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Olivier Elemento
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Journal Articles

Disrupting IL10 Signaling Overcomes Compound Copy Number Variation-Driven Clinical Resistance to CDK4/6 and BTK Inhibition in Mantle Cell Lymphoma

Maurizio Di Liberto, Yang Hu, Xiangao Huang, Giorgio Inghirami, Kevin Wang, Christina Y. Lee, Kami J. Maddocks, Kristie A. Blum, Jia Ruan, John P. Leonard, Nancy L. Bartlett, Peter Martin, Olivier Elemento, Selina Chen-Kiang
Journal: Blood
Blood (2024) 144 (Supplement 1): 831.
https://doi.org/10.1182/blood-2024-209415
Published: 2024
Journal Articles

MRD-Driven Time-Limited Therapy of Acalabrutinib and Lenalidomide Plus Rituximab (ALR) or Obinutuzumab (ALO) in Patients with Treatment-Naïve Mantle Cell Lymphoma: Phase 2 Trial Outcomes with MRD and cfDNA Analyses

Jia Ruan, David A. Bond, Bijal D Shah, John N. Allan, Sarah C. Rutherford, Caitlin Gribbin, Zhengming Chen, Brittany Hobbie, Melinda Harbhajan, Tejasvi Sahni, Wayne Tam, Bhavneet Bhinder, Michael Sigouros, Giorgio Inghirami, Selina Chen-Kiang, Olivier Elemento, Kami J. Maddocks, John P. Leonard, Peter Martin
Journal: Blood
Blood (2024) 144 (Supplement 1): 746.
https://doi.org/10.1182/blood-2024-204495
Published: 2024
Journal Articles

Molecular Features Are Associated with Disease Stage in Diffuse Large B-Cell Lymphoma and Reveal Heterogeneity in Patient Outcomes

Manik Uppal, Ashwath Gurumurthi, Paul A. Hamlin, Lorenzo Falchi, Steven Horwitz, Anita Kumar, Ariela Noy, Jennifer Kimberly Lue, Pallawi Torka, Maria E. Arcila, Ahmet Dogan, Brandon S. Imber, Joachim Yahalom, Olivier Elemento, Andrew D. Zelenetz, Gilles Salles, Erel Joffe
Journal: Blood
Blood (2024) 144 (Supplement 1): 4346.
https://doi.org/10.1182/blood-2024-198931
Published: 2024
Journal Articles

Harnessing Btki Therapy By CDK4/6i Control of T Effector Memory Cells and T Cell Surveillance in Mantle Cell Lymphoma

Maurizio Di Liberto, Yang Hu, Xiangao Huang, Giorgio Inghirami, Kevin Wang, Christina Lee, Kami J. Maddocks, Kristie A. Blum, Jia Ruan, John P. Leonard, Nancy L. Bartlett, Peter Martin, Olivier Elemento, Selina Chen-Kiang
Journal: Blood
Blood (2023) 142 (Supplement 1): 50.
https://doi.org/10.1182/blood-2023-190308
Published: 2023
Journal Articles

PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma

Shelby L. Sloan, Fiona Brown, Mackenzie Long, Christoph Weigel, Shirsha Koirala, Ji-Hyun Chung, Betsy Pray, Lynda Villagomez, Claire Hinterschied, Anuvrat Sircar, JoBeth Helmig-Mason, Alexander Prouty, Eric Brooks, Youssef Youssef, Walter Hanel, Samir Parekh, Wing Keung Chan, Zhengming Chen, Rosa Lapalombella, Lalit Sehgal, Kris Vaddi, Peggy Scherle, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E. Mason, Robert A. Baiocchi, Lapo Alinari
Journal: Blood
Blood (2023) 142 (10): 887–902.
https://doi.org/10.1182/blood.2022019419
Published: 2023
Includes: Supplemental data
Journal Articles

Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL

Clinical Trials & Observations
Jia Ruan, Alison Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Nikita Kotlov, Grigorii Nos, Maria Sorokina, Vladislav Maksimov, Andrea Sboner, Michael Sigouros, Koen van Besien, Steven Horwitz, Sarah C. Rutherford, Erin Mulvey, Maria V. Revuelta, Jenny Xiang, Alicia Alonso, Ari Melnick, Olivier Elemento, Giorgio Inghirami, John P. Leonard, Leandro Cerchietti, Peter Martin
Journal: Blood
Blood (2023) 141 (18): 2194–2205.
https://doi.org/10.1182/blood.2022018254
Published: 2023
Includes: Supplemental data
Journal Articles

