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Ulrike Philippar
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Journal Articles

JNJ-87801493 (CD20xCD28), a Potential First-in-Class CD20 Targeted CD28 Costimulatory Bispecific Antibody, Enhances the Activity of B-Cell Targeting T-Cell Engagers in Preclinical Models

Lorena Fontan, Adam Zwolak, Irene Guimerans-Lorenzo, Mariette Bekkers, Nicholas Hein, Nele Vloemans, Emanuele Trella, Tina Smets, Ivo Cornelissen, Alemu Assefa, Bie Verbist, Ricardo Amorim, Pankaj Seth, Ranjeet Prasad Dash, Leopoldo Luistro, Bethany Mattson, Matthew A. Dragovich, Michael Hedvat, Gregory L. Moore, John R. Desjarlais, Olivia Kutlu, Joseph Erhardt, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (Supplement 1): 1408.
https://doi.org/10.1182/blood-2024-200666
Published: 2024
Journal Articles

Discovery of JNJ-89853413, a First-in-Class CD33xVδ2 T-Cell Engager for the Treatment of Acute Myeloid Leukemia

Sara El Ashkar, Lorena Kallal, Kavita Raman, Ranjeet Prasad Dash, Nirav Shah, Lore Delbroek, Lénárd Kertész, Heleen Van Acker, Steffie Junius, Ivo Cornelissen, Surendar Arumugam, Lauren Gerloff, Kathryn Bradford, E. Christine Pietsch, Leopoldo Luistro, Bethany Mattson, Christina Guttke, Karim Safer, Janine Arts, Sonal Patel, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (Supplement 1): 2054.
https://doi.org/10.1182/blood-2024-203248
Published: 2024
Journal Articles

CRISPR/Cas9 Library Screens Identified Atp2a2 As an In Vivo Specific Tumor Suppressor in Myeloid Neoplasms

Ruka Shimura, Moe Tamura, Keita Yamamoto, Kohei Iida, Shuhei Asada, Emi Sugimoto, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo M. Attar, Ulrike Philippar, Satoshi Yamasaki, Taisei Hirouchi, Kaoru Uchimaru, Toshio Kitamura, Susumu Goyama
Journal: Blood
Blood (2024) 144 (Supplement 1): 949.
https://doi.org/10.1182/blood-2024-206816
Published: 2024
Journal Articles

Phase 1b Study of Menin-KMT2A Inhibitor Bleximenib in Combination with Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia with KMT2Ar or NPM1 Alterations

Christian Recher, Jenny O'Nions, Ibrahim Aldoss, Ana Alfonso Pierola, Alicia Allred, Juan Manuel Alonso-Dominguez, Laura Barreyro, Pierre Bories, Martin Curtis, Nikki Daskalakis, Matteo Giovanni Della Porta, Hartmut Döhner, Amber D'Souza, James P. Dugan, Jordi Esteve Reyner, Matthew Exum, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Stan Gaj, Sylvain Garciaz, Ana Garrido, Sara Garrido Paniagua, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Madlen Jentzsch, Hagop M. Kantarjian, Marina Konopleva, Jan Krönke, Min Chul Kwon, Christina Loefgren, Oliver Lomas, Valentina Mancini, Ioannis Mantzaris, Giovanni Martinelli, Daniel Morillo Giles, Joseph Murphy, Kathryn Packman, Cristina Papayannidis, Ulrike Philippar, Uwe Platzbecker, Sravanti Rangaraju, Christoph Röllig, Olga Salamero, Madhu Sanga, Tim Sauer, Emma Searle, Natalia Tovar, Trevor Tucker, Nicolas Vallet, Lachlin Vaughan, Gala Vega, Paresh Vyas, Andrew Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 215.
https://doi.org/10.1182/blood-2024-207072
Published: 2024
Journal Articles

Bleximenib Dose Optimization and Determination of RP2D from a Phase 1 Study in Relapsed/Refractory Acute Leukemia Patients with KMT2A and NPM1 Alterations

Emma Searle, Christian Recher, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Pierola, Juan M. Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Stan Gaj, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Hagop M. Kantarjian, Min Chul Kwon, Anita J Kumar, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Olga Salamero, Madhu Sanga, Prathap Nagaraja Shastri, Richard M. Stone, Peter Tan, Trevor Tucker, Paresh Vyas, Sylvain Garciaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 212.
https://doi.org/10.1182/blood-2024-207106
Published: 2024
Journal Articles

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A - and NPM1 -altered leukemias

Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V. Wenge, Hong Yue, Jevon A. Cutler, Cyrus Jin, Florian Perner, Shanna M. Hogeling, Paul L. Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A. Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P. Edwards, Glenn S. Cowley, Robert Kirkpatrick, Ruth Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E. Christine Pietsch, David M. Wilson, Ricardo Attar, Yusri Elsayed, Eric S. Fischer, Jan Jacob Schuringa, Scott A. Armstrong, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (11): 1206–1220.
https://doi.org/10.1182/blood.2023022480
Published: 2024
Includes: Supplemental data
Journal Articles

A First-in-Human Phase 1 Study of the Menin-KMT2A (MLL1) Inhibitor JNJ-75276617 in Adult Patients with Relapsed/Refractory Acute Leukemia Harboring KMT2A or NPM1 Alterations

