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Journal Articles

Cephalochromin-Induced Mitochondrial Damage Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia Models

Mariane Cristina Do Nascimento, Diego A Pereira-Martins, Guilherme Augusto Sousa Alcântara, Keli Lima, Hugo Passos Vicari, Marcelo José Pena Ferreira, Leticia Veras Costa-Lotufo, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego
Journal: Blood
Blood (2023) 142 (Supplement 1): 5751.
https://doi.org/10.1182/blood-2023-189814
Published: 2023
Journal Articles

Potency and Efficacy of Pharmacological PIP4K2 Inhibitors in Acute Lymphoblastic Leukemia

Keli Lima, Maria Fernanda Lopes Carvalho, Diego A. Pereira-Martins, Wellington F Silva, Mariane Cristina do Nascimento, Lívia Bassani Lins de Miranda, Rita de Cássia Cavaglieri Medeiros, Luciana Nardinelli, Aline de Medeiros Leal, Elvira Deolinda Rodrigues Pereira Velloso, Israel Bendit, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego
Journal: Blood
Blood (2023) 142 (Supplement 1): 5786.
https://doi.org/10.1182/blood-2023-189786
Published: 2023
Journal Articles

Identification of Vulnerabilities for Pharmacological Inhibition of PIP4K2s in Acute Myeloid Leukemia

Keli Lima, Maria Fernanda Lopes Carvalho, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Mariane Cristina do Nascimento, Frederico Lisboa Nogueira, Rita de Cássia Cavaglieri Medeiros, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego
Journal: Blood
Blood (2023) 142 (Supplement 1): 5774.
https://doi.org/10.1182/blood-2023-189998
Published: 2023
Journal Articles

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Keli Lima, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Juan L Coelho-Silva, Giovana da Silva Leandro, Isabel Weinhäuser, Rita de Cassia Cavaglieri, Wellington F Silva, Aline Medeiros Leal, Ana Paula Alencar de Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger, Jacobien R Hilberink, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo M Rego
Journal: Blood
Blood (2022) 140 (Supplement 1): 5965–5966.
https://doi.org/10.1182/blood-2022-165172
Published: 2022