Endothelial cell–leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities

Luca Vincenzo Cappelli, Danilo Fiore, Jude M. Phillip, Liron Yoffe, Filomena Di Giacomo, William Chiu, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, Jose Gabriel Barcia Duran, Nahuel Zamponi, Ari M. Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foà, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2023) 141 (5): 503–518.
https://doi.org/10.1182/blood.2022015414
Published: 2023
Includes: Supplemental data
Journal Articles

PRMT5 Inhibition Alters Mitochondrial Dynamics in Mantle Cell Lymphoma Creating Vulnerability to BH3 Mimetic Compounds

Claire Hinterschied, Fiona Brown, Janani Ravikrishnan, JoBeth Helmig-Mason, Kaylee R. Harrison, Aneeq Yasin, Shelby Sloan, Mackenzie Long, Neha Bhagwat, Kris Vaddi, Peggy Scherle, Jennifer A. Woyach, Selina Chen-Kiang, Olivier Elemento, Jihye Paik, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3118–3119.
https://doi.org/10.1182/blood-2022-167712
Published: 2022
Journal Articles

PRMT5 Inhibition Potentiates Anti-Tumor Immune Targeting of EBV-Driven B Cell Lymphoproliferative Disease

Elshafa Hassan Ahmed, Christoph Weigel, Rachel Saadey, Eric Brooks, Taylor Cash, Charlene Mao, Aneeq Yasin, Alexa Wandke, Ethan Baiocchi, Anna Mozhenkova, Fiona Brown, Shelby Sloan, JoBeth Helmig-Mason, Kaylee Harrison, Kris Vaddi, Peggy Scherle, Neha Bhagwat, Wing Keung Chan, Olivier Elemento, Christopher E Mason, Christopher C. Oakes, Robert A. Baiocchi, Polina Shindiapina
Journal: Blood
Blood (2022) 140 (Supplement 1): 3116–3117.
https://doi.org/10.1182/blood-2022-167988
Published: 2022
Journal Articles

The FOXO1 TAD -p300-Mediated Lineage Survival Transcription Program Is a Targetable Dependency of Mantle Cell Lymphoma

Ja-Young Jang, Heng Pan, Maurizio Di Liberto, Lapo Alinari, Giorgio Inghirami, Robert A. Baiocchi, Olivier Elemento, Selina Chen-Kiang, Jihye Paik
Journal: Blood
Blood (2022) 140 (Supplement 1): 1692–1693.
https://doi.org/10.1182/blood-2022-165655
Published: 2022
Journal Articles

Phase 2 Trial of Acalabrutinib-Lenalidomide-Rituximab (ALR) with Real-Time Monitoring of MRD in Patients with Treatment-Naïve Mantle Cell Lymphoma

Jia Ruan, John P. Leonard, Gui Zhen Chen, Zhengming Chen, John N. Allan, Sarah C. Rutherford, Brittany Hobbie, Katie Greig, Amelyn Rodriguez, Wayne Tam, David A. Bond, Bijal D. Shah, Kami J. Maddocks, Bhavneet Binder, Giorgio Inghirami, Olivier Elemento, Selina Chen-Kiang, Peter Martin
Journal: Blood
Blood (2022) 140 (Supplement 1): 175–177.
https://doi.org/10.1182/blood-2022-158656
Published: 2022
Journal Articles

Quantitative Cytogenetic Analysis with karyoParser Allows for More Precise Identification of Disease Biology, Clonal Evolution, and Etiology of Relapse in Acute Myeloid Leukemia

Deepika Dilip, Andriy Derkach, Kamal Menghrajani, Aaron D Goldberg, Hannah May, Virginia M. Klimek, Pallavi K Galera, Wenbin Xiao, Yanming Zhang, Olivier Elemento, Ross L. Levine, Jacob L Glass
Journal: Blood
Blood (2022) 140 (Supplement 1): 9119–9121.
https://doi.org/10.1182/blood-2022-170847
Published: 2022
Journal Articles

Combined Inhibition of CDK2 and BCL2 Overrides Resistance to Targeting BTK and CDK4/6 in Mantle Cell Lymphoma Therapy

