doi.org/10.1182/blood-2022-168178

Published: 2022

Journal Articles

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Keli Lima, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Juan L Coelho-Silva, Giovana da Silva Leandro, Isabel Weinhäuser, Rita de Cassia Cavaglieri, Wellington F Silva, Aline Medeiros Leal, Ana Paula Alencar de Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger, Jacobien R Hilberink, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo M Rego

Blood (2022) 140 (Supplement 1): 5965–5966.

https://doi.org/10.1182/blood-2022-165172

Published: 2022

Journal Articles

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

Natasha Peixoto Fonseca, Bruna Alves Fenerich, Diego A Pereira-Martins, Pedro Manoel Marques Garibaldi, Juan L Coelho-Silva, Antonio Bruno Alves Silva, Jaqueline Cristina Fernandes, Cleide Lucia Silva, Eduardo M Rego, João Agostinho Machado-Neto, Fabiola Traina

Blood (2022) 140 (Supplement 1): 12153–12154.

https://doi.org/10.1182/blood-2022-167392

Published: 2022

Journal Articles

Outpatient Administration of High-Dose Methotrexate for Leukemia and Lymphoma in Adults without Drug Monitoring: Risk Factors for Acute Kidney Injury

Camila Alves da Silva, Juliana Pereira, Eduardo M Rego, Vanderson Rocha, Wellington F Silva

Blood (2022) 140 (Supplement 1): 8032–8033.

https://doi.org/10.1182/blood-2022-160366

Published: 2022

Journal Articles

Dietary methionine starvation impairs acute myeloid leukemia progression

Blood (2022) 140 (19): 2037–2052.

https://doi.org/10.1182/blood.2022017575

Published: 2022

Includes: Supplemental data

Journal Articles

IGF1R-IRS1/2 Pharmacological Inhibitors Act By Distinct Cellular and Molecular Mechanisms and Reveals Vulnerabilities for Treatment of Acute Myeloid Leukemia

Juan L Coelho-Silva, Diego A Pereira-Martins, Virginia Campos Silvestrini, João Agostinho Machado-Neto, Eduardo M Rego, Marcus Smolka, Vitor Marcel Faca, Fabiola Traina

Blood (2021) 138 (Supplement 1): 1869.

https://doi.org/10.1182/blood-2021-153105

Published: 2021

NARROW

High Leukemic Stem Cell Frequency in FLT3-Mutated Acute Myeloid Leukemia Patients with Normal Karyotype: Implications for Prognosis

MLL5-Driven Leukemic Transformation Is Linked to Chromatin Remodeling and Can be Targeted with ATRA in Combination with PARP1 Inhibition

Challenges in Predicting Thromboembolic Risk in Acute Leukemia: Clinical Profiling and Limitations of Current Scoring Systems

Disparities in Clinical Outcomes in Patients with Newly Diagnosed Acute Myeloid Leukemia Treated in Public Versus Private Services in Brazil: Analysis of the Brazilian Acute Myeloid Leukemia Registry

Plinabulin and Selumetinib Enhance M1 Macrophage Traits and Trigger Cell Death in AML

The Oncogenic ΔNp73α Isoform Contributes to Aggressiveness in APL By Leading to ATRA Resistance through NANOG/BMP4 Axis Upregulation

The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

Impact of Ph-like Gene Signatures on Clinical Outcomes in Adult B-ALL Patients in Resource-Constrained Settings

Clinical networking results in continuous improvement of the outcome of patients with acute promyelocytic leukemia

M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment

Functional Drug Screen Identifies Thiostrepton, NAMPT Inhibitors and Metformin As Potential Candidates to Target the Macrophage Tumor Microenvironment in Acute Myeloid Leukemia

High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia

Patterns and Prognostic Impact of CNS Infiltration in Adults with Newly Diagnosed Acute Lymphoblastic Leukemia

Ezrin Is a Potential Druggable Target in Chronic Lymphocytic Leukemia

Dysregulated Activating and Inhibitory Receptors on Natural Killer Cells Predicts Immune Escape and Poor Outcomes in Acute Myeloid Leukemia

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

Outpatient Administration of High-Dose Methotrexate for Leukemia and Lymphoma in Adults without Drug Monitoring: Risk Factors for Acute Kidney Injury

Dietary methionine starvation impairs acute myeloid leukemia progression

IGF1R-IRS1/2 Pharmacological Inhibitors Act By Distinct Cellular and Molecular Mechanisms and Reveals Vulnerabilities for Treatment of Acute Myeloid Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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