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Journal Articles

MALT1 Degradation with a Proteolysis-Targeting Chimera for the Treatment of Activated B-Cell Type Diffuse Large B-Cell Lymphoma

Madhav R Seshadri, Lorena Fontan, Prasanna Sreevatsan, David Scott, John Hatcher, Guangyan Du, Min Xia, Ilkay Us, Nathanael Gray, Ari Melnick
Journal: Blood
Blood (2021) 138 (Supplement 1): 269.
https://doi.org/10.1182/blood-2021-153855
Published: 2021
Journal Articles

Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL

Lorena Fontan, Rebecca Goldstein, Gabriella Casalena, Matthew Durant, Matthew R. Teater, Jimmy Wilson, Jude Phillip, Min Xia, Shivem Shah, Ilkay Us, Himaly Shinglot, Ankur Singh, Giorgio Inghirami, Ari Melnick
Journal: Blood
Blood (2021) 137 (6): 788–800.
https://doi.org/10.1182/blood.2019004713
Published: 2021
Includes: Supplemental data
Journal Articles

BCL10 Gain-of-Function Mutations Aberrantly Induce Canonical and Non-Canonical NF-Kb Activation and Resistance to Ibrutinib in ABC-DLBCL

Min Xia, Liron David, PhD, Matthew Teater, PhD, Ozlem Onder, PhD MSc, Kojo S. J. Elenitoba-Johnson, MD, Lorena Fontan, PhD, Hao Wu, PhD, Ari Melnick, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-141363
Published: 2020
Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2073.
https://doi.org/10.1182/blood-2019-130666
Published: 2019
Journal Articles

The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia

Nakhle S. Saba, MD, Jade Meyers, Lorena Fontan, PhD, Ari Melnick, MD, Adrian Wiestner, MD PhD, Patricia Lobelle-Rich, Ekaterina Kim, MS, Jan A. Burger, MD PhD, Yara Mouawad, MD, Prescott L. Deininger, PhD, Francisco Socola, MD, Hana Safah, MD, Erik K Flemington, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1288.
https://doi.org/10.1182/blood-2019-131376
Published: 2019
Journal Articles

Mapping MALT1 Signaling Connectivity Unveils Novel B-Cell Feedback Mechanisms Directing Assembly of Potent Anti-Lymphoma Regimens

Lorena Fontan, PhD, Matthew Durant, Rebecca Goldstein, PhD, Matthew R Teater, PhD, Gabriella Casalena, PhD, Min Xia, PhD, Jimmy Wilson, Ilkay Us, Giorgio Inghirami, MD, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 173.
https://doi.org/10.1182/blood-2019-130516
Published: 2019
Journal Articles

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival

Xiaoqing Lu, Tharu M. Fernando, Chen Lossos, Nevin Yusufova, Fan Liu, Lorena Fontán, Matthew Durant, Huimin Geng, Jacob Melnick, Yuan Luo, Francisco Vega, Vincent Moy, Giorgio Inghirami, Stephen Nimer, Ari M. Melnick, Izidore S. Lossos
Journal: Blood
Blood (2018) 132 (19): 2026–2039.
https://doi.org/10.1182/blood-2018-02-831438
Published: 2018
Includes: Supplemental data
Journal Articles

RNA Interference Screen Implicates TNFAIP3 and FOXO1 in MALT1 Inhibition Resistance

Lorena Fontan, PhD, Rebecca Goldstein, PhD, Gabriella Casalena, PhD, Himaly Shinglot, MS, Ilkay Us, MS, Haiying Ju, MS, Yanwen Jiang, PhD, Natalia Bilchuk, MS, Ari Melnick, MD
Journal: Blood
Blood (2016) 128 (22): 837.
https://doi.org/10.1182/blood.V128.22.837.837
Published: 2016
Journal Articles

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

Nakhle S. Saba, Delong Liu, Sarah E. M. Herman, Chingiz Underbayev, Xin Tian, David Behrend, Marc A. Weniger, Martin Skarzynski, Jennifer Gyamfi, Lorena Fontan, Ari Melnick, Cliona Grant, Mark Roschewski, Alba Navarro, Sílvia Beà, Stefania Pittaluga, Kieron Dunleavy, Wyndham H. Wilson, Adrian Wiestner
Journal: Blood
Blood (2016) 128 (1): 82–92.
https://doi.org/10.1182/blood-2015-11-681460
Published: 2016
Includes: Supplemental data
Journal Articles

Downregulation of FOXP1 is required during germinal center B-cell function

Ainara Sagardoy, Jose I. Martinez-Ferrandis, Sergio Roa, Karen L. Bunting, María Angela Aznar, Olivier Elemento, Rita Shaknovich, Lorena Fontán, Vicente Fresquet, Ignacio Perez-Roger, Eloy F. Robles, Linde De Smedt, Xavier Sagaert, Ari Melnick, Jose A. Martinez-Climent
Journal: Blood
Blood (2013) 121 (21): 4311–4320.
https://doi.org/10.1182/blood-2012-10-462846
Published: 2013
Includes: Supplemental data
Journal Articles

Splenic Marginal Zone Lymphoma Shows a Distinct Pattern of DNA Copy Number Aberrations That Correlates with Tumor Characteristics and Predicts Disease Outcome.

Jose A. Martinez-Climent, MD, PhD, Cristina Robledo, MSc, Manuela Mollejo, MD, Anton Parker, MD, Juan L. Garcia, PhD, Carlos Panizo, MD, Lorena Fontan, PhD, Vicente Fresquet, PhD, Ellen D. Remstein, MD, Sara Mould, MD, Ahmet Dogan, MD, Mark Law, MD, Isabel Marugan, MD, Maria J. Terol, MD, Esperanza Vizcarra, MD, David Graham Oscier, MD, Miguel A. Piris, MD, Jose M. Hernandez-Rivas, MD
Journal: Blood
Blood (2006) 108 (11): 2422.
https://doi.org/10.1182/blood.V108.11.2422.2422
Published: 2006