Haya Y. Al-Ansari, Saira Bashir, Adrienne Cui, Xiangao Huang, Yang Hu, Peter Martin, Olivier Elemento, Maurizio Di Liberto, Selina Chen-Kiang
Journal: Blood
Blood (2022) 140 (Supplement 1): 495–496.
https://doi.org/10.1182/blood-2022-167307
Published: 2022
Journal Articles

The Single-Cell Pathology Landscape of Diffuse Large B Cell Lymphoma

Dylan McNally, Andrew Lytle, Hiranmayi Ravichandran, Wayne Tam, Christian Steidl, David W. Scott, Ari Melnick, Olivier Elemento
Journal: Blood
Blood (2022) 140 (Supplement 1): 162–163.
https://doi.org/10.1182/blood-2022-169912
Published: 2022
Journal Articles

FOXO1 Dependent Transcription Network Is a Targetable Vulnerability of Mantle Cell Lymphoma

Ja-Young Jang, Inah Hwang, Heng Pan, Michael Kluk, Jun Yao, Xiangao Huang, Maurizio Di Liberto, Zhengming Chen, Karla V Ballman, Lewis C Cantley, Giorgio Inghirami, Olivier Elemento, Robert Baiocchi, Selina Chen-Kiang, Sandro Belvedere, Hongwu Zheng, Jihye Paik
Journal: Blood
Blood (2021) 138 (Supplement 1): 30.
https://doi.org/10.1182/blood-2021-153378
Published: 2021
Journal Articles

A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments

Luca Vincenzo Cappelli, Danilo Fiore, Jude M Phillip, Liron Yoffe, Filomena Di Giacomo, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, José Gabriel Barcia Durán, Nahuel Zamponi, Ari Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foa, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 704.
https://doi.org/10.1182/blood-2021-153300
Published: 2021
Journal Articles

PRMT5 Inhibition Promotes FOXO1 Tumor Suppressor Activity to Drive a Pro-Apoptotic Program That Creates Vulnerability to Combination Treatment with Venetoclax in Mantle Cell Lymphoma

Fiona Brown, Inah Hwang, Shelby Sloan, Claire Hinterschied, JoBeth Helmig-Mason, Mackenzie Long, Youssef Youssef, Wing Keung Chan, Alexander Prouty, Ji Hyun Chung, Yang Zhang, Kris Vaddi, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Lalit Sehgal, Lapo Alinari, Peggy Scherle, Rosa Lapalombella, Jihye Paik, Robert Baiocchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 681.
https://doi.org/10.1182/blood-2021-153733
Published: 2021
Journal Articles

Single Cell ATAC Lineage Deconvolution Reveals Overlapping Subclones in Epigenetically Distinct AML Samples

Deepika Dilip, Richard Koche, Kamal Menghrajani, Ari Melnick, Olivier Elemento, Ross L. Levine, Jacob L Glass
Journal: Blood
Blood (2021) 138 (Supplement 1): 2381.
https://doi.org/10.1182/blood-2021-154517
Published: 2021
Journal Articles

Dynamic Immune Surveillance in Durable Clinical Response to Combined BTK and BCL2 Inhibition in MCL at Longitudinal Single-Cell Resolution

Kevin Wang, Maurizio Di Liberto, Yang Hu, Xiangao Huang, Rachel M Koldej, David Ritchie, Peter Martin, Giorgio Inghirami, Olivier Elemento, Constantine S. Tam, Selina Chen-Kiang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1323.
https://doi.org/10.1182/blood-2021-152908
Published: 2021
Journal Articles

Molecular Evolution of Classical Hodgkin Lymphoma Revealed Though Whole Genome Sequencing of Hodgkin and Reed-Sternberg Cells

Francesco Maura, Marcin Imielinski, Jenny Z Xiang, Bhavneet Binder, Kenneth Eng, Manik Uppal, Feng He, Wei Zhang, Qi Gao, Sunita I. Park, Matthew J. Oberley, Elizabeth Ruckdeschel, Megan S. Lim, Gerald Wertheim, Matthew J. Barth, Terzah M. Horton, Bachisio Ziccheddu, Federico Abascal, Kylee H Maclachlan, Venkata D Yellapantula, Ola Landgren, Craig H. Moskowitz, Ethel Cesarman, Mikhail Roshal, Olivier Elemento, Lisa Giulino Roth
Journal: Blood
Blood (2021) 138 (Supplement 1): 805.
https://doi.org/10.1182/blood-2021-148663
Published: 2021