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Shanna M. Hogeling
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Journal Articles

Preclinical efficacy of potent and selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias

Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V. Wenge, Hong Yue, Jevon A. Cutler, Cyrus Jin, Florian Perner, Shanna M. Hogeling, Paul L Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A. Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P Edwards, Glenn S. Cowley, Robert Kirkpatrick, Ruth Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E. Christine Pietsch, David Matthew Wilson, Ricardo M Attar, Yusri A Elsayed, Eric S Fischer, Jan Jacob Schuringa, Scott A. Armstrong, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood blood.2023022480.
https://doi.org/10.1182/blood.2023022480
Published: 2024
Includes: Supplemental data
Journal Articles

Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia

Min Chul Kwon, Olivier Querolle, Xuedong Dai, Jan Willem Thuring, Tinne Verhulst, Ann Marien, Dries Goffin, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Karin Verstraeten, Sara El Ashkar, Shanna M Hogeling, Frank Jacob, Petra Vinken, Nicolas Darville, Vineet Pande, Daniel Krosky, Gregor Urbanietz, Bie Verbist, Lucille A. Ferrante, Christina Diane Drenberg, David Wilson, Ricardo M. Attar, Jan Jacob Schuringa, Nikki Daskalakis, Kathryn Packman, Christine Pietsch, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2022) 140 (Supplement 1): 5928–5929.
https://doi.org/10.1182/blood-2022-168921
Published: 2022
Journal Articles

Functional and Molecular Characterisation of Prospectively Isolated Subclones in Individual AML Patients Reveals Distinct Gene Regulatory Networks Linked to Targetable Metabolic Vulnerabilities

Shanna M Hogeling, Roos Houtsma, Nisha K Van Der Meer, Salam A. Assi, Paulynn Chin, Alan Cunningham, Peter Keane, Dominique Sternadt Alexandre Ramos, Lieve Oudejans, Gerwin A. Huls, Constance Bonifer, Jan Jacob Schuringa
Journal: Blood
Blood (2022) 140 (Supplement 1): 5844–5845.
https://doi.org/10.1182/blood-2022-159999
Published: 2022
Journal Articles

Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2 -Mutant Acute Myeloid Leukemia

Dominique Sternadt, Diego Pereira-Martins, Douglas RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Isabel Weinhaeuser, Shanna M Hogeling, Emanuele Ammatuna, Gerwin A. Huls, Lynn Quek, Jan Jacob Schuringa
Journal: Blood
Blood (2022) 140 (Supplement 1): 8813–8814.
https://doi.org/10.1182/blood-2022-163282
Published: 2022
Journal Articles

Dietary methionine starvation impairs acute myeloid leukemia progression

Alan Cunningham, Ayşegül Erdem, Islam Alshamleh, Marjan Geugien, Maurien Pruis, Diego Antonio Pereira-Martins, Fiona A. J. van den Heuvel, Albertus T. J. Wierenga, Hilde ten Berge, Robin Dennebos, Vincent van den Boom, Shanna M. Hogeling, Isabel Weinhäuser, Ruth Knops, Pim de Blaauw, M. Rebecca Heiner-Fokkema, Carolien Woolthuis, Ulrich L. Günther, Eduardo M. Rego, Joost H. A. Martens, Joop H. Jansen, Harald Schwalbe, Gerwin Huls, Jan Jacob Schuringa
Journal: Blood
Blood (2022) 140 (19): 2037–2052.
https://doi.org/10.1182/blood.2022017575
Published: 2022
Includes: Supplemental data
Journal Articles

Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo

Isabel Weinhäuser, Diego A Pereira-Martins, Jacobien R Hilberink, Luciana Yamamoto Almeida, Douglas RA Silveira, Lynn Quek, Shanna M Hogeling, Jose Mauricio Mota, Emanuele Ammatuna, Antonio R. Lucena-Araujo, Gerwin A. Huls, Jan Jacob Schuringa, Eduardo M Rego
Journal: Blood
Blood (2021) 138 (Supplement 1): 3472.
https://doi.org/10.1182/blood-2021-150699
Published: 2021