Elias Jabbour, Emma Searle, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Piérola, Juan Manuel Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Sylvain Garciaz, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Min Chul Kwon, Jonathan Miller, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Christian Recher, Olga Salamero, Madhu Sanga, Richard M Stone, Peter Tan, Jan Willem Thuring, Trevor Tucker, Paresh Vyas
Journal: Blood
Blood (2023) 142 (Supplement 1): 57.
https://doi.org/10.1182/blood-2023-172422
Published: 2023
Journal Articles

Discovery of a Novel, First-in-Class Bfl-1 BH3 Mimetic with Pro-Apoptotic Activity

Maarten Derks, Marian C. Bryan, Cindy Rockx, Tamara Schults, Tinne Verhulst, Beth Pietrak, Tatsuya Maehigashi, James C. Robertson, Andrew H. DeMaria, Kimberly Holt, Shaofei Ji, Victoria Wong, Ruud Bueters, Seong Joo Koo, Stefan Masure, Balpreet Bhogal, Christopher B. Kelly, Kaushik Mitra, Leopoldo Luistro, Paul L. Shaffer, Lawrence Szewczuk, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 2824.
https://doi.org/10.1182/blood-2023-188516
Published: 2023
Journal Articles

Characterization of JNJ-79635322, a Novel BCMAxGPRC5DxCD3 T-Cell Redirecting Trispecific Antibody, for the Treatment of Multiple Myeloma

Ram Pillarisetti, Danlin Yang, Jianhong Yao, Melissa Smith, Leopoldo Luistro, Peter Vulfson, James Testa, Jr., Kathryn Packman, Scott Brodeur, Ricardo M. Attar, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 456.
https://doi.org/10.1182/blood-2023-174941
Published: 2023
Journal Articles

Discovery of JNJ-88549968, a Novel, First-in-Class CALRmutxCD3 T-Cell Redirecting Antibody for the Treatment of Myeloproliferative Neoplasms

Anna Kuchnio, Elsie Samakai, Eva Hug, Meritxell Balmaña, Lut Janssen, Ricardo Amorim, Ivo Cornelissen, Andrea Majoros, Michaël Broux, Isha Taneja, Vince Torti, Azra Agic, Stefan Moritsch, Filippo Benedetti, Felix Rosebrock, Kathryn Packman, Janine Arts, Sonal Patel, Oliver Christopher Lomas, M. Phillip Deyoung, Oleh Zagrijtschuk, Yusri Elsayed, Stefan Constantinescu, Robert Kralovics, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 1777.
https://doi.org/10.1182/blood-2023-173430
Published: 2023
Journal Articles

SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML

Yu-Hsuan Chang, Keita Yamamoto, Takeshi Fujino, Teh-Wei Wang, Emi Sugimoto, Wenyu Zhang, Tomohiro Yabushita, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo M. Attar, Ulrike Philippar, Yutaka Enomoto, Yoichi Imai, Toshio Kitamura, Susumu Goyama
Journal: Blood
Blood (2023) 142 (Supplement 1): 713.
https://doi.org/10.1182/blood-2023-177531
Published: 2023
Journal Articles

Preclinical Efficacy of the Menin-KMT2A Inhibitor JNJ-75276617 in Combination with Venetoclax and Azacitidine in AML

Min Chul Kwon, Tinne Verhulst, Dries Goffin, Ann Marien, Bie Verbist, Christina Guttke, Jan Willem Thuring, Lucille Ferrante, Nikki Daskalakis, E. Christine Pietsch, Yusri Elsayed, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 4167.
https://doi.org/10.1182/blood-2023-186204
Published: 2023
Journal Articles

Characterization of JNJ-80948543, a Novel CD79bxCD20xCD3 Trispecific T-Cell Redirecting Antibody for the Treatment of B-Cell Non-Hodgkin Lymphoma

Anna Kuchnio, Danlin Yang, Nele Vloemans, Cassandra Lowenstein, Ivo Cornelissen, Ricardo Amorim, Chao Han, Siddharth Sukumaran, Lut Janssen, Toon Suls, Mariette Bekkers, Elena Lasorsa, Lorena Fontana, Nicole Medeiros, Bingyuan Wu, Jun Chen, Michael Feldkamp, Sheng-Jiun Wu, Habtom Habte, John Krayer, Cam Holland, M. Phillip Deyoung, Yusri A Elsayed, Ulrike Philippar
Journal: Blood
Blood (2022) 140 (Supplement 1): 3105–3106.
https://doi.org/10.1182/blood-2022-168739
Published: 2022
Journal Articles

Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia

Min Chul Kwon, Olivier Querolle, Xuedong Dai, Jan Willem Thuring, Tinne Verhulst, Ann Marien, Dries Goffin, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Karin Verstraeten, Sara El Ashkar, Shanna M Hogeling, Frank Jacob, Petra Vinken, Nicolas Darville, Vineet Pande, Daniel Krosky, Gregor Urbanietz, Bie Verbist, Lucille A. Ferrante, Christina Diane Drenberg, David Wilson, Ricardo M. Attar, Jan Jacob Schuringa, Nikki Daskalakis, Kathryn Packman, Christine Pietsch, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2022) 140 (Supplement 1): 5928–5929.
https://doi.org/10.1182/blood-2022-168921
Published: 2022